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Volumn 32, Issue 11, 2013, Pages 594-603

Fusion genes in solid tumors: An emerging target for cancer diagnosis and treatment

Author keywords

Cancer genomics; Chromosomal instability; Fusion genes; Therapy; Tumorigenesis

Indexed keywords

CRIZOTINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 3; HYBRID PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAS PROTEIN; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; TRANSFORMING ACIDIC COILED COIL CONTAINING PROTEIN 3; UNCLASSIFIED DRUG;

EID: 84887375179     PISSN: 1000467X     EISSN: 1944446X     Source Type: Journal    
DOI: 10.5732/cjc.013.10178     Document Type: Review
Times cited : (79)

References (102)
  • 1
    • 0015757986 scopus 로고
    • The nucleotide sequence of the lac operator
    • Gilbert W, Maxam A. The nucleotide sequence of the lac operator. Proc Natl Acad Sci U S A, 1973,70:3581-3584.
    • (1973) Proc Natl Acad Sci U S A , vol.70 , pp. 3581-3584
    • Gilbert, W.1    Maxam, A.2
  • 3
    • 0022372670 scopus 로고
    • Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia
    • Saiki RK, Scharf S, Faloona F, et al. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science, 1985,230:1350-1354.
    • (1985) Science , vol.230 , pp. 1350-1354
    • Saiki, R.K.1    Scharf, S.2    Faloona, F.3
  • 4
    • 37749031255 scopus 로고    scopus 로고
    • Next-generation sequencing transforms today's biology
    • Schuster SC. Next-generation sequencing transforms today's biology. Nat Methods, 2008,5:16-18.
    • (2008) Nat Methods , vol.5 , pp. 16-18
    • Schuster, S.C.1
  • 5
    • 0015694748 scopus 로고
    • Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley JD. Letter: a new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature, 1973,243:290-293.
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 7
    • 0000286732 scopus 로고
    • A minute chromosome in human chronic granulocytic leukemia
    • Nowell PC, Hungerford DA. A minute chromosome in human chronic granulocytic leukemia. Science, 1960,132:1497.
    • (1960) Science , vol.132 , pp. 1497
    • Nowell, P.C.1    Hungerford, D.A.2
  • 8
    • 0023621311 scopus 로고
    • Multiple molecular abnormalities in Ph1 chromosome positive acute lymphoblastic-leukemia
    • Dreazen O, Klisak I, Jones G, et al. Multiple molecular abnormalities in Ph1 chromosome positive acute lymphoblastic-leukemia. Brit J Haematol, 1987,67:319-374.
    • (1987) Brit J Haematol , vol.67 , pp. 319-374
    • Dreazen, O.1    Klisak, I.2    Jones, G.3
  • 9
    • 0021802841 scopus 로고
    • Fused transcript of abl and bcr genes in chronic myelogenous leukemia
    • Shtivelman E, Lifshitz B, Gale RP, et al. Fused transcript of abl and bcr genes in chronic myelogenous leukemia. Nature, 1985,315:550-554.
    • (1985) Nature , vol.315 , pp. 550-554
    • Shtivelman, E.1    Lifshitz, B.2    Gale, R.P.3
  • 10
    • 0015494783 scopus 로고
    • Marker band in one chromosome-14 from Burkitt lymphomas
    • Manolov G, Manolova Y. Marker band in one chromosome-14 from Burkitt lymphomas. Nature, 1972,237:33-34.
    • (1972) Nature , vol.237 , pp. 33-34
    • Manolov, G.1    Manolova, Y.2
  • 11
    • 0017285882 scopus 로고
    • Characteristic chromosomalabnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas
    • Zech L, Haglund U, Nilsson K, et al. Characteristic chromosomalabnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas. Int J Cancer, 1976,17:47-56.
    • (1976) Int J Cancer , vol.17 , pp. 47-56
    • Zech, L.1    Haglund, U.2    Nilsson, K.3
  • 12
    • 0000538165 scopus 로고
    • Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells
    • Dalla-Favera R, Bregni M, Erikson J, et al. Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci U S A, 1982,79:7824-7827.
    • (1982) Proc Natl Acad Sci U S A , vol.79 , pp. 7824-7827
    • Dalla-Favera, R.1    Bregni, M.2    Erikson, J.3
  • 13
    • 84887378291 scopus 로고    scopus 로고
    • New hope for cancer
    • San Francisco: Time Inc., May 28
    • Park MDLaA. New hope for cancer. Time Magazine. San Francisco: Time Inc., May 28, 2001.
