메뉴 건너뛰기




Volumn 12, Issue 11, 2013, Pages 2436-2445

177Lu-EC0800 combined with the antifolate pemetrexed: Preclinical pilot study of folate receptor targeted radionuclide tumor therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; EC 0800; FOLATE RECEPTOR; PEMETREXED; RADIOPHARMACEUTICAL AGENT; SUCCIMER TC 99M; TETRAXETAN FOLATE CONJUGATE LUTETIUM 177; UNCLASSIFIED DRUG;

EID: 84887425141     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-13-0170     Document Type: Article
Times cited : (20)

References (50)
  • 1
    • 71749098171 scopus 로고    scopus 로고
    • Endoradiotherapy in cancer treatment-basic concepts and future trends
    • Zoller F, Eisenhut M, Haberkorn U, Mier W. Endoradiotherapy in cancer treatment-basic concepts and future trends. Eur J Pharmacol 2009;625:55-62.
    • (2009) Eur J Pharmacol , vol.625 , pp. 55-62
    • Zoller, F.1    Eisenhut, M.2    Haberkorn, U.3    Mier, W.4
  • 3
    • 84864504946 scopus 로고    scopus 로고
    • Radioimmunotherapy for B-cell non-Hodgkin lymphomas
    • Tomblyn M. Radioimmunotherapy for B-cell non-Hodgkin lymphomas. Cancer Contr 2012;19:196-203.
    • (2012) Cancer Contr , vol.19 , pp. 196-203
    • Tomblyn, M.1
  • 4
    • 14644392093 scopus 로고    scopus 로고
    • Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
    • Parker N, Turk MJ, Westrick E, Lewis JD, Low PS, Leamon CP. Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay. Anal Biochem 2005;338: 284-93.
    • (2005) Anal Biochem , vol.338 , pp. 284-293
    • Parker, N.1    Turk, M.J.2    Westrick, E.3    Lewis, J.D.4    Low, P.S.5    Leamon, C.P.6
  • 5
    • 67649849650 scopus 로고    scopus 로고
    • Folate-targeted therapeutic and imaging agents for cancer
    • Low PS, Kularatne SA. Folate-targeted therapeutic and imaging agents for cancer. Curr Opin Chem Biol 2009;13:256-62.
    • (2009) Curr Opin Chem Biol , vol.13 , pp. 256-262
    • Low, P.S.1    Kularatne, S.A.2
  • 6
    • 33947362046 scopus 로고    scopus 로고
    • The folate receptor: What does it promise in tissue-targeted therapeutics?
    • Salazar MD, Ratnam M. The folate receptor: what does it promise in tissue-targeted therapeutics? Cancer Metastasis Rev 2007;26:141-52.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 141-152
    • Salazar, M.D.1    Ratnam, M.2
  • 7
    • 79952746215 scopus 로고    scopus 로고
    • EC-145, a folate-targeted Vinca alkaloid conjugate for the potential treatment of folate receptor-expressing cancers
    • Dosio F, Milla P, Cattel L. EC-145, a folate-targeted Vinca alkaloid conjugate for the potential treatment of folate receptor-expressing cancers. Curr Opin Investig Drugs 2010;11:1424-33.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 1424-1433
    • Dosio, F.1    Milla, P.2    Cattel, L.3
  • 8
    • 84859727702 scopus 로고    scopus 로고
    • EC145: A novel targeted agent for adenocarcinoma of the lung
    • Pribble P, Edelman MJ. EC145: a novel targeted agent for adenocarcinoma of the lung. Expert Opin Investig Drugs 2012;21:755-61.
    • (2012) Expert Opin Investig Drugs , vol.21 , pp. 755-761
    • Pribble, P.1    Edelman, M.J.2
  • 9
    • 0026542407 scopus 로고
    • A high-affinity folate binding-protein in proximal tubule cells of human kidney
    • Holm J, Hansen SI, Hoiermadsen M, Bostad L. A high-affinity folate binding-protein in proximal tubule cells of human kidney. Kidney Int 1992;41:50-5.
