Mid-infrared spectroscopy-based antibody aggregate quantification in cell culture fluids

Biotechnology Journal

Volumn 8, Issue 8, 2013, Pages 912-917

  Capito, Florian ^a,b   Skudas, Romas ^b   Kolmar, Harald ^a   Hunzinger, Christian ^b  

^a DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^b MERCK KGAA   (Germany)

Author keywords

Analytical biotechnology; Downstream processing; Infrared spectroscopy; Process monitoring

Indexed keywords

ANTIBODY AGGREGATION; DOWNSTREAM-PROCESSING; LIGHT SCATTERING TECHNIQUES; MID-INFRARED SPECTROSCOPY; MULTIVARIATE MODELS; PROCESS INFORMATION; QUANTIFICATION MODEL; THERAPEUTIC ANTIBODIES;

ANTIBODIES; CELL CULTURE; CHROMATOGRAPHY; INFRARED DEVICES; INFRARED SPECTROSCOPY; PROCESS MONITORING; PURIFICATION;

AGGREGATES;

ANTIBODY; CELL PROTEIN; MONOCLONAL ANTIBODY;

ARTICLE; CELL CULTURE; CULTURE MEDIUM; INFRARED SPECTROSCOPY; MID INFRARED SPECTROSCOPY; PRIORITY JOURNAL; SPECTROMETER;

ANALYTICAL BIOTECHNOLOGY; DOWNSTREAM PROCESSING; INFRARED SPECTROSCOPY; PROCESS MONITORING;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETINAE; CRICETULUS; RECOMBINANT PROTEINS; SOLUBILITY; SPECTROPHOTOMETRY, INFRARED;

EID: 84881296592     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201300164     Document Type: Article

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