메뉴 건너뛰기




Volumn 152, Issue 2, 2011, Pages 651-658

Loss of canonical insulin signaling accelerates vascular smooth muscle cell proliferation and migration through changes in p27Kip1 regulation

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P27; RAPAMYCIN;

EID: 79951602737     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0722     Document Type: Article
Times cited : (29)

References (39)
  • 1
    • 0000352972 scopus 로고    scopus 로고
    • Receptor for advanced glycation endproducts (RAGE) and vascular inflammation: Insights into the pathogenesis of macrovascular complications in diabetes
    • Wendt T, Bucciarelli L, Qu W, Lu Y, Yan SF, Stern DM, Schmidt AM 2002 Receptor for advanced glycation endproducts (RAGE) and vascular inflammation: insights into the pathogenesis of macrovascular complications in diabetes. Curr Atheroscler Rep 4:228-237
    • (2002) Curr Atheroscler Rep , vol.4 , pp. 228-237
    • Wendt, T.1    Bucciarelli, L.2    Qu, W.3    Lu, Y.4    Yan, S.F.5    Stern, D.M.6    Schmidt, A.M.7
  • 2
    • 34249794018 scopus 로고    scopus 로고
    • Hyperglycemia alters the responsiveness of smooth muscle cells to insulin-like growth factor-I
    • DOI 10.1210/en.2006-1440
    • Maile LA, Capps BE, Ling Y, Xi G, Clemmons DR 2007 Hyperglycemia alters the responsiveness of smooth muscle cells to insulin-like growth factor-I. Endocrinology 148:2435-2443 (Pubitemid 46997046)
    • (2007) Endocrinology , vol.148 , Issue.5 , pp. 2435-2443
    • Maile, L.A.1    Capps, B.E.2    Ling, Y.3    Xi, G.4    Clemmons, D.R.5
  • 4
    • 0030723979 scopus 로고    scopus 로고
    • Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels: A potential role for serine phosphorylation in insulin/angiotensin II crosstalk
    • Folli F, Kahn CR, Hansen H, Bouchie JL, Feener EP 1997 Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/ angiotensin II crosstalk. J Clin Invest 100:2158-2169 (Pubitemid 27500137)
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.9 , pp. 2158-2169
    • Folli, F.1    Kahn, C.R.2    Hansen, H.3    Bouchie, J.L.4    Feener, E.P.5
  • 5
    • 0033765672 scopus 로고    scopus 로고
    • High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells
    • Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, Aoki T, Etoh T, Hashimoto T, Naruse M, Sano H, Utsumi H, Nawata H 2000 High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 49:1939-1945
    • (2000) Diabetes , vol.49 , pp. 1939-1945
    • Inoguchi, T.1    Li, P.2    Umeda, F.3    Yu, H.Y.4    Kakimoto, M.5    Imamura, M.6    Aoki, T.7    Etoh, T.8    Hashimoto, T.9    Naruse, M.10    Sano, H.11    Utsumi, H.12    Nawata, H.13
  • 6
    • 20144367205 scopus 로고    scopus 로고
    • Mechanisms of reactive oxygen species-dependent downregulation of insulin receptor substrate-1 by angiotensin II
    • DOI 10.1161/01.ATV.0000164313.17167.df
    • Taniyama Y, Hitomi H, Shah A, Alexander RW, Griendling KK 2005 Mechanisms of reactive oxygen species-dependent downregulation of insulin receptor substrate-1 by angiotensin II. Arterioscler Thromb Vasc Biol 25:1142-1147 (Pubitemid 40776600)
    • (2005) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.25 , Issue.6 , pp. 1142-1147
    • Taniyama, Y.1    Hitomi, H.2    Shah, A.3    Alexander, R.W.4    Griendling, K.K.5
  • 7
    • 0027535742 scopus 로고
    • Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate
    • Nakanishi H, Brewer KA, Exton JH 1993 Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 268:13-16 (Pubitemid 23021278)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.1 , pp. 13-16
    • Nakanishi, H.1    Brewer, K.A.2    Exton, J.H.3
  • 8
    • 77951883237 scopus 로고    scopus 로고
    • Vascular inflammation in patients with impaired glucose tolerance and type 2 diabetes: Analysis with 18F-fluorodeoxyglucose positron emission tomography
    • Kim TN, Kim S, Yang SJ, Yoo HJ, Seo JA, Kim SG, Kim NH, Baik SH, Choi DS, Choi KM 2010 Vascular inflammation in patients with impaired glucose tolerance and type 2 diabetes: analysis with 18F-fluorodeoxyglucose positron emission tomography. Circ Cardiovasc Imaging 3:142-148
    • (2010) Circ Cardiovasc Imaging , vol.3 , pp. 142-148
