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Volumn 10, Issue 1, 1999, Pages 55-65

Novel artificial endonucleases inhibit base excision repair and potentiate the cytotoxicity of DNA-damaging agents on L1210 cells

Author keywords

Abasic site; Alkylating agents; Artificial endonucleases; Excision repair; Potentiation

Indexed keywords

ALKYLATING AGENT; ANTINEOPLASTIC AGENT; CARMUSTINE; DACTINOMYCIN; ENDONUCLEASE; METHOXYAMINE; NITROSOUREA; POLYAMINOACID; PURINE; THIOTEPA;

EID: 0032989828     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-199901000-00008     Document Type: Article
Times cited : (13)

References (35)
  • 1
    • 0029929867 scopus 로고    scopus 로고
    • Clinical multidrug resistance in cancer: A multifactorial problem
    • Lehnert M. Clinical multidrug resistance in cancer: a multifactorial problem. Eur J Cancer 1996; 32A: 912-20.
    • (1996) Eur J Cancer , vol.32 A , pp. 912-920
    • Lehnert, M.1
  • 2
    • 0030038297 scopus 로고    scopus 로고
    • Drag resistance: An overview of the current state of the art
    • Hill BT. Drag resistance: an overview of the current state of the art. Int J Oncol 1996; 9: 197-203.
    • (1996) Int J Oncol , vol.9 , pp. 197-203
    • Hill, B.T.1
  • 3
    • 0029762815 scopus 로고    scopus 로고
    • DNA repair enzymatic mechanisms and relevance to drug response
    • Chancy SG, Sancar A. DNA repair enzymatic mechanisms and relevance to drug response. J Natl Cancer Inst 1996; 88: 1346-60.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1346-1360
    • Chancy, S.G.1    Sancar, A.2
  • 5
    • 0025116511 scopus 로고
    • DNA alkylation by haloethylnitrosoureas: Nature of modifications produced and their enzymatic repair of removal
    • Ludlum DB. DNA alkylation by haloethylnitrosoureas: nature of modifications produced and their enzymatic repair of removal. Mutat Res 1990; 233: 117-26.
    • (1990) Mutat Res , vol.233 , pp. 117-126
    • Ludlum, D.B.1
  • 6
    • 0030041960 scopus 로고    scopus 로고
    • Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing
    • Engelward BP, Dreslin A, Christensen J, Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing. EMBO J 1996; 15: 945-52.
    • (1996) EMBO J , vol.15 , pp. 945-952
    • Engelward, B.P.1    Dreslin, A.2    Christensen, J.3
  • 7
    • 0027136120 scopus 로고
    • Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase
    • Matijasevic Z, Boosalis M, Mackay W, Samson L, Ludlum DB. Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase. Proc Natl Acad Sci USA 1993; 90: 11855-9.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11855-11859
    • Matijasevic, Z.1    Boosalis, M.2    Mackay, W.3    Samson, L.4    Ludlum, D.B.5
  • 8
    • 0027340166 scopus 로고
    • 3-methyladenine-DNA-glycosylase in human cells exposed to DMA damaging agents
    • 3-methyladenine-DNA-glycosylase in human cells exposed to DMA damaging agents. DNA Cell Biol 1993; 12: 233-41.
    • (1993) DNA Cell Biol , vol.12 , pp. 233-241
    • Lefebvre, P.1    Zak, P.2    Laval, F.3
  • 9
    • 0026465075 scopus 로고
    • Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells
    • Ibeanu G, Hartenstein B, Dunn WC, et al. Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells. Carcinogenesis 1992; 13: 1989-95.
    • (1992) Carcinogenesis , vol.13 , pp. 1989-1995
    • Ibeanu, G.1    Hartenstein, B.2    Dunn, W.C.3
  • 10
    • 0030962270 scopus 로고    scopus 로고
    • 6-methylguanine-DNA methyltransferase associated with resistance to alkylating drugs in a mammalian cell line
