ABCG5/ABCG8 in cholesterol excretion and atherosclerosis

Clinica Chimica Acta

Volumn 428, Issue , 2014, Pages 82-88

  Yu, Xiao Hua ^a   Qian, Kun ^b   Jiang, Na ^b   Zheng, Xi Long ^c   Cayabyab, Francisco S ^d   Tang, Chao Ke ^a  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b THE SECOND AFFILIATED HOSPITAL OF UNIVERSITY OF SOUTH CHINA   (China)

^c UNIVERSITY OF CALGARY   (Canada)

^d UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

ABCG5; ABCG8; Atherosclerosis; Cholesterol; Sitosterolemia

Indexed keywords

ABCG5 PROTEIN; ABCG8 PROTEIN; CARRIER PROTEIN; CHOLESTEROL; MESSENGER RNA; UNCLASSIFIED DRUG; ABC TRANSPORTER; ABCG5 PROTEIN, HUMAN; ABCG8 PROTEIN, HUMAN; LIPOPROTEIN;

ABCG5 GENE; ABCG8 GENE; ATHEROSCLEROSIS; AUTOSOMAL RECESSIVE DISORDER; BIOACCUMULATION; CHOLESTEROL METABOLISM; DISEASE ACTIVITY; DISEASE COURSE; GENE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENETIC POLYMORPHISM; HUMAN; LIPID ANALYSIS; LIPID TRANSPORT; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW; SITOSTEROLEMIA; UPREGULATION; ANIMAL; METABOLISM;

MAMMALIA; MUS;

ANIMALS; ATHEROSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; CHOLESTEROL; HUMANS; LIPOPROTEINS;

EID: 84888226567     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2013.11.010     Document Type: Review

References (69)

