-
1
-
-
79551583056
-
Hepcidin and disorders of iron metabolism
-
Ganz T, Nemeth E,. Hepcidin and disorders of iron metabolism. Annu Rev Med 2011; 62: 347-360.
-
(2011)
Annu Rev Med
, vol.62
, pp. 347-360
-
-
Ganz, T.1
Nemeth, E.2
-
3
-
-
78649634981
-
Hepcidin in human iron disorders: Therapeutic implications
-
Pietrangelo A., Hepcidin in human iron disorders: therapeutic implications. J Hepatol 2011; 54: 173-181.
-
(2011)
J Hepatol
, vol.54
, pp. 173-181
-
-
Pietrangelo, A.1
-
4
-
-
69949088488
-
Hepcidin, the iron watcher
-
Viatte L, Vaulont S,. Hepcidin, the iron watcher. Biochimie 2009; 91: 1223-1228.
-
(2009)
Biochimie
, vol.91
, pp. 1223-1228
-
-
Viatte, L.1
Vaulont, S.2
-
5
-
-
84863531503
-
Inhibition of hepcidin transcription by growth factors
-
Goodnough JB, Ramos E, Nemeth E, et al., Inhibition of hepcidin transcription by growth factors. Hepatology 2012; 56: 291-299.
-
(2012)
Hepatology
, vol.56
, pp. 291-299
-
-
Goodnough, J.B.1
Ramos, E.2
Nemeth, E.3
-
6
-
-
68949220321
-
ER stress controls iron metabolism through induction of hepcidin
-
Vecchi C, Montosi G, Zhang K, et al., ER stress controls iron metabolism through induction of hepcidin. Science 2009; 325: 877-880.
-
(2009)
Science
, vol.325
, pp. 877-880
-
-
Vecchi, C.1
Montosi, G.2
Zhang, K.3
-
7
-
-
0037174609
-
C/EBPα regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism
-
Courselaud B, Pigeon C, Inoue Y, et al., C/EBPα regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. J Biol Chem 2002; 277: 41163-41170.
-
(2002)
J Biol Chem
, vol.277
, pp. 41163-41170
-
-
Courselaud, B.1
Pigeon, C.2
Inoue, Y.3
-
8
-
-
80052657110
-
Pathology of hepatic iron overload
-
Deugnier Y, Turlin B,. Pathology of hepatic iron overload. Semin Liver Dis 2011; 31: 260-271.
-
(2011)
Semin Liver Dis
, vol.31
, pp. 260-271
-
-
Deugnier, Y.1
Turlin, B.2
-
9
-
-
84855338121
-
Hepatocarcinogenesis in hepatitis C: HCV shrewdly exacerbates oxidative stress by modulating both production and scavenging of reactive oxygen species
-
Fujinaga H, Tsutsumi T, Yotsuyanagi H, et al., Hepatocarcinogenesis in hepatitis C: HCV shrewdly exacerbates oxidative stress by modulating both production and scavenging of reactive oxygen species. Oncology 2011; 81: 11-17.
-
(2011)
Oncology
, vol.81
, pp. 11-17
-
-
Fujinaga, H.1
Tsutsumi, T.2
Yotsuyanagi, H.3
-
10
-
-
33744517652
-
Iron, HCV, and liver cancer: Hard metal setting the pace?
-
Mueller S, Afdhal NH, Schuppan D,. Iron, HCV, and liver cancer: hard metal setting the pace? Gastroenterology 2006; 130: 2229-2234.
-
(2006)
Gastroenterology
, vol.130
, pp. 2229-2234
-
-
Mueller, S.1
Afdhal, N.H.2
Schuppan, D.3
-
11
-
-
37349033182
-
Liver iron, HFE gene mutations, and hepatocellular carcinoma occurrence in patients with cirrhosis
-
Nahon P, Sutton A, Rufat P, et al., Liver iron, HFE gene mutations, and hepatocellular carcinoma occurrence in patients with cirrhosis. Gastroenterology 2008; 134: 102-110.
-
(2008)
Gastroenterology
, vol.134
, pp. 102-110
-
-
Nahon, P.1
Sutton, A.2
Rufat, P.3
-
12
-
-
33644773569
-
Hepcidin is down-regulated in alcoholic liver injury: Implications for the pathogenesis of alcoholic liver disease
-
Bridle KR, Cheung T, Murphy TL, et al., Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease. Alcohol Clin Exp Res 2006; 30: 106-112.
-
(2006)
Alcohol Clin Exp Res
, vol.30
, pp. 106-112
-
-
Bridle, K.R.1
Cheung, T.2
Murphy, T.L.3
-
13
-
-
37349065804
-
Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription
-
Nishina S, Hino K, Korenaga M, et al., Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology 2008; 134: 226-238.