    • (1992) Kidney Int , vol.41 , pp. 50-55
    • Holm, J.1    Hansen, S.I.2    Hoiermadsen, M.3    Bostad, L.4
  • 10
    • 3242726883 scopus 로고    scopus 로고
    • Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy
    • Sandoval RM, Kennedy MD, Low PS, Molitoris BA. Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy. Am J Physiol Cell Physiol 2004;287:C517-26.
    • (2004) Am J Physiol Cell Physiol , vol.287
    • Sandoval, R.M.1    Kennedy, M.D.2    Low, P.S.3    Molitoris, B.A.4
  • 11
    • 77950571314 scopus 로고    scopus 로고
    • Effects of the antifolates pemetrexed and CB3717 on the tissue distribution of 99mTc-EC20 in xenografted and syngeneic tumor-bearing mice
    • Müller C, Reddy JA, Leamon CP, Schibli R. Effects of the antifolates pemetrexed and CB3717 on the tissue distribution of 99mTc-EC20 in xenografted and syngeneic tumor-bearing mice. Mol Pharm 2010;7: 597-604.
    • (2010) Mol Pharm , vol.7 , pp. 597-604
    • Müller, C.1    Reddy, J.A.2    Leamon, C.P.3    Schibli, R.4
  • 12
    • 42049086345 scopus 로고    scopus 로고
    • Pemetrexed improves tumor selectivity of 111In-DTPA-folate in mice with folate receptorpositive ovarian cancer
    • Müller C, Schibli R, Krenning EP, de Jong M. Pemetrexed improves tumor selectivity of 111In-DTPA-folate in mice with folate receptorpositive ovarian cancer. J Nucl Med 2008;49:623-9.
    • (2008) J Nucl Med , vol.49 , pp. 623-629
    • Müller, C.1    Schibli, R.2    Krenning, E.P.3    De Jong, M.4
  • 13
    • 67349088706 scopus 로고    scopus 로고
    • Evaluation of a novel radiofolate in tumour-bearing mice: Promising prospects for folatebased radionuclide therapy
    • Müller C, Mindt TL, de Jong M, Schibli R. Evaluation of a novel radiofolate in tumour-bearing mice: promising prospects for folatebased radionuclide therapy. Eur J Nucl Med Mol Imaging 2009;36: 938-46.
    • (2009) Eur J Nucl Med Mol Imaging , vol.36 , pp. 938-946
    • Müller, C.1    Mindt, T.L.2    De Jong, M.3    Schibli, R.4
  • 14
    • 34547831118 scopus 로고    scopus 로고
    • Effects of antifolate drugs on the cellular uptake of radiofolates in vitro and in vivo
    • Müller C, Brühlmeier M, Schubiger AP, Schibli R. Effects of antifolate drugs on the cellular uptake of radiofolates in vitro and in vivo. J Nucl Med 2006;47:2057-64.
    • (2006) J Nucl Med , vol.47 , pp. 2057-2064
    • Müller, C.1    Brühlmeier, M.2    Schubiger, A.P.3    Schibli, R.4
  • 15
    • 34547830383 scopus 로고    scopus 로고
    • Dose-dependent effects of (anti)folate preinjection on 99mTc-radiofolate uptake in tumors and kidneys
    • Müller C, Schibli R, Forrer F, Krenning EP, de Jong M. Dose-dependent effects of (anti)folate preinjection on 99mTc-radiofolate uptake in tumors and kidneys. Nucl Med Biol 2007;34:603-8.
    • (2007) Nucl Med Biol , vol.34 , pp. 603-608
    • Müller, C.1    Schibli, R.2    Forrer, F.3    Krenning, E.P.4    De Jong, M.5
  • 16
    • 84874628244 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of an innocuous drug cocktail to improve the quality of folic acid targeted nuclear imaging in preclinical research
    • Müller C, Reber J, Schlup C, Leamon CP, Schibli R. In vitro and in vivo evaluation of an innocuous drug cocktail to improve the quality of folic acid targeted nuclear imaging in preclinical research. Mol Pharm 2013; 10:967-74.
