N,N′-Dicyclohexylsulfamide and N,N′-diphenethylsulfamide are anticonvulsant sulfamides with affinity for the benzodiazepine binding site of the GABA A receptor and anxiolytic activity in mice

Biochemical Pharmacology

Volumn 83, Issue 2, 2012, Pages 253-259

  Wasowski, Cristina ^a   Gavernet, Luciana ^b   Barrios, Ivana A ^b   Villalba, Maria L ^b   Pastore, Valentina ^b   Samaja, Gisela ^b   Enrique, Andrea ^b   Bruno Blanch, Luis E ^b   Marder, Mariel ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

Author keywords

Anticonvulsant; Anxiolytic; Benzodiazepine binding site; GABA A receptor; Sulfamides

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ANTICONVULSIVE AGENT; ANXIOLYTIC AGENT; BENZODIAZEPINE; DIAZEPAM; FLUMAZENIL; FLUNITRAZEPAM; N,N' DICYCLOHEXYLSULFAMIDE; N,N' DIPHENETHYLSULFAMIDE; SULFAMIDE DERIVATIVE; UNCLASSIFIED DRUG; BENZODIAZEPINE DERIVATIVE; SULFONAMIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG SYNTHESIS; EPILEPSY; LOCOMOTION; MALE; MAXIMAL ELECTROSHOCK SEIZURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE; TRANQUILIZING ACTIVITY; ANIMAL; ANXIETY; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; METABOLISM; MOTOR ACTIVITY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT;

ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; ANXIETY; BENZODIAZEPINES; BINDING SITES; FLUNITRAZEPAM; MALE; MICE; MOTOR ACTIVITY; RECEPTORS, GABA-A; SULFONAMIDES;

EID: 83955162265     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.10.015     Document Type: Article

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