Interaction of radiation and pemetrexed on a human malignant mesothelioma cell line in vitro

Anticancer Research

Volumn 31, Issue 9, 2011, Pages 2847-2851

  Yoshida, Daisaku ^a   Ebara, Takeshi ^a   Sato, Yumi ^a   Kaminuma, Takuya ^a   Takahashi, Takeo ^a   Asao, Takayuki ^a   Nakano, Takashi ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Human mesothelioma cell line; Pemetrexed; Radiation; Radiosensitivity

Indexed keywords

PEMETREXED; THYMIDYLATE SYNTHASE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SENSITIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALIGNANT MESOTHELIOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION RESPONSE; RADIOSENSITIVITY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; COMBINED MODALITY THERAPY; GLUTAMATES; GUANINE; HUMANS; MESOTHELIOMA; RADIATION TOLERANCE; RADIOTHERAPY;

EID: 80051630642     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Buduhan G, Menon S, Aye R, Louie B, Mehta V and Vallières E: Trimodality therapy for malignant pleural mesothelioma. Ann Thorac Surg 88: 870-875, 2009.
2. Van Schil PE, Baas P, Gaafar R, Maat AP, Van de Pol M, Hasan B, Klomp HM, Abdelrahman AM, Welch J and Van Meerbeeck J: Trimodality therapy for malignant pleural mesothelioma: results from an EROTC phase II multicenter trial. Eur Respir J 36: 1362-1369, 2010.
3. Krug LM, Pass HI, Rusch VW, Kindler HL, Sugarbaker DJ, Rosenzweig KE, Flores R, Friedberg JS, Pisters K, Monberg M, Obasaju CK and Vogelzang NJ: Multicenter phase II trial of neoadjuvant pemetrexed plus cisplatin followed by extrapleural pneumonectomy and radiation for malignant pleural mesothelioma. J Clin Oncol 27: 3007-3013, 2009.
4. Adjei AA: Pemetrexed: a multitargeted antifolate agent with promising activity in solid tumors. Ann Oncol 11: 1335-1341, 2000.
5. Shih C, Chen VJ, Gossett LS, Gates SB, MacKellar WC, Habeck LL, Shackelford KA, Mendelsohn LG, Soose DJ, Patel VF, Andis SL, Bewley JR, Rayl EA, Moroson BA, Beardsley GP, Kohler W, Ratnam M and Schultz RM: LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res 57: 1116-1123, 1997. (Pubitemid 27138611)
6. Righi L, Papotti MG, Ceppi P, Billè A, Bacillo E, Molinaro L, Ruffini E, Scagliotti GV and Selvaggi G: Thymidylate synthase but not excision repair cross-complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy. J Clin Oncol 28: 1534-1539, 2010.
7. Jagadeeswaran R, Ma PC, Seiwert TY, Jagadeeswaran S, Zumba O, Nallasura V, Ahmed S, Filiberti R, Paganuzzi M, Puntoni R, Kratzke RA, Gordon GJ, Sugarbaker DJ, Bueno R, Janamanchi V, Bindokas VP, Kindler HL and Salgia R: Functional analysis of c-Met/hepatocyte growth factor pathway in malignant pleural mesothelioma. Cancer Res 66: 352-361, 2006. (Pubitemid 43166042)
8. Kaminuma T, Suzuki Y, Shirai K, Mizui T, Noda S, Yoshida Y, Funayama T, Takahashi T, Kobayashi Y, Shirao T and Nakano T: Effectiveness of carbon-ion beams for apoptosis induction in rat primary immature hippocampal neurons. J Radiat Res 51: 627-631, 2010.
9. Häkkinen AM, Laasonen A, Linnainmaa K, Mattson K and Pyrhönen S: Radiosensitivity of mesothelioma cell lines. Acta Oncol 35: 451-456, 1996.
10. Stephens LC, Ang KK, Schultheiss TE, Milas L and Meyn RE: Apoptosis in irradiated murine tumors. Radiat Res 127: 308-316, 1991.
11. Welsh SJ, Titley J, Brunton L, Valenti M, Monaghan P, Jackman AL and Aherne GW: Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues. Clin Cancer Res 6: 2538-2546, 2000. (Pubitemid 30399226)
12. Tesei A, Ricotti L, De Paola F, Amadori D, Frassineti GL and Zoli W: In vitro schedule-dependent interactions between the multitargeted antifolate LY231514 and gemcitabine in human colon adenocarcinoma cell lines. Clin Cancer Res 8: 233-239, 2002.
13. 1 restriction point into S-phase: implications for fluoropyrimidine radiosensitization. Cancer Res 60: 92-100, 2000. (Pubitemid 30058737)
14. Britten CD, Izbicka E, Hilsenbeck S, Lawrence R, Davidson K, Cerna C, Gomez L, Rowinsky EK, Weitman S and Von Hoff DD: Activity of the multitargeted antifolate LY231514 in the human tumor cloning assay. Cancer Chemother Pharmacol 44: 105-110, 1999. (Pubitemid 29297055)