    • (2013) Mol Pharm , vol.10 , pp. 967-974
    • Müller, C.1    Reber, J.2    Schlup, C.3    Leamon, C.P.4    Schibli, R.5
  • 17
    • 0041629528 scopus 로고    scopus 로고
    • Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
    • Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 2003;21:2636-44.
    • (2003) J Clin Oncol , vol.21 , pp. 2636-2644
    • Vogelzang, N.J.1    Rusthoven, J.J.2    Symanowski, J.3    Denham, C.4    Kaukel, E.5    Ruffie, P.6
  • 19
    • 27744438167 scopus 로고    scopus 로고
    • Pemetrexed: A multitargeted antifolate
    • Rollins KD, Lindley C. Pemetrexed: a multitargeted antifolate. Clin Ther 2005;27:1343-82.
    • (2005) Clin Ther , vol.27 , pp. 1343-1382
    • Rollins, K.D.1    Lindley, C.2
  • 20
    • 0034861227 scopus 로고    scopus 로고
    • Pemetrexed disodium: A novel antifolate clinically active against multiple solid tumors
    • Hanauske AR, Chen V, Paoletti P, Niyikiza C. Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors. Oncologist 2001;6:363-73.
    • (2001) Oncologist , vol.6 , pp. 363-373
    • Hanauske, A.R.1    Chen, V.2    Paoletti, P.3    Niyikiza, C.4
  • 22
    • 33745622428 scopus 로고    scopus 로고
    • Review of the pemetrexed and gemcitabine combination in patients with advanced-stage non-small cell lung cancer
    • Monnerat C, Le Chevalier T. Review of the pemetrexed and gemcitabine combination in patients with advanced-stage non-small cell lung cancer. Ann Oncol 2006;17 Suppl 5:v86-90.
    • (2006) Ann Oncol , vol.17 , Issue.5 SUPPL.
    • Monnerat, C.1    Le Chevalier, T.2
  • 23
    • 80051742422 scopus 로고    scopus 로고
    • Randomized phase II study of pemetrexed, carboplatin, and thoracic radiation with or without cetuximab in patients with locally advanced unresectable non-small-cell lung cancer: Cancer and Leukemia Group B trial 30407
    • Govindan R, Bogart J, Stinchcombe T, Wang X, Hodgson L, Kratzke R, et al. Randomized phase II study of pemetrexed, carboplatin, and thoracic radiation with or without cetuximab in patients with locally advanced unresectable non-small-cell lung cancer: cancer and Leukemia Group B trial 30407. J Clin Oncol 2011;29:3120-5.
    • (2011) J Clin Oncol , vol.29 , pp. 3120-3125
    • Govindan, R.1    Bogart, J.2    Stinchcombe, T.3    Wang, X.4    Hodgson, L.5    Kratzke, R.6
  • 24
    • 33846881605 scopus 로고    scopus 로고
    • A phase i study of pemetrexed, carboplatin, and concurrent radiotherapy in patients with locally advanced or metastatic non-small cell lung or esophageal cancer
    • Seiwert TY, Connell PP, Mauer AM, Hoffman PC, George CM, Szeto L, et al. A phase I study of pemetrexed, carboplatin, and concurrent radiotherapy in patients with locally advanced or metastatic non-small cell lung or esophageal cancer. Clin Cancer Res 2007;13:515-22.
    • (2007) Clin Cancer Res , vol.13 , pp. 515-522
    • Seiwert, T.Y.1    Connell, P.P.2    Mauer, A.M.3    Hoffman, P.C.4    George, C.M.5    Szeto, L.6
  • 25
  • 26
    • 20944448672 scopus 로고    scopus 로고
    • Trimodal cancer treatment: Beneficial effects of combined antiangiogenesis, radiation, and chemotherapy
    • Huber PE, Bischof M, Jenne J, Heiland S, Peschke P, Saffrich R, et al. Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy. Cancer Res 2005; 65:3643-55.
