A WAO-ARIA-GA2LEN consensus document on molecular-based allergy diagnostics

World Allergy Organization Journal

Volumn 6, Issue 1, 2013, Pages

  Canonica, Giorgio Walter ^a   Ansotegui, Ignacio J ^b   Pawankar, Ruby ^b   Schmid Grendelmeier, Peter ^b   Van Hage, Marianne ^b   Baena Cagnani, Carlos E ^b   Melioli, Giovanni ^b   Nunes, Carlos ^b   Passalacqua, Giovanni ^b   Rosenwasser, Lanny ^b   Sampson, Hugh ^b   Sastre, Joaquin ^b   Bousquet, Jean ^b   Zuberbier, Torsten ^b   Allen, Katrina ^b   Asero, Riccardo ^b   Bohle, Barbara ^b   Cox, Linda ^b   De Blay, Frederic ^b   Ebisawa, Motohiro ^b   Maximiliano Gomez, Rene ^b   Gonzalez Diaz, Sandra ^b   Haahtela, Tari ^b   Holgate, Stephen ^b   Jakob, Thilo ^b   Larche, Mark ^b   Matricardi, Paolo Maria ^b   Oppenheimer, John ^b   Poulsen, Lars K ^b   Renz, Harald E ^b   Rosario, Nelson ^b   Rothenberg, Marc ^b   Sanchez Borges, Mario ^b   Scala, Enrico ^b   Valenta, Rudolf ^b   more..

^a UNIVERSITY OF GENOA   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY;

ALLERGY; ANXIETY; ARTICLE; BIOCHIP; CONSENSUS; CROSS REACTION; FOOD ALLERGY; HUMAN; IMMUNOTHERAPY; IN VITRO STUDY; MOLECULAR DIAGNOSTICS; PATIENT IDENTIFICATION; PRIORITY JOURNAL; PROGNOSIS;

EID: 84887590583     PISSN: 19394551     EISSN: None     Source Type: Journal    
DOI: 10.1186/1939-4551-6-17     Document Type: Article

References (109)

1. Valenta R, Duchene M, Vrtala S, Birkner T, Ebner C, Hirschwehr R, Breitenbach M, Rumpold H, Scheiner O, Kraft D: Recombinant allergens for immunoblot diagnosis of tree-pollen allergy. J Allergy Clin Immunol 1991, 88:889-894
2. Valenta R, Vrtala S, Ebner C, Kraft D, Scheiner O: Diagnosis of grass pollen allergy with recombinant timothy grass (Phleum pratense) pollen allergens. Int Arch Allergy Immunol 1992, 97:287-294.
3. Valenta R, Kraft D: Recombinant allergen molecules: tools to study effector cell activation. Immunol Rev 2001, 179:119-127. (Pubitemid 32171279)
4. Thomas WR, Stewart GA, Simpson RJ, Chua KY, Plozza TM, Dilworth RJ, Nisbet A, Turner KJ: Cloning and expression of DNA coding for the major house dust mite allergen Der p 1 in Escherichia coli. Int Arch Allergy Appl Immunol 1988, 85:127-129. (Pubitemid 18049337)
5. Valenta R, Lidholm J, Niederberger V, Hayek B, Kraft D, Gronlund H: The recombinant allergen-based concept of component-resolved diagnostics and immunotherapy (CRD and CRIT). Clin Exp Allergy 1999, 29:896-904. (Pubitemid 29317799)
6. Valenta R, Ferreira F, Focke-Tejkl M, Linhart B, Niederberger V, Swoboda I, Vrtala S: From allergen genes to allergy vaccines. Annu Rev Immunol 2010, 28:211-241.
7. Radauer C, Bublin M, Wagner S, Mari A, Breiteneder H: Allergens are distributed into few protein families and possess a restricted number of biochemical functions. J Allergy Clin Immunol 2008, 121:847-852. e847.