    • Kim, T.N.1    Kim, S.2    Yang, S.J.3    Yoo, H.J.4    Seo, J.A.5    Kim, S.G.6    Kim, N.H.7    Baik, S.H.8    Choi, D.S.9    Choi, K.M.10
  • 9
    • 65349085059 scopus 로고    scopus 로고
    • Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham heart study, 1950 to 2005
    • Preis SR, Hwang SJ, Coady S, Pencina MJ, D'Agostino Sr RB, Savage PJ, Levy D, Fox CS 2009 Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham heart study, 1950 to 2005. Circulation 119:1728-1735
    • (2009) Circulation , vol.119 , pp. 1728-1735
    • Preis, S.R.1    Hwang, S.J.2    Coady, S.3    Pencina, M.J.4    D'Agostino Sr., R.B.5    Savage, P.J.6    Levy, D.7    Fox, C.S.8
  • 13
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study Group
    • UK Prospective Diabetes Study Group 1998 Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352:854-865
    • (1998) Lancet , vol.352 , pp. 854-865
  • 18
    • 44949201143 scopus 로고    scopus 로고
    • MTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation
    • DOI 10.1016/j.molcel.2008.04.027, PII S1097276508003377
    • Hong F, Larrea MD, Doughty C, Kwiatkowski DJ, Squillace R, Slingerland JM 2008 mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol Cell 30:701-711 (Pubitemid 351815130)
    • (2008) Molecular Cell , vol.30 , Issue.6 , pp. 701-711
    • Hong, F.1    Larrea, M.D.2    Doughty, C.3    Kwiatkowski, D.J.4    Squillace, R.5    Slingerland, J.M.6
  • 19
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • DOI 10.1016/j.cub.2004.06.054, PII S0960982204004713
    • Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM 2004 Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14:1296-1302 (Pubitemid 38991819)
    • (2004) Current Biology , vol.14 , Issue.14 , pp. 1296-1302
    • Dos, D.S.1    Ali, S.M.2    Kim, D.-H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 20
    • 8344241891 scopus 로고    scopus 로고
    • Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro
    • DOI 10.1161/01.ATV.0000143936.77094.a4
    • Sakata Y, Xiang F, Chen Z, Kiriyama Y, Kamei CN, Simon DI, Chin MT 2004 Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro. Arterioscler Thromb Vasc Biol 24:2069-2074 (Pubitemid 39482432)
    • (2004) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.24 , Issue.11 , pp. 2069-2074
    • Sakata, Y.1    Xiang, F.2    Chen, Z.3    Kiriyama, Y.4    Kamei, C.N.5    Simon, D.I.6    Chin, M.T.7
  • 21
    • 77951229151 scopus 로고    scopus 로고
    • Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor, p27Kip1
    • Moss SC, Lightell Jr DJ, Marx SO, Marks AR, Woods TC 2010 Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor, p27Kip1. J Biol Chem 285:11991-11997
    • (2010) J Biol Chem , vol.285 , pp. 11991-11997
    • Moss, S.C.1    Lightell Jr., D.J.2    Marx, S.O.3    Marks, A.R.4    Woods, T.C.5
  • 22
    • 18244384200 scopus 로고    scopus 로고
    • Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action
    • DOI 10.1172/JCI200523096
    • Okamoto H, Obici S, Accili D, Rossetti L 2005 Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action. J Clin Invest 115:1314-1322 (Pubitemid 40629051)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.5 , pp. 1314-1322
    • Okamoto, H.1    Obici, S.2    Accili, D.3    Rossetti, L.4
  • 25
    • 20044368678 scopus 로고    scopus 로고
    • Insulin sensitivity, proinsulin and insulin as predictors of coronary heart disease. A population-based 10-year, follow-up study in 70-year old men using the euglycaemic insulin clamp
    • Zethelius B, Lithell H, Hales CN, Berne C 2005 Insulin sensitivity, proinsulin and insulin as predictors of coronary heart disease. A population-based 10-year, follow-up study in 70-year old men using the euglycaemic insulin clamp. Diabetologia 48:862-867
    • (2005) Diabetologia , vol.48 , pp. 862-867
    • Zethelius, B.1    Lithell, H.2    Hales, C.N.3    Berne, C.4
  • 26
    • 30744460648 scopus 로고    scopus 로고
    • Insulin resistance, the metabolic syndrome, and incident cardiovascular events in the Framingham Offspring Study
    • DOI 10.2337/diabetes.54.11.3252
