Design of benzothiazole-1,3,4-thiadiazole conjugates: Synthesis and anticonvulsant evaluation

Archiv der Pharmazie

Volumn 346, Issue 11, 2013, Pages 819-831

  Siddiqui, Nadeem ^a   Ahuja, Priya ^a   Malik, Sachin ^a   Arya, Satish K ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Anticonvulsants; Benzothiazole; Neurotoxicity; Phenytoin; Thiadiazole

Indexed keywords

1,3,4 THIADIAZOLE DERIVATIVE; 2 (1,3 BENZOTHIAZOL 2 YL AMINO) N [5 (4 HYDROXYPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 (1,3 BENZOTHIAZOL 2 YL AMINO) N [5 (4 METHOXYPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 (1,3 BENZOTHIAZOL 2 YL AMINO) N [5 (4 NITROPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 (1,3 BENZOTHIAZOL 2 YLAMINO) N (5 PHENYL 1,3,4 THIADIAZOL 2 YL)ACETAMIDE; 2 (6 BROMOBENZO[D]THIAZOL 2 YL AMINO) N [5 (4 BROMOPHENYL) 1,3,4 THIADIAZOL 2 YL)ACETAMIDE; 2 (6 BROMOBENZO[D]THIAZOL 2 YLAMINO) N [5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 [(6 BROMO 1,3 BENZOTHIAZOL 2 YL)AMINO] N (5 PHENYL 1,3,4 THIADIAZOL 2 YL)ACETAMIDE; 2 [(6 BROMO 1,3 BENZOTHIAZOL 2 YL)AMINO] N [5 (4 HYDROXYPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 [(6 BROMO 1,3 BENZOTHIAZOL 2 YL)AMINO] N [5 (4 METHOXYPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 [(6 BROMO 1,3 BENZOTHIAZOL 2 YL)AMINO] N [5 (4 NITROPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 [(6 CHLORO 1,3 BENZOTHIAZOL 2 YL)AMINO] N (5 PHENYL 1,3,4 THIADIAZOL 2 YL)ACETAMIDE; 2 [(6 CHLORO 1,3 BENZOTHIAZOL 2 YL)AMINO] N [5 (4 HYDROXYPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 [(6 CHLORO 1,3 BENZOTHIAZOL 2 YL)AMINO] N [5 (4 METHOXYPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 [(6 CHLORO 1,3 BENZOTHIAZOL 2 YL)AMINO] N [5 (4 NITROPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 [(6 FLUORO 1,3 BENZOTHIAZOL 2 YL)AMINO] N (5 PHENYL 1,3,4 THIADIAZOL 2 YL)ACETAMIDE; 2 [(6 FLUORO 1,3 BENZOTHIAZOL 2 YL)AMINO] N [5 (4 HYDROXYPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 [(6 FLUORO 1,3 BENZOTHIAZOL 2 YL)AMINO] N [5 (4 METHOXYPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 [(6 FLUORO 1,3 BENZOTHIAZOL 2 YL)AMINO] N [5 (4 NITROPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 [(6 METHYL 1,3 BENZOTHIAZOL 2 YL)AMINO] N (5 PHENYL 1,3,4 THIADIAZOL 2 YL)ACETAMIDE; 2 [(6 METHYL 1,3 BENZOTHIAZOL 2 YL)AMINO] N [5 (4 NITROPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; ANTICONVULSIVE AGENT; BENZOTHIAZOLE 1,3,4 THIADIAZOLE; CARBAMAZEPINE; N [5 (4 BROMOPHENYL) 1,3,4 THIADIAZOL 2 YL) 2 (6 CHLOROBENZO[D]THIAZOL 2 YL AMINO)ACETAMIDE; N [5 (4 HYDROXYPHENYL) 1,3,4 THIADIAZOL 2 YL] 2 [(6 METHYL 1,3 BENZOTHIAZOL 2 YL)AMINO]ACETAMIDE; N [5 (4 METHOXYPHENYL) 1,3,4 THIADIAZOL 2 YL] 2 [(6 METHYL 1,3 BENZOTHIAZOL 2 YL)AMINO]ACETAMIDE; PENTETRAZOLE; PHENYTOIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; 1,3,4-THIADIAZOLE; 4 AMINOBUTYRIC ACID; BENZOTHIAZOLE; BENZOTHIAZOLE DERIVATIVE; THIADIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ELECTRIC SHOCK; EPILEPSY; MOUSE; NEUROTOXICITY; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ANIMAL; BRAIN; CHEMICAL STRUCTURE; DISEASE MODEL; DRUG EFFECTS; LIVER; MALE; METABOLISM; SEIZURES; SYNTHESIS; WISTAR RAT;

ANIMALS; ANTICONVULSANTS; BENZOTHIAZOLES; BRAIN; DISEASE MODELS, ANIMAL; DRUG DESIGN; ELECTROSHOCK; GAMMA-AMINOBUTYRIC ACID; LIVER; MALE; MICE; MOLECULAR STRUCTURE; PENTYLENETETRAZOLE; RATS, WISTAR; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 84887444454     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201300083     Document Type: Article

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