    • (2001) Time Magazine.
    • Park, M.D.L.A.1
  • 14
    • 0021345113 scopus 로고
    • Evidence for a 15;17 translocation in every patient with acute promyelocytic leukemia
    • Larson RA, Kondo K, Vardiman JW, et al. Evidence for a 15;17 translocation in every patient with acute promyelocytic leukemia. Am J Med, 1984,76:827-841.
    • (1984) Am J Med , vol.76 , pp. 827-841
    • Larson, R.A.1    Kondo, K.2    Vardiman, J.W.3
  • 15
    • 0025089467 scopus 로고
    • Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17
    • Borrow J, Goddard AD, Sheer D, et al. Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science, 1990,249:1577-1580.
    • (1990) Science , vol.249 , pp. 1577-1580
    • Borrow, J.1    Goddard, A.D.2    Sheer, D.3
  • 17
    • 0023752982 scopus 로고
    • Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia
    • Huang ME, Ye YC, Chen SR, et al. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood, 1988,72:567-572.
    • (1988) Blood , vol.72 , pp. 567-572
    • Huang, M.E.1    Ye, Y.C.2    Chen, S.R.3
  • 18
    • 0025201879 scopus 로고
    • All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results
    • Castaigne S, Chomienne C, Daniel MT, et al. All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood, 1990,76:1704-1709.
    • (1990) Blood , vol.76 , pp. 1704-1709
    • Castaigne, S.1    Chomienne, C.2    Daniel, M.T.3
  • 19
    • 0025882306 scopus 로고
    • Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid)
    • Warrell RP Jr, Frankel SR, Miller WH Jr, et al. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med, 1991,324:1385-1393.
    • (1991) N Engl J Med , vol.324 , pp. 1385-1393
    • Warrell Jr., R.P.1    Frankel, S.R.2    Miller Jr., W.H.3
  • 20
    • 84873347374 scopus 로고    scopus 로고
    • The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma
    • Parker BC, Annala MJ, Cogdell DE, et al. The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. J Clin Invest, 2013,123:855-865.
    • (2013) J Clin Invest , vol.123 , pp. 855-865
    • Parker, B.C.1    Annala, M.J.2    Cogdell, D.E.3
  • 21
    • 84865805666 scopus 로고    scopus 로고
    • Transforming fusions of FGFR and TACC genes in human glioblastoma
    • Singh D, Chan JM, Zoppoli P, et al. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science, 2012,337:1231-1235.
    • (2012) Science , vol.337 , pp. 1231-1235
    • Singh, D.1    Chan, J.M.2    Zoppoli, P.3
  • 22
  • 23
    • 84878781242 scopus 로고    scopus 로고
    • Identification of targetable FGFR gene fusions in diverse cancers
    • Wu YM, Su FY, Kalyana-Sundaram S, et al. Identification of targetable FGFR gene fusions in diverse cancers. Cancer Discov, 2013,3:636-647.
    • (2013) Cancer Discov , vol.3 , pp. 636-647
    • Wu, Y.M.1    Su, F.Y.2    Kalyana-Sundaram, S.3
  • 24
    • 10744227336 scopus 로고    scopus 로고
    • Soft tissue sarcomas of adults: State of the translational science
    • Borden EC, Baker LH, Bell RS, et al. Soft tissue sarcomas of adults: State of the translational science. Clin Cancer Res, 2003,9:1941-1956.
    • (2003) Clin Cancer Res , vol.9 , pp. 1941-1956
    • Borden, E.C.1    Baker, L.H.2    Bell, R.S.3
  • 26
    • 0020956309 scopus 로고
    • Chromosomal translocations in Ewing's sarcoma
    • Aurias A, Rimbaut C, Buffe D, et al. Chromosomal translocations in Ewing's sarcoma. New Engl J Med, 1983,309:496-497.
    • (1983) New Engl J Med , vol.309 , pp. 496-497
    • Aurias, A.1    Rimbaut, C.2    Buffe, D.3
  • 27
    • 0021066625 scopus 로고
    • Chromosomal translocation (11; 22) in cell lines of Ewing's sarcoma
    • [in French]
    • Turc-Carel C, Philip I, Berger MP, et al. Chromosomal translocation (11; 22) in cell lines of Ewing's sarcoma. C R Seances Acad Sci III, 1983,296:1101-1103. [in French]
    • (1983) C R Seances Acad Sci III , vol.296 , pp. 1101-1103
    • Turc-Carel, C.1    Philip, I.2    Berger, M.P.3
  • 28
    • 0026686674 scopus 로고
    • Gene fusion with an ETS DNA-binding domain caused by chromosome-translocation in human tumors
    • Delattre O, Zucman J, Plougastel B, et al. Gene fusion with an ETS DNA-binding domain caused by chromosome-translocation in human tumors. Nature, 1992,359:162-165.
