Agaricus blazei murill - Immunomodulatory properties and health benefits

Functional Foods in Health and Disease

Volumn 2, Issue 11, 2012, Pages 428-447

  Biedron, R ^a,b   Tangen, J M ^c   Maresz, K ^a   Hetland, G ^d  

^a International Science and Health Foundation   (Poland)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^c Departmentts of Hematology ^*

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Agaricus blazei; Allergy; AndoSanTM; Asthma; Cancer; Immunomodulation; Infection; Inflammation

Indexed keywords

EID: 84888110987     PISSN: 23787007     EISSN: 21603855     Source Type: Journal    
DOI: 10.31989/ffhd.v2i11.72     Document Type: Review

References (82)

1. Mizuno T. Shiitake, Lentinus edodes. Functional properties for medicinal and food purposes. Food Reviews International 1995; 11:109-128.
2. Dias EqS, Abe C, Schwan RF. Truths and myths about the mushroom Agaricus blazei. Scientia Agricola 2004; 61:545-549.
3. Fujimiya Y, Suzuki Y, Katakura R, Ebina T. Tumor-specific cytocidal and immunopotentiating effects of relatively low molecular weight products derived from the basidiomycete, Agaricus blazei Murill. Anticancer Res 1999; 19:113-118.
4. Ebina T, Fujimiya Y. Antitumor effect of a peptide-glucan preparation extracted from Agaricus blazei in a double-grafted tumor system in mice. Biotherapy 1998; 11:259-265.
5. Gonzaga ML, Bezerra DP, Alves AP, de Alencar NM, Mesquita RO, Lima MW, Soares SA, Pessoa C, de Moraes MO, Costa-Lotufo LV. In vivo growth-inhibition of Sarcoma 180 by an alpha-(1->4)-glucan-beta-(1->6)-glucan-protein complex polysaccharide obtained from Agaricus blazei Murill. Nat Med(Tokyo) 2009; 63:32-40.
6. Gu Y, Fujimiya Y, Itokawa Y, Oshima M, Choi JS, Miura T, Ishida T. Tumoricidal effects of beta-glucans: mechanisms include both antioxidant activity plus enhanced systemic and topical immunity. Nutr Cancer 2008; 60:685-691.
7. Kawagishi H, Inagaki R, Kanao T, Mizuno T, Shimura K, Ito H, Hagiwara T, Nakamura T. Fractionation and antitumor activity of the water-insoluble residue of Agaricus blazei fruiting bodies. Carbohydr Res 1989; 186:267-273.
8. Ohno N, Furukawa M, Miura NN, Adachi Y, Motoi M, Yadomae T. Antitumor beta glucan from the cultured fruit body of Agaricus blazei. Biol Pharm Bull 2001; 24:820-828.
9. Yu CH, Kan SF, Shu CH, Lu TJ, Sun-Hwang L, Wang PS. Inhibitory mechanisms of Agaricus blazei Murill on the growth of prostate cancer in vitro and in vivo 2. J Nutr Biochem 2008.
10. Fujimiya Y, Suzuki Y, Oshiman K, Kobori H, Moriguchi K, Nakashima H, Matumoto Y, Takahara S, Ebina T, Katakura R. Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis. Cancer Immunol Immunother 1998; 46:147-159.
11. Grinde B, Hetland G, Johnson E. Effects on gene expression and viral load of a medicinal extract from Agaricus blazei in patients with chronic hepatitis C infection. Int Immunopharmacol 2006; 6:1311-1314.
12. Hsu CH, Hwang KC, Chiang YH, Chou P. The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B. J Altern Complement Med 2008; 14:299-301.
13. Ellertsen LK, Hetland G. An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy. Clin Mol Allergy 2009; 7:6.
14. Takimoto H, Kato H, Kaneko M, Kumazawa Y. Amelioration of skewed Th1/Th2 balance in tumor-bearing and asthma-induced mice by oral administration of Agaricus blazei extracts. Immunopharmacol Immunotoxicol 2008; 30:747-760.
15. Mizuno M, Morimoto M, Minato K, Tsuchida H. Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. Biosci Biotechnol Biochem 1998; 62:434-437.
16. Mizuno M, Minato K, Ito H, Kawade M, Terai H, Tsuchida H. Anti-tumor polysaccharide from the mycelium of liquid-cultured Agaricus blazei mill. Biochem Mol Biol Int 1999; 47:707-714.
17. Itoh H, Ito H, Amano H, Noda H. Inhibitory action of a (1->6)-beta-D-glucan-protein complex (F III-2-b) isolated from Agaricus blazei Murill ("himematsutake") on Meth A fibrosarcoma-bearing mice and its antitumor mechanism. Jpn J Pharmacol 1994; 66:265-271.
