Fragrance material review on 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (OTNE)

Food and Chemical Toxicology

Volumn 62, Issue , 2013, Pages

  Scognamiglio, J ^a   Letizia, C S ^a   Politano, V T ^a   Api, A M ^a  

^a RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS   (United States)

Author keywords

1 (1,2,3,4,5,6,7,8 Octahydro 2,3,8,8 tetramethyl 2 naphthalenyl)ethanone; Fragrance; Material; OTNE; Review

Indexed keywords

1 (1,2,3,4,5,6,7,8 OCTAHYDRO 2,3,8,8 TETRAMETHYL 2 NAPHTHALENYL)ETHANONE; ALKYLBENZENE; FRAGRANCE; HYDROCARBON; KETONE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; CONTROLLED STUDY; DERMATOLOGY; FEMALE; GENOTOXICITY; HUMAN; MALE; MUCOSA; NONHUMAN; PHOTOALLERGY; PHOTOTOXICITY; RAT; REPEATED DRUG DOSE; REVIEW; RISK ASSESSMENT; SKIN IRRITATION; SKIN SENSITIZATION; TOXICOKINETICS; TOXICOLOGY;

1-(1,2,3,4,5,6,7,8-OCTAHYDRO-2,3,8,8-TETRAMETHYL-2-NAPHTHALENYL)ETHANONE; FRAGRANCE; MATERIAL; OTNE; REVIEW;

ANIMALS; CONSUMER PRODUCT SAFETY; DERMATITIS, PHOTOALLERGIC; DERMATITIS, PHOTOTOXIC; DRUG HYPERSENSITIVITY; EYE; HUMANS; IRRITANTS; NAPHTHALENES; PERFUME; POLYCYCLIC HYDROCARBONS, AROMATIC; SKIN; TOXICITY TESTS;

EID: 84888024310     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.08.056     Document Type: Review

References (50)

