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Journal of Chromatography A

Volumn 1319, Issue , 2013, Pages 65-71

Highly linear pH gradients for analyzing monoclonal antibody charge heterogeneity in the alkaline range

(5) Lingg, Nico a,b Tan, Eddy b Hintersteiner, Beate a Bardor, Muriel b,c Jungbauer, Alois a

a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES (Austria)

b AGENCY FOR SCIENCE (Singapore)

c UNIVERSITÉ DE ROUEN (France)

Author keywords

Analytics; Ion exchange chromatography (IEC); Isoelectric point; Monoclonal antibody (mAb) variants; PH gradient

Indexed keywords

ANALYTICS; ION-EXCHANGE CHROMATOGRAPHY; ISO-ELECTRIC POINTS; MONOCLONAL ANTIBODIES (MAB); PH GRADIENTS;

ALKALINITY; MONOCLONAL ANTIBODIES; PH;

CHROMATOGRAPHY;

BUFFER; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; RECOMBINANT ANTIBODY;

ALKALINITY; ANTIBODY CHARGE HETEROGENEITY ANALYSIS; ARTICLE; BUFFERING CAPACITY; CHEMICAL PARAMETERS; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISSOCIATION CONSTANT; ELUTION; ION EXCHANGE CHROMATOGRAPHY; ISOELECTRIC POINT; LINEAR SYSTEM; PH GRADIENT; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; SURFACE CHARGE;

ANALYTICS; ION-EXCHANGE CHROMATOGRAPHY (IEC); ISOELECTRIC POINT; MONOCLONAL ANTIBODY (MAB) VARIANTS; PH GRADIENT;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, ION EXCHANGE; HYDROGEN-ION CONCENTRATION; ISOELECTRIC POINT;

EID: 84887609658 PISSN: 00219673 EISSN: 18733778 Source Type: Journal
DOI: 10.1016/j.chroma.2013.10.028 Document Type: Article

Times cited : (48)

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