Transplantation of quantum dot-labelled bone marrow-derived stem cells into the vitreous of mice with laser-induced retinal injury: Survival, integration and differentiation

Vision Research

Volumn 50, Issue 7, 2010, Pages 665-673

  Wang, Heuy Ching ^a   Brown, Jeremiah ^b   Alayon, Helena ^a   Stuck, Bruce E ^a  

^a USAF   (United States)

^b NORTHROP GRUMMAN CORPORATION   (United States)

Author keywords

Choroid neovascularization; Laser induced retinal injury; Lineage negative bone marrow cells; Photoreceptor apoptosis; Retinal pigment epithelium

Indexed keywords

BROXURIDINE; CHEMOKINE RECEPTOR CXCR4; MESSENGER RNA; QUANTUM DOT; RHODOPSIN; STROMAL CELL DERIVED FACTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARGON LASER; ARTICLE; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CELL INTERACTION; CELL LABELING; CELL LINEAGE; CELL MIGRATION; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MOUSE; NONHUMAN; PERICYTE; PHOTORECEPTOR CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RADIATION INJURY; RETINA CELL; RETINA INJURY; SCANNING LASER OPHTHALMOSCOPY; SUBRETINAL NEOVASCULARIZATION; THERAPY EFFECT; UPREGULATION; VITREOUS BODY;

ANIMALS; CELL DIFFERENTIATION; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CHEMOKINE CXCL12; DISEASE MODELS, ANIMAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; IMMUNOHISTOCHEMISTRY; INTRAVITREAL INJECTIONS; LASERS; MICE; MICE, INBRED BALB C; POLYMERASE CHAIN REACTION; QUANTUM DOTS; RETINA; VITREOUS BODY;

EID: 77950519282     PISSN: 00426989     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.visres.2009.09.003     Document Type: Article

References (40)

