An overview on the pharmacokinetics of quantum dots

Current Drug Metabolism

Volumn 14, Issue 8, 2013, Pages 820-831

  Meng, Xianwei ^a   Qiang, Li ^a,b   Wei, Jianfei ^a,b  

^a TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Nanoparticles; Pharmacokinetics; Preparation; Quantification; Quantum dots

Indexed keywords

CADMIUM; CADMIUM ACETATE; CADMIUM CHLORIDE; CADMIUM OXIDE; HYALURONIC ACID; LEAD; MACROGOL; MERCURY; PHOSPHATIDYLETHANOLAMINE; QUANTUM DOT;

ARTICLE; ATOMIC EMISSION SPECTROMETRY; CHEMICAL COMPOSITION; COMPUTER ASSISTED TOMOGRAPHY; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG SYNTHESIS; FLOW RATE; FLUORESCENCE; FLUORESCENCE ANALYSIS; GREEN CHEMISTRY; HALF LIFE TIME; HUMAN; HYDRODYNAMICS; ISOTOPE LABELING; KIDNEY CLEARANCE; MAGNETIC FIELD; NONHUMAN; PHAGOCYTE; PHOTOLUMINESCENCE; PLASMA CLEARANCE; PLASMA HALF LIFE; QUANTUM YIELD; RETICULOENDOTHELIAL SYSTEM; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SOLID PHASE EXTRACTION; SURFACE PROPERTY; T LYMPHOCYTE; URINARY EXCRETION;

ANIMALS; HUMANS; PHARMACOKINETICS; QUANTUM DOTS;

EID: 84887863847     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/138920021131400103     Document Type: Article

References (131)

1. Jiang, W.; Papa, E.; Fischer, H.; Mardyani, S.; Chan, W. C. W. Semiconductor quantum dots as contrast agents for whole animal imaging. Trends Biotechnol., 2004, 22, 607-609.
2. Venkatram, N.; Li, G. S.; Chin, W. S.; Ji, W. Synthesis of PbS/CdS Core-Shell QDs and their Nonlinear Optical Properties. J. Phys. Chem. C, 2010, 114, 18037-18044.
3. Stavis, S. M.; Edel, J. B.; Samiee, K. T.; Craighead, H. G. Single molecule studies of quantum dot conjugates in a submicrometer fluidic channel. Lab Chip, 2005, 5, 337-343.
4. Martinez, O.; Mazzoni, M.; Rossi, F.; Armani, N.; Salviati, G.; Lottici, P. P.; Bersani, D. Cathodoluminescence and micro-Raman characterisation of GaN/AlN QDs grown on Si (111). Phys. Stat. Sol., (a), 2003, 195, 26-31.
5. Maximov, M. V.; Krestnikov, I. L.; Makarov, A. G.; hukov, A. E. Z; Maleev, N. A.; Ustinov, V. M.; Tsatsulnikov, A. F.; Alferov, Z. I.; Chernyshov, A. Y.; Ledentsov, N. N.; Bimberg, D.; Sotomayor, C. M. Large spectral splitting of TE and TM components of QDs in a microcavity. Phys. Stat. Sol. (b), 2001, 224, 811-814.
6. Madl, M.; Brezna, W.; Strasser, G.; Klang, P.; Andrews, A. M.; Bodnarchuk, M. I.; Kovalenko, M. V.; Yarema, M.; Heiss, W.; Smoliner, J. AFM-based photocurrent imaging of epitaxial and colloidal QDs. Phys. Stat. Sol., (c), 2011, 8, 426-428.
7. Kaji, R.; Sasakura, H.; Adachi, S.; Muto, S. Excitation power dependence of optically pumped nuclear spin polarizations in single InAlAs QDs. Phys. Stat. Sol. (c), 2008, 5, 298-301.
8. Iwane, Y.; Kawashima, F.; Hirooka, M.; Saegusa, T.; Shimomura, K. InAs/InP QDs grown by selective MOVPE growth using double- cap procedure for broadband LED improved p-cladding layer. Phys. Stat. Sol. (c), 2012, 9, 210-213.
9. Raymo, F. M.; Yildiz, I. Luminescent chemosensors based on semiconductor quantum dots. Phys. Chem. Chem. Phys., 2007, 9, 2036-2043.
10. Han, S. H.; Mu, Y.; Zhu, Q. Y.; Gao, Y. B.; Li, Z. H.; Jin, Q. H.; Jin, W. Au:CdHgTe quantum dots for in vivo tumor-targeted multispectral fluorescence imaging. Anal. Bioanal. Chem., 2012, 403, 1343-1352.
11. Zheng, H.; Chen, G. C.; Song, F. M.; DeLouise, L. A.; Lou, Z. Y. The cytotoxicity of OPA-Modified CdSe/ZnS core/shell Quantum Dots and its modulation by silibinin in Human Skin Cells. J. Biomed. Nanotechnol., 2011, 7, 648-658.
