A toxicological and dermatological assessment of alkyl cyclic ketones when used as fragrance ingredients

Food and Chemical Toxicology

Volumn 62, Issue , 2013, Pages

  Belsito, D ^a   Bickers, D ^a   Bruze, M ^b   Calow, P ^c   Dagli, M L ^d   Fryer, A D ^e   Greim, H ^f   Miyachi, Y ^g   Saurat, J H ^h   Sipes, I G ⁱ  

^a NewYork Presbyterian Hospital   (United States)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^g KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^h UNIVERSITY OF GENEVA   (Switzerland)

ⁱ UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Alkyl cyclic ketone; Assessment; Dermatology; Group summary; Toxicology

Indexed keywords

1 (1,2,3,4,5,6,7,8 OCTAHYDRO 2,3,8,8 TETRAMETHYL 2 NAPHTHALENYL)ETHANONE; 1 (1,2,3,4,5,6,7,8,8A OCTAHYDRO 2,3,8,8 TETRAMETHYL 2 NAPHTHYL)ETHAN 1 ONE; 1 (1,2,3,4,6,7,8,8A OCTAHYDRO 2,3,8,8 TETRAMETHYL 2 NAPHTHYL)ETHAN 1 ONE; 1 (1,2,3,6,7,8,8A OCTAHYDRO 2,3,8,8 TETRAMETHYL 2 NAPHTHYL)ETHAN 1 ONE; 1 (2,3,4,7,8,8A HEXAHYDRO 3,6,8,8 TETRAMETHYL 1H 3A,7 METHANOAZULEN 5 YL)ETHAN 1 ONE; 1 (2,4 DIMETHYL 3 CYCLOHEXENYL) 2,2 DIMETHYLPROPAN 1 ONE; 1 (2,4,4,5,5 PENTAMETHYL 1 CYCLOPENTEN 1 YL)ETHAN 1 ONE; 1 (2,5,5 TRIMETHYLCYCLOHEPTYL)ETHAN 1 ONE; 1 (3,3 DIMETHYLBICYCLO HEPT 2 YL)ETHANE 1 ONE; 1 (3,3 DIMETHYLCYCLOHEX 1 EN 1 YL)ETHANONE; 1 (3,3 DIMETHYLCYCLOHEXYL)ETHAN 1 ONE; 1 (3,3 DIMETHYLCYCLOHEXYL)PENT 4 EN 1 ONE; 1 (3,5,6 TRIMETHYL 3 CYCLOHEXEN 1 YL)ETHAN 1 ONE; 1 (4 METHOXY 2,2,6,6 TETRAMETHYL 3 CYCLOHEXEN 1 YL)ETHAN 1 ONE; 1 (5,5 DIMETHYL 1 CYCLOHEXEN 1 YL)PENT 4 EN 1 ONE; 1 (6,6,9 TRIMETHYL 2 METHYLENE 4,8 CYCLOUNDECADIEN 1 YL) ETHANONE; 1 (PARA MENTHEN 6 YL) 1 PROPANONE; 1 [1 (1 OXOPROPOXY)CYCLOHEXYL] ETHANONE; 2 (3,7 DIMETHYL 2,6 NONADIEN 1 YL) CYCLOPENTANONE; 2 CYCLOHEXYL 1,6 HEPTADIEN 3 ONE; 5 ACETYL 2,2,8 TRIMETHYLTRICYCLO(6.2.2.01,6)DODEC 5 ENE; ACETYL CEDRENE; ACETYLCARENE; ALKYL GROUP; CYCLOHEXYL METHYL PENTANONE; FRAGRANCE; KETONE; METHYL 2,6,10 TRIMETHYLCYCLODODECA 2,5,9 TRIEN 1 YL KETONE; UNCLASSIFIED DRUG;

CHEMICAL STRUCTURE; DERMATOLOGY; EYE IRRITATION; GENOTOXICITY; HEMATOLOGICAL PARAMETERS; HUMAN; KIDNEY MASS; LIVER WEIGHT; MICRONUCLEUS; NONHUMAN; PATCH TEST; PHOTOSENSITIZATION; PHOTOTOXICITY; RAT; REVIEW; SKIN SENSITIZATION; TOXICOLOGY;

ANIMALIA; MAMMALIA;

ALKYL CYCLIC KETONE; ASSESSMENT; DERMATOLOGY; GROUP SUMMARY; TOXICOLOGY;

ANIMALS; CONSUMER PRODUCT SAFETY; HUMANS; IRRITANTS; KETONES; MICE; PATCH TESTS; PERFUME; RISK ASSESSMENT; TOXICITY TESTS;

EID: 84888062744     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.09.033     Document Type: Review

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92. RIFM (Research Institute for Fragrance Materials, Inc.), 1979h. Acute oral range-finding toxicity test with acetyl cedrene in mice. Unpublished report from Quest International, Report number 46454 (RIFM, Woodcliff Lake, NJ, USA).
93. RIFM (Research Institute for Fragrance Materials, Inc.), 1979i. Acute oral range-finding toxicity test with acetyl cedrene in mice. Unpublished report from Quest International, 20 April. Report number 46910 (RIFM, Woodcliff Lake, NJ, USA).
94. RIFM (Research Institute for Fragrance Materials, Inc.), 1979j. Determination of the acute oral toxicity of 1-[5(or 6)-methyl-7(or 8)-(1-methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one in rats. Unpublished report from Quest International, Report number 46009 (RIFM, Woodcliff Lake, NJ, USA).
95. RIFM (Research Institute for Fragrance Materials, Inc.), 1979k. 1-(2,4,4,5,5-Pentamethyl-1-cyclopenten-1-yl)ethan-1-one (Alpinone): Acute oral toxicity in rats. Unpublished report from Givaudan, Report number 56194 (RIFM, Woodcliff Lake, NJ, USA).
96. RIFM (Research Institute for Fragrance Materials, Inc.), 1979l. Evaluation of cyclohexyl methyl pentanone and heptyl dioxolane in Salmonella/microsome mutagenicity tests. Unpublished report from Naarden International, 01 November. Report number 1708 (RIFM, Woodcliff Lake, NJ, USA).
97. RIFM (Research Institute for Fragrance Materials, Inc.), 1979m. Evaluation of 6-butyl-2,4-dimethyldihydropyrane; 4-tricyclodecylidene butanal; 2-butyl-4,4,6-trimethyl-1,3-dioxane; 2,4-dimethyl-3-cyclohexen-1-carboxaldehdye; and ioshexenyl cyclohexenyl carboxaldehyde in the Salmonella/microsome mutagenicity test. Unpublished report from Naarden Inc., 01 August. Report number 8885 (RIFM, Woodcliff Lake, NJ, USA).
98. RIFM (Research Institute for Fragrance Materials, Inc.), 1979n. Repeated insult patch test/photosensitization study of 1-(5,5-dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one in human subjects. Unpublished report from Firmenich Incorporated, Report number 38416 (RIFM, Woodcliff Lake, NJ, USA).
99. RIFM (Research Institute for Fragrance Materials, Inc.), 1979o. Evaluation of potential hazards of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone by dermal contact in human subjects. Unpublished report from International Flavors and Fragrances, 17 September. Report number 19986 (RIFM, Woodcliff Lake, NJ, USA).
100. RIFM (Research Institute for Fragrance Materials, Inc.), 1979p. Rabbit covered patch skin irritation test with acetyl cedrene. Unpublished report from Quest International, 29 March. Report number 46404 (RIFM, Woodcliff Lake, NJ, USA).