8. Sastre J: Molecular diagnosis in allergy. Clin Exp Allergy 2010, 40:1442-1460.
9. Borres MP, Ebisawa M, Eigenmann PA: Use of allergen components begins a new era in pediatric allergology. Pediatr Allergy Immunol 2011, 22:454-461.
10. Shreffler WG: Microarrayed recombinant allergens for diagnostic testing. J Allergy Clin Immunol 2011, 127:843-849.
11. Sastre J, Landivar ME, Ruiz-Garcia M, Andregnette-Rosigno MV, Mahillo I: How molecular diagnosis can change allergen-specific immunotherapy prescription in a complex pollen area. Allergy 2012, 67:709-711.
12. Tripodi S, Frediani T, Lucarelli S, Macri F, Pingitore G, Di Rienzo Businco A, Dondi A, Pansa P, Ragusa G, Asero R, et al: Molecular profiles of IgE to Phleum pratense in children with grass pollen allergy: Implications for specific immunotherapy. J Allergy Clin Immunol 2012, 129:834-839. e838.
13. Muller U, Schmid-Grendelmeier P, Hausmann O, Helbling A: IgE to recombinant allergens Api m 1, Ves v 1, and Ves v 5 distinguish double sensitization from crossreaction in venom allergy. Allergy 2012, 67:1069-1073.
14. Mittermann I, Zidarn M, Silar M, Markovic-Housley Z, Aberer W, Korosec P, Kosnik M, Valenta R: Recombinant allergen-based IgE testing to distinguish bee and wasp allergy. J Allergy Clin Immunol 2010, 125:1300-1307. e1303.
15. Melioli G, Compalati E, Bonini S, Canonica GW: The added value of allergen microarray technique to the management of poly-sensitized allergic patients. Curr Opin Allergy Clin Immunol 2012, 12:434-439.
16. Pali-Scholl I, Jensen-Jarolim E: Anti-acid medication as a risk factor for food allergy. Allergy 2011, 66:469-477.
17. Mertens M, Brehler R: Suitability of different glycoproteins and test systems for detecting cross-reactive carbohydrate determinant-specific IgE in hymenoptera venom-allergic patients. Int Arch Allergy Immunol 2011, 156:43-50.
18. Ruiz-García M, García del Potro M, Fernández-Nieto M, Barber D, Jimeno-Nogales L, Sastre J: Profilin: A relevant aeroallergen? J Allergy Clin Immunol 2011, 128:416-418.
19. Ayuso R, Sanchez-Garcia S, Lin J, Fu Z, Ibanez MD, Carrillo T, Blanco C, Goldis M, Bardina L, Sastre J, Sampson HA: Greater epitope recognition of shrimp allergens by children than by adults suggests that shrimp sensitization decreases with age. J Allergy Clin Immunol 2010, 125:1286-1293. e1283.
20. Palacín A, Tordesillas L, Gamboa P, Sanchez-Monge R, Cuesta-Herranz J, Sanz ML, Barber D, Salcedo G, Díaz-Perales A: Characterization of peach thaumatin-like proteins and their identification as major peach allergens. Clin Exp Allergy 2010, 40:1422-1430.
21. Perez-Gordo M, Cuesta-Herranz J, Maroto AS, Cases B, Ibáñez MD, Vivanco F, Pastor-Vargas C: Identification of sole parvalbumin as a major allergen: study of cross-reactivity between parvalbumins in a Spanish fish-allergic population. Clin Exp Allergy 2011, 41:750-758.
22. Jin C, Hantusch B, Hemmer W, Stadlmann J, Altmann F: Affinity of IgE and IgG against cross-reactive carbohydrate determinants on plant and insect glycoproteins. J Allergy Clin Immunol 2008, 121:185-190. e182.
23. Mullins RJ, James H, Platts-Mills TA, Commins S: Relationship between red meat allergy and sensitization to gelatin and galactose-alpha-1,3-galactose. J Allergy Clin Immunol 2012, 129:1334-1342. e1331.