-
(2008)
Gastroenterology
, vol.134
, pp. 226-238
-
-
Nishina, S.1
Hino, K.2
Korenaga, M.3
-
14
-
-
33747359666
-
Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression
-
Harrison-Findik DD, Schafer D, Klein E, et al., Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem 2006; 281: 22974-22982.
-
(2006)
J Biol Chem
, vol.281
, pp. 22974-22982
-
-
Harrison-Findik, D.D.1
Schafer, D.2
Klein, E.3
-
15
-
-
0026546365
-
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription
-
Ron D, Habener JF,. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 1992; 6: 439-453.
-
(1992)
Genes Dev
, vol.6
, pp. 439-453
-
-
Ron, D.1
Habener, J.F.2
-
16
-
-
0029928173
-
Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element
-
Ubeda M, Wang XZ, Zinszner H, et al., Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Mol Cell Biol 1996; 16: 1479-1489.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 1479-1489
-
-
Ubeda, M.1
Wang, X.Z.2
Zinszner, H.3
-
17
-
-
68949162173
-
ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity
-
Oliveira SJ, Pinto JP, Picarote G, et al., ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity. PLoS One 2009; 4: e6618.
-
(2009)
PLoS One
, vol.4
-
-
Oliveira, S.J.1
Pinto, J.P.2
Picarote, G.3
-
18
-
-
41349120465
-
Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models
-
Strnad P, Tao GZ, Zhou Q, et al., Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models. Gastroenterology 2008; 134: 1169-1179.
-
(2008)
Gastroenterology
, vol.134
, pp. 1169-1179
-
-
Strnad, P.1
Tao, G.Z.2
Zhou, Q.3
-
19
-
-
70350077449
-
Targeting liver fibrosis: Strategies for development and validation of antifibrotic therapies
-
Popov Y, Schuppan D,. Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies. Hepatology 2009; 50: 1294-1306.
-
(2009)
Hepatology
, vol.50
, pp. 1294-1306
-
-
Popov, Y.1
Schuppan, D.2
-
20
-
-
0020678413
-
Studies of the mechanism of metabolism of thioacetamide s-oxide by rat liver microsomes
-
Dyroff MC, Neal RA,. Studies of the mechanism of metabolism of thioacetamide s-oxide by rat liver microsomes. Mol Pharmacol 1983; 23: 219-227.
-
(1983)
Mol Pharmacol
, vol.23
, pp. 219-227
-
-
Dyroff, M.C.1
Neal, R.A.2
-
21
-
-
33744770685
-
Oxidative stress in the development of liver cirrhosis: A comparison of two different experimental models
-
Natarajan SK, Thomas S, Ramamoorthy P, et al., Oxidative stress in the development of liver cirrhosis: a comparison of two different experimental models. J Gastroenterol Hepatol 2006; 21: 947-957.
-
(2006)
J Gastroenterol Hepatol
, vol.21
, pp. 947-957
-
-
Natarajan, S.K.1
Thomas, S.2
Ramamoorthy, P.3
-
23
-
-
0030765649
-
Disruption of the c/ebp alpha gene in adult mouse liver
-
Lee YH, Sauer B, Johnson PF, et al., Disruption of the c/ebp alpha gene in adult mouse liver. Mol Cell Biol 1997; 17: 6014-6022.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 6014-6022
-
-
Lee, Y.H.1
Sauer, B.2
Johnson, P.F.3
-
24
-
-
0026072529
-
Classification of chronic viral hepatitis: A need for reassessment
-
Scheuer PJ,. Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 1991; 13: 372-374.
-
(1991)
J Hepatol
, vol.13
, pp. 372-374
-
-
Scheuer, P.J.1
-
25
-
-
84855197344
-
Hepcidin is localised in gastric parietal cells, regulates acid secretion and is induced by Helicobacter pylori infection
-
Schwarz P, Kübler JAM, Strnad P, et al., Hepcidin is localised in gastric parietal cells, regulates acid secretion and is induced by Helicobacter pylori infection. Gut 2012; 61: 193-201.
-
(2012)
Gut
, vol.61
, pp. 193-201
-
-
Schwarz, P.1
Kübler, J.A.M.2
Strnad, P.3
-
26
-
-
84865536932
-
Hepatic activation of IKK/NF-κB signaling induces liver fibrosis via macrophage-mediated chronic inflammation
-
Sunami Y, Leithäuser F, Gul S, et al., Hepatic activation of IKK/NF-κB signaling induces liver fibrosis via macrophage-mediated chronic inflammation. Hepatology 2012; 56: 1117-1128.
