Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells

Journal of Experimental Medicine

Volumn 210, Issue 12, 2013, Pages 2773-2789

  Giltiay, Natalia V ^a   Chappell, Craig P ^a   Sun, Xizhang ^a   Kolhatkar, Nikita ^a   Teal, Thomas H ^a   Wiedeman, Alice E ^a   Kim, Jinoh ^a   Tanaka, Lena ^a   Buechler, Matthew B ^a,b   Hamerman, Jessica A ^a,b   Imanishi Kari, Thereza ^c   Clark, Edward A ^a   Elkon, Keith B ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b BENAROYA RESEARCH INSTITUTE   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN M ANTIBODY; INTERFERON; RIBONUCLEASE; RNA ANTIBODY; TOLL LIKE RECEPTOR 7;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL EXPANSION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; GENE OVEREXPRESSION; IN VITRO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; AUTOANTIBODIES; B-LYMPHOCYTE SUBSETS; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTIDINE DEAMINASE; HUMANS; IMMUNOGLOBULIN CLASS SWITCHING; INTERFERON TYPE I; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PRECURSOR CELLS, B-LYMPHOID; RECEPTORS, ANTIGEN, B-CELL; RNA; SPLEEN; T-BOX DOMAIN PROTEINS; TOLL-LIKE RECEPTOR 7; UP-REGULATION;

EID: 84888098197     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20122798     Document Type: Article

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