    • 6-methylguanine-DNA methyltransferase associated with resistance to alkylating drugs in a mammalian cell line. J Biol Chem 1997; 272: 13250-4.
    • (1997) J Biol Chem , vol.272 , pp. 13250-13254
    • Tano, K.1    Dunn, W.C.2    Darroudi, F.3
  • 11
    • 0024591908 scopus 로고
    • Induction of β-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells
    • Fornace AJ, Jr, Zmudzka B, Hollander C, Wilson SH. Induction of β-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells. Mol Cell Biol 1989; 9: 851-3.
    • (1989) Mol Cell Biol , vol.9 , pp. 851-853
    • Fornace A.J., Jr.1    Zmudzka, B.2    Hollander, C.3    Wilson, S.H.4
  • 12
    • 0028228297 scopus 로고
    • Elevated DNA polymerase α, DNA polymerase β, and topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan
    • Friedman HS, Dolan ME, Kaufmann SH, et al. Elevated DNA polymerase α, DNA polymerase β, and topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan. Cancer Res 1994; 54: 3487-93.
    • (1994) Cancer Res , vol.54 , pp. 3487-3493
    • Friedman, H.S.1    Dolan, M.E.2    Kaufmann, S.H.3
  • 13
    • 0030583583 scopus 로고    scopus 로고
    • Elevated expression of DNA polymerase β gene in glioma cell lines with acquired resistance to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea
    • Gomi A, Shinoda S, Sakai R, et al. Elevated expression of DNA polymerase β gene in glioma cell lines with acquired resistance to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea. Biochem Biophys Res Commun 1996; 227: 558-63.
    • (1996) Biochem Biophys Res Commun , vol.227 , pp. 558-563
    • Gomi, A.1    Shinoda, S.2    Sakai, R.3
  • 14
    • 0029878327 scopus 로고    scopus 로고
    • Enhancement of melphalan activity by inhibition of DNA polymerase-α and DNA polymerase-β
    • Moynihan K, Elion GB, Ali-Osman F, et al. Enhancement of melphalan activity by inhibition of DNA polymerase-α and DNA polymerase-β. Cancer Chemother Pharmacol 1996; 38: 349-54.
    • (1996) Cancer Chemother Pharmacol , vol.38 , pp. 349-354
    • Moynihan, K.1    Elion, G.B.2    Ali-Osman, F.3
  • 15
    • 0031439376 scopus 로고    scopus 로고
    • The apurinic/ apyrimidic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer
    • Xu Y, Moore DH, Broshears J, et al. The apurinic/ apyrimidic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer. Anticancer Res 1997; 17: 3713-20.
    • (1997) Anticancer Res , vol.17 , pp. 3713-3720
    • Xu, Y.1    Moore, D.H.2    Broshears, J.3
  • 16
    • 0038342180 scopus 로고    scopus 로고
    • Specific binding of designed pyrrolidine abasic site analog to multiple DNA glycosylases
    • Schärer OD, Nash HM, Jiricny J, Laval J, Verdine L. Specific binding of designed pyrrolidine abasic site analog to multiple DNA glycosylases. J Biol Chem 1998; 273: 8592-7.
    • (1998) J Biol Chem , vol.273 , pp. 8592-8597
    • Schärer, O.D.1    Nash, H.M.2    Jiricny, J.3    Laval, J.4    Verdine, L.5
  • 17
    • 0031034761 scopus 로고    scopus 로고
    • Overexpression of DNA polymerase β sensitizes mammalian cells to 2′,3′-deoxycytidine and 3′-azido-3′-deoxythymidine
    • Bouayadi K, Hoffman J-S, Fons P, et al. Overexpression of DNA polymerase β sensitizes mammalian cells to 2′,3′-deoxycytidine and 3′-azido-3′-deoxythymidine. Cancer Res 1997; 57: 110-6.
    • (1997) Cancer Res , vol.57 , pp. 110-116
    • Bouayadi, K.1    Hoffman, J.-S.2    Fons, P.3
  • 18
    • 0024296376 scopus 로고
    • 9-((10(aden-9-yl)-4,8-diazadecyl)amino)-6-chloro-2-methoxy-acridine incises DNA at apurinic sites