-
(2012)
Hepatology
, vol.56
, pp. 1117-1128
-
-
Sunami, Y.1
Leithäuser, F.2
Gul, S.3
-
27
-
-
79952708723
-
Endoplasmic reticulum stress in liver disease
-
Malhi H, Kaufman RJ,. Endoplasmic reticulum stress in liver disease. J Hepatol 2011; 54: 795-809.
-
(2011)
J Hepatol
, vol.54
, pp. 795-809
-
-
Malhi, H.1
Kaufman, R.J.2
-
28
-
-
79952135247
-
An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice
-
Sindrilaru A, Peters T, Wieschalka S, et al., An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest 2011; 121: 985-997.
-
(2011)
J Clin Invest
, vol.121
, pp. 985-997
-
-
Sindrilaru, A.1
Peters, T.2
Wieschalka, S.3
-
29
-
-
79957723868
-
Iron trafficking and metabolism in macrophages: Contribution to the polarized phenotype
-
Cairo G, Recalcati S, Mantovani A, et al., Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype. Trends Immunol 2011; 32: 241-247.
-
(2011)
Trends Immunol
, vol.32
, pp. 241-247
-
-
Cairo, G.1
Recalcati, S.2
Mantovani, A.3
-
30
-
-
0032077160
-
Effect of stobadine on carbon tetrachloride-induced erythrocyte membrane changes in rats
-
Mojzis J, Nicak A, Guzy J, et al., Effect of stobadine on carbon tetrachloride-induced erythrocyte membrane changes in rats. Free Radic Biol Med 1998; 24: 1347-1351.
-
(1998)
Free Radic Biol Med
, vol.24
, pp. 1347-1351
-
-
Mojzis, J.1
Nicak, A.2
Guzy, J.3
-
31
-
-
0023925720
-
Experimental study of iron effect on the liver function
-
Hasegawa M, Takenaka H, Shinotsuka A,. Experimental study of iron effect on the liver function. Ann Nucl Med 1988; 2: 27-34.
-
(1988)
Ann Nucl Med
, vol.2
, pp. 27-34
-
-
Hasegawa, M.1
Takenaka, H.2
Shinotsuka, A.3
-
32
-
-
0029039555
-
A long-term study of the interaction between iron and alcohol in an animal model of iron overload
-
Olynyk J, Hall P, Reed W, et al., A long-term study of the interaction between iron and alcohol in an animal model of iron overload. J Hepatol 1995; 22: 671-676.
-
(1995)
J Hepatol
, vol.22
, pp. 671-676
-
-
Olynyk, J.1
Hall, P.2
Reed, W.3
-
33
-
-
33751020540
-
Effects of iron overload in a rat nutritional model of non-alcoholic fatty liver disease
-
Kirsch R, Sijtsema HP, Tlali M, et al., Effects of iron overload in a rat nutritional model of non-alcoholic fatty liver disease. Liver Int 2006; 26: 1258-1267.
-
(2006)
Liver Int
, vol.26
, pp. 1258-1267
-
-
Kirsch, R.1
Sijtsema, H.P.2
Tlali, M.3
-
34
-
-
33644759724
-
Effect of hepatic iron concentration reduction on hepatic fibrosis and damage in rats with cholestatic liver disease
-
Peretz G, Link G, Pappo O, et al., Effect of hepatic iron concentration reduction on hepatic fibrosis and damage in rats with cholestatic liver disease. World J Gastroenterol 2006; 12: 240-245.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 240-245
-
-
Peretz, G.1
Link, G.2
Pappo, O.3
-
35
-
-
0035038751
-
RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays
-
Bulera SJ, Eddy SM, Ferguson E, et al., RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays. Hepatology 2001; 33: 1239-1258.
-
(2001)
Hepatology
, vol.33
, pp. 1239-1258
-
-
Bulera, S.J.1
Eddy, S.M.2
Ferguson, E.3
-
37
-
-
1842843855
-
Roles of CHOP/GADD153 in endoplasmic reticulum stress
-
Oyadomari S, Mori M,. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 2004; 11: 381-389.
-
(2004)
Cell Death Differ
, vol.11
, pp. 381-389
-
-
Oyadomari, S.1
Mori, M.2
-
38
-
-
0042824071
-
Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells
-
You K, Liu M, Han X, et al., Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells. Hepatology 2003; 38: 745-755.
-
(2003)
Hepatology
, vol.38
, pp. 745-755
-
-
You, K.1
Liu, M.2
Han, X.3
-
39
-
-
34547964642
-
Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses
-
Lawless MW, Mankan AK, White M, et al., Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses. BMC Cell Biol 2007; 8: 30.
