Decreased binding affinity of apolipoprotein E plays an important role in the reduced hepatic clearance of Lipid Nano-Sphere (LNS)

Journal of Drug Delivery Science and Technology

Volumn 14, Issue 3, 2004, Pages 173-179

  Seki, J ^a   Sonoke, S ^a   Saheki, A ^a   Fukui, H ^a   Mayumi, T ^b  

^a NIPPON SHINYAKU CO LTD   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Apo E; Hepatic uptake; Lactoferrin; Lipid nanoparticle; LNS

Indexed keywords

APOLIPOPROTEIN E; LACTOFERRIN; LIPID; NANOPARTICLE;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DISSOCIATION CONSTANT; EMULSION; HALF LIFE TIME; LIVER CELL; LIVER CLEARANCE; MALE; NONHUMAN; PARTICLE SIZE; PROTEIN BINDING; RAT;

EID: 2942737329     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1773-2247(04)50097-7     Document Type: Article

References (30)

1. MIZUSHIMA Y., HAMANO Y., YOKOYAMA K. - Tissue distribution and anti-inflammatory activity of corticosteroids incorporated in lipid emulsion. - Ann. Rehum. Dis., 41, 263-267, 1982.
2. MIZUSHIMA Y. - Lipid microsphere (lipid emulsions) as a drug carrier-An overview. - Adv. Drug Deliv. Rev., 20, 113-115, 1996.
3. YOKOYAMA K., WATANABE M. - Limethason as a lipid microsphere preparation: an overview. - Adv. Drug Deliv. Rev., 20, 195-201, 1996.
4. SEKI J., SASAKI H., DOI M., YOSHIKAWA H., TAKAHASHI Y., YAMANE S., FUKUI H., SONOKE S., YAMAMOTO H., HIROSE M., EZURE Y., ANDO T., USHIMARU K., SUGIYAMA M. - Lipid nano-sphere (LNS), a protein-free analogue of lipoproteins, as a novel drug carrier for parenteral administration. IV. - J. Controlled Release, 28, 352-353, 1994.
5. SUGIYAMA M., OKITA A., SEKI J. - Drug Carriers. - United States Patent #5,651,991, 1997.
6. FUKUI H., KOIKE T., SAHEKI A., SONOKE S., SEKI J. - A novel delivery system for amphotericin B with lipid nano-sphere (LNS). - Int. J. Pharm., 265, 37-45, 2003.
7. FUKUI H., KOIKE T., SAHEKI A., SONOKE S., TOMII Y., SEKI J. - Evaluation of the efficacy and toxicity of amphotericin B incorporated in lipid nano-sphere (LNS). - Int. J. Pharm., 263, 51-60, 2003.
8. FUKUI H., KOIKE T., NAKAGAWA T., SAHEKI A., SONOKE S., TOMII Y., SEKI J. - Comparison of LNS-AmB, a novel low-dose formulation of amphotericin B with lipid nano-sphere(LNS), with commercial lipid-based formulations. - Int. J. Pharm., 267, 101-112, 2003.
9. SEKI J., SONOKE S., SAHEKI A., FUKUI H., SASAKI H., MAYUMI T. - A nanometer lipid emulsion, Lipid Nano-Sphere (LNS), as a parenteral drug carrier for passive drug targeting. - Int. J. Pharm., 273, 75-83, 2004.
10. SEKI J., YAMAMOTO H., YAMANE S., TAKAHASHI Y., USHIMARU K. - Lyophilized fatty emulsions and a process for the production thereof. - United States Patent #5,635,491, 1997.
11. CONNELLY P.W., KUKSIS A. - Effect of core composition and particle size of lipid emulsions on apolipoprotein transfer of plasma lipoproteins in vivo. - Biochim. Biophys. Acta, 666, 80-89, 1981.
12. MAHLEY R.W. - Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. - Science, 240, 622-630, 1988.
13. RENSEN P.C.N., HERIJGERS N., NETSCHER M. H., MESKERS S.C.J., VAN ECK M., VAN BERKEL T.J.C. - Particle size determines the specificity of apolipoprotein E-containing triglyceride-rich emulsions for the LDL receptor versus hepatic remnant receptor in vivo. - J. Lipid Res., 38, 1070-1084, 1997.
