Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin

European Journal of Medicinal Chemistry

Volumn 71, Issue , 2014, Pages 148-159

  Yin, Ben Tao ^a   Yan, Cong Yan ^a   Peng, Xin Mei ^a   Zhang, Shao Lin ^a   Rasheed, Syed ^a   Geng, Rong Xia ^a   Zhou, Cheng He ^a  

^a SOUTHWEST UNIVERSITY   (China)

Author keywords

Antibacterial; Antifungal; Calf thymus DNA; Chalcone; Human serum albumin; Triazole

Indexed keywords

1 (2,4 DI(PIPERIDIN 1 YL)PHENYL) 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL) PROP 2 EN 1 ONE; 1 (2,4 DI(PIPERIDIN 1 YL)PHENYL) 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL)PROP-2 EN 1 ONE; 1 (2,4 DI(PYRROLIDIN 1 YL)PHENYL) 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; 1 (2,4 DIFLUOROPHENYL) 3 (4 (DIMETHYLAMINO)PHENYL) 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; 1 (2,4 DIFLUOROPHENYL) 3 (4 FLUOROPHENYL) 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; 1 (2,4 DIFLUOROPHENYL) 3 (4 METHOXYPHENYL) 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; 1 (2,4 DIFLUOROPHENYL) 3 (4 METHYLPHENYL) 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; 1 (2,4 DIFLUOROPHENYL) 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; 1 (2,4 DIMETHYLPHENYL) 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; 1 (3,4 DIMETHYLPHENYL) 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; 1 (4 FLUORO 2 (MORPHOLIN 4 YL)PHENYL) 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; 1 (4 FLUORO 2 (PIPERIDIN 1 YL)PHENYL) 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL) PROP 2 EN 1 ONE; 1 (4 FLUORO 2 (PYRROLIDIN 1 YL)PHENYL) 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL) PROP 2 EN 1 ONE; 1,3 BIS(4 CHLOROPHENYL) 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; 3 (4 CHLOROPHENYL) 1 (2,4 DIFLUOROPHENYL) 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; ALPHA TRIAZOLYL CHALCONE DERIVATIVE; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; CALF THYMUS DNA; CHALCONE DERIVATIVE; CHLOROMYCIN; DNA; FLUCONAZOLE; HUMAN SERUM ALBUMIN; IRON; MAGNESIUM ION; METAL ION; NORFLOXACIN; POTASSIUM ION; UNCLASSIFIED DRUG; 1 (2,4 DIFLUOROPHENYL) 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL) PROP 2 EN 1 ONE; 1 (2,4 DIFLUOROPHENYL) 3 [4 (DIMETHYLAMINO)PHENYL] 2 (1H 1,2,4 TRIAZOL 1YL)PROP 2 EN 1 ONE; 1 (4 CHLOROPHENYL) 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; 1 [2,4 DI(MORPHOLIN 4 YL)PHENYL] 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; 1 [2,4 DI(PIPERIDIN 1 YL)PHENYL] 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; 1 [2,4 DI(PYRROLIDIN 1 YL)PHENYL] 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; 1 [4 FLUORO 2 (MORPHOLIN 4 YL)PHENYL] 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL)PRO 2 EN 1 ONE; 1 [4 FLUORO 2 (PIPERIDIN 1 YL)PHENYL] 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; 1 [4 FLUORO 2 (PYRROLIDIN 1 YL)PHENYL] 3 PHENYL 2 (1H 1,2,4 TRIAZOL 1 YL)PROP 2 EN 1 ONE; ALPHA TRIAZOLYL CHALCONE; DRUG; IRON OXIDE; NEUTRAL RED;

ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; DNA REPLICATION; DRUG EFFICACY; DRUG INTERACTION; DRUG SCREENING; DRUG SYNTHESIS; HALF LIFE TIME; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROCOCCUS LUTEUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; ABSORPTION SPECTROSCOPY; ANTIBACTERIAL ACTIVITY; BACILLUS SUBTILIS; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CANDIDA ALBICANS; CONTROLLED STUDY; DNA DRUG COMPLEX; DRUG DNA BINDING; ESCHERICHIA COLI; FLUORESCENCE SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE; PICHIA NORVEGENSIS; PROTEUS VULGARIS; PSEUDOMONAS AERUGINOSA; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHI; STAPHYLOCOCCUS AUREUS; THERMODYNAMICS;

ANTIBACTERIAL; ANTIFUNGAL; CALF THYMUS DNA; CHALCONE; HUMAN SERUM ALBUMIN; TRIAZOLE;

ANIMALS; ANTI-INFECTIVE AGENTS; BACTERIA; BACTERIAL INFECTIONS; CATTLE; CHALCONES; DNA; FUNGI; HUMANS; MICROBIAL SENSITIVITY TESTS; MYCOSES; SERUM ALBUMIN; TRIAZOLES;

EID: 84888246755     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.11.003     Document Type: Article

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