    • Rutter MK, Meigs JB, Sullivan LM, D'Agostino Sr RB, Wilson PW 2005 Insulin resistance, the metabolic syndrome, and incident cardiovascular events in the Framingham offspring study. Diabetes 54:3252-3257 (Pubitemid 43334382)
    • (2005) Diabetes , vol.54 , Issue.11 , pp. 3252-3257
    • Rutter, M.K.1    Meigs, J.B.2    Sullivan, L.M.3    D'Agostino Sr., R.B.4    Wilson, P.W.5
  • 27
    • 0035985223 scopus 로고    scopus 로고
    • Insulin resistance in non-diabetic subjects is associated with increased incidence of myocardial infarction and death
    • DOI 10.1046/j.1464-5491.2002.00719.x
    • Hedblad B, Nilsson P, Engström G, Berglund G, Janzon L 2002 Insulin resistance in non-diabetic subjects is associated with increased incidence of myocardial infarction and death. Diabet Med 19:470-475 (Pubitemid 34639157)
    • (2002) Diabetic Medicine , vol.19 , Issue.6 , pp. 470-475
    • Hedblad, B.1    Nilsson, P.2    Engstrom, G.3    Berglund, G.4    Janzon, L.5
  • 28
    • 0034629365 scopus 로고    scopus 로고
    • FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions
    • DOI 10.1074/jbc.275.10.7416
    • Peterson RT, Beal PA, Comb MJ, Schreiber SL 2000 FKBP12-rapamycin- associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions. J Biol Chem 275:7416-7423 (Pubitemid 30146297)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.10 , pp. 7416-7423
    • Peterson, R.T.1    Beal, P.A.2    Comb, M.J.3    Schreiber, S.L.4
  • 30
    • 0032568269 scopus 로고    scopus 로고
    • Translation control: Connecting mitogens and the ribosome
    • Peterson RT, Schreiber SL 1998 Translation control: connecting mitogens and the ribosome. Curr Biol 8:R248-50
    • (1998) Curr Biol , vol.8
    • Peterson, R.T.1    Schreiber, S.L.2
  • 31
    • 0028876806 scopus 로고
    • Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells
    • Marx SO, Jayaraman T, Go LO, Marks AR 1995 Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells. Circ Res 76:412-417
    • (1995) Circ Res , vol.76 , pp. 412-417
    • Marx, S.O.1    Jayaraman, T.2    Go, L.O.3    Marks, A.R.4
  • 33
    • 1942466518 scopus 로고    scopus 로고
    • Kip1 modulates cell migration through the regulation of RhoA activation
    • DOI 10.1101/gad.1185504
    • Besson A, Gurian-West M, Schmidt A, Hall A, Roberts JM 2004 p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 18:862-876 (Pubitemid 38529656)
    • (2004) Genes and Development , vol.18 , Issue.8 , pp. 862-876
    • Besson, A.1    Gurian-West, M.2    Schmidt, A.3    Hall, A.4    Roberts, J.M.5
  • 34
    • 70349648329 scopus 로고    scopus 로고
    • Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: The role of endothelin-1
    • Gogg S, Smith U, Jansson PA 2009 Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of endothelin-1. Diabetes 58:2238-2245
    • (2009) Diabetes , vol.58 , pp. 2238-2245
    • Gogg, S.1    Smith, U.2    Jansson, P.A.3
  • 36
    • 26244463378 scopus 로고    scopus 로고
    • Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals
    • DOI 10.1161/01.RES.0000183730.52908.C6
    • Jonas M, Edelman ER, Groothuis A, Baker AB, Seifert P, Rogers C 2005 Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals. Circ Res 97:725-733 (Pubitemid 41416342)
    • (2005) Circulation Research , vol.97 , Issue.7 , pp. 725-733
    • Jonas, M.1    Edelman, E.R.2    Groothuis, A.3    Baker, A.B.4    Seifert, P.5    Rogers, C.6
  • 37
    • 61949252089 scopus 로고    scopus 로고
    • A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia
    • Liu X, Cheng Y, Zhang S, Lin Y, Yang J, Zhang C 2009 A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ Res 104:476-487
    • (2009) Circ Res , vol.104 , pp. 476-487
    • Liu, X.1    Cheng, Y.2    Zhang, S.3    Lin, Y.4    Yang, J.5    Zhang, C.6
  • 38
    • 63649147782 scopus 로고    scopus 로고
    • Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype
    • Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A 2009 Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J Biol Chem 284:3728-3738
    • (2009) J Biol Chem , vol.284 , pp. 3728-3738
    • Davis, B.N.1    Hilyard, A.C.2    Nguyen, P.H.3    Lagna, G.4    Hata, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.