    • (1992) Nature , vol.359 , pp. 162-165
    • Delattre, O.1    Zucman, J.2    Plougastel, B.3
  • 29
    • 0029838475 scopus 로고    scopus 로고
    • Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: A possible therapeutic target
    • Scotlandi K, Benini S, Sarti M, et al. Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target. Cancer Res, 1996,56:4570-4574.
    • (1996) Cancer Res , vol.56 , pp. 4570-4574
    • Scotlandi, K.1    Benini, S.2    Sarti, M.3
  • 30
    • 3543026281 scopus 로고    scopus 로고
    • EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
    • Prieur A, Tirode F, Cohen P, et al. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol, 2004,24:7275-7283.
    • (2004) Mol Cell Biol , vol.24 , pp. 7275-7283
    • Prieur, A.1    Tirode, F.2    Cohen, P.3
  • 31
    • 40549086265 scopus 로고    scopus 로고
    • A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature
    • Hancock JD, Lessnick SL. A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature. Cell Cycle, 2008,7:250-256.
    • (2008) Cell Cycle , vol.7 , pp. 250-256
    • Hancock, J.D.1    Lessnick, S.L.2
  • 32
    • 5644252461 scopus 로고    scopus 로고
    • Synergy between PI3K/ AKT and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells
    • Shelton JG, Steelman LS, White ER, et al. Synergy between PI3K/ AKT and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells. Cell Cycle, 2004,3:372-379.
    • (2004) Cell Cycle , vol.3 , pp. 372-379
    • Shelton, J.G.1    Steelman, L.S.2    White, E.R.3
  • 33
    • 0038398622 scopus 로고    scopus 로고
    • The insulin-like growth factor system and cancer
    • LeRoith D, Roberts CT Jr. The insulin-like growth factor system and cancer. Cancer Lett, 2003,195:127-137.
    • (2003) Cancer Lett , vol.195 , pp. 127-137
    • LeRoith, D.1    Roberts Jr., C.T.2
  • 34
    • 0036111682 scopus 로고    scopus 로고
    • Insulin-like growth factors and cancer
    • Furstenberger G, Senn HJ. Insulin-like growth factors and cancer. Lancet Oncol, 2002,3:298-302.
    • (2002) Lancet Oncol , vol.3 , pp. 298-302
    • Furstenberger, G.1    Senn, H.J.2
  • 35
    • 0034692430 scopus 로고    scopus 로고
    • Role of the insulin-like growth factor family in cancer development and progression
    • Yu H, Rohan T. Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst, 2000,92:1472-1489.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1472-1489
    • Yu, H.1    Rohan, T.2
  • 36
    • 69349103706 scopus 로고    scopus 로고
    • Inhibition of insulin-like growth factor 1 receptor by CP-751,871 radiosensitizes non-small cell lung cancer cells
    • Iwasa T, Okamoto I, Suzuki M, et al. Inhibition of insulin-like growth factor 1 receptor by CP-751,871 radiosensitizes non-small cell lung cancer cells. Clin Cancer Res, 2009,15:5117-5125.
    • (2009) Clin Cancer Res , vol.15 , pp. 5117-5125
    • Iwasa, T.1    Okamoto, I.2    Suzuki, M.3
  • 37
    • 79959265311 scopus 로고    scopus 로고
    • Targeting the insulinlike growth factor 1 receptor in Ewing's sarcoma: Reality and expectations
    • Olmos D, Martins AS, Jones RL, et al. Targeting the insulinlike growth factor 1 receptor in Ewing's sarcoma: reality and expectations. Sarcoma, 2011,2011:402508.
    • (2011) Sarcoma , pp. 402508
    • Olmos, D.1    Martins, A.S.2    Jones, R.L.3
  • 38
    • 65249099562 scopus 로고    scopus 로고
    • The NFATc2 gene is involved in a novel cloned translocation in a Ewing sarcoma variant that couples its function in immunology to oncology
    • Szuhai K, Ijszenga M, de Jong D, et al. The NFATc2 gene is involved in a novel cloned translocation in a Ewing sarcoma variant that couples its function in immunology to oncology. Clin Cancer Res, 2009,15:2259-2268.