101. RIFM (Research Institute for Fragrance Materials, Inc.), 1979q. The Magnusson and Kligman guinea pigs maximization test of acetyl cedrene. Unpublished report from Quest International, 01 November. Report number 30067 (RIFM, Woodcliff Lake, NJ, USA).
102. RIFM (Research Institute for Fragrance Materials, Inc.), 1979r. Guinea pig skin sensitisation test with acetyl cedrene. Unpublished report from Quest International, 16 July. Report number 46455 (RIFM, Woodcliff Lake, NJ, USA).
103. RIFM (Research Institute for Fragrance Materials, Inc.), 1979t. Primary skin irritation of 1-(5,5-dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one in rabbits. Unpublished report from Firmenich Incorporated, Report number 38413 (RIFM, Woodcliff Lake, NJ, USA).
104. RIFM (Research Institute for Fragrance Materials, Inc.), 1979u. Maximization test with 1-[5(or 6)-methyl-7(or 8)-(1-methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one in guinea pigs. Unpublished report from Quest International, Report number 46011 (RIFM, Woodcliff Lake, NJ, USA).
105. RIFM (Research Institute for Fragrance Materials, Inc.), 1979v. Rabbit eye irritation test with acetyl cedrene. Unpublished report from Quest International, 22 May. Report number 35831 (RIFM, Woodcliff Lake, NJ, USA).
106. RIFM (Research Institute for Fragrance Materials, Inc.), 1979w. Rabbit eye irritation test with acetyl cedrene. Unpublished report from Quest International, 22 May. Report number 46453 (RIFM, Woodcliff Lake, NJ, USA).
107. RIFM (Research Institute for Fragrance Materials, Inc.), 1979x. Rabbit eye irritation test with acetyl cedrene. Unpublished report from Quest International, 23 May. Report number 46913 (RIFM, Woodcliff Lake, NJ, USA).
108. RIFM (Research Institute for Fragrance Materials, Inc.), 1979y. Rabbit eye irritation test of acetyl cedrene. Unpublished report from Quest International, 23 May. Report number 30072 (RIFM, Woodcliff Lake, NJ, USA).
109. RIFM (Research Institute for Fragrance Materials, Inc.), 1979z. Rabbit eye irritation test of acetyl cedrene. Unpublished report from Givaudan, 23 May. Report number 30073 (RIFM, Woodcliff Lake, NJ, USA).
110. RIFM (Research Institute for Fragrance Materials, Inc.), 1979aa. Rabbit eye irritation test with acetyl cedrene. Unpublished report from Quest International, 22 May. Report number 46452 (RIFM, Woodcliff Lake, NJ, USA).
111. RIFM (Research Institute for Fragrance Materials, Inc.), 1979bb. Rabbit eye irritation test with acetyl cedrene. Unpublished report from Quest International, 23 May. Report number 46912 (RIFM, Woodcliff Lake, NJ, USA).
112. RIFM (Research Institute for Fragrance Materials, Inc.), 1979cc. Rabbit eye irritation test of acetyl cedrene. Unpublished report from Quest International, 23 May. Report number 30074 (RIFM, Woodcliff Lake, NJ, USA).
113. RIFM (Research Institute for Fragrance Materials, Inc.), 1979dd. Rabbit eye irritation test with acetyl cedrene. Unpublished report from Quest International, 22 May. Report number 46451 (RIFM, Woodcliff Lake, NJ, USA).
114. RIFM (Research Institute for Fragrance Materials, Inc.), 1979ee. Rabbit eye irritation test with acetyl cedrene. Unpublished report from Quest International, 23 May. Report number 46911 (RIFM, Woodcliff Lake, NJ, USA).
115. RIFM (Research Institute for Fragrance Materials, Inc.), 1979ff. Primary eye irritation study with 1-(5,5-dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one in rabbits. Unpublished report from Firmenich Incorporated, Report number 50158 (RIFM, Woodcliff Lake, NJ, USA).
116. RIFM (Research Institute for Fragrance Materials, Inc.), 1979gg. Primary ocular irritation study of 1-(5,5-dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one in rabbits. Unpublished report from Firmenich Incorporated, Report number 38414 (RIFM, Woodcliff Lake, NJ, USA).
117. RIFM (Research Institute for Fragrance Materials, Inc.), 1979hh. 1-(2,4,4,5,5-Pentamethyl-1-cyclopenten-1-yl)ethan-1-one (Alpinone): Eye irritation in rabbits. Unpublished report from Givaudan, Report number 56195 (RIFM, Woodcliff Lake, NJ, USA).
118. RIFM (Research Institute for Fragrance Materials, Inc.), 1979ii. Repeat insult patch test with 1-(2,4,4,5,5-pentamethyl-1-cyclopenten-1-yl)ethan-1-one (alpinone). Unpublished report from Givaudan, Report number 56199 (RIFM, Woodcliff Lake, NJ, USA).
119. RIFM (Research Institute for Fragrance Materials, Inc.), 1980a. Primary skin irritation and acute dermal toxicity studies with 1-[5(or 6)-methyl-7(or 8)-(1-methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one in albino rabbits. Unpublished report from Quest International, Report number 46013 (RIFM, Woodcliff Lake, NJ, USA).
120. RIFM (Research Institute for Fragrance Materials, Inc.), 1980b. Acute dermal toxicity of 2-acetoxy-2,3,8,8-tetramethyloctahydronaphthalene in rats. Unpublished report from International Flavors and Fragrances, 30 August. Report number 19988 (RIFM, Woodcliff Lake, NJ, USA).
121. RIFM (Research Institute for Fragrance Materials, Inc.), 1980c. Acute oral toxicity of 2-acetoxy-2,3,8,8-tetramethyloctahydronaphthalene in rats. Unpublished report from International Flavors and Fragrances, 30 August. Report number 19987 (RIFM, Woodcliff Lake, NJ, USA).
122. RIFM (Research Institute for Fragrance Materials, Inc.), 1980d. Primary skin irritation, eye irritation and phototoxicity test with cyclohexyl methyl pentanone in albino rabbits. Unpublished report from Naarden International, 01 November. Report number 1704 (RIFM, Woodcliff Lake, NJ, USA).
123. RIFM (Research Institute for Fragrance Materials, Inc.), 1980e. Maximization test with cyclohexyl methyl pentanone in guinea pigs. Unpublished report from Naarden International, 01 February. Report number 1705 (RIFM, Woodcliff Lake, NJ, USA).
124. RIFM (Research Institute for Fragrance Materials, Inc.), 1980f. Skin irritation and capacity of allergenic sensitization of 1-(2,4,4,5,5-pentamethyl-1-cyclopenten-1-yl)ethan-1-one (alpinone) determined by the open epicutaneous test (OET) on guinea pigs. Unpublished report from Givaudan, Report number 56198 (RIFM, Woodcliff Lake, NJ, USA).
125. RIFM (Research Institute for Fragrance Materials, Inc.), 1980g. Primary ocular irritation study of acetyl cedrene in rabbits. Unpublished report from International Flavors and Fragrances, 80 July. Report number 50417 (RIFM, Woodcliff Lake, NJ, USA).
126. RIFM (Research Institute for Fragrance Materials, Inc.), 1980h. A study to determine the photoallergic/phototoxic potential of fragrance materials in human subjects. Unpublished report from International Flavors and Fragrances, 16 December. Report number 19989 (RIFM, Woodcliff Lake, NJ, USA).
127. RIFM (Research Institute for Fragrance Materials, Inc.), 1980i. Phototoxicity in humans with fragrance materials. Unpublished report from International Flavors and Fragrances, 17 October. Report number 51016 (RIFM, Woodcliff Lake, NJ, USA).
