A novel type of dual-modality molecular probe for MR and nuclear imaging of tumor: Preparation, characterization and in vivo application

Molecular Pharmaceutics

Volumn 6, Issue 4, 2009, Pages 1074-1082

  Liu, Shujie ^a   Jia, Bing ^b   Qiao, Ruirui ^a   Yang, Zhi ^d   Yu, Zilin ^b   Liu, Zhaofei ^b   Liu, Kan ^c   Shi, Jiyun ^b   Ouyang, Han ^c   Wang, Fan ^b   Gao, Mingyuan ^a  

^a INSTITUTE OF CHEMISTRY   (China)

^b PEKING UNIVERSITY   (China)

^c CANCER HOSPITAL   (China)

^d PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

Dual modality molecular probe; Fe3O 4 nanocrystals; MRI; Nuclear imaging; Tumor

Indexed keywords

MAGNETITE MONOCLONAL ANTIBODY 3H11 I 125; MAGNETITE MURINE IMMUNOGLOBULIN G I 125; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER DIAGNOSIS; CANCER MODEL; CHEMICAL BOND; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG SYNTHESIS; FEMALE; IMAGING SYSTEM; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MOLECULAR PROBE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STOMACH CARCINOMA; TUMOR XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; DIAGNOSTIC IMAGING; FEMALE; FERROSOFERRIC OXIDE; HUMANS; IODINE RADIOISOTOPES; MAGNETIC RESONANCE IMAGING; METAL NANOPARTICLES; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR PROBES; NEOPLASMS, EXPERIMENTAL; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 68249099886     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp900143a     Document Type: Article

References (29)