    • (2009) Clin Cancer Res , vol.15 , pp. 2259-2268
    • Szuhai, K.1    Ijszenga, M.2    de Jong, D.3
  • 39
    • 50649097473 scopus 로고    scopus 로고
    • Synovial sarcoma: From genetics to genetic-based animal modeling
    • Haldar M, Randall RL, Capecchi MR. Synovial sarcoma: from genetics to genetic-based animal modeling. Clin Orthop Relat Res, 2008,466:2156-2167.
    • (2008) Clin Orthop Relat Res , vol.466 , pp. 2156-2167
    • Haldar, M.1    Randall, R.L.2    Capecchi, M.R.3
  • 40
    • 0004371659 scopus 로고
    • Involvement of chromosome X in primary cytogenetic change in human neoplasia: Nonrandom translocation in synovial sarcoma
    • Turc-Carel C, Dal Cin P, Limon J, et al. Involvement of chromosome X in primary cytogenetic change in human neoplasia: nonrandom translocation in synovial sarcoma. Proc Natl Acad Sci U S A, 1987,84:1981-1985.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 1981-1985
    • Turc-Carel, C.1    Dal Cin, P.2    Limon, J.3
  • 41
    • 0027933151 scopus 로고
    • Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma
    • Clark J, Rocques PJ, Crew AJ, et al. Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. Nat Genet, 1994,7:502-508.
    • (1994) Nat Genet , vol.7 , pp. 502-508
    • Clark, J.1    Rocques, P.J.2    Crew, A.J.3
  • 42
    • 0029066330 scopus 로고
    • Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma
    • Crew AJ, Clark J, Fisher C, et al. Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. EMBO J, 1995,14:2333-2340.
    • (1995) EMBO J , vol.14 , pp. 2333-2340
    • Crew, A.J.1    Clark, J.2    Fisher, C.3
  • 43
    • 0033516270 scopus 로고    scopus 로고
    • A novel fusion gene, SYTSSX4, in synovial sarcoma
    • Skytting B, Nilsson G, Brodin B, et al. A novel fusion gene, SYTSSX4, in synovial sarcoma. J Natl Cancer Inst, 1999,91:974-975.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 974-975
    • Skytting, B.1    Nilsson, G.2    Brodin, B.3
  • 44
    • 0035957396 scopus 로고    scopus 로고
    • Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin remodeling factor hBRM/hSNF2 alpha
    • Nagai M, Tanaka S, Tsuda M, et al. Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin remodeling factor hBRM/hSNF2 alpha. Proc Natl Acad Sci U S A, 2001,98:3843-3848.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 3843-3848
    • Nagai, M.1    Tanaka, S.2    Tsuda, M.3
  • 45
    • 0032532777 scopus 로고    scopus 로고
    • A KRAB-related domain and a novel transcription repression domain in proteins encoded by SSX genes that are disrupted in human sarcomas
    • Lim FL, Soulez M, Koczan D, et al. A KRAB-related domain and a novel transcription repression domain in proteins encoded by SSX genes that are disrupted in human sarcomas. Oncogene, 1998,17:2013-2018.
    • (1998) Oncogene , vol.17 , pp. 2013-2018
    • Lim, F.L.1    Soulez, M.2    Koczan, D.3
  • 46
    • 84863337645 scopus 로고    scopus 로고
    • Deconstruction of the SS18-SSX fusion oncoprotein complex: Insights into disease etiology and therapeutics
    • Su L, Sampaio AV, Jones KB, et al. Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell, 2012,21:333-347.
    • (2012) Cancer Cell , vol.21 , pp. 333-347
    • Su, L.1    Sampaio, A.V.2    Jones, K.B.3
  • 47
    • 19444376494 scopus 로고    scopus 로고
    • Significant growth suppression of synovial sarcomas by the histone deacetylase inhibitor FK228 in vitro and in vivo
    • Ito T, Ouchida M, Morimoto Y, et al. Significant growth suppression of synovial sarcomas by the histone deacetylase inhibitor FK228 in vitro and in vivo. Cancer Lett, 2005,224:311-319.