1. Barton M. Cholesterol and atherosclerosis: modulation by oestrogen. Curr Opin Lipidol 2013, 24:214-220.
2. Kihara S. Dyslipidemia. Nihon Rinsho 2013, 71:275-279.
3. Wellington C.L. Cholesterol at the crossroads: Alzheimer's disease and lipid metabolism. Clin Genet 2004, 66:1-16.
4. Robichon C., Dugail I. De novo cholesterol synthesis at the crossroads of adaptive response to extracellular stress through SREBP. Biochimie 2007, 89:260-264.
5. Wang L.J., Song B.L. Niemann-Pick C1-Like 1 and cholesterol uptake. Biochim Biophys Acta 1821, 2012:964-972.
6. Brown J.M., Yu L. Opposing gatekeepers of apical sterol transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-binding cassette transporters G5 and G8 (ABCG5/ABCG8). Immunol Endocr Metab Agents Med Chem 2009, 9:18-29.
7. Brown J.M., Yu L. Protein mediators of sterol transport across intestinal brush border membrane. Subcell Biochem 2010, 51:337-380.
8. Calandra S., Tarugi P., Speedy H.E., et al. Mechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease risk. J Lipid Res 2011, 52:1885-1926.
9. Dikkers A., Tietge U.J. Biliary cholesterol secretion: more than a simple ABC. World J Gastroenterol 2010, 16:5936-5945.
10. Sabeva N.S., Rouse E.J., Graf G.A. Defects in the leptin axis reduce abundance of the ABCG5-ABCG8 sterol transporter in liver. J Biol Chem 2007, 282:22397-22405.
11. Okiyoneda T., Kono T., Niibori A., et al. Calreticulin facilitates the cell surface expression of ABCG5/G8. Biochem Biophys Res Commun 2006, 347:67-75.
12. Graf G.A., Li W.P., Gerard R.D., et al. Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. J Clin Invest 2002, 110:659-669.
13. Hirata T., Okabe M., Kobayashi A., et al. Molecular mechanisms of subcellular localization of ABCG5 and ABCG8. Biosci Biotechnol Biochem 2009, 73:619-626.
14. Graf G.A., Cohen J.C., Hobbs H.H. Missense mutations in ABCG5 and ABCG8 disrupt heterodimerization and trafficking. J Biol Chem 2004, 279:24881-24888.
15. Zhang D.W., Graf G.A., Gerard R.D., et al. Functional asymmetry of nucleotide-binding domains in ABCG5 and ABCG8. J Biol Chem 2006, 281:4507-4516.
16. Wang J., Grishin N., Kinch L., et al. Sequences in the nonconsensus nucleotide-binding domain of ABCG5/ABCG8 required for sterol transport. J Biol Chem 2011, 286:7308-7314.
17. Yu L., Hammer R.E., Li-Hawkins J., et al. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci U S A 2002, 99:16237-16242.
18. Plosch T., Bloks V.W., Terasawa Y., et al. Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor. Gastroenterology 2004, 126:290-300.
19. Wang H.H., Patel S.B., Carey M.C., et al. Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion in Abcg8(-/-) mice. Hepatology 2007, 45:998-1006.
20. Yu L., Li-Hawkins J., Hammer R.E., et al. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest 2002, 110:671-680.
21. Coy D.J., Wooton-Kee C.R., Yan B., et al. ABCG5/ABCG8-independent biliary cholesterol excretion in lactating rats. Am J Physiol Gastrointest Liver Physiol 2010, 299:G228-G235.
22. Groen A., Kunne C., Jongsma G., et al. Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice. Gastroenterology 2008, 134:2091-2100.
23. Vrins C., Vink E., Vandenberghe K.E., et al. The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux. FEBS Lett 2007, 581:4616-4620.
24. Langheim S., Yu L., von Bergmann K., et al. ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile. J Lipid Res 2005, 46:1732-1738.
25. Duan L.P., Wang H.H., Wang D.Q. Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice. J Lipid Res 2004, 45:1312-1323.
26. Wu T., Fu J., Yang Y., et al. The effects of phytosterols/stanols on blood lipid profiles: a systematic review with meta-analysis. Asia Pac J Clin Nutr 2009, 18:179-186.
27. Brufau G., Kuipers F., Lin Y., et al. A reappraisal of the mechanism by which plant sterols promote neutral sterol loss in mice. PLoS One 2011, 6:e21576.
28. Renner O., Lutjohann D., Richter D., et al. Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease. BMC Gastroenterol 2013, 13:1-11.
29. Wei K.K., Zhang L.R., Zhang Y., et al. Interactions between CYP7A1 A-204C and ABCG8 C1199A polymorphisms on lipid lowering with atorvastatin. J Clin Pharm Ther 2011, 36:725-733.
30. Miwa K., Inazu A., Kobayashi J., et al. ATP-binding cassette transporter G8 M429V polymorphism as a novel genetic marker of higher cholesterol absorption in hypercholesterolaemic Japanese subjects. Clin Sci (Lond) 2005, 109:183-188.
31. Koeijvoets K.C., van der Net J.B., Dallinga-Thie G.M., et al. ABCG8 gene polymorphisms, plasma cholesterol concentrations, and risk of cardiovascular disease in familial hypercholesterolemia. Atherosclerosis 2009, 204:453-458.
32. Garcia-Rios A., Perez-Martinez P., Fuentes F., et al. Genetic variations at ABCG5/G8 genes modulate plasma lipids concentrations in patients with familial hypercholesterolemia. Atherosclerosis 2010, 210:486-492.
33. Caamano J.M., Pacheco A., Lanas F., et al. Single nucleotide polymorphisms in ABCG5 and ABCG8 genes in Chilean subjects with polygenic hypercholesterolemia and controls. Clin Chem Lab Med 2008, 46:1581-1585.
34. Yoon J.H., Choi H.S., Jun D.W., et al. ATP-binding cassette sterol transporters are differentially expressed in normal and diseased human gallbladder. Dig Dis Sci 2013, 58:431-439.
35. Gonzalez-Granillo M., Steffensen K.R., Granados O., et al. Soy protein isoflavones differentially regulate liver X receptor isoforms to modulate lipid metabolism and cholesterol transport in the liver and intestine in mice. Diabetologia 2012, 55:2469-2478.
36. Calpe-Berdiel L., Rotllan N., Fievet C., et al. Liver X receptor-mediated activation of reverse cholesterol transport from macrophages to feces in vivo requires ABCG5/G8. J Lipid Res 2008, 49:1904-1911.