-
(2007)
BMC Cell Biol
, vol.8
, pp. 30
-
-
Lawless, M.W.1
Mankan, A.K.2
White, M.3
-
40
-
-
0027929949
-
Induction of GADD153, a CCAAT/enhancer-binding protein (C/EBP)-related gene, during the acute phase response in rats. Evidence for the involvement of C/EBPs in regulating its expression
-
Sylvester SL, ap Rhys CM, Luethy-Martindale JD, et al., Induction of GADD153, a CCAAT/enhancer-binding protein (C/EBP)-related gene, during the acute phase response in rats. Evidence for the involvement of C/EBPs in regulating its expression. J Biol Chem 1994; 269: 20119-20125.
-
(1994)
J Biol Chem
, vol.269
, pp. 20119-20125
-
-
Sylvester, S.L.1
Ap Rhys, C.M.2
Luethy-Martindale, J.D.3
-
41
-
-
0037931782
-
Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury
-
Ikeyama S, Wang X, Li J, et al., Expression of the pro-apoptotic gene gadd153/chop is elevated in liver with aging and sensitizes cells to oxidant injury. J Biol Chem 2003; 278: 16726-16731.
-
(2003)
J Biol Chem
, vol.278
, pp. 16726-16731
-
-
Ikeyama, S.1
Wang, X.2
Li, J.3
-
42
-
-
79952264011
-
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
-
Tabas I, Ron D,. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nature Cell Biol 2011; 13: 184-190.
-
(2011)
Nature Cell Biol
, vol.13
, pp. 184-190
-
-
Tabas, I.1
Ron, D.2
-
43
-
-
78049480651
-
Stress signaling in the methionine-choline-deficient model of murine fatty liver disease
-
1739.e1.
-
Soon RK Jr, Yan JS, Grenert JP, et al., Stress signaling in the methionine-choline-deficient model of murine fatty liver disease. Gastroenterology 2010; 139: 1730-1739, 1739.e1.
-
(2010)
Gastroenterology
, vol.139
, pp. 1730-1739
-
-
Soon, Jr.R.K.1
Yan, J.S.2
Grenert, J.P.3
-
44
-
-
79952698822
-
ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes
-
Magne L, Blanc E, Legrand B, et al., ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes. J Hepatol 2011; 54: 729-737.
-
(2011)
J Hepatol
, vol.54
, pp. 729-737
-
-
Magne, L.1
Blanc, E.2
Legrand, B.3
-
45
-
-
38649124615
-
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
-
Puri P, Mirshahi F, Cheung O, et al., Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 2008; 134: 568-576.
-
(2008)
Gastroenterology
, vol.134
, pp. 568-576
-
-
Puri, P.1
Mirshahi, F.2
Cheung, O.3
-
46
-
-
78851468984
-
No evidence of the unfolded protein response in patients with chronic hepatitis C virus infection
-
McPherson S, Powell EE, Barrie HD, et al., No evidence of the unfolded protein response in patients with chronic hepatitis C virus infection. J Gastroenterol Hepatol 2011; 26: 319-327.
-
(2011)
J Gastroenterol Hepatol
, vol.26
, pp. 319-327
-
-
McPherson, S.1
Powell, E.E.2
Barrie, H.D.3
-
47
-
-
70349746734
-
Reduced serum hepcidin levels in patients with chronic hepatitis C
-
Girelli D, Pasino M, Goodnough JB, et al., Reduced serum hepcidin levels in patients with chronic hepatitis C. J Hepatol 2009; 51: 845-852.
-
(2009)
J Hepatol
, vol.51
, pp. 845-852
-
-
Girelli, D.1
Pasino, M.2
Goodnough, J.B.3
-
48
-
-
79952200317
-
Serum hepcidin levels are related to the severity of liver histological lesions in chronic hepatitis C
-
Tsochatzis E, Papatheodoridis GV, Koliaraki V, et al., Serum hepcidin levels are related to the severity of liver histological lesions in chronic hepatitis C. J Viral Hepat 2010; 17: 800-806.
-
(2010)
J Viral Hepat
, vol.17
, pp. 800-806
-
-
Tsochatzis, E.1
Papatheodoridis, G.V.2
Koliaraki, V.3
-
49
-
-
84866326268
-
Liver hepcidin mRNA expression is inappropriately low in alcoholic patients compared with healthy controls
-
Costa-Matos L, Batista P, Monteiro N, et al., Liver hepcidin mRNA expression is inappropriately low in alcoholic patients compared with healthy controls. Eur J Gastroenterol Hepatol 2012; 24: 1158-1165.
-
(2012)
Eur J Gastroenterol Hepatol
, vol.24
, pp. 1158-1165
-
-
Costa-Matos, L.1
Batista, P.2
Monteiro, N.3
|