    • (2005) Cancer Lett , vol.224 , pp. 311-319
    • Ito, T.1    Ouchida, M.2    Morimoto, Y.3
  • 48
    • 49849098245 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in clear cell sarcoma models
    • Liu S, Cheng H, Kwan W, et al. Histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in clear cell sarcoma models. Mol Cancer Ther, 2008,7:1751-1761.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1751-1761
    • Liu, S.1    Cheng, H.2    Kwan, W.3
  • 49
    • 33750539306 scopus 로고    scopus 로고
    • Clear cell sarcoma of tendons and aponeuroses: A historical perspective and tribute to the man behind the entity
    • Meis-Kindblom JM. Clear cell sarcoma of tendons and aponeuroses: a historical perspective and tribute to the man behind the entity. Adv Anat Pathol, 2006,13:286-292.
    • (2006) Adv Anat Pathol , vol.13 , pp. 286-292
    • Meis-Kindblom, J.M.1
  • 50
    • 0025095469 scopus 로고
    • Chromosomal-abnormalities in clear cell-sarcoma. Implications for histogenesis
    • Bridge JA, Borek DA, Neff JR, et al. Chromosomal-abnormalities in clear cell-sarcoma. Implications for histogenesis. Am J Clin Pathol, 1990,93:26-31.
    • (1990) Am J Clin Pathol , vol.93 , pp. 26-31
    • Bridge, J.A.1    Borek, D.A.2    Neff, J.R.3
  • 51
    • 0027183108 scopus 로고
    • EWS and ATF-1 gene fusion induced by t(12-22) translocation in malignant-melanoma of soft parts
    • Zucman J, Delattre O, Desmaze C, et al. EWS and ATF-1 gene fusion induced by t(12-22) translocation in malignant-melanoma of soft parts. Nat Genet, 1993,4:341-345.
    • (1993) Nat Genet , vol.4 , pp. 341-345
    • Zucman, J.1    Delattre, O.2    Desmaze, C.3
  • 52
    • 58249116717 scopus 로고    scopus 로고
    • The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ
    • Goransson M, Andersson MK, Forni C, et al. The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ. Oncogene, 2009,28:270-278.
    • (2009) Oncogene , vol.28 , pp. 270-278
    • Goransson, M.1    Andersson, M.K.2    Forni, C.3
  • 53
    • 13144272325 scopus 로고    scopus 로고
    • Tumor taxonomy for the developmental lineage classification of neoplasms
    • Berman JJ. Tumor taxonomy for the developmental lineage classification of neoplasms. BMC cancer, 2004,4:88.
    • (2004) BMC cancer , vol.4 , pp. 88
    • Berman, J.J.1
  • 54
    • 60849105360 scopus 로고    scopus 로고
    • International epidemiology of prostate cancer: Geographical distribution and secular trends
    • Baade PD, Youlden DR, Krnjacki LJ. International epidemiology of prostate cancer: geographical distribution and secular trends. Mol Nutr Food Res, 2009,53:171-184.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 171-184
    • Baade, P.D.1    Youlden, D.R.2    Krnjacki, L.J.3
  • 55
    • 27344451557 scopus 로고    scopus 로고
    • Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
    • Tomlins SA, Rhodes DR, Perner S, et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science, 2005,310:644-648.
    • (2005) Science , vol.310 , pp. 644-648
    • Tomlins, S.A.1    Rhodes, D.R.2    Perner, S.3
  • 56
    • 33645750799 scopus 로고    scopus 로고
    • TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer
    • Tomlins SA, Mehra R, Rhodes DR, et al. TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res, 2006,66:3396-3400.
    • (2006) Cancer Res , vol.66 , pp. 3396-3400
    • Tomlins, S.A.1    Mehra, R.2    Rhodes, D.R.3
  • 57
    • 77952103123 scopus 로고    scopus 로고
    • An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression
    • Yu JD, Yu JJ, Mani RS, et al. An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell, 2010,17:443-454.
    • (2010) Cancer Cell , vol.17 , pp. 443-454
    • Yu, J.D.1    Yu, J.J.2    Mani, R.S.3
  • 58
    • 77950518687 scopus 로고    scopus 로고
    • Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort
    • Esgueva R, Perner S, LaFargue CJ, et al. Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort. Modern Pathol, 2010,23:539-546.
    • (2010) Modern Pathol , vol.23 , pp. 539-546
    • Esgueva, R.1    Perner, S.2    LaFargue, C.J.3
  • 59
    • 48749094526 scopus 로고    scopus 로고
    • Cancer genomics and genetics of FGFR2 (Review)
    • Katoh M. Cancer genomics and genetics of FGFR2 (Review). Int J Oncol, 2008,33:233-237.