12. Holgate, S. T. Exposure, Uptake, Distribution and toxicity of nanomaterials in humans. J. Biomed. Nanotechnol., 2010, 6, 1-19.
13. Liu, B. R.; Huang, Y. W.; Chiang, H. J.; Lee, H. J. Cell-penetrating peptide-functionalized Quantum Dots for intracellular delivery. J. Nanosci. Nanotechnol. , 2010, 10, 7897-7905.
14. Elbayoumi, T.; Weissig, V. Implications of intracellular distribution of nanovesicles for bioimaging studies. J. Nanosci. Nanotechnol., 2009, 5, 620-633.
15. Huang, H. P.; Li, J. J.; Zhu, J. J. Electrochemiluminescence based on quantum dots and their analytical application. Anal. Methods, 2011, 3, 33-42.
16. Mote, U. S.; Tele, S. S.; Anbhule, P. V.; Rath, M. C.; Patil, S. R.; Kolekar, G. B. A novel method for ranitidine hydrochloride determination in aqueous solution based on fluorescence quenching of functionalised CdS QDs through photoinduced charge transfer process: Spectroscopic approach Anil Hanumant Gore. Analyst, 2011, 136, 2606-2612.
17. Peng, Y. R.; Qiu, C. M.; Jockusch, S.; Scott, A. M.; Li, Z. M.; Turro, N. J.; Ju, J. Y. CdSe/ZnS core shell quantum dot-based FRET binary oligonucleotide probes for detection of nucleic acids. Photochem. Photobiol. Sci., 2012, 11, 881-884.
18. Zhang, Y.; Deng, Z. T.; Yue, J. C.; Tang, F. Q.; Wei, Q. Using CdTe quantum dots as a proton flux sensor and applying to detect H9 avian influenza virus. Anal. Biochem., 2007, 364, 122-127.
19. Chan, W. C. W.; Nie, S. M. Quantum Dot bioconjugates for ultrasensitive nonisotopic detection. Science, 1998, 281, 2016-2018.
20. Bruchez, M. J.; Moronne, M.; Gin, P.; Weiss, S.; Alivisatos, A. P. Semiconductor nanocrystals as fluorescent biological labels. Science, 1998, 281, 2013-2015.
21. Hu, M.; He, Y.; Song, S. P.; Yan, J.; Lu, H. T.; Weng, L. X.; Wang, L. H.; Fan, C. H. DNA-bridged bioconjugation of fluorescent quantum dots for highly sensitive microfluidic protein chips. Chem. Commun., 2010, 46, 6126-6128.
22. Singh, R. Nalwa, H. S. Medical applications of nanoparticles in biological imaging, cell labeling, antimicrobial agents, and anticancer nanodrugs. J. Biomed. Nanotechnol., 2011, 7, 489-503.
23. Zheng, H.; Chen, G. C.; DeLouise, L. A.; Lou, Z. Y. Detection of the cancer marker CD146 expression in melanoma cells with semiconductor Quantum Dot label. J. Biomed. Nanotechnol., 2010, 6, 303-311.
24. Nair, A.; Thevenot, P.; Hu, W. J.; Tang, L. P. Nanotechnology in the treatment and detection of intraocular cancers. J. Biomed. Nanotechnol., 2008, 4, 410-418.
25. Ren, X. L.; Yang, L. Q.; Tang, F. Q.; Yan, C. M.; Ren, J. Enzyme biosensor based on NAD-sensitive quantum dots. Biosens. Bioelectron., 2010, 26, 271-274.
26. Yang, L. Q.; Ren, X. L.; Meng, X. W.; Li, H. B.; Tang, F. Q. Optical analysis of lactate dehydrogenase and Glucose by CdTe Quantum Dots and their dual simultaneous detection. Biosens. Bioelectron., 2011, 26, 3488-3493.
27. Chen, Z. Z.; Renhttp://pubs.acs.org/doi/abs/10.1021/nn200365a - notes-1#notes-1, X. L.; Meng, X. W.; Chen, D.; Yan, C. M.; Ren, J.; Yuan, Y.; Tang, F. Q. Optical detection of choline and acetylcholine based on H2O2-sensitive quantum dots. Biosens. Bioelectron., 2011, 28, 50-55.
28. Deng, Z. T.; Zhang, Y.; Yue, J. C.; Tang, F. Q.; Wei, Q. Green and orange CdTe quantum dots as effective pH-sensitive fluorescent probes for dual simultaneous and independent detection of viruses. J. Phys. Chem. B, 2007, 111, 12024-12031.
29. Kobayashi, H.; Hama, Y.; Koyama, Y.; Barrett, T.; Regino, C. A. S.; Urano, Y.; Choyke, P. Simultaneous multicolor imaging of five different lymphatic basins using Quantum Dots. Nano Lett., 2007, 7, 1711-1716.