128. RIFM (Research Institute for Fragrance Materials, Inc.), 1980j. Phototoxicity test of 2-acetoxy-2,3,8,8-tetramethyloctahydronaphthalene in mice. Unpublished report from International Flavors and Fragrances, 29 February. Report number 19990 (RIFM, Woodcliff Lake, NJ, USA).
129. RIFM (Research Institute for Fragrance Materials, Inc.), 1980k. Photosensitization test with cyclohexyl methyl pentanone and heptyl dioxolane in guinea pigs. Unpublished report from Naarden International, 01 March. Report number 1707 (RIFM, Woodcliff Lake, NJ, USA).
130. RIFM (Research Institute for Fragrance Materials, Inc.), 1980l. A guinea pig assay of photosensitizing potential of 1-(2,4,4,5,5-pentamethyl-1-cyclopenten-1-yl)ethan-1-one (alpinone). Unpublished report from Givaudan, Report number 56197 (RIFM, Woodcliff Lake, NJ, USA).
131. RIFM (Research Institute for Fragrance Materials, Inc.), 1980m. Primary ocular irritation study with ethanone, 1- [1-oxopropoxy) cyclohexyl]- in rabbits. Unpublished report from IFF Incorporated, 13 November. Report number 47628 (RIFM, Woodcliff Lake, NJ, USA).
132. RIFM (Research Institute for Fragrance Materials, Inc.), 1980n. Delayed contact sensitivity study in guinea pigs with ethanone, 1- [1-oxopropoxy) cyclohexyl]. Unpublished report from IFF Incorporated, 26 June. Report number 47629 (RIFM, Woodcliff Lake, NJ, USA).
133. RIFM (Research Institute for Fragrance Materials, Inc.), 1981a. Sensitization test with cyclohexyl methyl pentanone in guinea pigs (Buehler Test). Unpublished report from Naarden International, 01 February. Report number 1706 (RIFM, Woodcliff Lake, NJ, USA).
134. RIFM (Research Institute for Fragrance Materials, Inc.), 1981b. Eye irritation and phototoxicity tests with 1-[5(or 6)-methyl-7(or 8)-(1-methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one in albino rabbits. Unpublished report from Quest International, Report number 46012 (RIFM, Woodcliff Lake, NJ, USA).
135. RIFM (Research Institute for Fragrance Materials, Inc.), 1981c. Photosensitization test with 1-[5(or 6)-methyl-7(or 8)-(1-methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one in guinea pigs. Unpublished report from Quest International, Report number 46010 (RIFM, Woodcliff Lake, NJ, USA).
136. RIFM (Research Institute for Fragrance Materials, Inc.), 1982a. Ames Metabolic Activation Test to assess the potential mutagenic effect of acetyl cedrene. Unpublished report from Quest International, 18 June. Report number 30070 (RIFM, Woodcliff Lake, NJ, USA).
137. RIFM (Research Institute for Fragrance Materials, Inc.), 1982b. The rat topical application photoirritation test of acetyl cedrene. Unpublished report from Quest International, 02 February. Report number 30077 (RIFM, Woodcliff Lake, NJ, USA).
138. RIFM (Research Institute for Fragrance Materials, Inc.), 1982c. Determination of phototoxicity in guinea pigs with 1-(2,4,4,5,5-pentamethyl-1-cyclopenten-1-yl)ethan-1-one (alpinone). Unpublished report from Givaudan, Report number 56196 (RIFM, Woodcliff Lake, NJ, USA).
139. RIFM (Research Institute for Fragrance Materials, Inc.), 1982d. The mouse intraperitoneal injection photoirritation (range-finding) test of acetyl cedrene. Private communication. Unpublished report from Quest International, 12 July. Report number 31722 (RIFM, Woodcliff Lake, NJ, USA).
140. RIFM (Research Institute for Fragrance Materials, Inc.), 1983a. Acute oral toxicity study in rats of 1-(3,3-dimethylcyclohexyl)pent-4-en-1-one (galbaniff). Unpublished report from International Flavors and Fragrances, Report number 47550 (RIFM, Woodcliff Lake, NJ, USA).
141. RIFM (Research Institute for Fragrance Materials, Inc.), 1983b. Acute oral toxicity of 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)pent-3-en-2-one (sandex) in rats. Unpublished report from Givaudan, 20 June. Report number 60664 (RIFM, Woodcliff Lake, NJ, USA).
142. RIFM (Research Institute for Fragrance Materials, Inc.), 1983c. Human repeated insult patch test with 1-(3,3-dimethylcyclohexyl)pent-4-en-1-one. Unpublished report from International Flavors and Fragrances, 06 January. Report number 48458 (RIFM, Woodcliff Lake, NJ, USA).
143. RIFM (Research Institute for Fragrance Materials, Inc.), 1983d. Primary dermal irritation study in rabbits of 1-(3,3-dimethylcyclohexyl)pent-4-en-1-one. Unpublished report from International Flavors and Fragrances, Report number 47790 (RIFM, Woodcliff Lake, NJ, USA).
144. RIFM (Research Institute for Fragrance Materials, Inc.), 1983e. Determination of skin irritation and capacity of allergic sensitization by the Open Epicutaneous Test (OET) of 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)pent-3-en-2-one (sandex) on guinea pigs. Unpublished repor t from Givaudan, 26 October. Report number 60671(RIFM, Woodcliff Lake, NJ, USA).
145. RIFM (Research Institute for Fragrance Materials, Inc.), 1983f. Eye irritation study with 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)pent-3-en-2-one (sandex) in rabbits. Unpublished report from Givaudan, 15 June. Report number 60665 (RIFM, Woodcliff Lake, NJ, USA).
146. RIFM (Research Institute for Fragrance Materials, Inc.), 1983g. Capacity for allergic sensitization determined by the intradermal test with Freund's Complete Adjuvant on guinea pigs (FCAT). Unpublished report from Givaudan, 10 October. Report number 60669 (RIFM, Woodcliff Lake, NJ, USA).
147. RIFM (Research Institute for Fragrance Materials, Inc.), 1983h. 3-Methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)pent-3-en-2-one (sandex): Determination of photoxicity in guinea pigs. Unpublished report from Givaudan, 17 June. Report number 60667 (RIFM, Woodcliff Lake, NJ, USA).
148. RIFM (Research Institute for Fragrance Materials, Inc.), 1983i. 3-Methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)pent-3-en-2-one (sandex): Determination of photoallergenicity in guinea pigs. Unpublished report from Givaudan, 17 August. Report number 60668 (RIFM, Woodcliff Lake, NJ, USA).
149. RIFM (Research Institute for Fragrance Materials, Inc.), 1984a. Mutagenicity evaluation of 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)pent-3-en-2-one in the Ames Salmonella/Microsome Plate Test. Unpublished report from Givaudan, 1 May. Report number 60666 (RIFM, Woodcliff Lake, NJ, USA).
150. RIFM (Research Institute for Fragrance Materials, Inc.), 1984b. Acute eye irritation test in rabbits of 1-(3,3-dimethylcyclohexyl)pent-4-en-1-one (galbaniff). Unpublished report from International Flavors and Fragrances, Report number 47675 (RIFM, Woodcliff Lake, NJ, USA).
151. RIFM (Research Institute for Fragrance Materials, Inc.), 1984c. Repeated insult patch test with 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)pent-3-en-2-one (sandex). Unpublished report from Givaudan, 26 July. Report number 60670 (RIFM, Woodcliff Lake, NJ, USA).
152. RIFM (Research Institute for Fragrance Materials, Inc.), 1985a. Acute toxicity range-finding study with ethanone, 1-(3,3-dimethyl-1-cyclohexen-1-yl)-(artemone) in the mouse. Unpublished report from Givaudan, Report number 56210 (RIFM, Woodcliff Lake, NJ, USA).