24. Ebo DG, Bridts CH, Verweij MM, De Knop KJ, Hagendorens MM, De Clerck LS, Stevens WJ: Sensitization profiles in birch pollen-allergic patients with and without oral allergy syndrome to apple: lessons from multiplexed component-resolved allergy diagnosis. Clin Exp Allergy 2010, 40:339-347.
25. Hauser M, Roulias A, Ferreira F, Egger M: Panallergens and their impact on the allergic patient. Allergy Asthma Clin Immunol 2010, 6:1.
26. Wang J, Lin J, Bardina L, Goldis M, Nowak-Wegrzyn A, Shreffler WG, Sampson HA: Correlation of IgE/IgG4 milk epitopes and affinity of milkspecific IgE antibodies with different phenotypes of clinical milk allergy. J Allergy Clin Immunol 2010, 125:695-702. 702 e691-702 e696.
27. Nicolaou N, Custovic A: Molecular diagnosis of peanut and legume allergy. Curr Opin Allergy Clin Immunol 2011, 11:222-228. 210.1097/ ACI. 1090b1013e32834656c32834652.
28. Zijlstra WT, Flinterman AE, Soeters L, Knulst AC, Sinnema G, L'Hoir MP, Pasmans SG: Parental anxiety before and after food challenges in children with suspected peanut and hazelnut allergy. Pediatr Allergy Immunol 2010, 21:e439-445.
29. Klemans RJB, Otte D, Knol M, Knol EF, Meijer Y, Gmelig-Meyling FHJ, Bruijnzeel-Koomen CAFM, Knulst AC, Pasmans SGMA: The diagnostic value of specific IgE to Ara h 2 to predict peanut allergy in children is comparable to a validated and updated diagnostic prediction model. J Allergy Clin Immunol 2013, 131:157-163.
30. Dang TD, Tang M, Choo S, Licciardi PV, Koplin JJ, Martin PE, Tan T, Gurrin LC, Ponsonby A-L, Tey D, et al: Increasing the accuracy of peanut allergy diagnosis by using Ara h 2. J Allergy Clin Immunol 2012, 129:1056-1063.
31. Lizaso MT, Garcia BE, Tabar AI, Lasa E, Echechipia S, Alvarez MJ, Anda M, Gomez B: Comparison of conventional and component-resolved diagnostics by two different methods (Advia-Centaur/Microarray-ISAC) in pollen allergy. Ann Allergy Asthma Immunol 2011, 107:35-41.
32. Constantin C, Quirce S, Poorafshar M, Touraev A, Niggemann B, Mari A, Ebner C, Akerstrom H, Heberle-Bors E, Nystrand M, Valenta R: Micro-arrayed wheat seed and grass pollen allergens for component-resolved diagnosis. Allergy 2009, 64:1030-1037.
33. Mattsson L, Lundgren T, Everberg H, Larsson H, Lidholm J: Prostatic kallikrein: a new major dog allergen. J Allergy Clin Immunol 2009, 123:362-368
34. Treudler R, Simon JC: Overview of component resolved diagnostics. Curr Allergy Asthma Rep 2013, 13:110-117.
35. Glaumann S, Nopp A, Johansson SG, Rudengren M, Borres MP, Nilsson C: Basophil allergen threshold sensitivity, CD-sens, IgE-sensitization and DBPCFC in peanut-sensitized children. Allergy 2012, 67:242-247.
36. Vereda A, van Hage M, Ahlstedt S, Ibañez MD, Cuesta-Herranz J, van Odijk J, Wickman M, Sampson HA: Peanut allergy: clinical and immunologic differences among patients from 3 different geographic regions. J Allergy Clin Immunol 2011, 127:603-607.
37. Asarnoj A, Nilsson C, Lidholm J, Glaumann S, Ostblom E, Hedlin G, van Hage M, Lilja G, Wickman M: Peanut component Ara h 8 sensitization and tolerance to peanut. J Allergy Clin Immunol 2012, 130:468-472.