1. Ames B.N., McCann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutation Research 1975, 31:347-363. (submitted only for the methodology).
2. An S., Lee A.-Y., Lee C.H., Kim D.-W., Hahm J.H., Kim K.-J., Moon K.-C., Won Y.H., Ro Y.-S., Eun H.C. Fragrance contact dermatitis in Korea: a joint study. Contact Dermatitis 2005, 53(6):320-323.
3. Basketter D.A., Blaikie L., Dearman R.J., Kimber I., Ryan C.A., Gerberick G.F., Harvey P., Evans P., White I.R., Rycroft R.J.G. Use of the local lymph node assay for estimation of relative contact allergenic potential. Contact Dermatitis 2000, 42:344-348.
4. Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2013. A Toxicologic and dermatologic assessment of alkyl cyclic ketones when used as fragrance ingredients (submitted for publication).
5. Cadby P., Troy W., Vey M. Consumer exposure to fragrance ingredients: providing estimates for safety evaluation. Regulatory Toxicology and Pharmacology 2002, 36:246-252.
6. Draize J.H., Woodard G., Calvery H.O. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. Journal of pharmacology and Experimental Therapeutics 1944, 82:377-390. (submitted only for the methodology).
7. EPA (Environmental Protection Agency), 2010. Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.00 or Insert Version Used]. United States Environmental Protection Agency, Washington, DC, USA.
8. Ford R., Domeyer B., Easterday O., Maier K., Middleton J. Criteria for development of a database for safety evaluation of fragrance ingredients. Regulatory Toxicology and Pharmacology 2000, 31:166-181.
9. Frosch P.J., Pilz B., Andersen K.E., Burrows D., Camarasa J.G., Dooms-Goossens A., Ducombs G., Fuchs T., Hannuksela M., Lachapelle J.M., Lahti A., Maibach H.I., Menne T., Rycroft R.J.G., Shaw S., Wahlberg J.E., White I.R., Wilkinson J.D. Patch testing with fragrances: results of a multicenter study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes. Contact Dermatitis 1995, 33:333-342.
10. Frosch P.J., Johansen J.D., Menne T., Pirker C., Rastogi S.C., Andersen K.E., Bruze M., Goossens A., Lepoittevin J.P., White I.R. Further important sensitizers in patients sensitive to fragrances. I. Reactivity to 14 frequently used chemicals. Contact Dermatitis 2002, 47(2):78-85.
11. + Reversion in Escherichia coli in Handbook of Mutagenicity Test Procedures 1984, 161. Elsevier Science Publishers BV, Amsterdam. second ed. B.J. Kilbey, M. Legator, W. Nichols, C. Ramel (Eds.).
12. IFRA (International Fragrance Association), 2008. Code of Practice. Standard on OTNE, Brussels.
13. IFRA (International Fragrance Association), 2008. Volume of Use Survey (February 2008).
14. IFRA (International Fragrance Association), 2010. Use Level Survey (July 2010).
15. Isola D.A., Api A.M. In vitro human skin penetration of seven radiolabelled fragrance materials. The Toxicologist 2002, 66(1-S):165.
16. Larsen W., Nakayama H., Fischer T., Elsner P., Frosch P., Burrows D., Jordan W., Shaw S., Wilkinson J., Marks J., Sugawara M., Nethercott M., Nethercott J. Fragrance contact dermatitis: a worldwide multicenter investigation (Part II). Contact Dermatitis 2001, 44(6):344-346.
17. Letizia C.S., Cocchiara J., Isola D.A., Api A.M. Evaluation of the developmental toxicity of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone. Toxicologist 2004, 78(1-S):37.
18. Maguire H.C. The bioassay of contact allergens in the guinea pig. Journal of the Society of Cosmetic Chemists 1973, 24:151-162. (submitted only for the methodology).
19. Politano V.T., Letizia C.S., Christian M.S., Diener R.M., Api A.M. Evaluation of the developmental toxicity of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (OTNE) in rats. International Journal of Toxicology 2009, 28(3):213-218.
20. RIFM, Research Institute for Fragrance Materials, Inc., 1973a. Repeated Insult Patch Test in Humans with OTNE. Unpublished Report from IFF Incorporated, 26 September. Report Number 19978.
21. RIFM, Research Institute for Fragrance Materials, Inc., 1973b. Sensitization Study in Guinea Pigs with OTNE. Unpublished Report from IFF Incorporated, 20 December. Report Number 19979.
22. RIFM, Research Institute for Fragrance Materials, Inc., 1973c. Primary Skin Irritation Study in Rabbits with OTNE. Unpublished Report from IFF Incorporated, 12 June. Report Number 19976.
23. RIFM, Research Institute for Fragrance Materials, Inc., 1973d. Eye Irritation Study in Rabbits with OTNE. Unpublished Report from IFF Incorporated, 3 July. Report number 19977.
24. RIFM, Research Institute for Fragrance Materials, Inc., 1977a. Repeated Insult Patch Test in Humans with OTNE. Unpublished Report from IFF Incorporated, 15 November. Report Number 19981.
25. RIFM, Research Institute for Fragrance Materials, Inc., 1977b. Primary skin Irritation Study in Rabbits with OTNE. Unpublished Report from IFF Incorporated, 27 May. Report Number 19982.