37. van der Veen J.N., Havinga R., Bloks V.W., et al. Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor alpha. J Lipid Res 2007, 48:337-347.
38. Back S.S., Kim J., Choi D., et al. Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor. BMB Rep 2013, 46:322-327.
39. Bonde Y., Plosch T., Kuipers F., et al. Stimulation of murine biliary cholesterol secretion by thyroid hormone is dependent on a functional ABCG5/G8 complex. Hepatology 2012, 56:1828-1837.
40. Sumi K., Tanaka T., Uchida A., et al. Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8. Mol Cell Biol 2007, 27:4248-4260.
41. Kim E.H., Bae J.S., Hahm K.B., et al. Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease. Biochem Pharmacol 2012, 84:1359-1365.
42. de Souza M.O., Souza E.S.L., de Brito Magalhaes C.L., et al. The hypocholesterolemic activity of acai (Euterpe oleracea Mart.) is mediated by the enhanced expression of the ATP-binding cassette, subfamily G transporters 5 and 8 and low-density lipoprotein receptor genes in the rat. Nutr Res 2012, 32:976-984.
43. Takahashi Y. Soy protein and fish oil independently decrease serum lipid concentrations but interactively reduce hepatic enzymatic activity and gene expression involved in fatty acid synthesis in rats. J Nutr Sci Vitaminol (Tokyo) 2011, 57:56-64.
44. Tremblay A.J., Lamarche B., Lemelin V., et al. Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men. J Lipid Res 2011, 52:558-565.
45. Lodowska J., Wolny D., Weglarz L. The sugar 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) as a characteristic component of bacterial endotoxin - a review of its biosynthesis, function, and placement in the lipopolysaccharide core. Can J Microbiol 2013, 59:645-655.
46. Khovidhunkit W., Moser A.H., Shigenaga J.K., et al. Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR. J Lipid Res 2003, 44:1728-1736.
47. Yamazaki Y., Hashizume T., Morioka H., et al. Diet-induced lipid accumulation in liver enhances ATP-binding cassette transporter g5/g8 expression in bile canaliculi. Drug Metab Pharmacokinet 2011, 26:442-450.
48. Kim B., Park Y., Wegner C.J., et al. Polyphenol-rich black chokeberry (Aronia melanocarpa) extract regulates the expression of genes critical for intestinal cholesterol flux in Caco-2 cells. J Nutr Biochem 2013, 24:1564-1570.
49. Liu S., Tetzlaff M.T., Cui R., et al. miR-200c inhibits melanoma progression and drug resistance through down-regulation of BMI-1. Am J Pathol 2012, 181:1823-1835.
50. Salen G., Patel S., Batta A.K. Sitosterolemia. Cardiovasc Drug Rev 2002, 20:255-270.
51. Kanaji T., Kanaji S., Montgomery R.R., et al. Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia. Blood 2013, 122:2732-2742.
52. Berge K.E., Tian H., Graf G.A., et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 2000, 290:1771-1775.
53. Tsubakio-Yamamoto K., Nishida M., Nakagawa-Toyama Y., et al. Current therapy for patients with sitosterolemia-effect of ezetimibe on plant sterol metabolism. J Atheroscler Thromb 2010, 17:891-900.
54. Tang W., Ma Y., Jia L., et al. Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8. J Lipid Res 2009, 50:293-300.
55. Salen G., von Bergmann K., Lutjohann D., et al. Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia. Circulation 2004, 109:966-971.
56. Lutjohann D., von Bergmann K., Sirah W., et al. Long-term efficacy and safety of ezetimibe 10mg in patients with homozygous sitosterolemia: a 2-year, open-label extension study. Int J Clin Pract 2008, 62:1499-1510.
57. Wilund K.R., Yu L., Xu F., et al. High-level expression of ABCG5 and ABCG8 attenuates diet-induced hypercholesterolemia and atherosclerosis in Ldlr-/- mice. J Lipid Res 2004, 45:1429-1436.
58. Wei J., Ching L.C., Zhao J.F., et al. Essential role of transient receptor potential vanilloid type 1 in evodiamine-mediated protection against atherosclerosis. Acta Physiol (Oxf) 2013, 207:299-307.
59. Li X., Schulte P., Godin D.V., et al. Differential mRNA expression of seven genes involved in cholesterol metabolism and transport in the liver of atherosclerosis-susceptible and -resistant Japanese quail strains. Genet Sel Evol 2012, 44:20.
60. McGillicuddy F.C., de la Llera Moya M., Hinkle C.C., et al. Inflammation impairs reverse cholesterol transport in vivo. Circulation 2009, 119:1135-1145.
61. Ikewaki K., Nakada Y., Inoue Y. Sitosterolemia. Nihon Rinsho 2007, 65:371-374.
62. Xu J., Zhou X., Deng Q., et al. Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet. Lipids Health Dis 2011, 10:96.
63. Horenstein R.B., Mitchell B.D., Post W.S., et al. The ABCG8 G574R variant, serum plant sterol levels, and cardiovascular disease risk in the Old Order Amish. Arterioscler Thromb Vasc Biol 2013, 33:413-419.
64. Wilund K.R., Yu L., Xu F., et al. No association between plasma levels of plant sterols and atherosclerosis in mice and men. Arterioscler Thromb Vasc Biol 2004, 24:2326-2332.
65. Singh V., Jain M., Misra A., et al. Curcuma oil ameliorates hyperlipidaemia and associated deleterious effects in golden Syrian hamsters. Br J Nutr 2013, 110:437-446.
66. Ji W., Guo L., Lian J., et al. Hypolipidaemic mechanisms of action of CM108 (a flavone derivative) in hyperlipidaemic rats. J Pharm Pharmacol 2008, 60:1207-1212.
67. Ji W., Gong B.Q. Hypolipidemic effects and mechanisms of Panax notoginseng on lipid profile in hyperlipidemic rats. J Ethnopharmacol 2007, 113:318-324.
68. Wu J.E., Basso F., Shamburek R.D., et al. Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice. J Biol Chem 2004, 279:22913-22925.
69. Basso F., Freeman L.A., Ko C., et al. Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited. J Lipid Res 2007, 48:114-126.