    • (2008) Int J Oncol , vol.33 , pp. 233-237
    • Katoh, M.1
  • 60
    • 19044391610 scopus 로고    scopus 로고
    • Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma
    • Tognon C, Knezevich SR, Huntsman D, et al. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell, 2002,2:367-376.
    • (2002) Cancer Cell , vol.2 , pp. 367-376
    • Tognon, C.1    Knezevich, S.R.2    Huntsman, D.3
  • 61
    • 0031953233 scopus 로고    scopus 로고
    • A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma
    • Knezevich SR, McFadden DE, Tao W, et al. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet, 1998,18:184-187.
    • (1998) Nat Genet , vol.18 , pp. 184-187
    • Knezevich, S.R.1    McFadden, D.E.2    Tao, W.3
  • 62
    • 0034677550 scopus 로고    scopus 로고
    • The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells
    • Wai DH, Knezevich SR, Lucas T, et al. The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells. Oncogene, 2000,19:906-915.
    • (2000) Oncogene , vol.19 , pp. 906-915
    • Wai, D.H.1    Knezevich, S.R.2    Lucas, T.3
  • 63
    • 0035893926 scopus 로고    scopus 로고
    • The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation
    • Tognon C, Garnett M, Kenward E, et al. The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation. Cancer Res, 2001,61:8909-8916.
    • (2001) Cancer Res , vol.61 , pp. 8909-8916
    • Tognon, C.1    Garnett, M.2    Kenward, E.3
  • 64
    • 0034255538 scopus 로고    scopus 로고
    • The impact of characteristics of cigarette smoking on urinary tract cancer risk: A meta-analysis of epidemiologic studies
    • Zeegers MPA, Tan FES, Dorant E, et al. The impact of characteristics of cigarette smoking on urinary tract cancer risk: a meta-analysis of epidemiologic studies. Cancer, 2000,89:630-639.
    • (2000) Cancer , vol.89 , pp. 630-639
    • Zeegers, M.P.A.1    Tan, F.E.S.2    Dorant, E.3
  • 65
    • 84860418570 scopus 로고    scopus 로고
    • Src-stimulated IRTKS phosphorylation enhances cell migration
    • Chen G, Li T, Zhang L, et al. Src-stimulated IRTKS phosphorylation enhances cell migration. FEBS lett, 2011,585:2972-2978.
    • (2011) FEBS lett , vol.585 , pp. 2972-2978
    • Chen, G.1    Li, T.2    Zhang, L.3
  • 66
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R, Ward E, Brawley O, et al. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin, 2011,61:212-236.
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3
  • 67
    • 79960119923 scopus 로고    scopus 로고
    • Colon cancer: A civilization disorder
    • Watson AJ, Collins PD. Colon cancer: a civilization disorder. Dig Dis, 2011,29:222-228.
    • (2011) Dig Dis , vol.29 , pp. 222-228
    • Watson, A.J.1    Collins, P.D.2
  • 69
    • 84865459654 scopus 로고    scopus 로고
    • Recurrent R-spondin fusions in colon cancer
    • Seshagiri S, Stawiski EW, Durinck S, et al. Recurrent R-spondin fusions in colon cancer. Nature, 2012,488:660-664.
    • (2012) Nature , vol.488 , pp. 660-664
    • Seshagiri, S.1    Stawiski, E.W.2    Durinck, S.3
  • 70
    • 5044244757 scopus 로고    scopus 로고
    • R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis
    • Kazanskaya O, Glinka A, Barrantes ID, et al. R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell, 2004,7:525-534.
    • (2004) Dev Cell , vol.7 , pp. 525-534
    • Kazanskaya, O.1    Glinka, A.2    Barrantes, I.D.3
  • 71
    • 0035723399 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase genes downregulated in melanoma
    • McArdle L, Rafferty M, Maelandsmo GM, et al. Protein tyrosine phosphatase genes downregulated in melanoma. J Invest Dermatol, 2001,117:1255-1260.
    • (2001) J Invest Dermatol , vol.117 , pp. 1255-1260
    • McArdle, L.1    Rafferty, M.2    Maelandsmo, G.M.3
  • 72
    • 0037442987 scopus 로고    scopus 로고
    • Novel tumor suppressor loci on 6q22-23 in primary central nervous system lymphomas
    • Nakamura M, Kishi M, Sakaki T, et al. Novel tumor suppressor loci on 6q22-23 in primary central nervous system lymphomas. Cancer Res, 2003,63:737-741.