18. Ito H, Shimura K, Itoh H, Kawade M. Antitumor effects of a new polysaccharide-protein complex (ATOM) prepared from Agaricus blazei (Iwade strain 101) "Himematsutake" and its mechanisms in tumor-bearing mice. Anticancer Res 1997; 17:277-284.
19. Oshiman K, Fujimiya Y, Ebina T, Suzuki I, Noji M. Orally administered beta-1,6-Dpolyglucose extracted from Agaricus blazei results in tumor regression in tumor-bearing mice. Planta Med 2002; 68:610-614.
20. Bernardshaw S, Johnson E, Hetland G. An extract of the mushroom Agaricus blazei Murill administered orally protects against systemic Streptococcus pneumoniae infection in mice. Scand J Immunol 2005; 62:393-398.
21. Bernardshaw S, Hetland G, Grinde B, Johnson E. An extract of the mushroom Agaricus blazei Murill protects against lethal septicemia in a mouse model of fecal peritonitis. Shock 2006; 25:420-425.
22. Faccin LC, Benati F, Rincao VP, Mantovani MS, Soares SA, Gonzaga ML, Nozawa C, Carvalho Linhares RE. Antiviral activity of aqueous and ethanol extracts and of an isolated polysaccharide from Agaricus brasiliensis against poliovirus type 1. Lett Appl Microbiol 2007; 45:24-28.
23. Martins PR, Gameiro MC, Castoldi L, Romagnoli GG, Lopes FC, Pinto AV, Loyola W, Kaneno R. Polysaccharide-rich fraction of Agaricus brasiliensis enhances the candidacidal activity of murine macrophages. Mem Inst Oswaldo Cruz 2008; 103:244-250.
24. Forland DT, Johnson E, Tryggestad AM, Lyberg T, Hetland G. An extract based on the medicinal mushroom Agaricus blazei Murill stimulates monocyte-derived dendritic cells to cytokine and chemokine production in vitro. Cytokine 2010; 49:245-250.
25. Kim GY, Lee MY, Lee HJ, Moon DO, Lee CM, Jin CY, Choi YH, Jeong YK, Chung KT, Lee JY, Choi IH, Park YM. Effect of water-soluble proteoglycan isolated from Agaricus blazei on the maturation of murine bone marrow-derived dendritic cells. Int Immunopharmacol 2005; 5:1523-1532.
26. Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP. Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer 2004; 14:589-594.
27. Barton GM. A calculated response: control of inflammation by the innate immune system. J Clin Invest 2008; 118:413-420.
28. Medzhitov R, Janeway CA, Jr.. Innate immunity: impact on the adaptive immune response. Curr Opin Immunol 1997; 9:4-9.
29. Rot A, von Andrian UH. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 2004; 22:891-928.
30. Kurtz J. Memory in the innate and adaptive immune systems. Microbes Infect 2004; 6:1410-1417.
31. Barra NG, Gillgrass A, Ashkar AA. Effective control of viral infections by the adaptive immune system requires assistance from innate immunity. Expert Rev Vaccines 2010; 9:1143-1147.
32. Galli G, Nuti S, Tavarini S, Galli-Stampino L, De Lalla C, Casorati G, Dellabona P, Abrignani S. Innate immune responses support adaptive immunity: NKT cells induce B cell activation. Vaccine 2003; 21 (Suppl 2):48-54.
33. Liu YJ. Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell 2001; 106:259-262.
34. Das A, Maini MK. Innate and adaptive immune responses in hepatitis B virus infection. Dig Dis 2010; 28:126-132.
35. Benson RA, Patakas A, Conigliaro P, Rush CM, Garside P, McInnes IB, Brewer JM. Identifying the cells breaching self-tolerance in autoimmunity. J Immunol 2010; 184:6378-6385.
36. Thomas R. The balancing act of autoimmunity: central and peripheral tolerance versus infection control. Int Rev Immunol 2010; 29:211-233.
37. Chatila TA. Regulatory T cells: key players in tolerance and autoimmunity. Endocrinol Metab Clin North Am 2009; 38:265-272.
38. Pelanda R, Piccirillo CA. Tolerance, immune regulation, and autoimmunity: cells and cytokines that make a difference. Curr Opin Immunol 2008; 20:629-631.
39. Ooi VE, Liu F. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Curr Med Chem 2000; 7:715-729.
40. Takaku T, Kimura Y, Okuda H. Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. J Nutr 2001; 131:1409-1413.
41. Forland DT, Johnson E, Saetre L, Lyberg T, Lygren I, Hetland G. Effect of an Extract Based on the Medicinal Mushroom Agaricus blazei Murill on Expression of Cytokines and Calprotectin in Patients with Ulcerative Colitis and Crohn's disease. Scand J Immunol 2011; 73:66-75.