    • (2005) Cancer Res , vol.65 , pp. 3643-3655
    • Huber, P.E.1    Bischof, M.2    Jenne, J.3    Heiland, S.4    Peschke, P.5    Saffrich, R.6
  • 27
    • 80051630642 scopus 로고    scopus 로고
    • Interaction of radiation and pemetrexed on a human malignant mesothelioma cell line in vitro
    • Yoshida D, Ebara T, Sato Y, Kaminuma T, Takahashi T, Asao T, et al. Interaction of radiation and pemetrexed on a human malignant mesothelioma cell line in vitro. Anticancer Res 2011;31:2847-51.
    • (2011) Anticancer Res , vol.31 , pp. 2847-2851
    • Yoshida, D.1    Ebara, T.2    Sato, Y.3    Kaminuma, T.4    Takahashi, T.5    Asao, T.6
  • 28
    • 34748903527 scopus 로고    scopus 로고
    • Antimetabolite radiosensitizers
    • Shewach DS, Lawrence TS. Antimetabolite radiosensitizers. J Clin Oncol 2007;25:4043-50.
    • (2007) J Clin Oncol , vol.25 , pp. 4043-4050
    • Shewach, D.S.1    Lawrence, T.S.2
  • 29
    • 79959673834 scopus 로고    scopus 로고
    • Tumor targeting using 67Ga-DOTA-Bz-folate-investigations of methods to improve the tissue distribution of radiofolates
    • Müller C, Vlahov IR, Santhapuram HK, Leamon CP, Schibli R. Tumor targeting using 67Ga-DOTA-Bz-folate-investigations of methods to improve the tissue distribution of radiofolates. Nucl Med Biol 2011; 38:715-23.
    • (2011) Nucl Med Biol , vol.38 , pp. 715-723
    • Müller, C.1    Vlahov, I.R.2    Santhapuram, H.K.3    Leamon, C.P.4    Schibli, R.5
  • 30
    • 84872042051 scopus 로고    scopus 로고
    • DOTA conjugate with an albumin-binding entity enables the first folic acidtargeted 177Lu-radionuclide tumor therapy in mice
    • Müller C, Struthers H, Winiger C, Zhernosekov K, Schibli R. DOTA conjugate with an albumin-binding entity enables the first folic acidtargeted 177Lu-radionuclide tumor therapy in mice. J Nucl Med 2013;54:124-31.
    • (2013) J Nucl Med , vol.54 , pp. 124-131
    • Müller, C.1    Struthers, H.2    Winiger, C.3    Zhernosekov, K.4    Schibli, R.5
  • 31
    • 0026752798 scopus 로고
    • Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues
    • Weitman SD, Lark RH, Coney LR, Fort DW, Frasca V, Zurawski VR, et al. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res 1992;52:3396-401.
    • (1992) Cancer Res , vol.52 , pp. 3396-3401
    • Weitman, S.D.1    Lark, R.H.2    Coney, L.R.3    Fort, D.W.4    Frasca, V.5    Zurawski, V.R.6
  • 32
    • 33749251306 scopus 로고    scopus 로고
    • In Vitro and in Vivo Targeting of Different Folate Receptor-positive Cancer Cell Lines with A Novel 99mTc-radiofolate Tracer
    • Müller C, Schubiger PA, Schibli R. In vitro and in vivo targeting of different folate receptor-positive cancer cell lines with a novel 99mTc-radiofolate tracer. Eur J Nucl Med Mol Imaging 2006;33: 1162-70.
    • (2006) Eur J Nucl Med Mol Imaging , vol.33 , pp. 1162-1170
    • Müller, C.1    Schubiger, P.A.2    Schibli, R.3
  • 33
    • 30644479807 scopus 로고    scopus 로고
    • Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase
    • Hattori Y, Maitani Y. Folate-linked nanoparticle-mediated suicide gene therapy in human prostate cancer and nasopharyngeal cancer with herpes simplex virus thymidine kinase. Cancer Gene Ther 2005;12: 796-809.
    • (2005) Cancer Gene Ther , vol.12 , pp. 796-809
    • Hattori, Y.1    Maitani, Y.2
  • 35
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 36
    • 84860742706 scopus 로고    scopus 로고
    • Radioiodinated folic acid conjugates: Evaluation of a valuable concept to improve tumor-to-background contrast
    • Reber J, Struthers H, Betzel T, Hohn A, Schibli R, Müller C. Radioiodinated folic acid conjugates: evaluation of a valuable concept to improve tumor-to-background contrast. Mol Pharm 2012;9: 1213-21.