30. Liu, S. J.; Jia, B.; Qiao, R. R.; Yang, Z.; Yu, Z. L.; Liu, Z. F.; Liu, K.; Shi, J. Y.; Ouyang, H.; Wang, F.; Gao, M. Y. A novel type of dual-modality molecular probe for MR and nuclear imaging of tumor: preparation, characterization and in vivo application. Mol. Pharmaceut., 2009, 6, 1074-1082.
31. Park, J.; Bhuniya, S.; Lee, H.; Noh, Y.; Lim, Y. T.; Jung, J. H.; Hong, K. S.; Kim, J. S. A DTTA-ligated uridine-quantum dot conjugate as a bimodal contrast agent for cellular imaging. Chem. Commun., 2012, 48, 3218-3220.
32. L. W. Liu,; W. C. Law,; K. T. Yong,; I. Roy,; H. Ding,; F. Erogbogbo,; X. H. Zhang; Prasad, P. N. Multimodal imaging probes based on God-DOTA conjugated quantum dot nanomicelles. Analyst, 2011, 136, 1881-1886.
33. Oostendorp, M.; Douma, K.; Hackeng, T. M.; Post, M. J.; Zandvoort, M. A. M. J. van; Backes, W. H. Gadolinium-labeled Quantum Dots for molecular magnetic resonance imaging: R1 versus R2 mapping. Magn. Reson. Chem., 2010, 64, 291-298.
34. Tan, Y. F.; Chandrasekharan, P.; Maity, D.; Yong, C. X.; Chuang, K. H.; Zhao, Y.; Wang, S.; Ding, J.; Feng, S. S. Multimodal tumor imaging by iron oxides and quantum dots formulated in poly(lactic acid)-D-alpha-tocopheryl polyethylene glycol 1000 succinate nanoparticles. Biomaterials, 2011, 32, 2969-2978.
35. Erogbogbo, F.; Yong, K. T.; Hu, R.; Law, W. C.; Ding, H.; Chang, C. W.; Prasad, P. N.; Swihart, M. T. Biocompatible magnetofluorescent probes: luminescent silicon Quantum Dots coupled with superparamagnetic iron(III) oxide. ACS Nano, 2010, 4, 5131-5138.
36. Prinzen, L.; Miserus, R. J. H. M.; Dirksen, A.; Hackeng, T. M.; Deckers, N.; Bitsch, N. J.; Megens, R. T.A.; Douma, K.; Heemskerk, J. W.; Kooi, M. E.; Frederik, P. M.; Slaaf, D. W.; van Zandvoort, M. A. M. J.; Reutelingsperger, C. P. M. Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized Quantum Dots. Nano Lett., 2007, 7, 93-100.
37. Ducongé, F.; Pons, T.; Pestourie, C.; Hérin, L.; Thézé, B.; Gombert, K.; Mahler, B.; Hinnen, F.; Kühnast, B.; Dollé, F.; Dubertret, B.; Tavitian, B. Fluorine-18-labeled phospholipid Quantum Dot micelles for in vivo multimodal imaging from whole body to cellular scales. Bioconjugate Chem., 2008, 19, 1921-1926
38. Ho, Y. P.; Leong, K. W. Quantum dot-based theranostics. Nanoscale, 2010, 2, 60-68.
39. Saravanakumar, G.; Kim, K.; Park, J. H.; Rhee, K.; Kwon, I. C. Current status of nanoparticle-based imaging agents for early diagnosis of cancer and atherosclerosis. J. Biomed. Nanotechnol., 2009, 5, 20-35.
40. Zhou, S.; Chen, Q.; Hua, X.; Zhao, T. Bifunctional luminescent superparamagnetic nanocomposites of CdSe/CdS-Fe3O4 synthesized via a facile method. J. Mater. Chem., 2012, 22, 8263-8270.
41. Zhang, L.; Wang, T.; Li, L.; Wang, C.; Sua, Z.; Li, J. Multifunctional fluorescent-magnetic polyethyleneimine functionalized Fe3O4-mesoporous silica yolk-shell nanocapsules for siRNA delivery. Chem. Commun., 2012, 48, 8706-8708.
42. Li, L. L.; Chen, D.; Zhang, Y. Q.; Deng, Z. T.; Ren, X. L.; Meng, X. W.; Tang, F. Q.; Ren, J.; Zhang, L. Magnetic and fluorescent multifunctional chitosan nanoparticles as smart drug delivery system. Nanotechnology, 2007, 18, 405-102.
43. Li, L. L.; Li, H. B.; Chen, D.; Liu, H. Y.; Tang, F. Q.; Zhang, Y. Q.; Ren J.; Li, Y. Preparation and characterization of quantum dots coated magnetic hollow spheres for magnetic fluorescent multimodal imaging and drug delivery. J. Nanosci. Nanotechnol., 2009, 9, 2540-2545.
44. Singh, S. P. Multifunctional magnetic Quantum Dots for cancer theranostics. J. Biomed. Nanotechnol., 2011, 7, 95-97.
45. Murray, C. B.; Norris, D. J.; Bawend, M. G. Synthesis and characterization of nearly monodisperse CdE (E=sulfur, selenium, tellurium) semiconductor nanocrystallites. J. Am. Chem. Soc., 1993, 115, 8706-8715.
