MTor plays an important role in odontoblast differentiation

Journal of Endodontics

Volumn 37, Issue 8, 2011, Pages 1081-1085

  Kim, Jin Koo ^a   Baker, James ^b   Nor, Jacques E ^a   Hill, Elliott E ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

Author keywords

Rapamycin; regeneration; stem cell; tissue engineering; TORC1; TORC2

Indexed keywords

ANTIINFECTIVE AGENT; CARRIER PROTEIN; CRTC1 PROTEIN, HUMAN; CRTC2 PROTEIN, HUMAN; DENTIN SIALOPHOSPHOPROTEIN; MTOR PROTEIN, HUMAN; PHOSPHOPROTEIN; RAPAMYCIN; RICTOR PROTEIN, HUMAN; RPTOR PROTEIN, HUMAN; SCLEROPROTEIN; SIALOGLYCOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DECIDUOUS TOOTH; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; ODONTOBLAST; PHYSIOLOGY; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; STEM CELL; TOOTH DEVELOPMENT; TOOTH PULP;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTI-BACTERIAL AGENTS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; DENTAL PULP; EXTRACELLULAR MATRIX PROTEINS; HUMANS; ODONTOBLASTS; PHOSPHOPROTEINS; PROTEIN BIOSYNTHESIS; SIALOGLYCOPROTEINS; SIGNAL TRANSDUCTION; SIROLIMUS; STEM CELLS; TOOTH CALCIFICATION; TOOTH, DECIDUOUS; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 80955177159     PISSN: 00992399     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joen.2011.03.034     Document Type: Article

References (27)

1. R. Gassner, R. Bosch, T. Tuli, and R. Emshoff Prevalence of dental trauma in 6000 patients with facial injuries: implications for prevention Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87 1999 27 33
2. K.O. Jorge, S.J. Moyses, E. Ferreira e Ferreira, M.L. Ramos-Jorge, and P.M. de Araujo Zarzar Prevalence and factors associated with dental trauma in infants 1-3 years of age Dent Traumatol 25 2009 185 189
3. F.K. Kahabuka, A. Plasschaert, and M. van't Hof Prevalence of teeth with untreated dental trauma among nursery and primary school pupils in Dar es Salaam, Tanzania Dent Traumatol 17 2001 109 113 (Pubitemid 33699237)
4. G.T. Huang, S. Gronthos, and S. Shi Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine J Dent Res 88 2009 792 806
5. P.E. Murray, F. Garcia-Godoy, and K.M. Hargreaves Regenerative endodontics: a review of current status and a call for action J Endod 33 2007 377 390
6. M. Nakashima Induction of dentin formation on canine amputated pulp by recombinant human bone morphogenetic proteins (Bmp)-2 and (Bmp)-4 J Dent Res 73 1994 1515 1522
7. R.B. Rutherford, and K.N. Gu Treatment of inflamed ferret dental pulps with recombinant bone morphogenetic protein-7 Eur J Oral Sci 108 2000 202 206
8. E. Hoshino, N. Kurihara-Ando, and I. Sato In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline Int Endod J 29 1996 125 130 (Pubitemid 126445403)
9. I. Sato, N. Ando-Kurihara, K. Kota, M. Iwaku, and E. Hoshino Sterilization of infected root-canal dentine by topical application of a mixture of ciprofloxacin, metronidazole and minocycline in situ Int Endod J 29 1996 118 124 (Pubitemid 126445402)
10. S. Gronthos, M. Mankani, J. Brahim, P.G. Robey, and S. Shi Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo Proc Natl Acad Sci U S A 97 2000 13625 13630
11. D. Schmitt, J. Lee, and G. Bogen Multifaceted use of ProRoot MTA root canal repair material Pediatr Dent 23 2001 326 330 (Pubitemid 33699264)
12. M. Torabinejad, and N. Chivian Clinical applications of mineral trioxide aggregate J Endod 25 1999 197 205
13. D.A. Guertin, and D.M. Sabatini An expanding role for mTOR in cancer Trends Mol Med 11 2005 353 361 (Pubitemid 41080576)
14. E.A. Dunlop, K.M. Dodd, L.A. Seymour, and A.R. Tee Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition Cell Signal 21 2009 1073 1084
15. K.G. Foster, and D.C. Fingar Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony J Biol Chem 285 2010 14071 14077
16. J. Copp, G. Manning, and T. Hunter TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2 Cancer Res 69 2009 1821 1827
17. S. Rokutanda, T. Fujita, N. Kanatani, C.A. Yoshida, A. Mizuno, and T. Komori Akt regulates skeletal development through GSK3, mTOR, and FoxOs Dev Biol 328 2009 78 93
18. D.D. Sarbassov, D.A. Guertin, S.M. Ali, and D.M. Sabatini Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex Science 307 2005 1098 1101 (Pubitemid 40262113)
19. O.A. Ali, and D.J. Mooney Sustained GM-CSF and PEI condensed pDNA presentation increases the level and duration of gene expression in dendritic cells J Control Release 132 2008 273 278
20. C.A. Easley, A. Ben-Yehudah, and C.J. Redinger mTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells Cell Reprogram 12 2010 263 273
21. M. Miura, S. Gronthos, and M.R. Zhao SHED: stem cells from human exfoliated deciduous teeth Proc Nat Acad Sci U S A 100 2003 5807 5812 (Pubitemid 36576889)
22. R.B. Rutherford, J. Wahle, M. Tucker, D. Rueger, and M. Charette Induction of reparative dentin formation in monkeys by recombinant human osteogenic protein-1 Arch Oral Biol 38 1993 571 576 (Pubitemid 223068828)
23. M. Goldberg, J.C. Farges, and S. Lacerda-Pinheiro Inflammatory and immunological aspects of dental pulp repair Pharmacol Res 58 2008 137 147
24. B. Heissig, K. Hattori, and S. Dias Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand Cell 109 2002 625 637 (Pubitemid 34628725)
25. F. He Effects of Notch ligand Delta1 on the proliferation and differentiation of human dental pulp stem cells in vitro Arch Oral Biol 54 2009 216 222
26. P. Sampath, D.K. Pritchard, and L. Pabon A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation Cell Stem Cell 2 2008 448 460 (Pubitemid 351598082)
27. H.R. Turnquist, J. Cardinal, and C. Macedo mTOR and GSK-3 shape the CD4+ T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS Blood 115 2010 4758 4769