    • (2012) Mol Pharm , vol.9 , pp. 1213-1221
    • Reber, J.1    Struthers, H.2    Betzel, T.3    Hohn, A.4    Schibli, R.5    Müller, C.6
  • 37
    • 33748794547 scopus 로고    scopus 로고
    • Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies
    • Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 2006;58:621-81.
    • (2006) Pharmacol Rev , vol.58 , pp. 621-681
    • Chou, T.C.1
  • 38
    • 0030163022 scopus 로고    scopus 로고
    • Tumorselective radiopharmaceutical targeting via receptor-mediated endocytosis of gallium-67-deferoxamine-folate
    • Mathias CJ, Wang S, Lee RJ, Waters DJ, Low PS, Green MA. Tumorselective radiopharmaceutical targeting via receptor-mediated endocytosis of gallium-67-deferoxamine-folate. J Nucl Med 1996;37: 1003-8.
    • (1996) J Nucl Med , vol.37 , pp. 1003-1008
    • Mathias, C.J.1    Wang, S.2    Lee, R.J.3    Waters, D.J.4    Low, P.S.5    Green, M.A.6
  • 39
    • 33749243966 scopus 로고    scopus 로고
    • In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals
    • Forrer F, ValkemaR, Bernard B, Schramm NU, Hoppin JW, RollemanE, et al. In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals. Eur J Nucl Med Mol Imaging 2006;33:1214-7.
    • (2006) Eur J Nucl Med Mol Imaging , vol.33 , pp. 1214-1217
    • Forrer, F.1    Valkema, R.2    Bernard, B.3    Schramm, N.U.4    Hoppin, J.W.5    Rolleman, E.6
  • 40
    • 34447131647 scopus 로고    scopus 로고
    • Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145
    • Leamon CP, Reddy JA, Vlahov IR, Westrick E, Parker N, Nicoson JS, et al. Comparative preclinical activity of the folate-targeted Vinca alkaloid conjugates EC140 and EC145. Int J Cancer 2007;121: 1585-92.
    • (2007) Int J Cancer , vol.121 , pp. 1585-1592
    • Leamon, C.P.1    Reddy, J.A.2    Vlahov, I.R.3    Westrick, E.4    Parker, N.5    Nicoson, J.S.6
  • 41
    • 0037206936 scopus 로고    scopus 로고
    • Strong inhibition of Ewing tumor xenograft growth by combination of human interferon - A or interferon-b with ifosfamide
    • Sanceau J, Poupon MF, Delattre O, Sastre-Garau X, Wietzerbin J. Strong inhibition of Ewing tumor xenograft growth by combination of human interferon-a or interferon-b with ifosfamide. Oncogene 2002; 21:7700-9.
    • (2002) Oncogene , vol.21 , pp. 7700-7709
    • Sanceau, J.1    Poupon, M.F.2    Delattre, O.3    Sastre-Garau, X.4    Wietzerbin, J.5
  • 42
    • 58449103581 scopus 로고    scopus 로고
    • Cell line cross-contamination: KB is not an oral squamous cell carcinoma cell line
    • Jiang L, Zeng X, Wang Z, Chen Q. Cell line cross-contamination: KB is not an oral squamous cell carcinoma cell line. Eur J Oral Sci 2009;117:90-1.
    • (2009) Eur J Oral Sci , vol.117 , pp. 90-91
    • Jiang, L.1    Zeng, X.2    Wang, Z.3    Chen, Q.4
  • 43
    • 84872037153 scopus 로고    scopus 로고
    • Renal uptake of 99mTc-dimercaptosuccinic acid is dependent on normal proximal tubule receptor-mediated endocytosis
    • Weyer K, Nielsen R, Petersen SV, Christensen EI, Rehling M, Birn H. Renal uptake of 99mTc-dimercaptosuccinic acid is dependent on normal proximal tubule receptor-mediated endocytosis. J Nucl Med 2013;54:159-65.
