Lack of subchronic toxicity of an aqueous extract of Agaricus blazei Murrill in F344 rats

Food and Chemical Toxicology

Volumn 43, Issue 7, 2005, Pages 1047-1053

  Kuroiwa, Y ^a   Nishikawa, A ^a   Imazawa, T ^a   Kanki, K ^a   Kitamura, Y ^a   Umemura, T ^a   Hirose, M ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Agaricus blazei; F344 rat; Food additive; Murrill extract; Subchronic toxicity

Indexed keywords

CREATININE; FOOD ADDITIVE;

AGARICUS BLAZEI; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CAUSE OF DEATH; CHRONIC TOXICITY; CREATININE BLOOD LEVEL; DIETARY INTAKE; FEMALE; FOOD POISONING; HEMATOLOGY; HISTOPATHOLOGY; KIDNEY DISEASE; MALE; NONHUMAN; ORGAN WEIGHT; POWDER; RAT; RISK ASSESSMENT; UREA NITROGEN BLOOD LEVEL;

AGARICUS BLAZEI; BASIDIOMYCOTA;

EID: 17044365420     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2005.02.007     Document Type: Article

References (18)

1. L.F. Barbisan, M. Miyamoto, C. Scolastici, D.M.F. Salvadori, L.R. Ribeiro, A.F. Eira, and J.L.V. de Camargo Influence of aqueous extract of Agaricus blazei on rat liver toxicity induced by different doses of diethylnitrosamin Journal of Ethnopharmacology 83 2002 25 32
2. L.F. Barbisan, A.L Spinardi-Barbisan, E.L. Moreira, D.M. Salvadori, L.R. Ribeiro, A.F. da Eira, and J.L. de Camargo Agaricus blazei (Himematsutake) does not alter the development of rat diethylnitrosamine-initiated hepatic preneoplastic foci Cancer Science 94 2003 188 192
3. L.F. Barbisan, C. Scolastici, M. Miyamoto, D.M.F. Salvadori, L.R. Ribeiro, A.F. da Eira, and J.L.V. de Camargo Effects of crude extracts of Agaricus blazei on DNA damage and on rat liver carcinogenesis induced by diethylnitrosamine Genetics and Molecular Research 2 2003 295 308
4. G.A. Boorman S.L. Eustis M.R. Elwell C.A. Montgomery Jr. W.F. Mackenzie Pathology of the Fischer rat, references and atlas 1990 Academic Press San Diego
5. F. Furukawa, K. Kasahara, A. Nishikawa, T. Imazawa, and M. Hirose A 13-week subchronic oral toxicity study of chlorophyll in F344 rats Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku 116 1998 107 112 (in Japanese)
6. Z.R. Guterrez, M.S. Mantovani, A.F. Eira, L.R. Ribeiro, and B.Q. Jordao Variation of the antimutagenicity effects of water extracts of Agaricus blazei Murrill in vitro Toxicology In Vitro 18 2004 301 309
7. JETRO (Japan External Trade Organization), 2004. Specifications and Standards for Foods, Food Additives, etc. Under The Food Sanitation Law. Available from: 〈http://www.jetro.go.jp/se/e/standards_regulation/ foodadd2004apr-e.pdf〉
8. C. Karlson-Stiber, and H. Persson Cytotoxic fungi-an overview Toxicon 42 2003 339 349
9. 1) and repair deficient (xrs5) cells by chromosome aberration and sister chromatid exchange assays Mutation Research 528 2003 75 79
10. R.C. Menoli, M.S. Mantovani, L.R. Ribeiro, G. Speit, and B.Q. Jordao Antimutagenic effects of the mushroom Agaricus blazei Murrill extracts on V79 cells Mutation Research 496 2001 5 13
11. MHLW (Ministry of Health, Labor and Welfare of Japan), 1996a. List of existing food additives, Notification No. 120 of the Ministry of Health and Welfare
12. MHLW (Ministry of Health, Labor and Welfare of Japan), 1996b. Guidelines for Designation of Food Additives, and for Revision of Standard for Use of Food Additives, Article No. 29 of the Life and Sanitation Bureau
13. B.M. Mitruka, and H.M. Rawnsley (T. Ishii, T. Toyama, T. Sakaguchi, Trans.) Clinical biochemical and hematological reference values in normal experimental animals and normal humans second ed. 1983 Seishi Shoin Ltd. Tokyo p. 64-67 (in Japanese)
14. M. Miyauchi, F. Furukawa, A. Nishikawa, H. Nakamura, T. Imazawa, and M. Hirose A 13-week subchronic oral toxicity study of orange color in F344 rats Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku 117 1999 123 128 (in Japanese)
15. H. Onodera, K. Mitsumori, K. Yasuhara, K. Takegawa, and M. Takahashi 13-week subchronic oral toxicity study of phaffia colour in F344 rats Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku 115 1997 99 106 (in Japanese)
16. Y. Osaki, T. Kato, K. Yamamoto, J. Okubo, and T. Miyazaki Antimutagenic and bacterial substances in the fruit body of a basidiomycete Agaricus blazei Yakugaku Zasshi 114 1994 342 350 (in Japanese)
17. F. Pinheiro, R.R. Faria, J.L. de Camargo, A.L. Spinardi-Barbisan, A.F. da Eira, and L.F. Barbisan Chemoprevention of preneoplastic liver foci development by dietary mushroom Agaricus blazei Murrill in the rat Food and Chemical Toxicology 41 2003 1543 1550
18. K. Takada, K. Toyoda, T. Shoda, C. Uneyama, T. Tamura, and M. Takahashi A 13-week subchronic oral toxicity study of carob green colour in F344 rats Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku 115 1997 93 98 (in Japanese)