Angiogenesis and bone growth

Trends in Cardiovascular Medicine

Volumn 10, Issue 5, 2000, Pages 223-228

  Gerber, Hans Peter ^a   Ferrara, Napoleone ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; APOPTOSIS; BONE DEVELOPMENT; BONE GROWTH; CALCIFICATION; CARTILAGE; CARTILAGE CELL; CELL DEATH; CELL MATURATION; CHONDROGENESIS; FRACTURE HEALING; GROWTH PLATE; LONG BONE; OSTEOARTHRITIS; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; VASCULARIZATION;

BONE DEVELOPMENT; CONNECTIVE TISSUE CELLS; GROWTH PLATE; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC;

EID: 0034466380     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(00)00074-8     Document Type: Review

References (45)

1. A novel angiogenic molecule produced at the time of chondrocyte hypertrophy during endochondral bone formation
2. Induction of growth plate cartilage ossification by basic fibroblast growth factor
3. Development of the cartilage canals and the secondary center of ossification in the distal chondroepiphysis of the prenatal human femur
4. Transferrin promotes endothelial cell migration and invasion; implication in cartilage neovascularization
5. Vascular endothelial growth factor (VEGF) in cartilage neovascularization and chondrocyte differentiation; auto-paracrine role during endochondral bone formation
6. Nineteenth century research on naturally occurring cell death and related phenomena
7. Cellular turnover at the chondro-osseous junction of growth plate cartilage; analysis by serial sections at the light microscopical level
8. Vascular events associated with the appearance of the secondary center of ossification in the murine distal femoral epiphysis
9. Growth factors acting via endothelial cell-specific receptor tyrosine kinases; VEGFs, angiopoietins, and ephrins in vascular development
10. Development of vascularization in the chondroepiphysis of the rabbit
11. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
12. Apoptosis of terminally differentiated chondrocytes in culture
13. Chondrocyte apoptosis in endochondral ossification of chick sterna
14. Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state
15. Cartilage to bone; angiogenesis leads the way
16. Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis
17. Identification of chondromodulin I as a novel endothelial cell growth inhibitor. Purification and its localization in the avascular zone of epiphyseal cartilage
18. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
19. Immunolocalisation of vascular endothelial growth factor (VEGF) in human neonatal growth plate cartilage
20. Distribution of platelet-derived growth factor (PDGF) A chain mRNA, protein, and PDGF-alpha receptor in rapidly forming human bone
21. Quantitation of chondrocyte performance in growth-plate cartilage during longitudinal bone growth
22. Role of growth factors in fracture healing
23. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
24. Mechanisms of chondrocyte apoptosis
25. Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblasts
26. A cartilage-derived inhibitor of neovascularization and metalloproteinases
27. Identification of an inhibitor of neovascularization from cartilage
28. Isolation and characterization of an inhibitor of neovascularization from scapular chondrocytes
29. Expression of the growth factor-inducible immediate early gene cyr61 correlates with chondrogenesis during mouse embryonic development
30. Purification of an angiogenesis inhibitor from culture medium conditioned by a human chondrosarcoma-derived chondrocytic cell line, HCS-2/8
31. Osteonal and hemi-osteonal remodeling; the spatial and temporal framework for signal traffic in adult human bone
32. The vascular endothelial growth factor isoforms (VEGF); differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF
33. Chondrocytes inhibit endothelial sprout formation in vitro; evidence for involvement of a transforming growth factor-beta
34. 'Cell paralysis' as an intermediate stage in the programmed cell death of epiphyseal chondrocytes during development
35. Role of osteoblasts in hormonal control of bone resorption; a hypothesis
36. Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells
37. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
38. Inhibition of tubular morphogenesis in human microvascular endothelial cells by co-culture with chondrocytes and involvement of transforming growth factor beta; a model for avascularity in human cartilage
39. Immunohistochemical analysis of EGF in epiphyseal growth plate from normal, hypophysectomized, and growth hormone-treated hypophysectomized rats
40. Histochemical and molecular analyses of distraction osteogenesis in a mouse model
41. In situ localization of thrombospondin-1 and thrombospondin-3 transcripts in the avian embryo
42. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
43. Matrix-degrading proteases and angiogenesis during development and tumor formation