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Volumn 19, Issue 3, 2013, Pages 231-237

Process optimization for the production of bio-functional whey protein hydrolysates: Adopting response surface methodology

Author keywords

Antihypertensive activity; Antioxidant activity; Response surface method; Trypsin; Whey protein

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; MILK PROTEIN; PROTEIN HYDROLYSATE; UNCLASSIFIED DRUG; WHEY PROTEIN HYDROLYSATE;

EID: 84887420539     PISSN: 15733149     EISSN: 15733904     Source Type: Journal    
DOI: 10.1007/s10989-012-9340-x     Document Type: Article
Times cited : (32)

References (34)
  • 1
    • 0002494352 scopus 로고
    • A review of food protein hydrolysis-specific areas
    • Elsevier, New York
    • Adler-Nissen J (1986) A review of food protein hydrolysis-specific areas. In: Enzymic hydrolysis of food proteins. Elsevier, New York, pp 57-131
    • (1986) Enzymic Hydrolysis of Food Proteins , pp. 57-131
    • Adler-Nissen, J.1
  • 2
    • 2642581897 scopus 로고    scopus 로고
    • Peptides from milk protein hydrolysates to improve the growth of human keratinocytes in culture
    • 10.1016/j.idairyj.2003.11.007 1:CAS:528:DC%2BD2cXksVemu78%3D
    • Amiot J, Germain L, Turgeon S, Lemay M, Ory-Salam C, FrancÂ̧ ois FA, Auger A (2004) Peptides from milk protein hydrolysates to improve the growth of human keratinocytes in culture. Int Dairy J 14:619-626
    • (2004) Int Dairy J , vol.14 , pp. 619-626
    • Amiot, J.1    Germain, L.2    Turgeon, S.3    Lemay, M.4    Ory-Salam, C.5    Francâ̧ ois, F.A.6    Auger, A.7
  • 3
    • 33745955529 scopus 로고    scopus 로고
    • Health enhancing potential of whey proteins: A review
    • 1:CAS:528:DC%2BD3sXlvFWlur8%3D
    • Bajaj RK, Sangwan RB (2002) Health enhancing potential of whey proteins: a review. Indian J Dairy Sci 55(5):253-260
    • (2002) Indian J Dairy Sci , vol.55 , Issue.5 , pp. 253-260
    • Bajaj, R.K.1    Sangwan, R.B.2
  • 4
    • 78651237439 scopus 로고    scopus 로고
    • Milk and dairy products as functional foods: A review
    • 10.3923/ijds.2011.1.12
    • Bhat ZF, Bhat H (2011) Milk and dairy products as functional foods: a review. Int J Dairy Sci 6(1):1-12
    • (2011) Int J Dairy Sci , vol.6 , Issue.1 , pp. 1-12
    • Bhat, Z.F.1    Bhat, H.2
  • 5
    • 0034199281 scopus 로고    scopus 로고
    • Bioactive milk peptides, a prospectus
    • 10877382 10.3168/jds.S0022-0302(00)74983-6 1:CAS:528:DC%2BD3cXkt1amsrs%3D
    • Clare DA, Swaisgood HE (2000) Bioactive milk peptides, a prospectus. J Dairy Sci 83:1187-1195
    • (2000) J Dairy Sci , vol.83 , pp. 1187-1195
    • Clare, D.A.1    Swaisgood, H.E.2
  • 6
    • 77956875053 scopus 로고    scopus 로고
    • Production of antioxidant hydrolyzates from a whey protein concentrate with thermolysin: Optimization by response surface methodology
    • 10.1016/j.lwt.2010.06.017 1:CAS:528:DC%2BC3cXht1SrurjK
    • Contreras MM, Hernandez-Ledesma B, Amigo L, Martin-Alvarez Pedro J, Recio I (2011) Production of antioxidant hydrolyzates from a whey protein concentrate with thermolysin: optimization by response surface methodology. LWT Food Sci Technol 44:9-15
    • (2011) LWT Food Sci Technol , vol.44 , pp. 9-15
    • Contreras, M.M.1    Hernandez-Ledesma, B.2    Amigo, L.3    Martin-Alvarez, P.J.4    Recio, I.5
  • 7
    • 0015083353 scopus 로고
    • Spectrophotometric assay and properties of angiotensin converting enzyme of rabbit lung
    • 4355305 10.1016/0006-2952(71)90292-9 1:CAS:528:DyaE3MXltVGgs78%3D
    • Cushman DW, Cheung HS (1971) Spectrophotometric assay and properties of angiotensin converting enzyme of rabbit lung. Biochem Pharmacol 20(7):1637-1648
    • (1971) Biochem Pharmacol , vol.20 , Issue.7 , pp. 1637-1648
    • Cushman, D.W.1    Cheung, H.S.2