38. Holzhauser T, Wackermann O, Ballmer-Weber BK, Bindslev-Jensen C, Scibilia J, Perono-Garoffo L, Utsumi S, Poulsen LK, Vieths S: Soybean (Glycine max) allergy in Europe: Gly m 5 (beta-conglycinin) and Gly m 6 (glycinin) are potential diagnostic markers for severe allergic reactions to soy. J Allergy Clin Immunol 2009, 123:452-458.
39. Kosma P, Sjolander S, Landgren E, Borres MP, Hedlin G: Severe reactions after the intake of soy drink in birch pollen-allergic children sensitized to Gly m 4. Acta Paediatr 2011, 100:305-306.
40. Flinterman AE, Akkerdaas JH, Knulst AC, van Ree R, Pasmans SG: Hazelnut allergy: from pollen-associated mild allergy to severe anaphylactic reactions. Current opinion in allergy and clinical immunology 2008, 8:261-265.
41. Verweij MM, Hagendorens MM, De Knop KJ, Bridts CH, De Clerck LS, StevensWJ, Ebo DG: Young infants with atopic dermatitis can display sensitization to Cor a 9, an 11S legumin-like seed-storage protein from hazelnut (Corylus avellana). Pediatr Allergy Immunol 2011, 22:196-201.
42. Masthoff LJ, Mattsson L, Zuidmeer-Jongejan L, Lidholm J, Andersson K, Akkerdaas JH, Versteeg SA, Garino C, Meijer Y, Kentie P, et al: Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults. J Allergy Clin Immunol 2013.
43. Roux KH, Teuber SS, Sathe SK: Tree nut allergens. Int Arch Allergy Immunol 2003, 131:234-244. (Pubitemid 36980756)
44. Palosuo K, Varjonen E, Kekki OM, Klemola T, Kalkkinen N, Alenius H, Reunala T: Wheat omega-5 gliadin is a major allergen in children with immediate allergy to ingested wheat. J Allergy Clin Immunol 2001, 108:634-638. (Pubitemid 32978038)
45. Ebisawa M, Shibata R, Sato S, Borres MP, Ito K: Clinical utility of IgE antibodies to omega-5 gliadin in the diagnosis of wheat allergy: a pediatric multicenter challenge study. Int Arch Allergy Immunol 2012, 158:71-76.
46. Matsuo H, Dahlstrom J, Tanaka A, Kohno K, Takahashi H, Furumura M, Morita E: Sensitivity and specificity of recombinant omega-5 gliadin-specific IgE measurement for the diagnosis of wheat-dependent exercise-induced anaphylaxis. Allergy 2008, 63:233-236.
47. Fernandez-Rivas M, Bolhaar S, Gonzalez-Mancebo E, Asero R, van Leeuwen A, Bohle B, Ma Y, Ebner C, Rigby N, Sancho AI, et al: Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. J Allergy Clin Immunol 2006, 118:481-488. (Pubitemid 44160722)
48. Egger M, Hauser M, Mari A, Ferreira F, Gadermaier G: The role of lipid transfer proteins in allergic diseases. Curr Allergy Asthma Rep 2010, 10:326-335.
49. Pascal M, Munoz-Cano R, Reina Z, Palacin A, Vilella R, Picado C, Juan M, Sanchez-Lopez J, Rueda M, Salcedo G, et al: Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant-foods and pollens. Clin Exp Allergy 2012, 42:1529-1539.
50. Romano A, Scala E, Rumi G, Gaeta F, Caruso C, Alonzi C, Maggioletti M, Ferrara R, Palazzo P, Palmieri V, et al: Lipid transfer proteins: the most frequent sensitizer in Italian subjects with food-dependent exercise-induced anaphylaxis. Clin Exp Allergy 2012, 42:1643-1653.