153. RIFM (Research Institute for Fragrance Materials, Inc.), 1985b. Acute eye irritation test on rabbits with ethanone, 1-(3,3-dimethyl-1-cyclohexen-1-yl)-(artemone). Unpublished report from Givaudan, Report number 56218 (RIFM, Woodcliff Lake, NJ, USA).
154. RIFM (Research Institute for Fragrance Materials, Inc.), 1985c. Test for delayed hypersensitivity in the albino guinea pig with ethanone, 1-(3,3-dimethyl-1-cyclohexen-1-yl)-(artemone). Unpublished report from Givaudan, Report number 56224 (RIFM, Woodcliff Lake, NJ, USA).
155. RIFM (Research Institute for Fragrance Materials, Inc.), 1985d. Determination of photoallergenicity in guinea pigs with ethanone, 1-(3,3-dimethyl-1-cyclohexen-1-yl)-(artemone). Unpublished report from Givaudan, Report number 56220 (RIFM, Woodcliff Lake, NJ, USA).
156. RIFM (Research Institute for Fragrance Materials, Inc.), 1985e. Determination of phototoxicity in guinea pigs with ethanone, 1-(3,3-dimethyl-1-cyclohexen-1-yl)-(artemone). Unpublished report from Givaudan, Report number 56219 (RIFM, Woodcliff Lake, NJ, USA).
157. RIFM (Research Institute for Fragrance Materials, Inc.), 1986a. Determination of the acute oral toxicity of methyl 2,6,10-trimethylcyclododeca-2,5,9-trien-1-yl ketone in rats. Unpublished report from Quest International, 09 August. Report number 45839 (RIFM, Woodcliff Lake, NJ, USA).
158. RIFM (Research Institute for Fragrance Materials, Inc.), 1986b. Examination of methyl 2,6,10-trimethylcyclododeca-2,5,9-trien-1-yl ketone for mutagenic activity in the Ames Test. Unpublished report from Quest International, 24 December. Report number 45817 (RIFM, Woodcliff Lake, NJ, USA).
159. RIFM (Research Institute for Fragrance Materials, Inc.), 1987a. Determination in the rat of the median lethal dose of ethanone, 1-(3,3-dimethyl-1-cyclohexen-1-yl)-(artemone) administered orally. Unpublished report from Givaudan, Report number 56214 (RIFM, Woodcliff Lake, NJ, USA).
160. RIFM (Research Institute for Fragrance Materials, Inc.), 1987b. Evaluation of cutaneous irritation and/or corrosion in the rabbit with ethanone, 1-(3,3-dimethyl-1-cyclohexen-1-yl)-(artemone). Unpublished report from Givaudan, Report number 56217 (RIFM, Woodcliff Lake, NJ, USA).
161. RIFM (Research Institute for Fragrance Materials, Inc.), 1987c. Sensitization test with methyl 2,6,10-trimethylcyclododeca-2,5,9-trien-1-yl ketone in guinea pigs. Unpublished report from Quest International, 10 April. Report number 45838 (RIFM, Woodcliff Lake, NJ, USA).
162. RIFM (Research Institute for Fragrance Materials, Inc.), 1988a. Repeat insult patch test of ethylene brassylate, methyl 2-nonynoate, 6,7-dihydrogeraniol and cyclohexyl methyl pentanone in humans. RIFM Report number 6063, December 13 (RIFM, Woodcliff Lake, NJ, USA).
163. RIFM (Research Institute for Fragrance Materials, Inc.), 1988b. Primary skin irritation/corrosion study of methyl 2,6,10-trimethylcyclododeca-2,5,9-trien-1-yl ketone in the rabbit. Unpublished report from Quest International, 22 March. Report number 45843 (RIFM, Woodcliff Lake, NJ, USA).
164. RIFM (Research Institute for Fragrance Materials, Inc.), 1988c. Guinea pig skin sensitization test with methyl 2,6,10-trimethylcyclododeca-2,5,9-trien-1-yl ketone. Unpublished report from Quest International, 30 June. Report number 45851 (RIFM, Woodcliff Lake, NJ, USA).
165. RIFM (Research Institute for Fragrance Materials, Inc.), 1988d. Eye irritation/corrosion study of methyl 2,6,10-trimethylcyclododeca-2,5,9-trien-1-yl ketone in the rabbit. Unpublished report from Quest International, 08 March. Report number 45844 (RIFM, Woodcliff Lake, NJ, USA).
166. RIFM (Research Institute for Fragrance Materials, Inc.), 1990a. 1-(3,3-Dimethylcyclohexyl)pent-4-en-1-one: Bacterial mutation assay. Unpublished report from International Flavors and Fragrances, Report number 48162 (RIFM, Woodcliff Lake, NJ, USA).
167. RIFM (Research Institute for Fragrance Materials, Inc.), 1990b. Mouse micronucleus test on 1-(3,3-dimethylcyclohexyl)pent-4-en-1-one. Unpublished report from International Flavors and Fragrances, Report number 48251 (RIFM, Woodcliff Lake, NJ, USA).
168. RIFM (Research Institute for Fragrance Materials, Inc.), 1991a. 1-(2,4-Dimethyl-3-cyclohexenyl)-2,2-dimethylpropan-1-one (chrysantheme): Acute dermal toxicity (Limit Test) in the rat. Unpublished report from Symrise, 30 May. Report number 59223 (RIFM, Woodcliff Lake, NJ, USA).
169. RIFM (Research Institute for Fragrance Materials, Inc.), 1991b. Acute dermal toxicity study of 3-buten-2-one, 4-(2,2,3,6-tetramethylcyclohexyl)- in the rat. Unpublished report from Firmenich Incorporated, 17 October. Report number 41837 (RIFM, Woodcliff Lake, NJ, USA).
170. RIFM (Research Institute for Fragrance Materials, Inc.), 1991c. Acute oral toxicity test of cyclohexyl methyl pentanone in rats. Unpublished report from Dragoco Gerberding and Co. GmbH, Report number 37768 (RIFM, Woodcliff Lake, NJ, USA).
171. RIFM (Research Institute for Fragrance Materials, Inc.), 1991d. 1-(2,4-Dimethyl-3-cyclohexenyl)-2,2-dimethylpropan-1-one (chrysantheme): Acute oral toxicity (Limit Test) in the rat. Unpublished report from Symrise, 29 May. Report number 59219 (RIFM, Woodcliff Lake, NJ, USA).
172. RIFM (Research Institute for Fragrance Materials, Inc.), 1991e. Mutagenicity study of 1-(2,4-dimethyl-3-cyclohexenyl)-2,2-dimethylpropan-1-one (chrysantheme) in the Salmonella typhimurium/mammalian microsome reverse mutation assay (Ames Test). Unpublished report from Symrise, 22 March. Report number 59222 (RIFM, Woodcliff Lake, NJ, USA).
173. RIFM (Research Institute for Fragrance Materials, Inc.), 1991f. Bacterial reverse mutation assay with 3-buten-2-one, 4-(2,2,3,6-tetramethylcyclohexyl). Unpublished report from Firmenich Incorporated, 27 September. Report number 41841 (RIFM, Woodcliff Lake, NJ, USA).
174. RIFM (Research Institute for Fragrance Materials, Inc.), 1991g. Acute dermal irritation/corrosion test of cyclohexyl methyl pentanone in rabbits. Unpublished report from Dragoco Gerberding and Co. GmbH, Report number 37770 (RIFM, Woodcliff Lake, NJ, USA).
