Therapeutic hypothermia-induced pharmacokinetic alterations on CYP2E1 chlorzoxazone-mediated metabolism in a cardiac arrest rat model

Critical Care Medicine

Volumn 34, Issue 3, 2006, Pages 785-791

  Tortorici, Michael A ^a   Kochanek, Patrick M ^b,c   Bies, Robert R ^a   Poloyac, Samuel M ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Cardiac arrest; Chlorzoxazone; CYP2E1; Drug metabolism; Hypothermia; Pharmacokinetics

Indexed keywords

CHLORZOXAZONE; CYTOCHROME P450 2E1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPHYXIA; CONTROLLED STUDY; COOLING; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME KINETICS; ENZYME METABOLISM; ENZYME SUBSTRATE; HEART ARREST; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INCUBATION TIME; INDUCED HYPOTHERMIA; LIVER MICROSOME METABOLISM; MALE; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; SPECIES COMPARISON;

EID: 33644607442     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000201899.52739.4F     Document Type: Article

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