51. Caubet J-C, Kondo Y, Urisu A, Nowak-Wegrzyn A: Molecular diagnosis of egg allergy. Curr Opin Allergy Clin Immunol 2011, 11:210-215. 210.1097/ ACI.1090b1013e3283464d3283461b.
52. Caubet JC, Nowak-Wegrzyn A, Moshier E, Godbold J, Wang J, Sampson HA: Utility of casein-specific IgE levels in predicting reactivity to baked milk. J Allergy Clin Immunol 2013, 131:222-224. e224.
53. Bugajska-Schretter A, Elfman L, Fuchs T, Kapiotis S, Rumpold H, Valenta R, Spitzauer S: Parvalbumin, a cross-reactive fish allergen, contains IgEbinding epitopes sensitive to periodate treatment and Ca2+ depletion. J Allergy Clin Immunol 1998, 101:67-74.
54. Van Do T, Hordvik I, Endresen C, Elsayed S: Characterization of parvalbumin, the major allergen in Alaska pollack, and comparison with codfish Allergen M. Mol Immunol 2005, 42:345-353. (Pubitemid 39626767)
55. Torres Borrego J, Martinez Cuevas JF, Tejero Garcia J: Cross reactivity between fish and shellfish. Allergol Immunopathol (Madr) 2003, 31:146-151. (Pubitemid 36752925)
56. Seiki K, Oda H, Yoshioka H, Sakai S, Urisu A, Akiyama H, Ohno Y: A reliable and sensitive immunoassay for the determination of crustacean protein in processed foods. J Agric Food Chem 2007, 55:9345-9350. (Pubitemid 350205282)
57. Leung NY, Wai CY, Shu S, Wang J, Kenny TP, Chu KH, Leung PS: Current immunological and molecular biological perspectives on seafood allergy: a comprehensive review. Clin Rev Allergy Immunol 2012.
58. Commins SP, Satinover SM, Hosen J, Mozena J, Borish L, Lewis BD, Woodfolk JA, Platts-Mills TA: Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose. J Allergy Clin Immunol 2009, 123:426-433.
59. Hamsten C, Tran TA, Starkhammar M, Brauner A, Commins SP, Platts-Mills TA, van Hage M: Red meat allergy in Sweden: Association with tick sensitization and B-negative blood groups. J Allergy Clin Immunol. 2013, doi:10.1016/j.jaci. 2013.07.050. [Epub ahead of print].
60. Gronlund H, Adedoyin J, Commins SP, Platts-Mills TA, van Hage M: The carbohydrate galactose-alpha-1,3-galactose is a major IgE-binding epitope on cat IgA. J Allergy Clin Immunol 2009, 123:1189-1191.
61. Hamsten C, Starkhammar M, Tran TA, Johansson M, Bengtsson U, Ahlén G, Sällberg M, Grönlund H, van Hage M: Identification of galactose-α-1,3- galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy. Allergy 2013, 68:549-52.
62. Commins SP, James HR, Kelly LA, Pochan SL, Workman LJ, Perzanowski MS, Kocan KM, Fahy JV, Nganga LW, Ronmark E, et al: The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-alpha-1,3-galactose. J Allergy Clin Immunol 2011, 127:1286-1293. e1286.
63. Arkestål K, Sibanda E, Thors C, Troye-Blomberg M, Mduluza T, Valenta R, Grönlund H, van Hage M: Impaired allergy diagnostics among parasiteinfected patients caused by IgE antibodies to the carbohydrate epitope galactose-[alpha]1,3-galactose. J Allergy Clin Immunol 2011, 127:1024-1028.
