Pharmacokinetic changes of unbound theophylline are due to plasma protein binding displacement and CYP1A2 activity inhibition by baicalin in rats

Journal of Ethnopharmacology

Volumn 150, Issue 2, 2013, Pages 477-484

  Gao, Na ^a   Fang, Yan ^a   Qi, Bing ^a   Jia, Lin Jing ^a   Jin, Han ^a   Qiao, Hai Ling ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Baicalin; CYP1A2; Pharmacokinetics; Plasma protein binding; Theophylline

Indexed keywords

BAICALIN; CYTOCHROME P450 1A2; PHENACETIN; THEOPHYLLINE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG METABOLISM; ENZYME INHIBITION; ETHNOPHARMACOLOGY; MAXIMUM PLASMA CONCENTRATION; MICROSOME; NONHUMAN; PHARMACOKINETICS; PLASMA PROTEIN BINDING; RAT; ULTRAFILTRATION;

RATTUS; SCUTELLARIA RADIX;

BAICALIN; CYP1A2; PHARMACOKINETICS; PLASMA PROTEIN BINDING; THEOPHYLLINE;

ANIMALS; BLOOD PROTEINS; BRONCHODILATOR AGENTS; CYTOCHROMES; ENZYME INHIBITORS; FLAVONOIDS; MALE; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; THEOPHYLLINE;

EID: 84887480843     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.08.062     Document Type: Article

References (32)

