Synthesis of water-dispersible fluorescent, radio-opaque, and paramagnetic CdS:Mn/ZnS quantum dots: A multifunctional probe for bioimaging

Journal of the American Chemical Society

Volumn 127, Issue 6, 2005, Pages 1656-1657

  Santra, Swadeshmukul ^a   Yang, Heesun ^b   Holloway, Paul H ^b   Stanley, Jessie T ^a   Mericle, Robert A ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b University of Florida   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTALLIN; FLUORESCENT DYE; MANGANESE; QUANTUM DOT; TRANSACTIVATOR PROTEIN; ZINC SULFATE;

ARTICLE; BLOOD BRAIN BARRIER; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC IMAGING; DISPERSION; FIELD EMISSION; FLUORESCENCE; NEAR INFRARED SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE IMAGING; PHOTODEGRADATION; SEMICONDUCTOR; SPECTRAL SENSITIVITY;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CADMIUM COMPOUNDS; CONTRAST MEDIA; FLUORESCENCE; FLUORESCENT DYES; GENE PRODUCTS, TAT; MANGANESE; PEPTIDE FRAGMENTS; QUANTUM DOTS; RATS; SILICON DIOXIDE; SOLUBILITY; SULFIDES; WATER; ZINC COMPOUNDS;

EID: 13644251480     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0464140     Document Type: Article

References (21)

1. Bruchez, M.; Moronne, M.; Gin, P.; Weiss, S.; Alivisatos, A. P. Science 1998, 281, 2013-2016.
2. Derfus, A. M.; Chan, W. C. W.; Bhatia, S. N. Nano Lett. 2004, 4, 11-18.
3. (a) Chan, W. C. W.; Maxwell, D. J.; Gao, X. H.; Bailey, R. E.; Han, M. Y.; Nie, S. M. Curr. Opin. Biotechnol. 2002, 13, 40-46.
4. (b) Nie, S. M. Cytometry 2002, 25-25.
5. (a) Hoshino, A.; Hanaki, K.; Suzuki, K.; Yamamoto, K. Biochem. Biophys. Res. Commun. 2004, 314, 46-53.
6. (b) Ballou, B.; Lagerholm, B. C.; Ernst, L. A.; Bruchez, M. P.; Waggoner, A. S. Bioconjugate Chem. 2004, 15, 79-86.
7. Gao, X. H.; Cui, Y. Y.; Levenson, R. M.; Chung, L.; Nie, S. M. Nat. Biotechnol. 2004, 22, 969-976.
8. Josephson, L.; Kircher, M. F.; Mahmood, U.; Tang, Y.; Weissleder, R. Bioconjugate Chem. 2002, 13, 554-560.
9. (a) Schaller, R. D.; Petruska, M. A.; Klimov, V. I. J. Phys. Chem. B 2003, 107, 13765-13768.
10. (b) Gaponik, N.; Radtchenko, I. L.; Gerstenberger, M. R.; Fedutik, Y. A.; Sukhorukov, G. B.; Rogach, A. L. Nano Lett. 2003, 3, 369-372.
11. (a) van de Rijke, F.; Zijlmans, H.; Li, S.; Vail, T.; Raap, A. K.; Niedbala, R. S.; Tanke, H. J. Nat. Biotechnol. 2001, 19, 273-276.
12. (b) Zijlmans, H. J. M. A. A.; Bonnet, J.; Burton, J.; Kardos, K.; Vail, T.; Niedbala, R. S.; Tanke, H. J. Anal. Biochem. 1999, 267, 30-36.
13. Kircher, M. F.; Mahmood, U.; King, R. S.; Weissleder, R.; Josephson, L. Cancer Res. 2003, 63, 8122-8125.
14. Santra, S.; Yang, H.; Dutta, D.; Stanley, J. T.; Holloway, P. H.; Tan, W.; Moudgil, B. M.; Mericle, R. A. Chem. Commun. 2004, 2810-2811.
15. Fluorescent dyes were stable with silica encapsulation in dye-doped silica nanoparticles (ref 10). Similar silica coating is present on Qdots to obtain in vivo stability.
16. Yang, H.; Holloway, P. H. Appl. Phys. Lett. 2003, 82, 1965-1967.
17. Schroedter, A.; Weller, H. Angew. Chem., Int. Ed. 2002, 41, 3218-3221.
18. The fluorescence excitation band is broad (see Supporting Information). For minimizing tissue damage it is possible to generate a desired amount of emission photons by exciting Qdots in the longer wavelength range (i.e., 400 nm) rather than 366 nm. Pure silica nanoparticles (∼10 nm, control) are found to be nonfluorescent at 366-nm excitation (not shown here).
19. Yang, H.; Holloway, P. H. Adv. Funct. Mater. 2004, 14, 152-156.
20. Josephson, L.; Tung, C. H.; Moore, A.; Weissleder, R. Bioconjugate Chem. 1999, 10, 186-191.
21. Yang, H.; Holloway, P.; Santra, S. J. Chem. Phys. 2004, 121, 7421-7426.