Tumor targeting using 67Ga-DOTA-Bz-folate - investigations of methods to improve the tissue distribution of radiofolates

Nuclear Medicine and Biology

Volumn 38, Issue 5, 2011, Pages 715-723

  Müller, Cristina ^a   Vlahov, Iontcho R ^b   Santhapuram, Hari Krishna R ^b   Leamon, Christopher P ^b   Schibli, Roger ^a,c  

^a ETH Zurich   (Switzerland)

^b Endocyte Inc   (United States)

^c ETH ZURICH   (Switzerland)

Author keywords

67 68Ga; DOTA Bz folate; Folate receptor; Kidney; PET; SPECT

Indexed keywords

ACETAZOLAMIDE; AMINO ACID; DIURETIC AGENT; FOLIC ACID ANTAGONIST; FUROSEMIDE; GALLIUM 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID BENZYL ETHYLENEDIAMINE GAMMA FOLATE GA 67; HYDROCHLOROTHIAZIDE; MANNITOL; PEMETREXED; RADIOPHARMACEUTICAL AGENT; SORBITOL; UNCLASSIFIED DRUG; 2 (4 ISOTHIOCYANATOBENZYL) 1,4,7,10 TETRAAZACYCLODODECANE TETRAACETIC ACID; 2-(4-ISOTHIOCYANATOBENZYL)-1,4,7,10-TETRAAZACYCLODODECANE TETRAACETIC ACID; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FOLIC ACID; GALLIUM; GLUTAMIC ACID DERIVATIVE; GUANINE; HETEROCYCLIC COMPOUND; ISOTHIOCYANIC ACID DERIVATIVE; TRACER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EFFECT; DRUG HALF LIFE; DRUG SYNTHESIS; DRUG TARGETING; DRUG UPTAKE; DRUG USE; FEMALE; HUMAN; HUMAN CELL; IMAGE QUALITY; IN VITRO STUDY; ISOTOPE LABELING; MOLECULAR IMAGING; NONHUMAN; RADIOACTIVITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR XENOGRAFT; URINE PH; ANIMAL; CELL STRAIN KB; CHEMISTRY; HALF LIFE TIME; INJECTION; KIDNEY; METABOLISM; MOUSE; PH; RADIOGRAPHY; SCINTISCANNING; TRANSPORT AT THE CELLULAR LEVEL; URINE; UTERINE CERVIX TUMOR;

ANIMALS; BIOLOGICAL TRANSPORT; FEMALE; FOLIC ACID; FOLIC ACID ANTAGONISTS; GALLIUM RADIOISOTOPES; GLUTAMATES; GUANINE; HALF-LIFE; HETEROCYCLIC COMPOUNDS; HUMANS; HYDROGEN-ION CONCENTRATION; INJECTIONS; ISOTHIOCYANATES; KB CELLS; KIDNEY; MICE; RADIOACTIVE TRACERS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TOMOGRAPHY, X-RAY COMPUTED; URINE; UTERINE CERVICAL NEOPLASMS;

EID: 79959673834     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2010.12.013     Document Type: Article

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