    • (2003) Cancer Res , vol.63 , pp. 737-741
    • Nakamura, M.1    Kishi, M.2    Sakaki, T.3
  • 73
    • 84857220124 scopus 로고    scopus 로고
    • The nonreceptor-type tyrosine phosphatase PTPN13 is a tumor suppressor gene in nonsmall cell lung cancer
    • Scrima M, De Marco C, De Vita F, et al. The nonreceptor-type tyrosine phosphatase PTPN13 is a tumor suppressor gene in nonsmall cell lung cancer. Am J Pathol, 2012,180:1202-1214.
    • (2012) Am J Pathol , vol.180 , pp. 1202-1214
    • Scrima, M.1    De Marco, C.2    De Vita, F.3
  • 74
    • 84874309132 scopus 로고    scopus 로고
    • Identification of novel AR-targeted microRNAs mediating androgen signalling through critical pathways to regulate cell viability in prostate cancer
    • Mo W, Zhang J, Li X, et al. Identification of novel AR-targeted microRNAs mediating androgen signalling through critical pathways to regulate cell viability in prostate cancer. PloS one, 2013,8:e56592.
    • (2013) PloS one , vol.8
    • Mo, W.1    Zhang, J.2    Li, X.3
  • 75
    • 0035337708 scopus 로고    scopus 로고
    • Unified nomenclature for the subunits of eukaryotic initiation factor 3
    • 284
    • Browning KS, Gallie DR, Hershey JWB, et al. Unified nomenclature for the subunits of eukaryotic initiation factor 3. Trends Biochem Sci, 2001,26:284-284.
    • (2001) Trends Biochem Sci , vol.26 , pp. 284
    • Browning, K.S.1    Gallie, D.R.2    Hershey, J.W.B.3
  • 76
    • 80053330506 scopus 로고    scopus 로고
    • ESRRA-C11orf20 is a recurrent gene fusion in serous ovarian carcinoma
    • Salzman J, Marinelli RJ, Wang PL, et al. ESRRA-C11orf20 is a recurrent gene fusion in serous ovarian carcinoma. PLoS Biol, 2011,9:e1001156.
    • (2011) PLoS Biol , vol.9
    • Salzman, J.1    Marinelli, R.J.2    Wang, P.L.3
  • 77
    • 0037112441 scopus 로고    scopus 로고
    • Estrogen-related receptor alpha and estrogen-related receptor gamma associate with unfavorable and favorable biomarkers, respectively, in human breast cancer
    • Ariazi EA, Clark GM, Mertz JE. Estrogen-related receptor alpha and estrogen-related receptor gamma associate with unfavorable and favorable biomarkers, respectively, in human breast cancer. Cancer Res, 2002,62:6510-6518.
    • (2002) Cancer Res , vol.62 , pp. 6510-6518
    • Ariazi, E.A.1    Clark, G.M.2    Mertz, J.E.3
  • 78
    • 21544454405 scopus 로고    scopus 로고
    • Expression of estrogen receptor-related receptors, a subfamily of orphan nuclear receptors, as new tumor biomarkers in ovarian cancer cells
    • Sun PM, Sehouli J, Denkert C, et al. Expression of estrogen receptor-related receptors, a subfamily of orphan nuclear receptors, as new tumor biomarkers in ovarian cancer cells. J Mol Med-(Berl), 2005,83:457-467.
    • (2005) J Mol Med-(Berl) , vol.83 , pp. 457-467
    • Sun, P.M.1    Sehouli, J.2    Denkert, C.3
  • 79
    • 0037050352 scopus 로고    scopus 로고
    • Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
    • Schiller JH, Harrington D, Belani CP, et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med, 2002,346:92-98.
    • (2002) N Engl J Med , vol.346 , pp. 92-98
    • Schiller, J.H.1    Harrington, D.2    Belani, C.P.3
  • 80
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature, 2007,448:561-566.
    • (2007) Nature , vol.448 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3
  • 81
    • 79954592031 scopus 로고    scopus 로고
    • Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer
    • Takezawa K, Okamoto I, Nishio K, et al. Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer. Clin Cancer Res, 2011,17:2140-2148.
    • (2011) Clin Cancer Res , vol.17 , pp. 2140-2148
    • Takezawa, K.1    Okamoto, I.2    Nishio, K.3
  • 82
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med, 2010,363:1693-1703.
