Synthesis of novel fluconazoliums and their evaluation for antibacterial and antifungal activities

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4391-4402

  Zhang, Yi Yi ^a   Mi, Jia Li ^c   Zhou, Cheng He ^a   Zhou, Xiang Dong ^b  

^a SOUTHWEST UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c People's Hospital of Suining   (China)

Author keywords

Antibacterial; Antifungal; Fluconazole; Triazole; Triazolium

Indexed keywords

1 (2,4 DIFLUOROBENZYL) 4 [2 (NAPHTHALEN 2 YLOXY)ETHYL] 1H 1,2,4 TRIAZOL 4 IUM BROMIDE; 1,1' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIY]BIS[4 (3 CHLOROBENZYL) 1H 1,2,4 TRIAZOL 4 IUM)CHLORIDE; 1,1' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL) 4 (4 NITROBENZYL) 1H 1,2,4 TRIAZOL 4 IUM)BROMIDE; 1,1' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL)BIS[4 (2 CHLOROBENZYL) 1H 1,2,4 TRIAZOL 4 IUM)CHLORIDE; 1,1' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL)BIS[4 (2,4 DICHLOROBENZYL) 1H 1,2,4 TRIAZOL 4 IUM)HEXAFLUOROPHOSPHATEE; 1,1' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL)BIS[4 (2,4 DICHLOROBENZYL) 1H 1,2,4 TRIAZOL 4 IUM)IODIDE; 1,1' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL]BIS(4 CETYL 1H 1,2,4 TRIAZOL 4 IUM)BROMIDE; 1,1' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL]BIS(4 DODECYL 1H 1,2,4 TRIAZOL 4 IUM)BROMIDE; 1,1' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL]BIS(4 OCTYL 1H 1,2,4 TRIAZOL 4 IUM)BROMIDE; 1,1' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL]BIS[4 (2,4 DICHLOROBENZYL) 1H 1,2,4 TRIAZOL 4 IUM)CHLORIDE; 1,1' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL]BIS[4 (2,4 DIFLUOROBENZYL) 1H 1,2,4 TRIAZOL 4 IUM]BROMIDE; 1,1' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL]BIS[4 (3 METHYLBENZYL) 1H 1,2,4 TRIAZOL 4 IUM)BROMIDE; 1,1' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL]BIS[4 (4 CHLOROBENZYL) 1H 1,2,4 TRIAZOL 4 IUM]CHLORIDE; 1,1' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL]BIS[4 [2 (NAPHTHALEN 2 YLOXY)ETHYL] 1H 1,2,4 TRIAZOL 4 IUM)BROMIDE; 1,1' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL]BIS[4 [3 (4 BROMO 1,8 NAPHTHALIMIDE)PROPYL] 1H 1,2,4 TRIAZOL 4 IUM)BROMIDE; 1,1' [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL]BIS[4 [6 (4 BROMO 1,8 NAPHTHALIMIDE) HEXYL] 1H 1,2,4 TRIAZOL 4 IUM]BROMIDE; 1,10 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL]BIS(4 BUTYL 1H 1,2,4 TRIAZOL 4 IUM)BROMIDE; 1,10 [2 (2,4 DIFLUOROPHENYL) 2 HYDROXYPROPANE 1,3 DIYL]BIS[4 (3,4 DICHLOROBENZYL) 1H 1,2,4 TRIAZOL 4 IUM)CHLORIDE; 2 (2 BROMOETHOXY)NAPHTHALENE; 2 (4 BROMOPROPYL) 4 BROMO 1,8 NAPHTHALIMIDE; 2 96 BROMOHEXYL) 4 BROMO 1,8 NAPHTHALIMIDE; 2 [6 (1H 1,2,4 TRIAZOL 1 YL)HEXYL] 4 BROMO 1,8 NAPHTHALIMIDE; 4 (2,4 DICHLOROBENZYL) 1 (2,4 DIFLUOROBENZYL) 1H 1,2,4 TRIAZOL 4 IUM BROMIDE; 4 BROMO 1,8 NAPHTHALIMIDE; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; FLUCONAZOLE; NORFLOXACIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; BACILLUS CEREUS; BACTERIAL STRAIN; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; EVALUATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; PROTEUS VULGARIS; PSEUDOMONAS AERUGINOSA;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; FLUCONAZOLE; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED;

EID: 80052938876     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.010     Document Type: Article

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