42. Chihara G. Recent progress in immunopharmacology and therapeutic effects of polysaccharides. Dev Biol Stand 1992; 77:191-197.
43. Weitberg AB. A phase I/II trial of beta-(1,3)/(1,6) D-glucan in the treatment of patients with advanced malignancies receiving chemotherapy. J Exp Clin Cancer Res 2008; 27:40.
44. Adachi Y, Okazaki M, Ohno N, Yadomae T. Enhancement of cytokine production by macrophages stimulated with (1->3)-beta-D-glucan, grifolan (GRN), isolated from Grifola frondosa. Biol Pharm Bull 1994; 17:1554-1560.
45. Amino M, Noguchi R, Yata J, Matsumura J, Hirayama R, Abe O, Enomoto K, Asato Y. [Studies on the effect of lentinan on human immune system. II. In vivo effect on NK activity, MLR induced killer activity and PHA induced blastic response of lymphocytes in cancer patients]. Gan To Kagaku Ryoho 1983; 10:2000-2006.
46. Bogwald J, Johnson E, Seljelid R. The cytotoxic effect of mouse macrophages stimulated in vitro by a beta-1,3-D-glucan from yeast cell walls. Scand J Immunol 1982; 15:297-304.
47. Czop JK, Austen KF. Properties of glycans that activate the human alternative complement pathway and interact with the human monocyte beta-glucan receptor. J Immunol 1985; 135:3388-3393.
48. Vetvicka V, Thornton BP, Ross GD. Soluble beta-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3bopsonized target cells. J Clin Invest 1996; 98:50-61.
49. Akramiene D, Kondrotas A, Didziapetriene J, Kevelaitis E. Effects of beta-glucans on the immune system. Medicina (Kaunas) 2007; 43:597-606.
50. Chan GC, Chan WK, Sze DM. The effects of beta-glucan on human immune and cancer cells. J Hematol Oncol 2009; 2:25.
51. Kawamura M, Kasai H, He L, Deng X, Yamashita A, Terunuma H, Horiuchi I, Tanabe F, Ito M. Antithetical effects of hemicellulase-treated Agaricus blazei on the maturation of murine bone-marrow-derived dendritic cells. Immunology 2005; 114:397-409.
52. Hetland G, Johnson E, Lyberg T, Bernardshaw S, Tryggestad AMA, Grinde B. Effects of the medicinal mushroom Agaricus blazei murill on immunity, infection and cancer. Scand J Immunol 2008; 68:363-370.
53. Levitz SM. Interactions of Toll-like receptors with fungi. Microbes Infect 2004; 6:1351-1355.
54. Kennedy AD, Willment JA, Dorward DW, Williams DL, Brown GD, DeLeo FR. Dectin-1 promotes fungicidal activity of human neutrophils. Eur J Immunol 2007; 37:467-478.
55. Ohno N, Egawa Y, Hashimoto T, Adachi Y, Yadomae T. Effect of beta-glucans on the nitric oxide synthesis by peritoneal macrophage in mice. Biol Pharm Bull 1996; 19:608-612.
56. Shimizu S, Kitada H, Yokota H, Yamakawa J, Murayama T, Sugiyama K, Izumi H, Yamaguchi N. Activation of the alternative complement pathway by Agaricus blazei Murill. Phytomedicine 2002; 9:536-545.
57. Anand P, Kunnumakara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB. Cancer is a Preventable Disease that Requires Major Lifestyle Changes. Pharmaceutical Research 2008; 25:2097-2116.
58. Kobayashi H, Yoshida R, Kanada Y, Fukuda Y, Yagyu T, Inagaki K, Kondo T, Kurita N, Suzuki M, Kanayama N, Terao T. Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model. J Cancer Res Clin Oncol 2005; 131:527-538.
59. Kimura Y, Kido T, Takaku T, Sumiyoshi M, Baba K. Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions. Cancer Sci 2004; 95:758-764.
60. Tian X, Lun Z, Ito J. Clinical observation on treatment of acute non lymphocytic leukemia with Agaricus blazei. Lanzhou Med Coll 1994; 20:169-171.
61. Mukai H, Watanabe T, Ando M, Katsumato N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Japanese Journal of Clinical Oncology 2006; 36:808-810.
62. Jiang J, Sliva D. Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells. International Journal of Oncology 2010; 37:1529-1536.
63. Becker N. Epidemiology of multiple myeloma. Recent results in cancer research 2011; 183:25-35.
