Displacement of bilirubin from albumin by ibuprofen in vitro

Pediatric Research

Volumn 67, Issue 6, 2010, Pages 614-618

  Soligard, Hanne T ^a   Nilsen, Odd G ^a   Bratlid, Dag ^b,c  

^a Departments of Cancer Research and Molecular Medicine   (United Kingdom)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; BILIRUBIN; IBUPROFEN; SULFAFURAZOLE;

ARTICLE; BILIRUBIN BLOOD LEVEL; BLOOD SAMPLING; CONTROLLED STUDY; HUMAN; IN VITRO STUDY; INFANT; MOLECULAR MECHANICS; NEWBORN; NEWBORN JAUNDICE; PRIORITY JOURNAL;

BILIRUBIN; BINDING SITES; BINDING, COMPETITIVE; CYCLOOXYGENASE INHIBITORS; HUMANS; HYPERBILIRUBINEMIA, NEONATAL; IBUPROFEN; INFANT, NEWBORN; JAUNDICE, NEONATAL; SERUM ALBUMIN; SULFISOXAZOLE; TIME FACTORS;

EID: 77952553873     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e3181da7578     Document Type: Article

References (36)

1. Ebbesen F, Andersson C, Verder H, Grytter C, Pedersen-Bjergaard L, Petersen JR, Scharup J 2005 Extreme hyperbilirubinemia in term and near-term infants in Denmark. Acta Paediatr 94:59-64
2. Ahlfors CE, Wennberg RP 2004 Bilirubin-albumin binding and neonatal jaundice. Semin Perinatol 28:334-339
3. Wennberg RP, Ahlfors CE, Bhutani VK, Johnson LH, Shapiro SM 2006 Toward understanding kernicterus: a challenge to improve the management of jaundiced newborns. Pediatrics 117:474-485
4. Hsia DY, Allen FH, Gellis SS, Diamond LK 1952 Erythroblastosis fetalis. VIII. Studies of serum bilirubin in relation to kernicterus. N Engl J Med 247:668-671
5. Odell GB 1959 Studies in kernicterus. I. The protein binding of bilirubin. J Clin Invest 38:823-833
6. Oh W, Tyson JE, Fanaroff AA, Vohr BR, Perritt R, Stoll BJ, Ehrenkranz RA, Carlo WA, Shankaran S, Poole K, Wright LL 2003 Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infants. Pediatrics 112:773-779
7. Sampath V, Bowen J, Gibson F 2005 Risk factors for adverse neurodevelopment in extremely low birth weight infants with normal neonatal cranial ultrasound. J Perinatol 25:210-215
8. Jacobsen J 1969 Binding of bilirubin to human serum albumin\determination of binding constants. FEBS Lett 5:112-114
9. Odell GB 1970 The distribution and toxicity of bilirubin. Pediatrics 46:16-24
10. Siam M, Blaha G, Lehner H 1998 Maximum binding capacity of serum albumin for bilirubin is one, as revealed by circular dichroism. J Chem Soc Perkin Trans 2:853-856
11. Bratlid D 1990 How bilirubin gets into the brain. Clin Perinatol 17:449-465
12. Bratlid D 1972 The effect of free fatty acids, bile acids, and hematin on bilirubin binding by human erythrocytes. Scand J Clin Lab Invest 30:107-112
13. Bratlid D 1972 The effect of antimicrobial agents on bilirubin binding by human erythrocytes. Scand J Clin Lab Invest 30:331-337
14. Brodersen R 1974 Competitive binding of bilirubin and drugs to human serum albumin studied by enzymatic oxidation. J Clin Invest 54:1353-1364
15. Andersen DH, Blanc WA, Crozier DN, Silverman WA 1956 A difference in mortality rate and incidence of kernicterus among premature infants allotted to two prophylactic antibacterial regimens. Pediatrics 18:614-625
16. Johnson L, Sarmiento F, Blanc WA, Day R 1959 Kernicterus in rats with an inherited deficiency of glucuronyl transferase. AMA J Dis Child 97:591-608