  • 9
    • 40749088092 scopus 로고    scopus 로고
    • Emerging health properties of whey proteins and their clinical implications
    • 10.1080/07315724.2007.10719652
    • Geoffrey WK (2007) Emerging health properties of whey proteins and their clinical implications. J Am Coll Nutr 26(6):713-723
    • (2007) J Am Coll Nutr , vol.26 , Issue.6 , pp. 713-723
    • Geoffrey, W.K.1
  • 10
    • 18344401716 scopus 로고    scopus 로고
    • Assessment of the spectrophotometric method for determination of angiotensin-converting-enzyme activity: Influence of the inhibition type
    • 12848480 10.1021/jf034148o 1:CAS:528:DC%2BD3sXkslGqs74%3D
    • Hernandez-Ledesma B, Martin-Alvarez PJ, Pueyo E (2003) Assessment of the spectrophotometric method for determination of angiotensin-converting-enzyme activity: influence of the inhibition type. J Agric Food Chem 51:4175-4179
    • (2003) J Agric Food Chem , vol.51 , pp. 4175-4179
    • Hernandez-Ledesma, B.1    Martin-Alvarez, P.J.2    Pueyo, E.3
  • 11
    • 17444431559 scopus 로고    scopus 로고
    • Identification of antioxidant and ACE-inhibitorypeptides in fermented milk
    • 10.1002/jsfa.2063 1:CAS:528:DC%2BD2MXjsFWgurg%3D
    • Hernandez-Ledesma B, Beatriz M, Lourdes A, Mercedes R, Isidra R (2005) Identification of antioxidant and ACE-inhibitorypeptides in fermented milk. J Sci Food Agric 85:1041-1048
    • (2005) J Sci Food Agric , vol.85 , pp. 1041-1048
    • Hernandez-Ledesma, B.1    Beatriz, M.2    Lourdes, A.3    Mercedes, R.4    Isidra, R.5
  • 12
    • 0037433480 scopus 로고    scopus 로고
    • Antioxidant peptides with angiotensin converting enzyme inhibitory activities and applications for angiotensin converting enzyme purification
    • 12617609 10.1021/jf0260242 1:CAS:528:DC%2BD3sXhtVOjurg%3D
    • Hou WC, Chen HJ, Lin YH (2003) Antioxidant peptides with angiotensin converting enzyme inhibitory activities and applications for angiotensin converting enzyme purification. J Agric Food Chem 51:1706-1709
    • (2003) J Agric Food Chem , vol.51 , pp. 1706-1709
    • Hou, W.C.1    Chen, H.J.2    Lin, Y.H.3
  • 13
    • 64549156088 scopus 로고    scopus 로고
    • Milk-derived bioactive peptides: From science to applications
    • 10.1016/j.jff.2009.01.007 1:CAS:528:DC%2BC3cXhsFKntbbO
    • Korhonen H (2009) Milk-derived bioactive peptides: from science to applications. J Funct Foods 1:177-187
    • (2009) J Funct Foods , vol.1 , pp. 177-187
    • Korhonen, H.1
  • 14
    • 0038397146 scopus 로고    scopus 로고
    • Food-derived bioactive peptides-opportunities for designing future foods
    • 12769738 10.2174/1381612033454892 1:CAS:528:DC%2BD3sXjslagtL4%3D
    • Korhonen H, Pihlanto LA (2003) Food-derived bioactive peptides-opportunities for designing future foods. Curr Pharm Des 9:1297-1308
    • (2003) Curr Pharm des , vol.9 , pp. 1297-1308
    • Korhonen, H.1    Pihlanto, L.A.2
  • 15
    • 0039984616 scopus 로고    scopus 로고
    • The functional and biological properties of whey proteins: Prospects for the development of functional foods
    • 1:CAS:528:DyaK1cXlslWku7s%3D
    • Korhonen H, Pihlanto LA, Rantamaki P, Tupasela T (1998) The functional and biological properties of whey proteins: prospects for the development of functional foods. Agri Food Sci 7:283-296
    • (1998) Agri Food Sci , vol.7 , pp. 283-296
    • Korhonen, H.1    Pihlanto, L.A.2    Rantamaki, P.3    Tupasela, T.4
  • 16
    • 33748297647 scopus 로고    scopus 로고
    • Physiological, chemical and technological aspects of milk-protein-derived peptides with antihypertensive and ACE-inhibitory activity
    • 10.1016/j.idairyj.2006.06.004 1:CAS:528:DC%2BD28XpsVOisb4%3D
    • Lopez-Fandino R, Otte J, van-Camp J (2006) Physiological, chemical and technological aspects of milk-protein-derived peptides with antihypertensive and ACE-inhibitory activity. Int Dairy J 16:1277-1293
