Riluzole series. synthesis and in vivo 'antiglutamate' activity of 6- substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines

Journal of Medicinal Chemistry

Volumn 42, Issue 15, 1999, Pages 2828-2843

  Jimonet, Patrick ^a   Audiau, François ^a   Barreau, Michel ^a   Blanchard, Jean Charles ^a   Boireau, Alain ^a   Bour, Yvette ^a   Coléno, Marie Annick ^a   Doble, Adam ^a   Doerflinger, Gilles ^a   Do Huu, Claudine ^a   Donat, Marie Hélène ^a   Duchesne, Jean Marie ^a   Ganil, Pierre ^a   Guérémy, Claude ^a   Honoré, Eliane ^a   Just, Bernard ^a   Kerphirique, Roselyne ^a   Gontier, Sylvie ^a   Hubert, Philippe ^a   Laduron, Pierre M ^a   Blevec, Joseph Le ^a   Meunier, Mireille ^a   Miquet, Jean Marie ^a   Nemecek, Conception ^a   Pasquet, Martine ^a   Piot, Odile ^a   Pratt, Jeremy ^a   Rataud, Jean ^a   Reibaud, Michel ^a   Stutzmann, Jean Marie ^a   Mignani, Serge ^a   more..

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZOTHIAZOLAMINE DERIVATIVE; 2 IMINOBENZOTHIAZOLINE DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; BENZOTHIAZOLINE DERIVATIVE; GLUTAMIC ACID; RILUZOLE; SULFONE; SULFOXIDE; UNCLASSIFIED DRUG;

ANTICONVULSANT ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG DOSE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HYPOXIA; MOUSE; NEUROTRANSMISSION; NONHUMAN; RAT;

ANIMALS; ANOXIA; BENZOTHIAZOLES; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; IMINES; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RILUZOLE; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFOXIDES; THIAZOLES;

EID: 0033614947     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980202u     Document Type: Article

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