The development of an in vitro assay to screen lipid based nanoparticles for siRNA delivery

Journal of Controlled Release

Volumn 174, Issue 1, 2014, Pages 7-14

  Zhang, Ye ^a   Arrington, Leticia ^a   Boardman, David ^a   Davis, Jared ^a   Xu, Yan ^a   Difelice, Katie ^a   Stirdivant, Steve ^a   Wang, Weimin ^a   Budzik, Brian ^a   Bawiec, Jack ^a   Deng, James ^a   Beutner, Greg ^a   Seifried, Darla ^a   Stanton, Matthew ^a   Gindy, Marian ^a   Leone, Anthony ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Endosome escape; Lipid nanoparticles; Serum stability; siRNA delivery; siRNA release

Indexed keywords

ENDOSOMES; LIPID NANOPARTICLES; SERUM STABILITY; SIRNA DELIVERY; SIRNA RELEASE;

BODY FLUIDS; LIPIDS; PH; RNA;

NANOPARTICLES;

CHOLESTEROL; GOLD; LIPID; LIPID NANOPARTICLE; MEMBRANE LIPID; NANOPARTICLE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG RELEASE; ENDOSOME; FEMALE; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; LIPOSOMAL GENE DELIVERY SYSTEM; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SPECTROPHOTOMETRY; TEMPERATURE;

ENDOSOME ESCAPE; LIPID NANOPARTICLES; SERUM STABILITY; SIRNA DELIVERY; SIRNA RELEASE;

ANIMALS; APOLIPOPROTEINS B; BIOLOGICAL ASSAY; ENDOSOMES; FEMALE; HYDROGEN-ION CONCENTRATION; LIPIDS; LIPOSOMES; LIVER; MACACA MULATTA; MICE; NANOPARTICLES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; RNA, SMALL INTERFERING; SERUM;

EID: 84888188837     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.11.006     Document Type: Article

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