46. Biju, V.; Itoh, T.; Ishikawa, M. Delivering quantum dots to cells: bioconjugated quantum dots for targeted and nonspecific extracellular and intracellular imaging. Chem. Soc. Rev., 2010, 39, 3031-3056.
47. Peng, Z. A.; Peng, X. G. Formation of high-quality CdTe, CdSe, and CdS nanocrystals using CdO as precursor. J. Am. Chem. Soc., 2001, 123, 183-184.
48. Qu, L. H.; Peng, Z. A.; Peng, X. G. Alternative routes toward high quality CdSe nanocrystals. Nano Lett., 2001, 1, 333-337.
49. Deng, Z. T.; Cao, L.; Tang, F. Q.; Zou, B. S. A new route to Zincblende CdSe nanocrystals: mechanism and synthesis. J. Phys. Chem. B, 2005, 109, 16671-16675.
50. Peng, Z. A.; Peng, X. G. Nearly monodisperse and shapecontrolled CdSe nanocrystals via alternative routes: nucleation and growth. J. Am. Chem. Soc., 2002, 124, 3343-3353.
51. Sapra, S.; Rogach, A. L.; Feldmann, J. Phosphine-free synthesis of monodisperse CdSe nanocrystals in olive oil. J. Mater. Chem., 2006, 16, 3391-3395.
52. Zhang, H.; Zhou, Z.; Yang, B.; Gao, M. Y. The influence of carboxyl groups on the photoluminescence of mercaptocarboxylic acid-stabilized CdTe nanoparticles. J. Phys. Chem. B, 2003, 107, 8-13.
53. Kumar, S. A.; Ansary, A. A.; Ahmad, A.; Khan, M. I. Extracellular biosynthesis of CdSe Quantum Dots by the fungus, fusarium xxysporum, J. Biomed. Nanotechnol., 2007, 3, 190-194.
54. Yu, W. W.; Chang, E.; Drezek, R.; Colvin, V. L. Stable and bright water-soluble Quantum Dots. J. Biomed. Nanotechnol., 2006, 2, 225-228.
55. Wang, Q.; Chen, J. N.; Zhang, H. Y.; Lu, M. Z.; Qiu, D. Y.; Wen, Y. F.; Kong, Q. Q. Synthesis of water soluble Quantum Dots for monitoring carrier-DNA nanoparticles in plant cells. J. Nanosci. Nanotechnol., 2011, 11, 2208-2214.
56. Wei, G. C.; Yan, M. M.; Ma, L. Y.; Zhang, H. B. The synthesis of highly water-dispersible and targeted CdS quantum dots and it is used for bioimaging by confocal microscopy. Spectrochim. Acta. A Mol. Biomol. Spectrosc., 2012, 85, 288-292.
57. Rajh, T.; Micic, O. I.; Nozik, A. J. Synthesis and characterization of surface-modified colloidal cadmium telluride quantum dots. J. Phys. Chem., 1993, 97, 11999-12003.
58. Rogach, A. L.; Katsikas, L.; Kornowski, A.; Su, D. S.; Eychmüller, A.; Weller, H. Synthesis and characterization of thiol-stabilized CdTe nanocrystals. Ber. Bunsen-Ges Phys. Chem., 1996, 100, 1772-1778.
59. Gaponik, N.; Talapin, D. V.; Rogach, A. L.; Hoppe, K.; Shevchenko, E. V.; Kornowski, A.; Eychmuller, A.; Weller, H. Thiol-capping of CdTe nanocrystals: an alternative to organometallic synthetic route. J. Phys. Chem. B, 2002, 106, 7177-7185.
60. Gao M. Y.,; Kirstein, S.; Mohwald, H.; Rogach, A. L.; Kornowski, A.; Eychmuller, A.; H. Weller, Strongly photoluminescent CdTe nanocrystals by proper surface modification. J. Phys. Chem. B, 1998, 102, 8360-8363.
61. H. Zhang,; Z. Zhou,; B. Yang,; Gao, M. Y. The influence of carboxyl groups on the photoluminescence of mercaptocarboxylic acid-stabilized CdTe nanoparticles. J. Phys. Chem. B, 2003, 107, 8-13.
62. Zheng, Y. G.; Gao, S. J.; Ying, J. Y. Synthesis and cell-imaging applications of glutathione-capped CdTe Quantum Dots. Adv. Mater., 2007, 19, 376-380.
63. Li, H. B.; Tang, F. Q.; Li, L. L.; Yan, C. M.; Huang, X. L.; Chen, D. Ultrafast synthesis of water-soluble nanocrystals by chemical aerosol flow method. Cryst. Eng. Comm., 2009, 11, 1231-1235.
