Activation of m TOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation

Cardiovascular Research

Volumn 100, Issue 3, 2013, Pages 450-460

  Ma, Kun Ling ^a   Liu, Jing ^a   Wang, Chang Xian ^a   Ni, Jie ^a   Zhang, Yang ^a   Wu, Yu ^a   Lv, Lin Li ^a   Ruan, Xiong Zhong ^b   Liu, Bi Cheng ^a  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Foam cell formation; Inflammation; LDL receptor pathway; Mammalian target of rapamycin

Indexed keywords

APOLIPOPROTEIN E; CASEIN; INITIATION FACTOR 4E BINDING PROTEIN 1; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; RETINOBLASTOMA PROTEIN; S6 KINASE; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TUMOR SUPPRESSOR PROTEIN; CARRIER PROTEIN; CHOLESTEROL; EIF4EBP1 PROTEIN, MOUSE; EIF4EBP1 PROTEIN, RAT; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MEMBRANE PROTEIN; MTOR PROTEIN, MOUSE; MTOR PROTEIN, RAT; MULTIPROTEIN COMPLEX; PHOSPHOPROTEIN; PROTEIN KINASE INHIBITOR; SIGNAL PEPTIDE; SREBF2 PROTEIN, MOUSE; SREBF2 PROTEIN, RAT; SREBP CLEAVAGE ACTIVATING PROTEIN; SREBP CLEAVAGE-ACTIVATING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROSCLEROSIS; CELL CYCLE S PHASE; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME INHIBITION; FOAM CELL; GENE TRANSLOCATION; GOLGI COMPLEX; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LIPID STORAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RETINOBLASTOMA; SMOOTH MUSCLE FIBER; STIMULATION; VASCULAR SMOOTH MUSCLE; ANIMAL; AORTA DISEASE; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FOAM CELL FORMATION; GENETIC TRANSFECTION; GENETICS; KNOCKOUT MOUSE; LDL RECEPTOR PATHWAY; METABOLISM; MOUSE; PATHOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

FOAM CELL FORMATION; INFLAMMATION; LDL RECEPTOR PATHWAY; MAMMALIAN TARGET OF RAPAMYCIN;

ANIMALS; AORTA; AORTIC DISEASES; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CARRIER PROTEINS; CELLS, CULTURED; CHOLESTEROL; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; FOAM CELLS; GOLGI APPARATUS; INFLAMMATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; MUSCLE, SMOOTH, VASCULAR; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RATS; RECEPTORS, LDL; RETINOBLASTOMA PROTEIN; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA INTERFERENCE; S PHASE; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; STEROL REGULATORY ELEMENT BINDING PROTEINS; TOR SERINE-THREONINE KINASES; TRANSFECTION;

EID: 84887863897     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt203     Document Type: Article

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