Fragrance material review on 1-[5(or 6)-methyl-7(or 8)-1-(methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one

Food and Chemical Toxicology

Volumn 62, Issue , 2013, Pages

  Scognamiglio, J ^a   Letizia, C S ^a   Api, A M ^a  

^a RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS   (United States)

Author keywords

1 5(Or 6) Methyl 7(or 8) 1 (methylethyl)bicyclo 2.2.2 oct 5 en 2 yl ethan 1 one; Fragrance material; Review

Indexed keywords

1 [5(OR 6) METHYL 7(OR 8) 1 (METHYLETHYL)BICYCLO[2.2.2]OCT 5 EN 2 YL]ETHAN 1 ONE; FRAGRANCE; HYDROCARBON; KETONE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; CHEMICAL STRUCTURE; EYE IRRITATION; GENOTOXICITY; HUMAN; NONHUMAN; PATCH TEST; PHOTOALLERGY; PHOTOTOXICITY; PHYSICAL CHEMISTRY; REVIEW; SKIN IRRITATION; SKIN SENSITIZATION; SKIN TOXICITY; TOXICITY TESTING;

1-[5(OR 6)-METHYL-7(OR 8)-1-(METHYLETHYL)BICYCLO[2.2.2]OCT-5-EN-2-YL]ETHAN-1-ONE; FRAGRANCE MATERIAL; REVIEW;

ANIMALS; BICYCLO COMPOUNDS; CONSUMER PRODUCT SAFETY; CYCLOOCTANES; DERMATITIS, PHOTOALLERGIC; DERMATITIS, PHOTOTOXIC; DRUG HYPERSENSITIVITY; EYE; HUMANS; IRRITANTS; PERFUME; SKIN; TOXICITY TESTS;

EID: 84888048966     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.08.066     Document Type: Review

References (13)

1. Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2013. A Toxicologic and Dermatologic Assessment of Alkyl Cyclic Ketones When Used as Fragrance Ingredients. (submitted for publication).
2. Cadby P., Troy W., Vey M. Consumer exposure to fragrance ingredients: providing estimates for safety evaluation. Regulatory Toxicology and Pharmacology 2002, 36:246-252.
3. EPA (Environmental Protection Agency), 2010. Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.00 or insert version used. United States Environmental Protection Agency, Washington, DC, USA.
4. Ford R., Domeyer B., Easterday O., Maier K., Middleton J. Criteria for development of a database for safety evaluation of fragrance ingredients. Regulatory Toxicology and Pharmacology 2000, 31:166-181.
5. IFRA (International Fragrance Association), 2010. Use Level Survey, July 2010.
6. IFRA (International Fragrance Association), 2008. Volume of Use Survey, February 2008.
7. Kligman A.M. The identification of contact allergens by animal assay. The guinea pig maximization test. Journal of Investigative Dermatology 1969, 52(3):268-276.
8. RIFM (Research Institute for Fragrance Materials, Inc.), 1979a. Determination of the acute oral toxicity of 1-[5(or 6)-methyl-7(or 8)-(1-methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one in rats. Unpublished report from Quest International, Report number 46009 (RIFM, Woodcliff Lake, NJ, USA).
9. RIFM (Research Institute for Fragrance Materials, Inc.), 1979b. Maximization test with 1-[5(or 6)-methyl-7(or 8)-(1-methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one in guinea pigs. Unpublished report from Quest International, Report number 46011 (RIFM, Woodcliff Lake, NJ, USA).
10. RIFM (Research Institute for Fragrance Materials, Inc.), 1979c. Evaluation of 6-butyl-2,4-dimethyldihydropyrane; 4-tricyclodecylidene butanal; 2-butyl-4,4,6-trimethyl-1,3-dioxane; 2,4-dimethyl-3-cyclohexen-1-carboxaldehdye; and ioshexenyl cyclohexenyl carboxaldehyde in the Salmonella/microsome mutagenicity test. Unpublished report from Naarden Inc., 01 August. Report number 8885 (RIFM, Woodcliff Lake, NJ, USA).
11. RIFM (Research Institute for Fragrance Materials, Inc.), 1980a. Primary skin irritation and acute dermal toxicity studies with 1-[5(or 6)-methyl-7(or 8)-(1-methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one in albino rabbits. Unpublished report from Quest International, Report number 46013 (RIFM, Woodcliff Lake, NJ, USA).
12. RIFM (Research Institute for Fragrance Materials, Inc.), 1981a. Eye irritation and phototoxicity tests with 1-[5(or 6)-methyl-7(or 8)-(1-methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one in albino rabbits. Unpublished report from Quest International, Report number 46012 (RIFM, Woodcliff Lake, NJ, USA).
13. RIFM (Research Institute for Fragrance Materials, Inc.), 1981b. Photosensitization test with 1-[5(or 6)-methyl-7(or 8)-(1-methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one in guinea pigs. Unpublished report from Quest International, Report number 46010 (RIFM, Woodcliff Lake, NJ, USA).