64. Li, H. B.; Chen, D.; Li, L. L.; Tang, F. Q.; Zhang, L.; Ren, J. Sizeand shape-controlled synthesis of PbSe and PbS nanocrystals via a facile method. Cryst. Eng. Comm., 2010, 12, 1127-1133.
65. Yan, C. M.; Tang, F. Q.; Li, L. L.; Li, H. B.; Huang, X. L.; Chen, D.; Meng, X. W.; Ren, J. Synthesis of aqueous CdTe/CdS/ZnS core/shell/shell quantum dots by a chemical aerosol flow method. Nanoscale Res. Lett., 2010, 5, 189-194.
66. Xue, B.; Deng, D. W.; Cao, J.; Liu, F.; Li, X.; Akers, W.; Achilefub, S.; Gu, Y. Q. Synthesis of NAC capped near infrared-emitting CdTeS alloyed quantum dots and application for in vivo early tumor imaging. Dalton Trans., 2012, 41, 4935-4947.
67. Hu, D. H.; Zhang, P. F.; Gong, P.; Lian, S. H.; Lu, Y. Y.; Gao, D. Y.; Cai, L. C. A fast synthesis of near-infrared emitting CdTe/CdSe quantum dots with small hydrodynamic diameter for in vivo imaging probes. Nanoscale, 2011, 3, 4724-4732.
68. Taniguchi, S.; Green, M.; Rizvi, S. B.; Seifalian, A. The one-pot synthesis of core/shell/shell CdTe/CdSe/ZnSe quantum dots in aqueous media for in vivo deep tissue imaging. J. Mater. Chem., 2011, 21, 2877-2882.
69. Cao, J.; Zhu, H. Y.; Deng, D. W.; Xue, B.; Tang, L. P.; Mahounga, D.; Qian, Z. Y.; Gu, Y. Q. In vivo NIR imaging with PbS quantum dots entrapped in biodegradable micelles. J. Biomed. Mater. Res. Part A, 2012, 100A, 958-968.
70. Biju, V.; Mundayoor, S.; Omkumar, R. V.; Anas, A.; Ishikawa, M. Bioconjugated quantum dots for cancer research: Present status, prospects and remaining issues. Biotechnol. Adv., 2010, 28, 199-213.
71. Bharali, D. J.; Lucey, D. W.; Jayakumar, H.; Pudavar, H. E.; Prasad, P. N. Folate-receptor-mediated delivery of InP Quantum Dots for bioimaging using confocal and two-photon microscopy. J. Am. Chem. Soc., 2005, 127, 11364-11371.
72. Chibli, H.; Carlini, L.; Park, S.; Dimitrijevic, N. M.; Nadeau, J. L. Cytotoxicity of InP/ZnS quantum dots related to reactive oxygen species generation. Nanoscale, 2011, 3, 2552-2559.
73. Battaglia, D.; Peng, X. G. Formation of high quality InP and InAs nanocrystals in a noncoordinating solvent. Nano Lett., 2002, 2, 1027-1030.
74. Li, L.; Reiss, P. One-pot synthesis of highly luminescent InP/ZnS nanocrystals without precursor injection. J. Am. Chem. Soc., 2008, 130, 11588-11589.
75. Hussain, S.; Won, N.; Nam, J.; Bang, J.; Chung, H.; Kim, S. One-Pot fabrication of high-quality InP/ZnS (core/shell) Quantum Dots and their application to cellular imaging. Chem. Phys. Chem., 2009, 10, 1466-1470.
76. Ryu, E.; Kim, S.; Jang, E.; Jun, S.; Jang, H.; Kim, B.; Kim, S. W. Step-wise synthesis of InP/ZnS core shell Quantum Dots and the role of zinc acetate. Chem. Mater., 2009, 21, 573-575.
77. Xie, R. G.; Chen, K.; Chen, X. Y.; Peng, X. G. InAs / InP/ZnSe core /shell /shell Quantum Dots as near-infrared emitters: bright, narrow-band, non-cadmium containing, and biocompatible. Nano Res., 2008, 1, 457-464.
78. Zan, F.; Ren, J. C. Gas-liquid phase synthesis of highly luminescent InP/ZnS core/shell quantum dots using zinc phosphide as a new phosphorus source. J. Mater. Chem., 2012, 22, 1794-1799.
79. Li, L.; Daou, T. J.; Texier, I.; Chi, T. T. K.; Liem, N. Q.; Reiss, P. Highly luminescent CuInS2/ZnS core/shell nanocrystals: cadmiumfree Quantum Dots for in vivo Imaging. Chem. Mater., 2009, 21, 2422-2429.
80. Tavares, A. J.; Chong, L.; Petryayeva, E.; Algar, W. R.; Krull, U. J. Quantum dots as contrast agents for in vivo tumor imaging: progress and issues. Anal. Bioanal. Chem., 2011, 399, 2331-2342.
81. Pons, T.; Pic, E.; Lequeux, N.; Cassette, E.; Bezdetnaya, L.; Guillemin, F. O. Cadmium-free CuInS2/ZnS Quantum Dots for sentinel lymph node imaging with reduced toxicity. ACS Nano, 2010, 4, 2531-2538.