64. Chung CH, Mirakhur B, Chan E, Le QT, Berlin J, Morse M, Murphy BA, Satinover SM, Hosen J, Mauro D, et al: Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose. N Engl J Med 2008, 358:1109-1117. (Pubitemid 351398485)
65. Vicente-Serrano J, Caballero ML, Rodriguez-Perez R, Carretero P, Perez R, Blanco JG, Juste S, Moneo I: Sensitization to serum albumins in children allergic to cow's milk and epithelia. Pediatr Allergy Immunol 2007, 18:503-507. (Pubitemid 47206742)
66. Gronlund H, Adedoyin J, Reininger R, Varga EM, Zach M, Fredriksson M, Kronqvist M, Szepfalusi Z, Spitzauer S, Gronneberg R, et al: Higher immunoglobulin E antibody levels to recombinant Fel d 1 in cat-allergic children with asthma compared with rhinoconjunctivitis. Clin Exp Allergy 2008, 38:1275-1281. (Pubitemid 352019659)
67. Nordlund B, Konradsen JR, Kull I, Borres MP, Onell A, Hedlin G, Gronlund H: IgE antibodies to animal-derived lipocalin, kallikrein and secretoglobin are markers of bronchial inflammation in severe childhood asthma. Allergy 2012, 67:661-669.
68. Barber D, de la Torre F, Feo F, Florido F, Guardia P, Moreno C, Quiralte J, Lombardero M, Villalba M, Salcedo G, Rodriguez R: Understanding patient sensitization profiles in complex pollen areas: a molecular epidemiological study. Allergy 2008, 63:1550-1558.
69. Bronnert M, Mancini J, Birnbaum J, Agabriel C, Liabeuf V, Porri F, Cleach I, Fabre A, Deneux I, Grandne V, et al: Component-resolved diagnosis with commercially available D. pteronyssinus Der p 1, Der p 2 and Der p 10: relevant markers for house dust mite allergy. Clin Exp Allergy 2012, 42:1406-1415.
70. Resch Y, Weghofer M, Seiberler S, Horak F, Scheiblhofer S, Linhart B, Swoboda I, Thomas WR, Thalhamer J, Valenta R, Vrtala S: Molecular characterization of Der p 10: a diagnostic marker for broad sensitization in house dust mite allergy. Clinical & Experimental Allergy 2011, 41:1468-1477.
71. Lopata AL, Lehrer SB: New insights into seafood allergy. Current opinion in allergy and clinical immunology 2009, 9:270-277.
72. Kurup VP, Banerjee B, Hemmann S, Greenberger PA, Blaser K, Crameri R: Selected recombinant Aspergillus fumigatus allergens bind specifically to IgE in ABPA. Clin Exp Allergy 2000, 30:988-993. (Pubitemid 30427040)
73. Casaulta C, Fluckiger S, Crameri R, Blaser K, Schoeni MH: Time course of antibody response to recombinant Aspergillus fumigatus antigens in cystic fibrosis with and without ABPA. Pediatr Allergy Immunol 2005, 16:217-225. (Pubitemid 40638048)
74. LeeMF, Song PP, Hwang GY, Lin SJ, Chen YH: Sensitization to Per a 2 of the American cockroach correlates with more clinical severity among airway allergic patients in Taiwan. Ann Allergy Asthma Immunol 2012, 108:243-248.
75. Ott H, Schroder C, Raulf-Heimsoth M, Mahler V, Ocklenburg C, Merk HF, Baron JM: Microarrays of recombinant Hevea brasiliensis proteins: a novel tool for the component-resolved diagnosis of natural rubber latex allergy. J Investig Allergol Clin Immunol 2010, 20:129-138.
76. Ebo DG, Hagendorens MM, De Knop KJ, Verweij MM, Bridts CH, De Clerck LS, Stevens WJ: Component-resolved diagnosis from latex allergy by microarray. Clin Exp Allergy 2010, 40:348-358.