175. RIFM (Research Institute for Fragrance Materials, Inc.), 1991h. Guinea pig maximization test of skin sensitization with cyclohexyl methyl pentanone. Unpublished report from Dragoco Gerberding and Co. GmbH, Report number 37771 (RIFM, Woodcliff Lake, NJ, USA).
176. RIFM (Research Institute for Fragrance Materials, Inc.), 1991i. Assessment of the skin irritant effect of 1-(2,4-dimethyl-3-cyclohexenyl)-2,2-dimethylpropan-1-one (chrysantheme) in rabbits. Unpublished report from Symrise, 9 April. Report number 59220 (RIFM, Woodcliff Lake, NJ, USA).
177. RIFM (Research Institute for Fragrance Materials, Inc.), 1991j. 1-(2,4-Dimethyl-3-cyclohexenyl)-2,2-dimethylpropan-1-one (chrysantheme): Magnusson & Kligman maximization study in the guinea pig. Unpublished report from Symrise, 24 May. Report number 59221 (RIFM, Woodcliff Lake, NJ, USA).
178. RIFM (Research Institute for Fragrance Materials, Inc.), 1991k. Acute eye irritation/corrosion test cyclohexyl methyl pentanone in rabbits. Unpublished report from Dragoco Gerberding and Co. GmbH, Report number 37769 (RIFM, Woodcliff Lake, NJ, USA).
179. RIFM (Research Institute for Fragrance Materials, Inc.), 1992a. Acute oral toxicity study of 3-buten-2-one, 4-(2,2,3,6-tetramethylcyclohexyl)- in the rat. Unpublished report from Firmenich Incorporated, 13 January. Report number 41836 (RIFM, Woodcliff Lake, NJ, USA).
180. RIFM (Research Institute for Fragrance Materials, Inc.), 1992b. Acute dermal irritation/corrosion study of 3-buten-2-one, 4-(2,2,3,6-tetramethylcyclohexyl)- in rabbits. Unpublished report from Firmenich Incorporated, 17 February. Report number 41838 (RIFM, Woodcliff Lake, NJ, USA).
181. RIFM (Research Institute for Fragrance Materials, Inc.), 1992c. Acute eye irritation study of 3-buten-2-one, 4-(2,2,3,6-tetramethylcyclohexyl)- in rabbits. Unpublished report from Firmenich Incorporated, 06 April. Report number 41839 (RIFM, Woodcliff Lake, NJ, USA).
182. RIFM (Research Institute for Fragrance Materials, Inc.), 1992d. Guinea-pig maximisation test with 3-buten-2-one, 4-(2,2,3,6-tetramethylcyclohexyl). Unpublished report from Firmenich Incorporated, 01 February. Report number 41840 (RIFM, Woodcliff Lake, NJ, USA).
183. RIFM (Research Institute for Fragrance Materials, Inc.), 1993a. Report on cyclohexyl methyl pentanone. RIFM Report number 20500, (RIFM, Woodcliff Lake, NJ, USA).
184. RIFM (Research Institute for Fragrance Materials, Inc.), 1993b. Methyl 2,6,10-trimethylcyclododeca-2,5,9-trien-1-yl ketone: Acute dermal toxicity to the rat. Unpublished report from Quest International, 28 July. Report number 45816 (RIFM, Woodcliff Lake, NJ, USA).
185. RIFM (Research Institute for Fragrance Materials, Inc.), 1993c. Methyl 2,6,10-trimethylcyclododeca-2,5,9-trien-1-yl ketone: Mutagenicity study in Salmonella typhimurium. Unpublished report from Quest International, 23 August. Report number 45815 (RIFM, Woodcliff Lake, NJ, USA).
186. RIFM (Research Institute for Fragrance Materials, Inc.), 1993d. Methyl 2,6,10-trimethylcyclododeca-2,5,9-trien-1-yl ketone: In vitro cytogenetics study in human lymphocytes. Unpublished report from Quest International, 10 January. Report number 45814 (RIFM, Woodcliff Lake, NJ, USA).
187. RIFM (Research Institute for Fragrance Materials, Inc.), 1994a. Ethanone, 1-(3,3-dimethyl-1-cyclohexen-1-yl)- (Artemone): Acute oral toxicity (limit) test in rats. Unpublished report from Givaudan, Report number 56211 (RIFM, Woodcliff Lake, NJ, USA).
188. RIFM (Research Institute for Fragrance Materials, Inc.), 1994b. Methyl 2,6,10-trimethylcyclododeca-2,5,9-trien-1-yl ketone: 28 day subacute oral toxicity study in rats. Unpublished report from Quest International, 31 January. Report number 45813 (RIFM, Woodcliff Lake, NJ, USA).
189. RIFM (Research Institute for Fragrance Materials, Inc.), 1994c. Evaluation of the perfumery ingredient ethanone, 1-(3,3-dimethyl-1-cyclohexen-1-yl)- (artemone) for mutagenic activity in the Ames Test. Unpublished report from Givaudan, Report number 56223 (RIFM, Woodcliff Lake, NJ, USA).
190. RIFM (Research Institute for Fragrance Materials, Inc.), 1994d. Ethanone, 1-(3,3-dimethyl-1-cyclohexen-1-yl)- (Artemone): Acute dermal irritation test in rabbits. Unpublished report from Givaudan, Report number 56209 (RIFM, Woodcliff Lake, NJ, USA).
191. RIFM (Research Institute for Fragrance Materials, Inc.), 1995a. Iso E super - Seven day oral toxicity study in the rat. Unpublished report from International Flavors and Fragrances, 08 February. Report number 31710 (RIFM, Woodcliff Lake, NJ, USA).
192. RIFM (Research Institute for Fragrance Materials, Inc.), 1995b. 1-(2,4-Dimethyl-3-cyclohexenyl)-2,2-dimethylpropan-1-one (chrysantheme): Local Lymph Node Assay. Unpublished report from Symrise, 20 December. Report number 59224 (RIFM, Woodcliff Lake, NJ, USA).
193. RIFM (Research Institute for Fragrance Materials, Inc.), 1996a. Partition coefficient n-octanol/water of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8.8-tetramethyl-2-naphthalenyl)ethanone. Unpublished report from Givaudan, 4 December. Report number 33494 (RIFM, Woodcliff Lake, NJ, USA).
194. RIFM (Research Institute for Fragrance Materials, Inc.), 1996b. 1-(3,3-Dimethylcyclohexyl)pent-4-en-1-one (galbaniff): Acute dermal toxicity to the rat. Unpublished report from International Flavors and Fragrances, Report number 47585 (RIFM, Woodcliff Lake, NJ, USA).
195. RIFM (Research Institute for Fragrance Materials, Inc.), 1996c. Acute dermal toxicity study with ethanone, 1-[(1R,2S)-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethyl-2-naphthalenyl]-, rel- (georgywood) in rats. Unpublished report from Givaudan, 11 November. Report number 58391 (RIFM, Woodcliff Lake, NJ, USA).
196. RIFM (Research Institute for Fragrance Materials, Inc.), 1996d. Acute oral toxicity study in the rat with ethanone, 1-[(1R,2S)-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethyl-2-naphthalenyl]-, rel- (georgywood). Limit Test. Unpublished report from Givaudan, 16 February. Report number 58390 (RIFM, Woodcliff Lake, NJ, USA).
197. RIFM (Research Institute for Fragrance Materials, Inc.), 1996e. 1-(3,3-Dimethylcyclohexyl)pent-4-en-1-one: Twenty-eight day oral toxicity study in the rat. Unpublished report from International Flavors and Fragrances, Report number 48024 (RIFM, Woodcliff Lake, NJ, USA).