    • (2006) Int Dairy J , vol.16 , pp. 1277-1293
    • Lopez-Fandino, R.1    Otte, J.2    Van-Camp, J.3
  • 17
    • 71849104860 scopus 로고
    • Protein measurement with the Folin phenol reagent
    • 14907713 1:CAS:528:DyaG38XhsVyrsw%3D%3D
    • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
    • (1951) J Biol Chem , vol.193 , pp. 265-275
    • Lowry, O.H.1    Rosebrough, N.J.2    Farr, A.L.3    Randall, R.J.4
  • 18
    • 77949290825 scopus 로고    scopus 로고
    • Physiological properties of bioactive peptides obtained from whey proteins
    • 10.3168/jds.2009-2566
    • Madureira AR, Tavares T, Gomes AMP, Pintado ME, Malcata FX (2009) Physiological properties of bioactive peptides obtained from whey proteins. J Dairy Sci 93:437-455
    • (2009) J Dairy Sci , vol.93 , pp. 437-455
    • Madureira, A.R.1    Tavares, T.2    Gomes, A.M.P.3    Pintado, M.E.4    Malcata, F.X.5
  • 19
    • 3042686006 scopus 로고    scopus 로고
    • Therapeutic applications of whey protein
    • Marshall K (2004) Therapeutic applications of whey protein. Altern Med Rev 9(2):136-56
    • (2004) Altern Med Rev , vol.9 , Issue.2 , pp. 136-156
    • Marshall, K.1
  • 20
    • 16444386368 scopus 로고    scopus 로고
    • Multifunctional peptides encrypted in milk proteins
    • 15630170 10.1002/biof.552210111 1:CAS:528:DC%2BD2cXhtFGnsr3J
    • Meisel H (2004) Multifunctional peptides encrypted in milk proteins. BioFactors 21:55-61
    • (2004) BioFactors , vol.21 , pp. 55-61
    • Meisel, H.1
  • 21
    • 0038397187 scopus 로고    scopus 로고
    • Biofunctional peptides from milk proteins, mineral binding and cytomodulatory effects
    • 12769737 10.2174/1381612033454847 1:CAS:528:DC%2BD3sXjslagt7c%3D
    • Meisel H, FitzGerald RJ (2003) Biofunctional peptides from milk proteins, mineral binding and cytomodulatory effects. Curr Pharm Des 9:1289-1295
    • (2003) Curr Pharm des , vol.9 , pp. 1289-1295
    • Meisel, H.1    Fitzgerald, R.J.2
  • 22
  • 23
    • 0031464182 scopus 로고    scopus 로고
    • Angiotensin-I-converting enzyme inhibitory activities of gastric and pancreatic proteinase digests of whey proteins
    • 10.1016/S0958-6946(97)00018-6 1:CAS:528:DyaK1cXnvVOrtQ%3D%3D
    • Mullally MM, Meisel H, FitzGerald RJ (1997) Angiotensin-I-converting enzyme inhibitory activities of gastric and pancreatic proteinase digests of whey proteins. Int Dairy J 7:299-303
    • (1997) Int Dairy J , vol.7 , pp. 299-303
    • Mullally, M.M.1    Meisel, H.2    Fitzgerald, R.J.3
  • 24
    • 0031760413 scopus 로고    scopus 로고
    • Screening of dietary carotenoids and carotenoid-rich fruit extracts for antioxidant activities applying 2,2′-azinobis(3-ethylbenzothiazolyne-6- sulfonic acid) radical cation decolorization assay
    • (Oxidants and antioxidants part A)
    • Pellegrini N, Re R, Yang M, Rice-Evans C (1999) Screening of dietary carotenoids and carotenoid-rich fruit extracts for antioxidant activities applying 2,2′-azinobis(3-ethylbenzothiazolyne-6-sulfonic acid) radical cation decolorization assay. Methods Enzymol 299 (Oxidants and antioxidants part A):379-389
    • (1999) Methods Enzymol , vol.299 , pp. 379-389
    • Pellegrini, N.1    Re, R.2    Yang, M.3    Rice-Evans, C.4
  • 25
    • 52949091925 scopus 로고    scopus 로고
    • Antioxidant activity of peptide fractions from whey protein hydrolysates as measured by electron spin resonance
    • 10.1016/j.foodchem.2008.07.068 1:CAS:528:DC%2BD1cXhtF2ntb7N
    • Peng X, Xiong YL, Kong B (2009) Antioxidant activity of peptide fractions from whey protein hydrolysates as measured by electron spin resonance. Food Chem 113:196-201
    • (2009) Food Chem , vol.113 , pp. 196-201