77. Sanchez-Monge R, Blanco C, Lopez-Torrejon G, Cumplido J, Recas M, Figueroa J, Carrillo T, Salcedo G: Differential allergen sensitization patterns in chestnut allergy with or without associated latex-fruit syndrome. J Allergy Clin Immunol 2006, 118:705-710. (Pubitemid 44313971)
78. Bousquet J, Lockey R, Malling HJ, Alvarez-Cuesta E, Canonica GW, Chapman MD, Creticos PJ, Dayer JM, Durham SR, Demoly P, et al: Allergen immunotherapy: therapeutic vaccines for allergic diseases. Ann Allergy Asthma Immunol 1998, 81:401-405. (Pubitemid 28555527)
79. Canonica GW, Bousquet J, Casale T, Lockey RF, Baena-Cagnani CE, Pawankar R, Potter PC, Bousquet PJ, Cox LS, Durham SR, et al: Sub-lingual immunotherapy: world allergy organization position paper 2009. Allergy 2009, 64(Suppl 91):1-59.
80. Jutel M, Akdis CA: Immunological mechanisms of allergen-specific immunotherapy. Allergy 2011, 66:725-732.
81. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, Zuberbier T, Baena-Cagnani CE, Canonica GW, van Weel C, et al: Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the world health organization, GA(2)LEN and AllerGen). Allergy 2008, 63(Suppl 86):8-160. (Pubitemid 351357811)
82. Ciprandi G, Alesina R, Ariano R, Aurnia P, Borrelli P, Cadario G, Capristo A, Carosso A, Casino G, Castiglioni G, et al: Characteristics of patients with allergic polysensitization: the POLISMAIL study. Eur Ann Allergy Clin Immunol 2008, 40:77-83.
83. Marogna M, Massolo A, Berra D, Zanon P, Chiodini E, Canonica GW, Passalacqua G: The type of sensitizing allergen can affect the evolution of respiratory allergy. Allergy 2006, 61:1209-1215. (Pubitemid 44326358)
84. Cox L, Jacobsen L: Comparison of allergen immunotherapy practice patterns in the United States and Europe. Ann Allergy Asthma Immunol 2009, 103:451-459. quiz 459-461, 495.
85. Cox L, Nelson H, Lockey R, Calabria C, Chacko T, Finegold I, Nelson M, Weber R, Bernstein DI, Blessing-Moore J, et al: Allergen immunotherapy: a practice parameter third update. J Allergy Clin Immunol 2011, 127:S1-55.
86. Nelson HS: Specific immunotherapy with allergen mixes: what is the evidence? Curr Opin Allergy Clin Immunol 2009, 9:549-553
87. Weber RW: Cross-reactivity of pollen allergens: impact on allergen immunotherapy. Ann Allergy Asthma Immunol 2007, 99:203-211. quiz 212-203, 231.
88. Santos A, Van Ree R: Profilins: mimickers of allergy or relevant allergens? Int Arch Allergy Immunol 2011, 155:191-204.
89. Valenta R, Twaroch T, Swoboda I: Component-resolved diagnosis to optimize allergen-specific immunotherapy in the Mediterranean area. Journal of investigational allergology & clinical immunology 2007, 17(Suppl 1):36-40.
90. Focke M, Marth K, Flicker S, Valenta R: Heterogeneity of commercial timothy grass pollen extracts. Clin Exp Allergy 2008, 38:1400-1408. (Pubitemid 352019672)
91. Focke M, Marth K, Valenta R: Molecular composition and biological activity of commercial birch pollen allergen extracts. Eur J Clin Invest 2009, 39:429-436.
92. Schmid-Grendelmeier P: Recombinant allergens. For routine use or still only science? Hautarzt 2010, 61:946-953.
93. Jutel M, Jaeger L, Suck R, Meyer H, Fiebig H, Cromwell O: Allergen-specific immunotherapy with recombinant grass pollen allergens. Journal of Allergy & Clinical Immunology 2005, 116:608-613. (Pubitemid 41267135)
94. Pauli G, Larsen TH, Rak S, Horak F, Pastorello E, Valenta R, Purohit A, Arvidsson M, Kavina A, Schroeder JW, et al: Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis. J Allergy Clin Immunol 2008, 122:951-960.