198. RIFM (Research Institute for Fragrance Materials, Inc.), 1996f. Mutagenicity evaluation of ethanone, 1-[(1R,2S)-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethyl-2-naphthalenyl]-, rel- (georgywood) in the Ames Test. Unpublished report from Givaudan, 18 September. Report number 58392 (RIFM, Woodcliff Lake, NJ, USA).
199. RIFM (Research Institute for Fragrance Materials, Inc.), 1996g. 1-(3,3-Dimethylcyclohexyl)pent-4-en-1-one: Metaphase chromosome analysis of human lymphocytes cultured in vitro. Unpublished report from International Flavors and Fragrances, Report number 48245 (RIFM, Woodcliff Lake, NJ, USA).
200. RIFM (Research Institute for Fragrance Materials, Inc.), 1996h. Clinical safety evaluation of ethanone, 1-(3,3-dimethyl-1-cyclohexen-1-yl)- (artemone): Repeated insult patch test. Unpublished report from Givaudan, 3 July. Report number 56225 (RIFM, Woodcliff Lake, NJ, USA).
201. RIFM (Research Institute for Fragrance Materials, Inc.), 1996i. 1-(3,3-Dimethylcyclohexyl)pent-4-en-1-one: Skin sensitisation in the guinea pig. Unpublished report from International Flavors and Fragrances, Report number 47894 (RIFM, Woodcliff Lake, NJ, USA).
202. RIFM (Research Institute for Fragrance Materials, Inc.), 1996j. Primary skin irritation study with ethanone, 1-[(1R,2S)-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethyl-2-naphthalenyl]-, rel- (georgywood) in rabbits (4-hour semi-occlusive application). Unpublished report from Givaudan, 07 November. Report number 58388 (RIFM, Woodcliff Lake, NJ, USA).
203. RIFM (Research Institute for Fragrance Materials, Inc.), 1996k. Contact hypersensitivity to ethanone, 1-[(1R,2S)-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethyl-2-naphthalenyl]-, rel- (georgywood), in albino guinea pigs maximization-test. Unpublished report from Givaudan, 14 November. Report number 58387 (RIFM, Woodcliff Lake, NJ, USA).
204. RIFM (Research Institute for Fragrance Materials, Inc.), 1996l. Primary eye irritation study with ethanone, 1-[(1R,2S)-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethyl-2-naphthalenyl]-, rel- (georgywood) in rabbits. Unpublished report from Givaudan, 07 November. Report number 58389 (RIFM, Woodcliff Lake, NJ, USA).
205. RIFM (Research Institute for Fragrance Materials, Inc.), 1997a. Ethanone, 1-[(1R,2S)-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethyl-2-naphthalenyl]-, rel- (georgywood): Four-week oral (gavage) toxicity study in rats. Unpublished report from Givaudan, 03 March. Report number 58385 (RIFM, Woodcliff Lake, NJ, USA).
206. RIFM (Research Institute for Fragrance Materials, Inc.), 1997b. Iso E super - Four week oral toxicity study in the rat with two week recovery period. Unpublished report from International Flavors and Fragrances, 13 October. Report number 31713 (RIFM, Woodcliff Lake, NJ, USA).
207. RIFM (Research Institute for Fragrance Materials, Inc.), 1997c. Iso E super - Bacterial mutation assay. Unpublished report from International Flavors and Fragrances, 08 October. Report number 31711 (RIFM, Woodcliff Lake, NJ, USA).
208. RIFM (Research Institute for Fragrance Materials, Inc.), 1997d. Chromosome analysis in cultured Chinese hamster V79 cells treated with ethanone, 1-[(1R,2S)-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethyl-2-naphthalenyl]-, rel- (georgywood) in the presence and abscence of a metabolic activation system.Unpublished report from Givaudan, 04 February. Report number 58393 (RIFM, Woodcliff Lake, NJ, USA).
209. RIFM (Research Institute for Fragrance Materials, Inc.), 1997e. Iso E super - Metaphase chromosome analysis of human lymphocytes cultured in vitro. Unpublished report from International Flavors and Fragrances, 12 August. Report number 31712 (RIFM, Woodcliff Lake, NJ, USA).
210. RIFM (Research Institute for Fragrance Materials, Inc.), 1998. Ethanone, 1-[(1R,2S)-1,2,3,4,5,6,7,8-octahydro-1,2,8,8-tetramethyl-2-naphthalenyl]-, rel- (georgywood): Repeated insult patch test. Unpublished report from Givaudan, 03 March. Report number 58386 (RIFM, Woodcliff Lake, NJ, USA).
211. RIFM (Research Institute for Fragrance Materials, Inc.), 1999a. 1-(5,5-Dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one: Acute oral toxicity study, limit test, in rats. Unpublished report from Firmenich Incorporated, 27 January. Report number 42137 (RIFM, Woodcliff Lake, NJ, USA).
212. RIFM (Research Institu te for Fragrance Materials, Inc.), 1999b. Repeated insult patch test of 1-(5,5-dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one. Unpublished report from Firmenich Incorporated, 29 June. Report number 42138 (RIFM, Woodcliff Lake, NJ, USA).
213. RIFM (Research Institute for Fragrance Materials, Inc.), 1999c. Repeated insult patch test with 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone. Unpublished report from IFF Incorporated, 22 April. Report number 47085 (RIFM, Woodcliff Lake, NJ, USA).
214. RIFM (Research Institute for Fragrance Materials, Inc.), 1999d. 1-(5,5-Dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one: Delayed contact hypersensitivity modified Buehler method. Unpublished report from Firmenich Incorporated, 01 March. Report number 42136 (RIFM, Woodcliff Lake, NJ, USA).
215. RIFM (Research Institute for Fragrance Materials, Inc.), 1999e. 1-(5,5-Dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one: Primary skin irritation study in rabbits (4-hour semi-occlusive application). Unpublished report from Givaudan, 15 July. Report number 42070 (RIFM, Woodcliff Lake, NJ, USA).
216. RIFM (Research Institute for Fragrance Materials, Inc.), 1999f. 1-(5,5-Dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one: Study of skin sensitization in albino guinea pigs maximization-test. Unpublished report from Givaudan, 20 August. Report number 42076 (RIFM, Woodcliff Lake, NJ, USA).
217. RIFM (Research Institute for Fragrance Materials, Inc.), 1999g. 1-(5,5-Dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one: Primary eye irritation study in rabbits. Unpublished report from Givaudan, 23 July. Report number 42071 (RIFM, Woodcliff Lake, NJ, USA).
218. RIFM (Research Institute for Fragrance Materials, Inc.), 2000a. 4-Penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- and 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- (spirogalbanone): Acute oral toxicity study in rats. Unpublished report from Givaudan, 29 May. Report number 60581 (RIFM, Woodcliff Lake, NJ, USA).
219. RIFM (Research Institute for Fragrance Materials, Inc.), 2000b. 2-Week dermal toxicity range-finding study with acetyl cedrene and alpha-methyl-3,4-methylene-dioxy-hydrocinnamic aldehyde in rats. RIFM Report number 35257 (RIFM, Woodcliff Lake, NJ, USA).
220. RIFM (Research Institute for Fragrance Materials, Inc.), 2000c. Salmonella typhimurium reverse mutation assay with 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- and 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl-(spirogalbanone). AMENDMENT ATTACHED. Unpublished report from Givaudan, 13 June. Report number 60591 (RIFM, Woodcliff Lake, NJ, USA).