82. Li, L.; Daou, T. J.; Texier, I.; Chi, T. T. K.; Liem, N. Q.; Reiss, P. Highly luminescent CuInS2/ZnS core/shell nanocrystals: Cadmiumfree Quantum Dots for in vivo imaging. Chem. Mater., 2009, 21, 2422-2429.
83. Hsu, J. C.; Huang, C. C.; Ou, K. L.; Lu, N.; Mai, F. D.; Chenf, J. K.; Chang, J. Y. Silica nanohybrids integrated with CuInS2/ZnS quantum dots and magnetite nanocrystals: multifunctional agents for dual-modality imaging and drug delivery. J. Mater. Chem., 2011, 21, 19257-19266.
84. Liu, S. Y.; Zhang, H.; Qiao, Y.; Su, X. G. One-pot synthesis of ternary CuInS2 quantum dots with near-infrared fluorescence in aqueous solution. RSC Adv., 2012, 2, 819-825.
85. Nicolas, J.; Brambilla, D.; Carion, O.; Pons, T.; Maksimovic, I.; Larquet, E.; Droumaguet, B. L.; Andrieux, K.; Dubertret, B.; Couvreur, P. Quantum dot-loaded PEG-ylated poly(alkyl cyanoacrylate) nanoparticles for in vitro and in vivo imaging. Soft Matter, 2011, 7, 6187-6193.
86. Cassette, E.; Pons, T.; Bouet, C.; Helle, M.; Bezdetnaya, L.; Marchal, F.; Dubertret, B. Synthesis and characterization of nearinfrared Cu-In-Se/ZnS core/shell Quantum Dots for in vivo imaging. Chem. Mater., 2010, 22, 6117-6124.
87. Rogach, A. L.; Eychmüller, A.; Hickey, S. G.; Kershaw, S. V. Infrared-emitting colloidal nanocrystals: synthesis, assembly, spectroscopy, and applications. Small, 2007, 3, 536-557.
88. Rosenblum, L. T.; Kosaka, N.; M. Mitsunaga,; P. L. Choyke,; Kobayashi, H. Optimizing quantitative in vivo fluorescence imaging with near-infrared quantum dots. Contrast Media Mol. Imaging, 2011, 6, 148-152.
89. Fischer, H. C.; Liu, L.; Pang, K. S.; Chan, W. C. W. Pharmacokinetics of nanoscale Quantum Dots: In vivo distribution, sequestration, and clearance in the rat. Adv. Funct. Mater., 2006, 16, 1299-1305.
90. Sewell, S. L; Higgins, M. M.; Bell. C. S.; Giorgio, T. D. Quantification of Quantum Dot concentration using inductively coupled plasma-mass spectrometry (ICP-MS). J. Biomed. Nanotechnol., 2011, 7, 685-690.
91. Park, J. J.; Lee, T. S.; Kang, J. H.; Song, R.; Cheon, G. J. Radioiodination and biodistribution of quantum dots using Bolton-Hunter reagent. Appl. Radiat. Isot., 2011, 69, 56-62.
92. Terada, N.; Saitoh, Y.; Saitoh, S.; Ohno, N.; Jin, T.; Ohno, S. Visualization of microvascular blood flow in mouse kidney and spleen by quantum dot injection with "in vivo cryotechnique". Microvasc. Res., 2010, 80, 491-498.
93. Su, C. K.; Huang, C. W.; Yang, C. S.; Wang, Y. J.; Sun, Y. C. In vivo monitoring of Quantum Dots in the extracellular space using push pull perfusion sampling, online in-tube solid phase extraction, and inductively coupled plasma mass spectrometry. Anal. Chem., 2010, 82, 7096-7102.
94. Liu, L.; Zhang, J.; Su, X.; Mason, R. P. In vitro and in vivo assessment of CdTe and CdHgTe toxicity and clearance. J. Biomed. Nanotechnol., 2008, 4, 524-528.
95. Umemura, T. Experimental reproduction of itai-itai disease, a chronic cadmium poisoning of humans, in rats and monkeys. Jpn. J. Vet. Res., 2000, 48, 15-28.
96. Vinceti, M.; Wei, E. T.; Malagoli, C.; Bergomi, M.; Vivoli, G. Adverse health effects of selenium in humans. Rev. Envir. Health, 2001, 16, 233-251.
97. Widy-Tyszkiewicz, E.; Piechal, A.; Gajkowska, B.; Smialek, M. Tellurium-induced cognitive deficits in rats are related to neuropathological changes in the central nervous system. Toxicol. Lett., 2002, 131, 203-214.
98. Yang, R. S. H.; Chang, L. W.; Wu, J. P.; Tsai, M. H.; Wang, H. J.; Kuo, Y. C.; Yeh, T. K.; Yang, C. S.; Lin, P. Persistent tissue kinetics and redistribution of nanoparticles, Quantum Dot 705, in Mice: ICP-MS quantitative assessment. Environ. Health Perspect., 2007, 115, 1339-1343.
