Berberine acts as a natural inhibitor of Wnt/β-catenin signaling-Identification of more active 13-arylalkyl derivatives

BioFactors

Volumn 39, Issue 6, 2013, Pages 652-662

  Albring, Kai Frederik ^a   Weidemüller, Julia ^a   Mittag, Sonnhild ^a   Weiske, Jörg ^b,d   Friedrich, Karlheinz ^a   Geroni, M Cristina ^c   Lombardi, Paolo ^c   Huber, Otmar ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c Naxospharma Srl   (Italy)

^d BAYER PHARMA AG   (Germany)

Author keywords

catenin; Berberine; Colorectal cancer; E cadherin; Isoquinoline alkaloid; Phytochemicals; Plant micronutrient; Wnt

Indexed keywords

13 ARYLALKYL DERIVATIVE; ALKYL GROUP; ANTINEOPLASTIC AGENT; BERBERINE DERIVATIVE; BETA CATENIN; CYCLIN D1; UNCLASSIFIED DRUG; UVOMORULIN; WNT PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HCT116; CELL STRAIN HEK293; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSIENT TRANSFECTION; WESTERN BLOTTING; WNT BETA CATENIN PATHWAY;

BERBERINE; COLORECTAL CANCER; E-CADHERIN; ISOQUINOLINE ALKALOID; PHYTOCHEMICALS; PLANT MICRONUTRIENT; WNT; Β-CATENIN;

ANTINEOPLASTIC AGENTS; BERBERINE; BETA CATENIN; CADHERINS; CELL PROLIFERATION; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; WNT SIGNALING PATHWAY;

EID: 84888134699     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1133     Document Type: Article

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