221. RIFM (Research Institute for Fragrance Materials, Inc.), 2000d. 4-Penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- and 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl-(spirogalbanone): Primary skin irritation study in rabbits (4-hour semi-occlusive application). Unpublished report from Givaudan, 23 June. Report number 60590 (RIFM, Woodcliff Lake, NJ, USA).
222. RIFM (Research Institute for Fragrance Materials, Inc.), 2000e. 4-Penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- and 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- (spirogalbanone): Study of skin sensitization in the guinea pig; Open Epicutaneous Test (ethanol as vehicle). Unpublished report from Givaudan, 31 March. Report number 60599 (RIFM, Woodcliff Lake, NJ, USA).
223. RIFM (Research Institute for Fragrance Materials, Inc.), 2000f. 4 4-Penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- and 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl-(spirogalbanone): Contact hypersensitivity in guinea pigs, maximization-test. Unpublished report from Givaudon, 25 September. Report number 60595 (RIFM, Woodcliff Lake, NJ, USA).
224. RIFM (Research Institute for Fragrance Materials, Inc.), 2000g. 1-(5,5-Dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one: Study of skin sensitization in the guinea pig; Open Epicutaneous Test (ethanol as vehichle). Unpublished report from Givaudan, 31 March. Report number 42074 (RIFM, Woodcliff Lake, NJ, USA).
225. RIFM (Research Institute for Fragrance Materials, Inc.), 2000h. 1-(5,5-Dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one: Study of skin sensitization in the guinea pig; Open Epicutaneous Test. Unpublished report from Givaudan, 10 January. Report number 42075 (RIFM, Woodcliff Lake, NJ, USA).
226. RIFM (Research Institute for Fragrance Materials, Inc.), 2000i. 4-Penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- and 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl-(spirogalbanone): Primary eye irritation study in rabbits. Unpublished report from Givaudan, 30 May. Report number 60589 (RIFM, Woodcliff Lake, NJ, USA).
227. RIFM (Research Institute for Fragrance Materials, Inc.), 2001a. In-vitro human skin penetration of methyl eugenol, estragole, acetyl cedrene and OTNE. RIFM Report number 37084, April 01 (RIFM, Woodcliff Lake, NJ, USA).
228. RIFM (Research Institute for Fragrance Materials, Inc.), 2001b. (14)C-OTNE: Investigation of the transfer across the placenta and into milk of rats during and after pregnancy following repeated oral administration. RIFM Report number 38108 (RIFM, Woodcliff Lake, NJ, USA).
229. RIFM (Research Institute for Fragrance Materials, Inc.), 2001c. 1,6-Heptadien-3-one, 2-cyclohexyl- (pharaone): Acute oral toxicity study in rats. Unpublished report from Givaudon, 08 October. Report number 59371 (RIFM, Woodcliff Lake, NJ, USA).
230. RIFM (Research Institute for Fragrance Materials, Inc.), 2001d. Salmonella typhimurium reverse mutation assay with 1,6-heptadien-3-one, 2-cyclohexyl- (pharaone). [Amendment Attached] Unpublished report from Givaudon, 16 November. Report number 59404 (RIFM, Woodcliff Lake, NJ, USA).
231. RIFM (Research Institute for Fragrance Materials, Inc.), 2001e. Repeated insult patch test with 1-(5,5-dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one. Unpublished report from International Flavors and Fragrances, 29 October. Report number 51118 (RIFM, Woodcliff Lake, NJ, USA).
232. RIFM (Research Institute for Fragrance Materials, Inc.), 2001f. 1,6-Heptadien-3-one, 2-cyclohexyl- (pharaone): Primary skin irritation study in rabbits (4-hour semi-occlusive application). Unpublished report from Givaudon, 19 October. Report number 59379 (RIFM, Woodcliff Lake, NJ, USA).
233. RIFM (Research Institute for Fragrance Materials, Inc.), 2001g. 1,6-Heptadien-3-one, 2-cyclohexyl- (pharaone): Contact hypersensitivity in albino guinea pigs, maximization-test. Unpublished report from Givaudon, 04 December. Report number 59410 (RIFM, Woodcliff Lake, NJ, USA).
234. RIFM (Research Institute for Fragrance Materials, Inc.), 2001h. 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- and 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl-(spirogalbanone): Determination of photoallergenicity in albino guinea pigs (including information about allergenicity, photoirritation and irritation). Unpublished report from Givaudon, 15 November. Report number 60593 (RIFM, Woodcliff Lake, NJ, USA).
235. RIFM (Research Institute for Fragrance Materials, Inc.), 2001i. 1-(5,5-Dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one: Local Lymph Node Assay (LLNA) in mice (identification of contact allergens). Unpublished report from Givaudan, 16 May. Report number 42073 (RIFM, Woodcliff Lake, NJ, USA).
236. RIFM (Research Institute for Fragrance Materials, Inc.), 2001j. 4-Penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- and 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- (spirogalbanone) non-stabilized: Local Lymph Node Assay (LLNA) in mice (identification of contact allergens). Unpublished report from Givaudon, 16 May. Report number 60597 (RIFM, Woodcliff Lake, NJ, USA).
237. RIFM (Research Institute for Fragrance Materials, Inc.), 2001k. 4-Penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- and 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- (spirogalbanone) stabilized with 0.1% alpha-tocopherol: Local Lymph Node Assay (LLNA) in mice (identification of contact allergens). Unpublished report from Givaudon, 16 May. Report number 60598 (RIFM, Woodcliff Lake, NJ, USA).
238. RIFM (Research Institute for Fragrance Materials, Inc.), 2002a. 13-Week dermal toxicity study with acetyl cedrene in rats with a 4-week recovery. RIFM Report number 40242, April 29 (RIFM, Woodcliff Lake, NJ, USA).
239. RIFM (Research Institute for Fragrance Materials, Inc.), 2002b. Oral (gavage) dosage-range developmental toxicity study of acetyl cedrene in rats. RIFM Report number 44880, May 17 (RIFM, Woodcliff Lake, NJ, USA).
240. RIFM (Research Institute for Fragrance Materials, Inc.), 2002c. Oral (gavage) dosage-range developmental toxicity study of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (OTNE) in rats. RIFM Report number 39734 (RIFM, Woodcliff Lake, NJ, USA).
241. RIFM (Research Institute for Fragrance Materials, Inc.), 2002d. Oral (gavage) developmental toxicity study of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (OTNE) in rats. RIFM Report number 39733 (RIFM, Woodcliff Lake, NJ, USA).
242. RIFM (Research Institute for Fragrance Materials, Inc.), 2002e. Clinical safety evaluation repeated insult patch test of 1-(5,5-dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one. Unpublished report from Givaudan, 11 June. Report number 42072 (RIFM, Woodcliff Lake, NJ, USA).
243. RIFM (Research Institute for Fragrance Materials, Inc.), 2002f. 1,6-Heptadien-3-one, 2-cyclohexyl- (pharaone): Determination of photoallergenicity in albino guinea pigs (including information about allergenicity, photoirritation and irritation). Unpublished report from Givaudon, 15 February. Report number 59408 (RIFM, Woodcliff Lake, NJ, USA).
244. RIFM (Research Institute for Fragrance Materials, Inc.), 2002g. 2-Buten-1-one, 1-(2,2,6-trimethylcyclohexyl)-: Human patch test. Unpublished report from Takasago International Corporation, 12 July. Report number 50541 (RIFM, Woodcliff Lake, NJ, USA).
245. RIFM (Research Institute for Fragrance Materials, Inc.), 2003a. In vitro mammalian chromosome aberration test with acetyl cedrene. RIFM report number 43491, November 21 (RIFM, Woodcliff Lake, NJ, USA).