1. T.D. Bjornsson, J.T. Callaghan, H.J. Einolf, V. Fischer, L. Gan, S. Grimm, J. Kao, S.P. King, G. Miwa, L. Ni, G. Kumar, J. McLeod, R.S. Obach, S. Roberts, A. Roe, A. Shah, F. Snikeris, J.T. Sullivan, D. Tweedie, J.M. Vega, J. Walsh, and S.A. Wrighton The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective Drug Metabolism and Disposition 31 2003 815 832
2. W.J. Busby, J.M. Ackermann, and C.L. Crespi Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450 Drug Metabolism and Disposition 27 1999 246 249
3. J.T. Buters, B.K. Tang, T. Pineau, H.V. Gelboin, S. Kimura, and F.J. Gonzalez Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2 Pharmacogenetics 6 1996 291 296
4. C.F. Chien, Y.T. Wu, W.C. Lee, L.C. Lin, and T.H. Tsai Herb-drug interaction of Andrographis paniculata extract and andrographolide on the pharmacokinetics of theophylline in rats Chemico-Biological Interactions. 184 2010 458 465
5. H. Christensen, M. Baker, G.T. Tucker, and A. Rostami-Hodjegan Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data Journal of Pharmaceutical Sciences 95 2006 2778 2787
6. J.F. Donohue Therapeutic responses in asthma and COPD. Bronchodilators Chest 126 2004 125S 137S discussion 159S-161S
7. L. Fan, J.C. Wang, F. Jiang, Z.R. Tan, Y. Chen, Q. Li, W. Zhang, G. Wang, H.P. Lei, D.L. Hu, D. Wang, and H.H. Zhou Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation European Journal of Clinical Pharmacology 65 2009 403 409
8. N. Gao, D. Zou, and H.L. Qiao Concentration-dependent inhibitory effect of Baicalin on the plasma protein binding and metabolism of chlorzoxazone, a CYP2E1 probe substrate, in rats in vitro and in vivo PLoS One 8 2013 e53038
9. V. Gayrard, N. Picard-Hagen, C. Viguie, and P.L. Toutain Competitive binding to plasma thyroid hormone transport proteins and thyroid disruption by phenylbutazone used as a probe General and Comparative Endocrinology 174 2011 225 231
10. J. Kojima, H. Katoh, T. Taniguchi, H. Kawai, H. Fukui, A. Ohnishi, and K. Onodera Usefulness and safety of theophylline injection form (Theodrip) for the treatment of acute asthma Methods and Findings in Experimental and Clinical Pharmacology. 22 2000 247 252
11. N. Kuga, N. Shikano, N. Takamura, R. Nishii, K. Yamasaki, M. Kobayashi, S. Nagamachi, S. Tamura, and K. Kawai Competitive displacement of serum protein binding of radiopharmaceuticals with amino acid infusion investigated with N-isopropyl-p-123I-iodoamphetamine Journal of Nuclear Medicine 50 2009 1378 1383
12. M.Y. Lai, S.L. Hsiu, S.Y. Tsai, Y.C. Hou, and P.D. Chao Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats Journal of Pharmacy and Pharmacology 55 2003 205 209
13. K.S. Lee, and S.K. Kim Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions Journal of Applied Toxicology 33 2013 100 108
14. A.M. Maza, A.R. Gascon, R.M. Hernandez, M.A. Solinis, M.B. Calvo, and J.L. Pedraz Influence of hepatic regeneration after partial hepatectomy on theophylline pharmacokinetics in rats European Journal of Drug Metabolism and Pharmacokinetics. 26 2001 53 58
15. H. Nosaka, M. Nadai, M. Kato, K. Yasui, H. Yoshizumi, M. Miyoshi, Y.L. Zhao, K. Baba, K. Takagi, and T. Hasegawa Effect of a newly developed ketolide antibiotic, telithromycin, on metabolism of theophylline and expression of cytochrome P450 in rats Life Sciences 79 2006 50 56
16. K. Ogawa, T. Mukai, K. Kawai, N. Takamura, H. Hanaoka, K. Hashimoto, K. Shiba, H. Mori, and H. Saji Usefulness of competitive inhibitors of protein binding for improving the pharmacokinetics of 186Re-MAG3-conjugated bisphosphonate (186Re-MAG3-HBP), an agent for treatment of painful bone metastases European Journal of Nuclear Medicine and Molecular Imaging 36 2009 115 121
17. S.C. Paterson, C.K. Lim, and K.D. Smith Analysis of the interaction between alpha-1-acid glycoprotein and tamoxifen and its metabolites Biomedical Chromatography 17 2003 143 148
18. F. Qiu, G. Wang, Y. Zhao, H. Sun, G.A.J. Mao, and J. Sun Effect of danshen extract on pharmacokinetics of theophylline in healthy volunteers British Journal of Clinical Pharmacology 65 2008 270 274
19. K. Rockich, and R. Blouin Effect of the acute-phase response on the pharmacokinetics of chlorzoxazone and cytochrome P-450 2E1 in vitro activity in rats Drug Metabolism and Disposition 27 1999 1074 1077
20. Y. Saito, Y. Nishimura, N. Kurata, M. Iwase, K. Aoki, and H. Yasuhara In vivo inhibition of CYP3A-mediated midazolam metabolism by anchusan in rats Journal of Pharmaceutical Sciences 115 2011 399 407
21. T. Shimada, H. Yamazaki, M. Mimura, Y. Inui, and F.P. Guengerich Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians Journal of Pharmacology and Experimental Therapeutics 270 1994 414 423
22. H.T. Soligard, D. Bratlid, C. Cao, A. Liang, and O.G. Nilsen Displacement of bilirubin from albumin in plasma from jaundiced newborns. An in vitro study of purified Chinese herbal constituents and sulfisoxazole Phytotherapy Research 25 2011 1068 1072
23. H.T. Soligard, O.G. Nilsen, and D. Bratlid Displacement of bilirubin from albumin by ibuprofen in vitro Pediatric Research 67 2010 614 618
24. G. Sudlow, D.J. Birkett, and D.N. Wade The characterization of two specific drug binding sites on human serum albumin Molecular Pharmacology 11 1975 824 832
25. G. Sudlow, D.J. Birkett, and D.N. Wade Further characterization of specific drug binding sites on human serum albumin Molecular Pharmacology 12 1976 1052 1061
26. Y. Tang, H. Zhu, Y. Zhang, and C. Huang Determination of human plasma protein binding of baicalin by ultrafiltration and high-performance liquid chromatography Biomedical Chromatography 20 2006 1116 1119
27. X. Tian, Z.Y. Cheng, J. Gao, and H.L. Qiao Inhibitory effects of baicalin on the expression and activity of CYP3A induce the pharmacokinetic changes of midazolam in rats Evidence Based Complementary and Alternative Medicine 2013 2013 179643
28. X. Tian, Z.Y. Cheng, J. He, L.J. Jia, and H.L. Qiao Concentration- dependent inhibitory effects of baicalin on the metabolism of dextromethorphan, a dual probe of CYP2D and CYP3A, in rats Chemico-Biological Interactions 203 2013 522 529
29. M.A. Tortorici, P.M. Kochanek, R.R. Bies, and S.M. Poloyac Therapeutic hypothermia-induced pharmacokinetic alterations on CYP2E1 chlorzoxazone-mediated metabolism in a cardiac arrest rat model Critical Care Medicine 34 2006 785 791
30. Y. Wang, J. Yang, X. Li, and J. Wang The metabolism of baicalin in rat and the biological activities of the metabolites Evidence Based Complementary and Alternative Medicine 2012 2012 404529
31. J.D. Wright, F.D. Boudinot, and M.R. Ujhelyi Measurement and analysis of unbound drug concentrations Clinical Pharmacokinetics 30 1996 445 462
32. M.F. Zeng, L.M. Pan, H.X. Zhu, Q.C. Zhang, and L.W. Guo Comparative pharmacokinetics of baicalin in plasma after oral administration of Huang-Lian-Jie-Du-Tang or pure baicalin in MCAO and sham-operated rats Fitoterapia 81 2010 490 496