99. Davis, M. E.; Chen, Z. G.; Shin, D. M. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat. Rev. Drug Discov., 2008, 7, 771-782.
100. Peer, D.; Karp, J. M.; Hong, S.; Farokhzad, O. C.; Margalit, R.; Langer, R. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol., 2007, 2, 751-760.
101. Choi, H. S.; Ipe, B. I.; Misra, P.; Lee, J. H.; Bawendi, M. G.; Frangioni, J. V. Tissue- and organ-selective biodistribution of NIR fluorescent Quantum Dots. Nano Lett., 2009, 9, 2354-2359.
102. Choi, H. S.; Liu, W. h.; Misra, P.; Tanaka, E.; Zimmer, J. P.; Ipe, B. I.; Bawendi, M. G.; Frangioni, J. V. Renal clearance of quantum dots. Nat. Biotechnol., 2007, 25, 1165-1170.
103. Choi, C. H. J.; Zuckermana, J. E.; Webster, P.; Davis, M. E. Targeting kidney mesangium by nanoparticles of defined size. PNAS, 2011, 108, 6656-6661.
104. Su, Y. Y.; Peng, F.; Jiang, Z. Y.; Zhong, Y. L.; Lu, Y. M.; Jiang, X. X.; Huang, Q.; Fan, C. H.; Lee, S. T.; He, Y. In vivo distribution, pharmacokinetics, and toxicity of aqueous synthesized cadmiumcontaining quantum dots. Biomaterials, 2011, 32, 5855-5862.
105. Schipper, M. L.; Cheng, Z.; Lee, S. W.; Bentolila, L. A.; Iyer, G.; Rao, J.; Chen, X.; Wu, A. M.; Weiss, S.; Gambhir, S. S. MicroPET- based biodistribution of quantum dots in living mice. J. Nucl. Med., 2007, 48, 1511-1518.
106. Daou, T. J.; Reiss, L. Li, P.; Josserand, V.; Texier, I. Effect of poly(ethylene glycol) length on the in vivo behavior of coated Quantum Dots. Langmuir, 2009, 25, 3040 -3044.
107. Yang, R. S. H.; Chang, L. W.; Yang, C. S.; Lin, P. Pharmacokinetics and physiologically-based pharmacokinetic modeling of nanoparticles. J. Nanosci. Nanotechnol., 2010, 10, 8482-8490.
108. Lee, J.; Im, J. H.; Huh, K. M.; Lee, Y. K.; Shin, H. Preparation and characterization of CdSe/ZnS quantum dots encapsulated in poly(ethylene glycol)-b-poly(D,L-lactide) micelle nanoparticles. J. Nanosci. Nanotechnol., 2010, 10, 487-496.
109. Chang, E.; Yu, W. W.; Colvin, V. L.; Drezek, R. Quantifying the influence of surface coatings on Quantum Dot uptake in cells. J. Biomed. Nanotechnol., 2005, 1, 397-401.
110. Ballou, B.; Lagerholm, B. C.; Ernst, L. A.; Bruchez, M. P.; Waggoner, A. S. Noninvasive imaging of Quantum Dots in Mice. Bioconjugate Chem., 2004, 15, 79-86.
111. Ballou, B.; Ernst, L. A.; Andreko, S.; Eructiez, M. P.; Lagerholm, B. C.; Waggoner, A. S. Long-term retention of fluorescent Quantum Dots In vivo. Proceedings of the NATO Advanced Research Workshop on Nanomaterials for Application in Medicine and Biology, Bonn, Germany, 2008, 127-137.
112. Praetner, M.; Rehberg, M.; Bihari, P.; Lerchenberger, M.; Uhl, B.; Holzer, M.; Eichhorn, M. E.; Fürst, R.; Perisic, T.; Reichel, C. A.; Welsch, U.; Krombach, F. The contribution of the capillary endothelium to blood clearance and tissue deposition of anionic quantum dots in vivo, Biomaterials, 2010, 31, 6692-6700.
113. Dubertret, B.; Skourides, P.; Norris, D. J.; Noireaux, V.; Brivanlou, A. H.; Libchaber, A. In vivo imaging of Quantum Dots encapsulated in phospholipid micelles. Science, 2002, 298, 1759-1762.
114. Kim, K. S.; Hur, W.; Park, S. J.; Hong, S. W.; Choi, J. E. Goh,; E. J.; Yoon, S. K.; Hahn, S. K. Bioimaging for targeted delivery of hyaluronic acid derivatives to the livers in cirrhotic mice using Quantum Dots. ACS Nano, 2010, 4, 3005-3014.
115. Yong, K. Y.; Roy, I.; Lawb, W. C.; Hub, R. Synthesis of cRGDpeptide conjugated near-infrared CdTe/ZnSe core-shell quantum dots for in vivo cancer targeting and imaging. Chem. Commun., 2010, 46, 7136-7138.