    • Peng, X.1    Xiong, Y.L.2    Kong, B.3
  • 26
    • 0034633086 scopus 로고    scopus 로고
    • Bioactive peptides derived from bovine whey proteins: Opioid and ACE-inhibitory peptides
    • Pihlanto-Leppala A (2001) Bioactive peptides derived from bovine whey proteins: opioid and ACE-inhibitory peptides. Trends Food Sci Technol 11:347-356
    • (2001) Trends Food Sci Technol , vol.11 , pp. 347-356
    • Pihlanto-Leppala, A.1
  • 27
    • 85009363833 scopus 로고    scopus 로고
    • The emerging role of dairy proteins and bioactive peptides in nutrition and health: Hypotensive peptides from milk proteins
    • Richard JF, Brian AM, Daniel JW (2004) The emerging role of dairy proteins and bioactive peptides in nutrition and health: hypotensive peptides from milk proteins. J Nutr 134:980-988
    • (2004) J Nutr , vol.134 , pp. 980-988
    • Richard, J.F.1    Brian, A.M.2    Daniel, J.W.3
  • 28
    • 82455188365 scopus 로고    scopus 로고
    • Stability and mechanism of whey protein soluble aggregates thermally treated with salts
    • 10.1016/j.foodhyd.2011.11.006 1:CAS:528:DC%2BC3MXhs1Kqu7%2FO
    • Ryan KN, Vardhanabhuti B, Jaramillo DP, van Zanten JH, Coupland JN, Foegeding EA (2012) Stability and mechanism of whey protein soluble aggregates thermally treated with salts. Food Hydrocoll 27(2):411-420
    • (2012) Food Hydrocoll , vol.27 , Issue.2 , pp. 411-420
    • Ryan, K.N.1    Vardhanabhuti, B.2    Jaramillo, D.P.3    Van Zanten, J.H.4    Coupland, J.N.5    Foegeding, E.A.6
  • 29
    • 77956688199 scopus 로고    scopus 로고
    • Antioxidative peptides from food proteins: A review
    • 10.1016/j.peptides.2010.06.020
    • Sarmadia BH, Ismail A (2010) Antioxidative peptides from food proteins: a review. Peptides 31:1949-1956
    • (2010) Peptides , vol.31 , pp. 1949-1956
    • Sarmadia, B.H.1    Ismail, A.2
  • 30
    • 44549084148 scopus 로고    scopus 로고
    • Whey and whey proteins: From 'gutter-to-gold'
    • 10.1016/j.idairyj.2008.03.008 1:CAS:528:DC%2BD1cXmvFWqsrs%3D
    • Smithers GW (2008) Whey and whey proteins: from 'gutter-to-gold'. Int Dairy J 18:695-704
    • (2008) Int Dairy J , vol.18 , pp. 695-704
    • Smithers, G.W.1
  • 32
    • 79955468271 scopus 로고    scopus 로고
    • Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: In vitro effect and stability to gastrointestinal enzymes
    • 21335046 10.1016/j.peptides.2011.02.005 1:CAS:528:DC%2BC3MXltFeqsLg%3D
    • Tavares T, Contreras MM, Amorim M, Pintado ME, Recio I, Malcata FX (2011b) Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: in vitro effect and stability to gastrointestinal enzymes. Peptides 32:1013-1019
    • (2011) Peptides , vol.32 , pp. 1013-1019
    • Tavares, T.1    Contreras, M.M.2    Amorim, M.3    Pintado, M.E.4    Recio, I.5    Malcata, F.X.6
  • 33
    • 0036397541 scopus 로고    scopus 로고
    • Optimisation of the angiotensin converting enzyme inhibition by whey protein hydrolysates using response surface methodology
    • 10.1016/S0958-6946(02)00077-8
    • van der Ven C, Harry G, Dries BA, de Bont Alphons GJ, Voragen AGV (2002) Optimisation of the angiotensin converting enzyme inhibition by whey protein hydrolysates using response surface methodology. Int Dairy J 12:813-820
    • (2002) Int Dairy J , vol.12 , pp. 813-820
    • Van Der Ven, C.1    Harry, G.2    Dries, B.A.3    De Bont Alphons, G.J.4    Voragen, A.G.V.5
  • 34
    • 0032222184 scopus 로고    scopus 로고
    • Bioactive peptides in milk and their biological and health implications
    • 10.1080/87559129809541147
    • Xu RJ (1998) Bioactive peptides in milk and their biological and health implications. Food Rev Int 14:1-16
    • (1998) Food Rev Inter , vol.14 , pp. 1-16
    • Xu, R.J.1


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