246. RIFM (Research Institute for Fragrance Materials, Inc.), 2003b. Repeated insult patch test with 1,6-heptadien-3-one, 2-cyclohexyl- (pharaone). Unpublished report from Givaudon, 24 Januuary. Report number 59411 (RIFM, Woodcliff Lake, NJ, USA).
247. RIFM (Research Institute for Fragrance Materials, Inc.), 2003c. Repeated insult patch study of 1-(5,5-dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one at 1% in diethyl phthalate (DEP). Unpublished report from Firmenich Incorporated, 25 February. Report number 42658 (RIFM, Woodcliff Lake, NJ, USA).
248. RIFM (Research Institute for Fragrance Materials, Inc.), 2003d. Dermal sensitization test with 1-(5,5-dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one - Magnusson-Kligman Method (OECD 406). Unpublished report from Firmenich Incorporated, 18 December. Report number 44320 (RIFM, Woodcliff Lake, NJ, USA).
249. RIFM (Research Institute for Fragrance Materials, Inc.), 2004a. 1,6-Heptadien-3-one, 2-cyclohexyl- (pharaone): Acute dermal toxicity study in rats. Unpublished report from Givaudon, 09 July. Report number 59370 (RIFM, Woodcliff Lake, NJ, USA).
250. RIFM (Research Institute for Fragrance Materials, Inc.), 2004b. Five day dose range finding and 28-day oral toxicity (gavage) study and 5 day range-finding oral toxicity study in the Wistar rat with 1,6-heptadien-3-one, 2-cyclohexyl- (pharaone). Unpublished report from Givaudon, 15 December. Report number 59412 (RIFM, Woodcliff Lake, NJ, USA).
251. RIFM (Research Institute for Fragrance Materials, Inc.), 2004c. In vitro chromosome aberration test in Chinese hamster V79 cells with 1,6-heptadien-3-one, 2-cyclohexyl- (pharaone).Unpublished report from Givaudon, 11 October. Report number 59406 (RIFM, Woodcliff Lake, NJ, USA).
252. RIFM (Research Institute for Fragrance Materials, Inc.), 2004d. Oral (gavage) developmental toxicity study of acetyl cedrene in rats. RIFM Report number 44881, January 23 (RIFM, Woodcliff Lake, NJ, USA).
253. RIFM (Research Institute for Fragrance Materials, Inc.), 2004e. Developmental toxicity of acetyl cedrene in rats. RIFM Report number 44451 (RIFM, Woodcliff Lake, NJ, USA).
254. RIFM (Research Institute for Fragrance Materials, Inc.), 2004f Modified primary dermal irritation test with acetyl cedrene. RIFM Report number 47276, March 10 (RIFM, Woodcliff Lake, NJ, USA).
255. RIFM (Research Institute for Fragrance Materials, Inc.), 2004g. Repeated insult patch test with acetyl cedrene (modified Draize procedure). RIFM Report number 45125, June 28 (RIFM, Woodcliff Lake, NJ, USA).
256. RIFM (Research Institute for Fragrance Materials, Inc.), 2004h. Modified primary dermal irritation test with 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone. RIFM Report number 47275, March 10 (RIFM, Woodcliff Lake, NJ, USA).
257. RIFM (Research Institute for Fragrance Materials, Inc.), 2004i. Repeated insult patch test with 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (modified Draize procedure). RIFM Report number 45124, June 28 (RIFM, Woodcliff Lake, NJ, USA).
258. RIFM (Research Institute for Fragrance Materials, Inc.), 2005a. 4-Penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- and 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl-(spirogalbanone): Acute dermal toxicity study in rats. Unpublished report from Givaudon, 29 March. Report number 60580 (RIFM, Woodcliff Lake, NJ, USA).
259. RIFM (Research Institute for Fragrance Materials, Inc.), 2005b. 4-Penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- and 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl-(spirogalbanone): 28-Day oral toxicity (gavage) study in the Wistar rat. Unpublished report from Givaudon, 17 August. Report number 60600 (RIFM, Woodcliff Lake, NJ, USA).
260. RIFM (Research Institute for Fragrance Materials, Inc.), 2005c. 1-(5,5-Dimethyl-1-cyclohexen-1-yl)pent-4-en-1-one (dynascone): Reverse mutation assay "Ames Test" using Salmonella typhimurium and Escherichia coli. Unpublished report from Firmenich, 18 October. Report number 61258 (RIFM, Woodcliff Lake, NJ, USA).
261. RIFM (Research Institute for Fragrance Materials, Inc.), 2005d. 3-Buten-2-one, 4-(2,2,3,6-tetramethylcyclohexyl)- (myrrhone): Reverse mutation assay "Ames Test" using Salmonella typhimurium. [Addendum Attached] Unpublished report from Firmenich, 28 January. Report number 61251 (RIFM, Woodcliff Lake, NJ, USA).
262. RIFM (Research Institute for Fragrance Materials, Inc.), 2005e. In vitro chromosome aberration test in Chinese hamster V79 cells 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- and 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl-(spirogalbanone). Unpublished report from Givaudon, 28 July. Report number 60592 (RIFM, Woodcliff Lake, NJ, USA).
263. RIFM (Research Institute for Fragrance Materials, Inc.), 2005f. Micronucleus assay in bone marrow cells of the mouse with 1,6-heptadien-3-one, 2-cyclohexyl- (pharaone). Unpublished report from Givaudon, 12 April. Report number 59407 (RIFM, Woodcliff Lake, NJ, USA).
264. RIFM (Research Institute for Fragrance Materials, Inc.), 2005g. Topical photoallergy screening test of acetyl cedrene in male albino hairless guinea pigs (Crl: IAF(HA)-hrBR (Outbred)], including primary irritation, phototoxicity and contact hypersensitivity evaluations. RIFM Report number 51356, June 22 (RIFM, Woodcliff Lake, NJ, USA).
265. RIFM (Research Institute for Fragrance Materials, Inc.), 2005h. Acetyl cedrene: Local Lymph Node Assay. RIFM Report number 51629, November 09 (RIFM, Woodcliff Lake, NJ, USA).
266. RIFM (Research Institute for Fragrance Materials, Inc.), 2005i. 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone: Local Lymph Node Assay. RIFM Report number 51630, November 09 (RIFM, Woodcliff Lake, NJ, USA).
267. RIFM (Research Institute for Fragrance Materials, Inc.), 2006a. Mutagenicity test of 1-(3,3-dimethylcyclohexyl)ethan-1-one using microorganisms. Unpublished report from International Flavors and Fragrances, 14 November. Report number 53437 (RIFM, Woodcliff Lake, NJ, USA).
268. RIFM (Research Institute for Fragrance Materials, Inc.), 2006b. Repeated insult patch test with 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl- and 4-penten-1-one, 1-spiro[4.5]dec-7-en-7-yl-(spirogalbanone). Unpublished report from Givaudon, 12 April. Report number 60596 (RIFM, Woodcliff Lake, NJ, USA).
269. RIFM (Research Institute for Fragrance Materials, Inc.), 2007a. Acetic acid, anhydride, reaction products with 1,5,10-trimethyl-1,5,9-cyclododecatriene (Trimofix O): Acute dermal toxicity to the rat. Unpublished report from IFF, Report number 56696 (RIFM, Woodcliff Lake, NJ, USA).
270. RIFM (Research Institute for Fragrance Materials, Inc.), 2007b. Acetic acid, anhydride, reaction products with 1,5,10-trimethyl-1,5,9-cyclododecatriene (Trimofix O): Toxicity study by oral administration to CD rats for 4 weeks followed by a 2 week recovery period. Unpublished report from IFF, Report number 56700 (RIFM, Woodcliff Lake, NJ, USA).
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