64. Johnson E, Forland DT, Saetre L, Bernardshaw SV, Lyberg T, Hetland G. Effect of an extract based on the medicinal mushroom Agaricus blazei murill on release of cytokines, chemokines and leukocyte growth factors in human blood ex vivo and in vivo. Scand J Immunol 2009; 69:242-250.
65. Mowat AM. Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 2003; 3:331-341.
66. Firenzuoli F, Gori L, Lombardo G. The medicinal mushroom Agaricus blazei Murrill: Review of literature and pharmaco-toxicological problems. Evidence-Based Complementary and Alternative Medicine 2008; 5:3-15.
67. Colavita AM, Reinach AJ, Peters SP. Contributing factors to the pathobiology of asthma. The Th1/Th2 paradigm. Clin Chest Med 2000; 21:263-277.
68. Krenger W, Ferrara JL. Graft-versus-host disease and the Th1/Th2 paradigm. Immunol Res 1996; 15:50-73.
69. Bouike G, Nishitani Y, Shiomi H, Yoshida M, Azuma T, Hashimoto T, Kanazawa K, Mizuno M. Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in Mice. Evid Based Complement Alternat Med 2011, 2011:532180.
70. Oh TW, Kim YA, Jang WJ, Byeon JI, Ryu CH, Kim JO, Ha YL. Semipurified fractions from the submerged-culture broth of Agaricus blazei Murill reduce blood glucose levels in streptozotocin-induced diabetic rats. J Agric Food Chem 2010; 58:4113-4119.
71. Hsu C-H, Liao Y-L, Lin S-C, Hwang K-C, Chou P. The mushroom Agaricus blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: A randomized, double-blinded, and placebo-controlled clinical trial. Journal of Alternative and Complementary Medicine 2007; 13:97-102.
72. Niwa A, Tajiri T, Higashino H. lpomoea batatas and Agarics blazei ameliorate diabetic disorders with therapeutic antioxidant potential in streptozotocin-induced diabetic rats. Journal of Clinical Biochemistry and Nutrition 2011; 48:194-202.
73. Volman JJ, Helsper JP, Wei S, Baars JJ, van Griensven LJ, Sonnenberg AS, Mensink RP, Plat J. Effects of mushroom-derived beta-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-kappaB transactivation in Caco-2 reporter cells: can effects be explained by structure? Mol Nutr Food Res 2010; 54:268-276.
74. Sorimachi K, Akimoto K, Ikehara Y, Inafuku K, Okubo A, Yamazaki S. Secretion of TNF-alpha, IL-8 and nitric oxide by macrophages activated with Agaricus blazei Murill fractions in vitro. Cell Struct Funct 2001; 26:103-108.
75. Kuroiwa Y, Nishikawa A, Imazawa T, Kanki K, Kitamura Y, Umemura T, Hirose M. Lack of subchronic toxicity of an aqueous extract of Agaricus blazei Murrill in F344 rats. Food and Chemical Toxicology 2005; 43:1047-1053.
76. Kasai H, He LM, Kawamura M, Yang PT, Deng XW, Munkanta M, Yamashita A, Terunuma H, Hirama M, Horiuchi I, Natori T, Koga T, Amano Y, Yamaguchi N, Ito M. IL-12 Production Induced by Agaricus blazei Fraction H (ABH) Involves Toll-like Receptor (TLR). Evid Based Complement Alternat Med 2004; 1:259-267.
77. Bernardshaw S, Lyberg T, Hetland G, Johnson E. Effect of an extract of the mushroom Agaricus blazei Murill on expression of adhesion molecules and production of reactive oxygen species in monocytes and granulocytes in human whole blood ex vivo. APMIS 2007; 115:719-725.
78. Ellertsen LK, Hetland G, Johnson E, Grinde B. Effect of a medicinal extract from Agaricus blazei Murill on gene expression in a human monocyte cell line as examined by microarrays and immuno assays. Int Immunopharmacol 2006; 6:133-143.
79. Hsu C-H, Hwang K-C, Chiang Y-H, Chou P. The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B. Journal of Alternative and Complementary Medicine 2008; 14:299-301.
80. Yuminamochi E, Koike T, Takeda K, Horiuchi I, Okumura K. Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill. Immunology 2007; 121:197-206.
81. Lima CUJO, Souza VC, Morita MC, Chiarello MD, de Oliveira Karnikowski MG. Agaricus blazei Murrill and Inflammatory Mediators in Elderly Women: A Randomized Clinical Trial. Scandinavian Journal of Immunology 2012; 75:336-41
82. Joanna Oliveira Lima CU, de Almeida Cordova CO, Nobrega OdT, Funghetto SS, de Oliveira Karnikowski MG. Does the Agaricus blazei Murill Mushroom Have Properties That Affect the Immune System? An Integrative Review. Journal of Medicinal Food 2011; 14:2-8.