1. Allen R.D., Brown J., Zwick H., Schuschereba S.T., Lund D.J., Stuck B.E. Laser-induced macular holes demonstrate impaired choroidal perfusion. Retina 2004, 24(1):92-97.
2. Arnhold S., Absenger Y., Klein H., Addicks K., Schraermeyer U. Transplantation of bone marrow-derived mesenchymal stem cells rescue photoreceptor cells in the dystrophic retina of the rhodopsin knockout mouse. Graefes Archive for Clinical and Experimental Ophthalmology 2007, 245(3):414-422.
3. Brazelton T.R., Rossi F.M., Keshet G.I., Blau H.M. From marrow to brain: Expression of neuronal phenotypes in adult mice. Science 2000, 290(5497):1775-1779.
4. Brown J., Hacker H., Schuschereba S.T., Zwick H., Lund D.J., Stuck B.E. Steroidal and nonsteroidal antiinflammatory medications can improve photoreceptor survival after laser retinal photocoagulation. Ophthalmology 2007, 114(10):1876-1883.
5. Ceradini D.J., Kulkarni A.R., Callaghan M.J., Tepper O.M., Bastidas N., Kleinman M.E., et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nature Medicine 2004, 10(8):858-864.
6. Chan-Ling T., Baxter L., Afzal A., Sengupta N., Caballero S., Rosinova E., et al. Hematopoietic stem cells provide repair functions after laser-induced Bruch's membrane rupture model of choroidal neovascularization. American Journal of Pathology 2006, 168(3):1031-1044.
7. Dimmeler S., Zeiher A.M. Vascular repair by circulating endothelial progenitor cells: The missing link in atherosclerosis?. Journal of Molecular Medicine 2004, 82(10):671-677.
8. Dorrell M.I., Otani A., Aguilar E., Moreno S.K., Friedlander M. Adult bone marrow-derived stem cells use R-cadherin to target sites of neovascularization in the developing retina. Blood 2004, 103(9):3420-3427.
9. Espinosa-Heidmann D.G., Caicedo A., Hernandez E.P., Csaky K.G., Cousins S.W. Bone marrow-derived progenitor cells contribute to experimental choroidal neovascularization. Investigative Ophthalmology and Visual Science 2003, 44(11):4914-4919.
10. Ferrari G., Cusella-De Angelis G., Coletta M., Paolucci E., Stornaiuolo A., Cossu G., et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 1998, 279(5356):1528-1530.
11. Grant M.B., May W.S., Caballero S., Brown G.A., Guthrie S.M., Mames R.N., et al. Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization. Nature Medicine 2002, 8(6):607-612.
12. Hammes H.P., Lin J., Wagner P., Feng Y., Vom Hagen F., Krzizok T., et al. Angiopoietin-2 causes pericyte dropout in the normal retina: Evidence for involvement in diabetic retinopathy. Diabetes 2004, 53(4):1104-1110.
13. Harris J.R., Brown G.A., Jorgensen M., Kaushal S., Ellis E.A., Grant M.B., et al. Bone marrow-derived cells home to and regenerate retinal pigment epithelium after injury. Investigative Ophthalmology and Visual Science 2006, 47(5):2108-2113.
14. Harris R.G., Herzog E.L., Bruscia E.M., Grove J.E., Van Arnam J.S., Krause D.S. Lack of a fusion requirement for development of bone marrow-derived epithelia. Science 2004, 305(5680):90-93.
15. Hughes S., Gardiner T., Baxter L., Chan-Ling T. Changes in pericytes and smooth muscle cells in the kitten model of retinopathy of prematurity: Implications for plus disease. Investigative Ophthalmology and Visual Science 2007, 48(3):1368-1379.
16. Inoue Y., Iriyama A., Ueno S., Takahashi H., Kondo M., Tamaki Y., et al. Subretinal transplantation of bone marrow mesenchymal stem cells delays retinal degeneration in the RCS rat model of retinal degeneration. Experimental Eye Research 2007, 85(2):234-241.
17. Jonas J.B., Witzens-Harig M., Arseniev L., Ho A.D. Intravitreal autologous bone marrow-derived mononuclear cell transplantation: A feasibility report. Acta Ophthalmologica 2008, 86(2):225-226.
18. Kearney J.J., Cohen H.B., Stuck B.E., Rudd G.P., Beresky D.E., Wertz F.D. Laser injury to multiple retinal foci. Lasers in Surgery and Medicine 1987, 7(6):499-502.
19. Khurana S., Mukhopadhyay A. Characterization of the potential subpopulation of bone marrow cells involved in the repair of injured liver tissue. Stem Cells 2007, 25(6):1439-1447.
20. Kicic A., Shen W.Y., Wilson A.S., Constable I.J., Robertson T., Rakoczy P.E. Differentiation of marrow stromal cells into photoreceptors in the rat eye. Journal of Neuroscience 2003, 23(21):7742-7749.
21. Kopen G.C., Prockop D.J., Phinney D.G. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proceedings of the National Academy of Sciences of the United States of America 1999, 96(19):10711-10716.
22. Kucia M., Ratajczak J., Ratajczak M.Z. Bone marrow as a source of circulating CXCR4+ tissue-committed stem cells. Biology of the Cell 2005, 97(2):133-146.
23. Mainster M.A., Stuck B.E., Brown J. Assessment of alleged retinal laser injuries. Archives of Ophthalmology 2004, 122(8):1210-1217.
24. Mezey E., Chandross K.J., Harta G., Maki R.A., McKercher S.R. Turning blood into brain: Cells bearing neuronal antigens generated in vivo from bone marrow. Science 2000, 290(5497):1779-1782.
25. Minamino K., Adachi Y., Yamada H., Higuchi A., Suzuki Y., Iwasaki M., et al. Long-term survival of bone marrow-derived retinal nerve cells in the retina. NeuroReport 2005, 16(12):1255-1259.
26. Muniz A., Yarbrough H.D., Edsall P.R., Stuck B.E., Wang H.-C. A mouse model of retinal laser injury with apoptotic photoreceptor cell death. Investigative Ophthalmology and Visual Science 2009, 50 ARVO E-abstract 4467.
27. Orlic D., Kajstura J., Chimenti S., Jakoniuk I., Anderson S.M., Li B., et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001, 410(6829):701-705.
28. Otani A., Dorrell M.I., Kinder K., Moreno S.K., Nusinowitz S., Banin E., et al. Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells. Journal of Clinical Investigation 2004, 114(6):765-774.
29. Pak N.V., Podgornyi O.V., Aleksandrova M.A., Chentsova E.V., Ivanov A.N., Golubeva O.N., et al. Transplantation of cultured human neural stem cells in rabbits with experimental laser-induced damage to the retina. Bulletin of Experimental Biology and Medicine 2004, 138(5):525-528.
30. Pfister F., Feng Y., vom Hagen F., Hoffmann S., Molema G., Hillebrands J.L., et al. Pericyte migration: A novel mechanism of pericyte loss in experimental diabetic retinopathy. Diabetes 2008, 57(9):2495-2502.
31. Sasahara M., Otani A., Oishi A., Kojima H., Yodoi Y., Kameda T., et al. Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal degeneration. American Journal of Pathology 2008, 172(6):1693-1703.
32. Schmidt-Lucke C., Rossig L., Fichtlscherer S., Vasa M., Britten M., Kamper U., et al. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: Proof of concept for the clinical importance of endogenous vascular repair. Circulation 2005, 111(22):2981-2987.
33. Schuschereba S.T., Bowman P.D., Ferrando R.E., Lund D.J., Quong J.A., Vargas J.A. Accelerated healing of laser-injured rabbit retina by basic fibroblast growth factor. Investigative Ophthalmology and Visual Science 1994, 35(3):945-954.
34. Sengupta N., Caballero S., Mames R.N., Butler J.M., Scott E.W., Grant M.B. The role of adult bone marrow-derived stem cells in choroidal neovascularization. Investigative Ophthalmology and Visual Science 2003, 44(11):4908-4913.
35. Song S., Ewald A.J., Stallcup W., Werb Z., Bergers G. PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nature Cell Biology 2005, 7(9):870-879.
36. Thompson D.A., Gal A. Vitamin A metabolism in the retinal pigment epithelium: Genes, mutations, and diseases. Progress in Retinal and Eye Research 2003, 22(5):683-703.
37. Tomita M., Adachi Y., Yamada H., Takahashi K., Kiuchi K., Oyaizu H., et al. Bone marrow-derived stem cells can differentiate into retinal cells in injured rat retina. Stem Cells 2002, 20(4):279-283.
38. Wang H.C., Zwick H., Edsall P.R., Cheramie R.D., Lund D.J., Stuck B.E. In vivo visualizing the dynamics of bone marrow stem cells in mouse retina and choroidal-retinal circulation. Proceedings of SPIE 2007, 6426:642621.
39. Ying H.S., Symons R.C., Lin K.L., Solomon S.D., Gehlbach P.L. Accidental Nd:YAG laser-induced choroidal neovascularization. Lasers in Surgery and Medicine 2008, 40(4):240-242.
40. Yodoi Y., Sasahara M., Kameda T., Yoshimura N., Otani A. Circulating hematopoietic stem cells in patients with neovascular age-related macular degeneration. Investigative Ophthalmology and Visual Science 2007, 48(12):5464-5472.