Effects on gene expression and viral load of a medicinal extract from Agaricus blazei in patients with chronic hepatitis C infection

International Immunopharmacology

Volumn 6, Issue 8, 2006, Pages 1311-1314

  Grinde, B ^a   Hetland, G ^a   Johnson, E ^a  

^a ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

Agaricus blazei Murill; Cancer; G protein coupled receptors; Gene expression; Hepatitis C virus; Microarray

Indexed keywords

AGARICUS BLAZEI EXTRACT; BETA GLUCAN; CYTOKINE; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; PLANT EXTRACT;

ADULT; AGARICUS BLAZEI; ARTICLE; BLOOD CELL; CELL CYCLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENE EXPRESSION; HEPATITIS C; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MEDICINAL PLANT; MICROARRAY ANALYSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; VIRUS LOAD;

EID: 33744986241     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2006.04.005     Document Type: Article

References (23)

1. Ito H., Shimura K., Itoh H., and Kawade M. Antitumor effects of a new polysaccharide-protein complex (ATOM) prepared from Agaricus blazei (Iwade strain 101) "Himematsutake" and its mechanisms in tumor-bearing mice. Anticancer Res 17 (1997) 277-284
2. Lee Y.L., Kim H.J., Lee M.S., Kim J.M., Han J.S., Hong E.K., et al. Oral administration of Agaricus blazei (H1 strain) inhibited tumor growth in a sarcoma 180 inoculation model. Exp Anim 52 (2003) 371-375
3. Oshiman K., Fujimiya Y., Ebina T., Suzuki I., and Noji M. Orally administered beta-1,6-d-polyglucose extracted from Agaricus blazei results in tumor regression in tumor-bearing mice. Planta Med 68 (2002) 610-614
4. Takimoto H., Wakita D., Kawaguchi K., and Kumazawa Y. Potentiation of cytotoxic activity in naive and tumor-bearing mice by oral administration of hot-water extracts from Agaricus brazei fruiting bodies. Biol Pharm Bull 27 (2004) 404-406
5. Ahn W.S., Kim D.J., Chae G.T., Lee J.M., Bae S.M., Sin J.I., et al. Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer 14 (2004) 589-594
6. Kawamura M., Kasai H., He L., Deng X., Yamashita A., Terunuma H., et al. Antithetical effects of hemicellulase-treated Agaricus blazei on the maturation of murine bone-marrow-derived dendritic cells. Immunology 114 (2005) 397-409
7. Kuo Y.C., Huang Y.L., Chen C.C., Lin Y.S., Chuang K.A., and Tsai W.J. Cell cycle progression and cytokine gene expression of human peripheral blood mononuclear cells modulated by Agaricus blazei. J Lab Clin Med 140 (2002) 176-187
8. Mizuno M., Morimoto M., Minato K., and Tsuchida H. Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. Biosci Biotechnol Biochem 62 (1998) 434-437
9. Nakajima A., Ishida T., Koga M., Takeuchi T., Mazda O., and Takeuchi M. Effect of hot water extract from Agaricus blazei Murill on antibody-producing cells in mice. Int Immunopharmacol 2 (2002) 1205-1211
10. Shimizu S., Kitada H., Yokota H., Yamakawa J., Murayama T., Sugiyama K., et al. Activation of the alternative complement pathway by Agaricus blazei Murill. Phytomedicine 9 (2002) 536-545
11. Sorimachi K., Ikehara Y., Maezato G., Okubo A., Yamazaki S., Akimoto K., et al. Inhibition by Agaricus blazei Murill fractions of cytopathic effect induced by western equine encephalitis (WEE) virus on VERO cells in vitro. Biosci Biotechnol Biochem 65 (2001) 1645-1647
12. Ellertsen L.K., Hetland G., Johnson E., and Grinde B. Effect of a medicinal extract from Agaricus blazei Murill on gene expression in human monocytes. Int Immunopharmacol 6 (2005) 133-143
13. Bernardshaw S., Johnson E., and Hetland G. An extract of the mushroom Agaricus blazei Murill administered orally protects against systemic Streptococcus pneumoniae infection in mice. Scand J Immunol 62 (2005) 393-398
14. Bernardshaw S., Hetland G., Grinde B., and Johnson E. An extract of the mushroom Agaricus blazei Murill protects against lethal septicemia in a mouse model for fecal periotonitis. Shock 24 (2006) 319-320
15. Roeder A., Kirschning C.J., Rupec R.A., Schaller M., Weindl G., and Korting H.C. Toll-like receptors as key mediators in innate antifungal immunity. Med Mycol 42 (2004) 485-498
16. Schmitz F., Mages J., Heit A., Lang R., and Wagner H. Transcriptional activation induced in macrophages by Toll-like receptor (TLR) ligands: from expression profiling to a model of TLR signaling. Eur J Immunol 34 (2004) 2863-2873
17. Fujimiya Y., Suzuki Y., Katakura R., and Ebina T. Tumor-specific cytocidal and immunopotentiating effects of relatively low molecular weight products derived from the basidiomycete, Agaricus blazei Murill. Anticancer Res 19 (1999) 113-118
18. Kimura Y., Kido T., Takaku T., Sumiyoshi M., and Baba K. Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions. Cancer Sci 95 (2004) 758-764
19. Kimura Y. New anticancer agents: in vitro and in vivo evaluation of the antitumor and antimetastatic actions of various compounds isolated from medicinal plants. In Vivo 19 (2005) 37-60
20. Rainen L., Oelmueller U., Jurgensen S., Wyrich R., Ballas C., Schram J., et al. Stabilization of mRNA expression in whole blood samples. Clin Chem 48 (2002) 1883-1890
21. Dysvik B., and Jonassen I. J-Express: exploring gene expression data using Java. Bioinformatics 17 (2001) 369-370
22. Vetvicka V., Thornton B.P., and Ross G.D. Soluble beta-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells. J Clin Invest 98 (1996) 50-61
23. Shimizu S., Kitada H., Yokota H., Yamakawa J., Murayama T., Sugiyama K., et al. Activation of the alternative complement pathway by Agaricus blazei Murill. Phytomedicine 9 (2002) 536-545