116. Li, Z. M.; Huang, P.; Lin, J.; He, R.; Liu, B.; Zhang, X. M.; Yang, S.; Xi, P.; Zhang, X. J.; Ren, Q. S.; Cui, D. X. Arginine-glycineaspartic acid-conjugated dendrimer-modified Quantum Dots for targeting and imaging melanoma. J. Nanosci. Nanotechnol., 2010, 10, 4859-4867.
117. Ansary, A. A.; Kumar, S. A.; Krishnasastry, M. V.; Abyaneh, M. K.; Kulkarni, S. K.; Ahmad, A.; Khan, M. I. CdS Quantum Dots: enzyme mediated in vitro synthesis, characterization and conjugation with plant lectins. J. Biomed. Nanotechnol., 2007, 3, 406-413.
118. Chen, H. Y.; Li, L.; Cui, S. S.; Mahounga, D.; Zhang, J.; Gu, Y. Q. Folate conjugated CdHgTe Quantum Dots with high targeting affinity and sensitivity for in vivo early tumor diagnosis. J. Fluoresc., 2011, 21, 793-801.
119. Slotkin, J. R.; Chakrabarti, L.; Dai, H. N.; Carney, R. S. E.; Hirata, T.; Bregman, B. S.; Gallicano, G.; Corbin, J. G.; Haydar, T. F. In vivo Quantum Dot labeling of mammalian stem and progenitor cells. Dev. Dynam., 2007, 236, 3393-401.
120. Wang, H. C.; Brown, J.; Alayon, H.; Stuck, B. E. Transplantation of quantum dot-labelled bone marrow-derived stem cells into the vitreous of mice with laser-induced retinal injury: Survival, integration and differentiation. Vision Res., 2010, 50, 665-673.
121. Boeneman, K.; Delehanty, J. B.; Susumu, K.; Stewart, M. H.; Medintz, I. L. Intracellular bioconjugation of targeted proteins with semiconductor Quantum Dots. J. Am. Chem. Soc., 2010, 132, 5975-5977.
122. Biswas, P.; Cella, L. N.; Kang, S. H.; Mulchandani, A.; Yates, M. V.; Chen, W. A quantum-dot based protein module for in vivo monitoring of protease activity through fluorescence resonance energy transfer. Chem. Commun., 2011, 47, 5259-5261.
123. Li, D. W.; Qin, L. X.; Li, Y.; Nia, R. P.; Long, Y. T.; Chen, H. Y. CdSe/ZnS quantum dot-Cytochrome c bioconjugates for selective intracellular O2.- sensing. Chem. Commun., 2011, 47, 8539-8541.
124. Tan, W. B.; Jiang, S.; Zhang, Y. Biomaterials-Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference. Biomaterials, 2007, 28, 1565-1571.
125. Shi, C. M.; Zhu, Y.; Xie, Z. H.; Qian, W. P.; Hsieh, C. L.; Nie, S.; Su, Y. P.; Zhau, H. Y. E.; Chun, L. W. K. Visualizing human prostate cancer cells in mouse skeleton using bioconjugated nearinfrared fluorescent Quantum Dots. Urology, 2009, 74, 446-451.
126. Hoshino, A.; Hanaki, K. I.; Suzuki, K.; Yamamotoa, K. Applications of T-lymphoma labeled with fluorescent quantum dots to cell tracing markers in mouse body. Biochem. Biophys. Res. Commun., 2004, 314, 46-53.
127. Santra, S.; Yang, H.; Stanley, J. T.; Holloway, P. H.; Moudgil, B. M.; Walter, G.; Mericle, R. A. Rapid and effective labeling of brain tissue using TAT-conjugated CdS:Mn/ZnS quantum dots. Chem. Commun., 2005, 25, 3144-3146.
128. Santra, S.; Yang, H.; Holloway, P. H.; Stanley, J. T.; Mericle, R. A. Synthesis of Water-Dispersible Fluorescent, Radio-Opaque, and Paramagnetic CdS:Mn/ZnS Quantum Dots: A Multifunctional Probe for Bioimaging. J. Am. Chem. Soc., 2005, 127, 1656-1657.
129. Chen, L. N.; Wang, J.; Li. W. T.; Han, H. Y. Aqueous one-pot synthesis of bright and ultrasmall CdTe/CdS near-infrared-emitting quantum dots and their application for tumor targeting in vivo. Chem. Commun., 2012, 48, 4971-4973.
130. Schroeder, J. E.; Shweky, I.; Shmeeda, H.; Banin, U.; Gabizon, A. Folate-mediated tumor cell uptake of quantum dots entrapped in lipid nanoparticles. J. Control. Release, 2007, 124, 28-34.
131. Savla, R.; Taratula, O.; Garbuzenko, O.; Minko, T. Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin conjugate for imaging and treatment of cancer. J. Control. Release, 2011,153, 16-22.