    • Constant J-F, O'Connor TR, Lhomme J, Laval J. 9-((10(aden-9-yl)-4,8-diazadecyl)amino)-6-chloro-2-methoxy-acridine incises DNA at apurinic sites. Nucleic Acids Res 1988; 16: 2691-703.
    • (1988) Nucleic Acids Res , vol.16 , pp. 2691-2703
    • Constant, J.-F.1    O'Connor, T.R.2    Lhomme, J.3    Laval, J.4
  • 19
    • 0025296127 scopus 로고
    • Design of molecules which specifically cleave abasic sites in DNA
    • Constant J-F, Fkyerat A, Demeunynck M, et al. Design of molecules which specifically cleave abasic sites in DNA. Anti-Cancer Drug Des 1990; 5: 59-62.
    • (1990) Anti-Cancer Drug Des , vol.5 , pp. 59-62
    • Constant, J.-F.1    Fkyerat, A.2    Demeunynck, M.3
  • 20
    • 0003102140 scopus 로고    scopus 로고
    • Efficient and versatile chemical tools for cleavage of abasic sites in DNA
    • Belmont P, Boudali A, Constant J-F, et al. Efficient and versatile chemical tools for cleavage of abasic sites in DNA. New J Chem 1997; 21: 47-54.
    • (1997) New J Chem , vol.21 , pp. 47-54
    • Belmont, P.1    Boudali, A.2    Constant, J.-F.3
  • 21
    • 0030770925 scopus 로고    scopus 로고
    • Search for DNA repair inhibitators: Selective binding of nucleic bases-acridine conjugates to a DNA duplex containing an abasic site
    • Berthet N, Constant J-F, Demeunynck M, Michon P, Lhomme J. Search for DNA repair inhibitators: selective binding of nucleic bases-acridine conjugates to a DNA duplex containing an abasic site. J Med Chem 1997; 40: 3346-52.
    • (1997) J Med Chem , vol.40 , pp. 3346-3352
    • Berthet, N.1    Constant, J.-F.2    Demeunynck, M.3    Michon, P.4    Lhomme, J.5
  • 22
    • 0001574268 scopus 로고
    • A new class of artificial nucleases that recognize and cleave apurinic sites in DNA with great selectivity and efficiency
    • Fkyerat A, Demeunynck M, Constant J-F, Michon P, Lhomme J. A new class of artificial nucleases that recognize and cleave apurinic sites in DNA with great selectivity and efficiency. J Am Chem Soc 1993; 115: 9952-9.
    • (1993) J Am Chem Soc , vol.115 , pp. 9952-9959
    • Fkyerat, A.1    Demeunynck, M.2    Constant, J.-F.3    Michon, P.4    Lhomme, J.5
  • 23
    • 0030971831 scopus 로고    scopus 로고
    • NMR and molecular modeling studies of the interaction of artificial AP lyases with a DNA duplex containing an apurinic abasic site model
    • Coppel Y, Constant J-F, Coulombeau C, et al. NMR and molecular modeling studies of the interaction of artificial AP lyases with a DNA duplex containing an apurinic abasic site model. Biochemistry 1997; 36: 4831-43.
    • (1997) Biochemistry , vol.36 , pp. 4831-4843
    • Coppel, Y.1    Constant, J.-F.2    Coulombeau, C.3
  • 24
    • 0031409892 scopus 로고    scopus 로고
    • Evaluation of DNA repair inhibition by antitumor or antibiotic drugs using a chemiluminescence microplate assay
    • Barret J-M, Salles B, Provot C, Hill B. Evaluation of DNA repair inhibition by antitumor or antibiotic drugs using a chemiluminescence microplate assay. Carcinogenesis 1997; 18: 2441-5.
    • (1997) Carcinogenesis , vol.18 , pp. 2441-2445
    • Barret, J.-M.1    Salles, B.2    Provot, C.3    Hill, B.4
  • 25
    • 0027440884 scopus 로고
    • Synthesis of purine-acridine hybrid molecules related to artificial endonucleases
    • Fkyerat A, Demeunynck M, Constant J-F, Lhomme J. Synthesis of purine-acridine hybrid molecules related to artificial endonucleases. Tetrahedron 1993; 49: 11237-52.
    • (1993) Tetrahedron , vol.49 , pp. 11237-11252
    • Fkyerat, A.1    Demeunynck, M.2    Constant, J.-F.3    Lhomme, J.4
  • 26
    • 0028843707 scopus 로고