26. RIFM, Research Institute for Fragrance Materials, Inc., 1977c. Eye Irritation Study in Rabbits with OTNE. Unpublished Report from IFF Incorporated, 31 May. Report Number 19980.
27. RIFM, Research Institute for Fragrance Materials, Inc., 1978a. Repeated Insult Patch Test in Humans with OTNE. Unpublished Report from IFF Incorporated, 15 August and 29 December. Report Number 19984.
28. RIFM, Research Institute for Fragrance Materials, Inc., 1978b. Primary Skin Irritation Study in Rabbits with OTNE. Unpublished Report from IFF Incorporated, 8 March. Report Number 19983.
29. RIFM, Research Institute for Fragrance Materials, Inc., 1978c. Eye Irritation Study in Rabbits with OTNE. Unpublished Report from IFF Incorporated, 9 March. Report Number 19985.
30. RIFM, Research Institute for Fragrance Materials, Inc., 1979. Evaluation of Potential Hazards of Fragrance Materials by Dermal Contact in Humans. Unpublished Report from IFF Incorporated, 17 September. Report Number 19986.
31. RIFM, Research Institute for Fragrance Materials, Inc., 1980a. Acute Oral Toxicity Study with OTNE in Rats. Unpublished Report from IFF Incorporated, 30 August. Report Number 19987.
32. RIFM, Research Institute for Fragrance Materials, Inc., 1980b. Acute Dermal Toxicity of OTNE in Rats. Unpublished Report from IFF Incorporated, 30 August. Report Number 19988.
33. RIFM, Research Institute for Fragrance Materials, Inc., 1980c. Photoallergic/Phototoxic Study in Humans with Fragrance Materials. Unpublished Report from IFF Incorporated, 16 December. Report Number 19989.
34. RIFM, Research Institute for Fragrance Materials, Inc., 1980d. Phototoxicity Test in Humans with Fragrance Materials. Unpublished Report from IFF Incorporated, 17 October. Report Number 51016.
35. RIFM, Research Institute for Fragrance Materials, Inc., 1980e. Phototoxicity Test in Hairless Mice with Fragrance Materials. Unpublished Report from IFF Incorporated, 29 February. Report Number 19990.
36. RIFM, Research Institute for Fragrance Materials, Inc., 1995. Seven Day oral Toxicity Study of OTNE in the Rat. Unpublished Report from IFF Incorporated, 8 February. Report Number 31710.
37. RIFM, Research Institute for Fragrance Materials, Inc., 1997a. Four Week Oral Toxicity Study in the Rat with Two Week Recovery Period. Unpublished Report from IFF Incorporated, 13 October. Report Number 31713.
38. RIFM, Research Institute for Fragrance Materials, Inc., 1997b. Bacterial Mutation Assay with Iso E Super. Unpublished Report from IFF Incorporated, 8 October. Report Number 31711.
39. RIFM, Research Institute for Fragrance Materials, Inc., 1997c. Metaphase Chromosome Analysis of Human Lymphocytes Cultured In Vitro. Unpublished Report from IFF Incorporated, 12 August. Report Number 31712.
40. RIFM, Research Institute for Fragrance Materials, Inc., 1999. Repeated Insult Patch Test with OTNE. Unpublished Report from IFF Incorporated, 26 April. Report Number 47085.
41. RIFM, Research Institute for Fragrance Materials, Inc., 2000. In Vitro Skin Penetration of Radiolabelled Fragrance Materials. RIFM Report Number 37084, January 4.
42. RIFM, Research Institute for Fragrance Materials, Inc., 2001. Investigation of the Transfer Across the Placenta Into the Milk of Rats During and After Pregnancy Following Repeated Oral Administration. RIFM Report Number 38108, October 2.
43. RIFM, Research Institute for Fragrance Materials, Inc., 2002a. Oral (Gavage) Dose-range Developmental Toxicity Study of 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)Ethanone (OTNE) in Rats. RIFM Report Number 39734, November 20.
44. RIFM, Research Institute for Fragrance Materials, Inc., 2002b. Oral (Gavage) Developmental Toxicity Study of 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)Ethanone (OTNE) in Rats. RIFM Report Number 39733, November 20.
45. RIFM, Research Institute for Fragrance Materials, Inc., 2004a. Repeated Insult Patch Test. RIFM Report Number 45124, June 28.
46. RIFM, Research Institute for Fragrance Materials, Inc., 2004b. Modified Primary Dermal Irritation Test with 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)Ethanone. RIFM Report Number 47275, March 10.
47. RIFM, Research Institute for Fragrance Materials, Inc., 2005. Local Lymph Node Assay. RIFM Report Number 51630, November 9.
48. RIFM, Research Institute for Fragrance Materials, Inc., 2008a. Local Lymph Node Assay with 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)Ethanone (OTNE). RIFM Report Number 55550, July 30.
49. RIFM, Research Institute for Fragrance Materials, Inc., 2008b. Local Lymph Node Assay with 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)Ethanone (OTNE). RIFM Report Number 55549, July 30.
50. Weinberg E.H., Springer S.T. The evaluation in vitro of fragrance materials for phototoxic activity. Journal of the Society of Cosmetic Chemists 1981, 32:303-315.