1. Weissleder, R.; Ntziachristos, V. Shedding light onto live molecular targets. Nat. Med. 2003, 9, 123-128. (Pubitemid 36098273)
2. Lee, J. H.; Huh, Y. M.; Jun, Y. W.; Seo, J. W.; Jang, J. T.; Song, H. T.; Kim, S.; Cho, E. J.; Yoon, H. G.; Suh, J. S.; Cheon, J. Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nat. Med. 2007, 13, 95-99. (Pubitemid 46067392)
3. Weissleder, R.; Pittet, M. J. Imaging in the era of molecular oncology. Nature 2008, 452, 580-589.
4. (a) Bruchez, M. J.; Moronne, M.; Gin, P.; Weiss, S.; Alivisatos, A. P. Semiconductor nanocrystals as fluorescent biological labels. Science 1998, 281, 2013-2016.
5. (b) Chan, W. C.; Nie, S. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 1998, 281, 2016-2018. (Pubitemid 28475486)
6. Gao, X.; Cui, Y.; Levenson, R. M.; Chung, L. W.; Nie, S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat. Biotechnol. 2004, 22, 969-976. (Pubitemid 39014473)
7. Wisniewski, T.; Pankiewicz, J.; Scholtzova, H.; Fernando, G.; Chabalgoity, J. A.; Ji, Y.; Wadghiri, Y. Z.; Gan, W. B.; Tang, C. Y.; Turnbull, D. H.; Mathis, C. A.; Kascsak, R.; Klunk, W. E.; Carp, R. I.; Frangione, B.; Sigurdsson, E. M.; Sadowski, M.; Carp, I. Imaging and therapeutic approaches for [beta]-sheet structures in prion and Alzheimer's diseases. Neurobiol. Aging 2004, 25, S30-S31.
8. De, V. I.; Lesterhuis, W. J.; Barentsz, J. O.; Verdijk, P.; van, K. J.; Boerman, O. C.; Oyen, W. J.; Bonenkamp, J. J.; Boezeman, J. B.; Adema, G. J.; Bulte, J. W.; Scheenen, T. W.; Punt, C. J.; Heerschap, A.; Figdor, C. G. Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat. Biotechnol. 2005, 23, 1407-1413.
9. Huh, Y. M.; Jun, Y. W.; Song, H. T.; Kim, S.; Choi, J. S.; Lee, J. H.; Yoon, S.; Kim, K. S.; Shin, J. S.; Suh, J. S.; Cheon, J. In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals. J. Am. Chem. Soc. 2005, 127, 12387-12391. (Pubitemid 41279266)
10. Hu, F. Q.; Wei, L.; Zhou, Z.; Ran, Y. L.; Li, Z.; Gao, M. Y. Preparation of Biocompatible Magnetite Nanocrystals for In Vivo Magnetic Resonance Detection of Cancer. Adv. Mater. 2006, 18, 2553-2556.
11. Sun, C.; Veiseh, O.; Gunn, J.; Fang, C.; Hansen, S.; Lee, D.; Sze, R.; Ellenbogen, R. G.; Olson, J.; Zhang, M. In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes. Small 2008, 4, 372-379.
12. Czernin, J.; Phelps, M. E. Positron emission tomography scanning: current and future applications. Annu. Rev. Med. 2002, 53, 89-112. (Pubitemid 34177873)
13. 64Cu-labeled tetrameric RGD peptide. J. Nucl. Med. 2005, 46, 1707-1718.
14. 99mTc-labeled cyclic RGDfK dimer: Initial evaluation for SPECT imaging of glioma integrin {alpha}v{beta}3 expression. Bioconjugate Chem. 2006, 17, 1069-1076.
15. Wang, Y. X.; Hussain, S. M.; Krestin, G. P. Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging. Eur. Radiol. 2001, 11, 2319-2331. (Pubitemid 33041104)
16. (a) Anzai, Y.; Blackwell, K. E.; Hirschowitz, S. L.; Rogers, J. W.; Sato, Y.; Yuh, W. T.; Runge, V. M.; Morris, M. R.; McLachlan, S. J.; Lufkin, R. B. Initial clinical experience with dextran-coated superparamagnetic iron oxide for detection of lymph node metastases in patients with head and neck cancer. Radiology 1994, 192, 709-715.
17. (b) Ros, P. R.; Freeny, P. C.; Harms, S. E.; Seltzer, S. E.; Davis, P. L.; Chan, T. W.; Stillman, A. E.; Muroff, L. R.; Runge, V. M.; Nissenbaum, M. A.; et al. Hepatic MR imaging with ferumoxides: a multicenter clinical trial of the safety and efficacy in the detection of focal hepatic lesions. Radiology 1995, 196, 481-488.
18. Corot, C.; Robert, P.; Idee, J. M.; Port, M. Recent advances in iron oxide nanocrystal technology for medical imaging. Adv. Drug Delivery Rev. 2006, 58, 1471-1504. (Pubitemid 44820503)
19. Harisinghani, M. G.; Barentsz, J.; Hahn, P. F.; Deserno, W. M.; Tabatabaei, S.; van, K. C.; de, R. J.; Weissleder, R. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N. Engl. J. Med 2003, 348, 2491-2499. (Pubitemid 36706536)
20. Qiao, R. R.; Yang, C. H.; Gao, M. Y. Superparamagnetic iron oxide nanoparticles: from preparations to in vivo MRI applications. J. Mater. Chem. 2009, DOI: 10.1039/b902394a.
21. Li, Z.; Chen, H.; Bao, H. B.; Gao, M. Y. One-pot reaction to synthesize water-soluble magnetite nanocrystals. Chem. Mater. 2004, 16, 1391-1393.
22. Hu, F.; Li, Z.; Tu, C.; Gao, M. Y. Preparation of magnetite nanocrystals with surface reactive moieties by one-pot reaction. J. Colloid Interface Sci. 2007, 311, 469-474.
23. Li, Z.; Wei, L.; Gao, M. Y.; Lei, H. One-pot reaction to synthesize biocompatible magnetite nanoparticles. Adv. Mater. 2005, 17, 1001-1005. (Pubitemid 40584337)
24. Wei, L.; Zhou, G.; Li, Z.; He, L.; Gao, M. Y.; Tan, J.; Lei, H. Detection of toxoplasmic lesions in mouse brain by USPIO-enhanced magnetic resonance imaging. Magn. Reson. Imaging 2007, 25, 1442-1448. (Pubitemid 350122921)
25. Catana, C.; Wu, Y.; Judenhofer, M. S.; Qi, J.; Pichler, B. J.; Cherry, S. R. Simultaneous acquisition of multislice PET and MR images: initial results with a MR-compatible PET scanner. J. Nucl. Med. 2006, 47, 1968-1976.
26. 111In-ChL6 nanoparticle AMF-induced thermoablative therapy for human breast cancer in mice. J. Nucl. Med. 2007, 48, 437-444.
27. (a) Guo, J.; Jin, G.; Meng, L.; Ma, H.; Nie, D.; Wu, J.; Yuan, L.; Shou, C. Subcellullar localization of tumor-associated antigen 3H11Ag. Biochem. Biophys. Res. Commun. 2004, 324, 922-930. (Pubitemid 39359196)
28. (b) Chen, D.; Shou, C. Molecular cloning of a tumor-associated antigen recognized by monoclonal antibody 3H11. Biochem. Biophys. Res. Commun. 2001, 280, 99-103. (Pubitemid 32917482)
29. Salacinski, P. R.; McLean, C.; Sykes, J. E.; Clement-Jones, V. V.; Lowry, P. J. Iodination of proteins, glycoproteins, and peptides using a solid-phase oxidizing agent, 1,3,4,6-tetrachloro-3 alpha,6 alpha-diphenyl glycoluril (Iodogen). Anal. Biochem. 1981, 117, 136-146.