    • (2013) J Nucl Med , vol.54 , pp. 159-165
    • Weyer, K.1    Nielsen, R.2    Petersen, S.V.3    Christensen, E.I.4    Rehling, M.5    Birn, H.6
  • 44
    • 0033179374 scopus 로고    scopus 로고
    • Cell cycle modulation by a multitargeted antifolate, LY231514, increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma
    • Tonkinson JL, Worzalla JF, Teng CH, Mendelsohn LG. Cell cycle modulation by a multitargeted antifolate, LY231514, increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma. Cancer Res 1999;59:3671-6.
    • (1999) Cancer Res , vol.59 , pp. 3671-3676
    • Tonkinson, J.L.1    Worzalla, J.F.2    Teng, C.H.3    Mendelsohn, L.G.4
  • 45
    • 0028307190 scopus 로고
    • The molecular basis for cell cycle delays following ionizing radiation: A review
    • Maity A, McKenna WG, Muschel RJ. The molecular basis for cell cycle delays following ionizing radiation: a review. Radiother Oncol 1994; 31:1-13.
    • (1994) Radiother Oncol , vol.31 , pp. 1-13
    • Maity, A.1    McKenna, W.G.2    Muschel, R.J.3
  • 46
    • 16044371194 scopus 로고    scopus 로고
    • Selective radiosensitization of p53-deficient cells by caffeine-mediatedactivation f p34cdc2 kinase
    • Yao SL, Akhtar AJ, McKenna KA, Bedi GC, Sidransky D, Mabry M, et al. Selective radiosensitization of p53-deficient cells by caffeine-mediatedactivation f p34cdc2 kinase. Nat Med 1996;2:1140-3.
    • (1996) Nat Med , vol.2 , pp. 1140-1143
    • Yao, S.L.1    Akhtar, A.J.2    McKenna, K.A.3    Bedi, G.C.4    Sidransky, D.5    Mabry, M.6
  • 47
    • 0034655281 scopus 로고    scopus 로고
    • The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1
    • Busby EC, Leistritz DF, Abraham RT, Karnitz LM, Sarkaria JN. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res 2000;60: 2108-12.
    • (2000) Cancer Res , vol.60 , pp. 2108-2112
    • Busby, E.C.1    Leistritz, D.F.2    Abraham, R.T.3    Karnitz, L.M.4    Sarkaria, J.N.5
  • 48
    • 0035890610 scopus 로고    scopus 로고
    • Radiosensitization of p53 mutant cells by PD0166285, a novel G2 checkpoint abrogator
    • Wang Y, Li J, Booher RN, Kraker A, Lawrence T, Leopold WR, et al. Radiosensitization of p53 mutant cells by PD0166285, a novel G2 checkpoint abrogator. Cancer Res 2001;61:8211-7.
    • (2001) Cancer Res , vol.61 , pp. 8211-8217
    • Wang, Y.1    Li, J.2    Booher, R.N.3    Kraker, A.4    Lawrence, T.5    Leopold, W.R.6
  • 49
    • 0029118446 scopus 로고
    • Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: Correlates of molecular- structure and biological activity
    • Westerhof GR, Schornagel JH, Kathmann I, Jackman AL, Rosowsky A, Forsch RA, et al. Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular- structure and biological activity. Mol Pharmacol 1995;48:459-71.
    • (1995) Mol Pharmacol , vol.48 , pp. 459-471
    • Westerhof, G.R.1    Schornagel, J.H.2    Kathmann, I.3    Jackman, A.L.4    Rosowsky, A.5    Forsch, R.A.6
  • 50
    • 50549085728 scopus 로고    scopus 로고
    • The protoncoupled folate transporter: Impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier
    • Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH, Goldman ID. The protoncoupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol Pharmacol 2008;74:854-62.
    • (2008) Mol Pharmacol , vol.74 , pp. 854-862
    • Zhao, R.1    Qiu, A.2    Tsai, E.3    Jansen, M.4    Akabas, M.H.5    Goldman, I.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.