17. Costeloe K, Hennessy E, Gibson AT, Marlow N, Wilkinson AR 2000 The EPICure study: outcome to discharge from hospital for infants born at the threshold of viability. Pediatrics 106:659-671
18. Ohlsson A, Walia R, Shah S 2008 Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants. Cochrane Database Syst Rev (1):CD003481
19. Rasmussen LF, Ahlfors CE, Wennberg RP 1978 Displacement of bilirubin from albumin by indomethacin. J Clin Pharmacol 18:477-481
20. Lam BC, Wong HN, Yeung CY 1990 Effects of indomethacin on binding of bilirubin to albumin. Arch Dis Child 65:690-691
21. Cooper-Peel C, Brodersen R, Robertson A 1996 Does ibuprofen affect bilirubin-albumin binding in newborn infant serum? Pharmacol Toxicol 79:297-299
22. Ahlfors CE 2004 Effect of ibuprofen on bilirubin-albumin binding. J Pediatr 144:386-388
23. Ambat MT, Ostrea EM, Aranda JV 2008 Effect of ibuprofen L-lysinate on bilirubin binding to albumin as measured by saturation index and horseradish peroxidase assay. J Perinatol 28:287-290
24. Jacobsen J, Wennberg RP 1974 Determination of unbound bilirubin in the serum of newborns. Clin Chem 20:783
25. Aranda JV, Varvarigou A, Beharry K, Bansal R, Bardin C, Modanlou H, Papageor-giou A, Chemtob S 1997 Pharmocokinetics and protein binding of intravenous ibuprofen in the premature newborn infant. Acta Paediatr 86:289-293
26. Hirt D, Van Overmeire B, Treluyer J-M, Langhendries J-P, Marguglio A, Eisinger MJ, Schepens P, Urien S 2008 An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic study. Br J Clin Pharmacol 65:629-636
27. Bhutani VK, Johnson L, Sivieri EM 1999 Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics 103:6-14
28. Rheinlaender C, Helfenstein D, Walch E, Berns M, Obladen M, Koehne P 2009 Total serum bilirubin levels during cyclooxygenase inhibitor treatment for patent ductus arteriosus in preterm infants. Acta Paediatr 98:36-42
29. Zecca E, Romagniol C, De Carolis MP, Costa S, Marra R, De Luca D 2009 Does ibuprofen increase neonatal hyperbilirubinemia? Pediatrics 124:480-484
30. Berg JM, Tymoczko JL, Stryer L 2002 Biochemistry. W.H. Freeman, New York, pp 209-213, 221-223
31. Bjerrum OJ 1968 Interaction of bromphenol blue and bilirubin with bovine and human serum albumin determined by gel filtration. Scand J Clin Lab Invest 22:41-48
32. Ahlfors CE 1981 Effect of serum dilution on apparent unbound bilirubin concentration as measured by the peroxidase method. Clin Chem 27:692-696
33. Ahlfors CE, Vreman HJ, Wong RJ, Bender GJ, Oh W, Morris BH, Stevenson DK 2007 Effects of sample dilution, peroxidase concentration, and chloride ion on the measurement of unbound bilirubin in premature newborns. Clin Biochem 40:261-267
34. Ghuman J, Zunszain PA, Petitpas I, Bhattacharya AA, Otagiri M, Curry S 2005 Structural basis of the drug binding specificity of human serum albumin. J Mol Biol 353:38-52 (Pubitemid 41338838)
35. Hankø E, Hansen TW, Almaas R, Lindstad J, Rootwelt T 2005 Bilirubin induces apoptosis and necrosis in human NT2-N neurons. Pediatr Res 57:179-184
36. Berns M, Toennessen M, Koehne P, Altmann R, Obladen M 2009 Ibuprofen augments bilirubin toxicity in rat cortical neuronal culture. Pediatr Res 65:392-396