    • A chemiluminescent microplate assay to detect DNA damage induced by genotoxic treatments
    • Salles B, Provot C, Calsou P, et al. A chemiluminescent microplate assay to detect DNA damage induced by genotoxic treatments. Anal Biochem 1995; 232: 37-42.
    • (1995) Anal Biochem , vol.232 , pp. 37-42
    • Salles, B.1    Provot, C.2    Calsou, P.3
  • 27
    • 0029618266 scopus 로고
    • DNA repair in humans
    • Sancar A. DNA repair in humans. Annu Rev Genet 1995; 29: 69-105.
    • (1995) Annu Rev Genet , vol.29 , pp. 69-105
    • Sancar, A.1
  • 28
    • 0021843514 scopus 로고
    • A new aproach to study of the base-excision repair pathway using methoxyamine
    • Liuzzi M, Talbaert-Borle MA. A new aproach to study of the base-excision repair pathway using methoxyamine. J Biol Chem 1985; 260: 5252-8.
    • (1985) J Biol Chem , vol.260 , pp. 5252-5258
    • Liuzzi, M.1    Talbaert-Borle, M.A.2
  • 29
    • 0027234007 scopus 로고
    • XB596, a promising bis-naphtalimide anti-cancer agent
    • Chen SF, Behrens DL, Czerniak PM, et al. XB596, a promising bis-naphtalimide anti-cancer agent. Anti-Cancer Drugs 1993; 4: 447-57.
    • (1993) Anti-Cancer Drugs , vol.4 , pp. 447-457
    • Chen, S.F.1    Behrens, D.L.2    Czerniak, P.M.3
  • 30
    • 0029922601 scopus 로고    scopus 로고
    • Role of the HAP1 protein in repair of oxidative DNA damage and regulation of transcription factors
    • Barzilay G, Walker LJ, Rothwell DG, Hickson ID. Role of the HAP1 protein in repair of oxidative DNA damage and regulation of transcription factors. Br J Cancer 1996; 74: S145-50.
    • (1996) Br J Cancer , vol.74
    • Barzilay, G.1    Walker, L.J.2    Rothwell, D.G.3    Hickson, I.D.4
  • 31
    • 0022627085 scopus 로고
    • Efficient breakage of DNA apurinic sites by indole-amine related 9-amino-ellipticine
    • Malvy C, Prévost P, Gansser C, Viel C, Paoletti C. Efficient breakage of DNA apurinic sites by indole-amine related 9-amino-ellipticine. Chem-Biol Interact 1986; 57: 41-53.
    • (1986) Chem-Biol Interact , vol.57 , pp. 41-53
    • Malvy, C.1    Prévost, P.2    Gansser, C.3    Viel, C.4    Paoletti, C.5
  • 32
    • 0023552139 scopus 로고
    • Structure of the adduct formed between 3-amino-carbazole and the apurinic site oligonucleotide model [Tp(Ap)pT]
    • Vasseur JJ, Rayner B, Imbach JL, et al. Structure of the adduct formed between 3-amino-carbazole and the apurinic site oligonucleotide model [Tp(Ap)pT]. J Org Chem 1987; 52: 4994-8.
    • (1987) J Org Chem , vol.52 , pp. 4994-4998
    • Vasseur, J.J.1    Rayner, B.2    Imbach, J.L.3
  • 33
    • 0019416108 scopus 로고
    • A tryptophan-containing peptide recognizes and cleaves DNA at apurinic sites
    • Behmoaras T, Toulmé J-J, Hélène C. A tryptophan-containing peptide recognizes and cleaves DNA at apurinic sites. Nature 1981; 292: 858-9.
    • (1981) Nature , vol.292 , pp. 858-859
    • Behmoaras, T.1    Toulmé, J.-J.2    Hélène, C.3
  • 35
    • 0013624137 scopus 로고    scopus 로고
    • Variation of DMP840 resistance and relationship to apurinic/apyrimidic endonuclease activity and alkylating agent sensitivity in 12 brain tumor cell lines
    • Bobola MS, Berger MS, Stevens B, Silber JR. Variation of DMP840 resistance and relationship to apurinic/apyrimidic endonuclease activity and alkylating agent sensitivity in 12 brain tumor cell lines. Proc Am Ass Cancer Res 1997; 38: 314.
    • (1997) Proc Am Ass Cancer Res , vol.38 , pp. 314
    • Bobola, M.S.1    Berger, M.S.2    Stevens, B.3    Silber, J.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.