95. Cromwell O, Häfner D, Nandy A: Recombinant allergens for specific immunotherapy. J Allergy Clin Immunol 2011, 127:865-872.
96. Hiller R, Laffer S, Harwanegg C, Huber M, Schmidt WM, Twardosz A, Barletta B, Becker WM, Blaser K, Breiteneder H, et al: Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment. FASEB J 2002, 16:414-416.
97. Melioli G, Bonifazi F, Bonini S, Maggi E, Mussap M, Passalacqua G, Rossi ER, Vacca A, Canonica GW: The ImmunoCAP ISAC molecular allergology approach in adult multi-sensitized Italian patients with respiratory symptoms. Clin Biochem 2011, 44:1005-1011.
98. Gadisseur R, Chapelle JP, Cavalier E: A new tool in the field of in-vitro diagnosis of allergy: preliminary results in the comparison of ImmunoCAP(c) 250 with the ImmunoCAP(c) ISAC. Clin Chem Lab Med 2011, 49:277-280.
99. Wohrl S, Vigl K, Zehetmayer S, Hiller R, Jarisch R, Prinz M, Stingl G, Kopp T: The performance of a component-based allergen-microarray in clinical practice. Allergy 2006, 61:633-639.
100. Jahn-Schmid B, Harwanegg C, Hiller R, Bohle B, Ebner C, Scheiner O, Mueller MW: Allergen microarray: comparison of microarray using recombinant allergens with conventional diagnostic methods to detect allergenspecific serum immunoglobulin E. Clin Exp Allergy 2003, 33:1443-1449. (Pubitemid 37289943)
101. Cabrera-Freitag P, Goikoetxea MJ, Beorlegui C, Gamboa P, Gastaminza G, Fernández-Benítez M, Ferrer M, Blanca M, Sanz ML: Can component-based microarray replace fluorescent enzimoimmunoassay in the diagnosis of grass and cypress pollen allergy? Clinical & Experimental Allergy 2011, 41:1440-1446.
102. Cabrera-Freitag P, Goikoetxea MJ, Gamboa PM, Martinez-Aranguren R, Beorlegui C, Fernandez J, Sanz ML: A study of the variability of the in vitro component-based microarray ISAC CDR 103 technique. J Investig Allergol Clin Immunol 2011, 21:414-415.
103. Twaroch T: Carrier-bound Alt a 1 peptides without allergenic activity for vaccination against Alternaria alternata allergy. Clin Exp All 2012, 42:966-975.
104. Balboni I, Limb C, Tenenbaum JD, Utz PJ: Evaluation of microarray surfaces and arraying parameters for autoantibody profiling. Proteomics 2008, 8:3443-3449.
105. Melioli G, Marcomini L, Agazzi A, Bazurro G, Tosca M, Rossi GA, Minale P, Rossi R, Reggiardo G, Canonica GW, Passalacqua G: The IgE repertoire in children and adolescents resolved at component level: A cross-sectional study. Pediatr Allergy Immunol 2012, 23:433-440.
106. Hatzler L, Panetta V, Lau S, Wagner P, Bergmann RL, Illi S, Bergmann KE, Keil T, Hofmaier S, Rohrbach A, et al: Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever. J Allergy Clin Immunol 2012, 130:894-901. e895.
107. Onell A, Hjalle L, Borres MP: Exploring the temporal development of childhood IgE profiles to allergen components. Clin Transl Allergy 2012, 2:24.
108. Gassner M, Gehrig R, Schmid-Grendelmeier P: Hay Fever as a Christmas Gift. N Engl J Med 2013, 368:393-394.
109. Walsh J, O'Flynn N: Diagnosis and assessment of food allergy in children and young people in primary care and community settings: NICE clinical guideline. CG116 Food allergy in children appendix 3 - health economics, appendix 3.1 - IgE-mediated food allergy - cost effectiveness analysis.