14. MORITA S., OKUHIRA K., TSUCHIMOTO N., VERTUT-DOÏ A., SAITO H., NAKANO M., HANDA T. - Effects of sphingomyelin on apolipoprotein E- and lipoprotein lipase-mediated cell uptake of lipid partiles. - Biochim. Biophys. Acta, 1631, 169-176, 2003.
15. HANDA T. - Stubility and plasma apolipoprotein binding of lipid emulsions. - Food Hydrocolloids, 15, 277-283, 2001.
16. BEISIEGEL U., WEBER W., IHRKE G., HERZ J., STANLEY K.K. - The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. - Nature, 341, 162-164, 1989.
17. IRIYAMA K. - The metabolic distinctiveness of emulsified lipid particles in the bloodstream and its clinical implications. - Surg. Today, 26, 673-678, 1996.
18. SAHEKI A., SEKI J. - Method of producing emulsions and an emulsification apparatus. - United States Patent #5,843,334, 1998.
19. ZHANG X., KIRSCH L.E. - An assessment of techniques for evaluating the physical stability of parenteral emulsions. - PDA J. Pharm. Sci. Tech., 57, 300-315, 2003.
20. FUKUI H., KOIKE T., SAHEKI A., SONOKE S., SEKI J. - A novel delivery system for amphotericin B with lipid nano-sphere (LNS). - Int. J. Pharm., 265, 37-45, 2003.
21. HUETTINGER M., RETZEK H., EDER M., GOLDENBERG H. - Characteristics of chylomicron remnant uptake into rat liver. - Clin. Biochem., 21, 87-92, 1988.
22. TAKINO T., KONISHI K., TAKAKURA Y., HASHIDA M. - Long circulating emulsion carrier systems for highly lipophilic drugs. - Biol. Pharm. Bull., 17, 121-125, 1994.
23. SEKI J., SONOKE S., SAHEKI A., FUKUI H., MAYUMI T. - Lipid transfer protein in plasma plays a key role in dissociation of compounds from lipid emulsion particles as a parenteral drug carrier. - Int. J. Pharm., 275, 239-248, 2004.
24. VAN DIJK M.C.M., ZIERE G.J., BOERS W.B., LINTHORST C., BIJSTERBOSCH M.K. - Recognition of chylomicron remnants and beta-migrating very-low-density lipoproteins by the remnant receptor of parenchymal liver cells is distinct from the liver alpha-2-macroglobulin-recognition site. - Biochem. J., 279, 863-870, 1991.
25. ARIMOTO I., MATSUMOTO C., TANAKA M., OKUHIRA K., SAITO H., HANDA T. - Surface composition regulates clearance from plasma and triolein lipolysis of lipid emulsions. - Lipids, 33, 773-779, 1998.
26. NILSSON A., EHNHOLM C., FLOREN C.H. - Uptake and degradation of rat chylomicron remnants, produced in vivo and in vitro, in rat hepatocyte monolayers. - Biochim. Biophys. Acta 633, 408-420, 1981.
27. YAMAMOTO M., MORITA S., KUMON M., KAWABE M., NISHITSUJI K., SAITO H., VERTUT-DOÏ A., NAKANO M., HANDA T. - Effects of plasma apolipoproteins on lipoprotein lipase-mediated lipolysis of small and large lipid emulsions. - Biochim. Biophys. Acta, 1632, 31-39, 2003.
28. SAITO H., DHANASEKARAN P., BALDWIN F., WEISGRABER K.H., LUND-KATZ S., PHILIPS M.C. - Lipid binding-induced conformational change in human apolipoprotein E. Evidence for two lipid-bound states on spherical particles. - J. Biol. Chem., 276, 40949-40954, 2001.
29. SEKI J., SAHEKI A., SONOKE S., FUKUI H., MAYUMI T. - Decreased binding affinity of apolipoprotein C-II to lipid nano-sphere (LNS) plays an important role in their prolonged plasma half-lives and reduced hemolytic activity. - J. Drug Del. Sci. Tech., in press.
30. HARASHIMA H., SAKATA K., FUNATO K., KIWADA H. - Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes. - Pharm. Res., 11, 402-406, 1994.