    • (2010) N Engl J Med , vol.363 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 83
    • 84857929267 scopus 로고    scopus 로고
    • KIF5B-RET fusions in lung adenocarcinoma
    • Kohno T, Ichikawa H, Totoki Y, et al. KIF5B-RET fusions in lung adenocarcinoma. Nat Med, 2012,18:375-377.
    • (2012) Nat Med , vol.18 , pp. 375-377
    • Kohno, T.1    Ichikawa, H.2    Totoki, Y.3
  • 84
    • 84857985225 scopus 로고    scopus 로고
    • RET, ROS1 and ALK fusions in lung cancer
    • Takeuchi K, Soda M, Togashi Y, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med, 2012,18:378-381.
    • (2012) Nat Med , vol.18 , pp. 378-381
    • Takeuchi, K.1    Soda, M.2    Togashi, Y.3
  • 85
    • 84868309107 scopus 로고    scopus 로고
    • The transcriptional landscape and mutational profile of lung adenocarcinoma
    • Seo JS, Ju YS, Lee WC, et al. The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome research, 2012,22:2109-2119.
    • (2012) Genome research , vol.22 , pp. 2109-2119
    • Seo, J.S.1    Ju, Y.S.2    Lee, W.C.3
  • 86
    • 0032972199 scopus 로고    scopus 로고
    • Adenoid cystic carcinoma of the head and neck-predictors of morbidity and mortality
    • Fordice J, Kershaw C, El-Naggar A, et al. Adenoid cystic carcinoma of the head and neck-predictors of morbidity and mortality. Arch Otolaryngol Head Neck Surg, 1999,125:149-152.
    • (1999) Arch Otolaryngol Head Neck Surg , vol.125 , pp. 149-152
    • Fordice, J.1    Kershaw, C.2    El-Naggar, A.3
  • 87
    • 0029122059 scopus 로고
    • Chromosomal localization of the 4 genes (NFIA, B, C, and X) for the human transcription factor nuclear factor-I by FISH
    • Qian F, Kruse U, Lichter P, et al. Chromosomal localization of the 4 genes (NFIA, B, C, and X) for the human transcription factor nuclear factor-I by FISH. Genomics, 1995,28:66-73.
    • (1995) Genomics , vol.28 , pp. 66-73
    • Qian, F.1    Kruse, U.2    Lichter, P.3
  • 88
    • 0032546037 scopus 로고    scopus 로고
    • Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas
    • Geurts JMW, Schoenmakers EFPM, Roijer E, et al. Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas. Oncogene, 1998,16:865-872.
    • (1998) Oncogene , vol.16 , pp. 865-872
    • Geurts, J.M.W.1    Schoenmakers, E.F.P.M.2    Roijer, E.3
  • 89
    • 73249115584 scopus 로고    scopus 로고
    • Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck
    • Persson M, Andren Y, Mark J, et al. Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc Natl Acad Sci U S A, 2009,106:18740-18744.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 18740-18744
    • Persson, M.1    Andren, Y.2    Mark, J.3
  • 90
    • 0037313331 scopus 로고    scopus 로고
    • Translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway
    • t(11;19)(q21;p13)
    • Tonon G, Modi S, Wu LZ, et al. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet, 2003,33:208-213.
    • (2003) Nat Genet , vol.33 , pp. 208-213
    • Tonon, G.1    Modi, S.2    Wu, L.Z.3
  • 92
    • 80955158735 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: Utility as a diagnostic test
    • Garcia JJ, Hunt JL, Weinreb I, et al. Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: Utility as a diagnostic test. Hum Pathol, 2011,42:2001-2009.
    • (2011) Hum Pathol , vol.42 , pp. 2001-2009
    • Garcia, J.J.1    Hunt, J.L.2    Weinreb, I.3
  • 94
    • 0034714190 scopus 로고    scopus 로고
    • PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]
    • Kroll TG, Sarraf P, Pecciarini L, et al. PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]. Science, 2000,289:1357-1360.
    • (2000) Science , vol.289 , pp. 1357-1360
    • Kroll, T.G.1    Sarraf, P.2    Pecciarini, L.3
  • 95
    • 20944439189 scopus 로고    scopus 로고
    • Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance
    • Jones JR, Barrick C, Kim KA, et al. Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A, 2005, 102:6207-6212.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 6207-6212
    • Jones, J.R.1    Barrick, C.2    Kim, K.A.3
  • 96
    • 2442697906 scopus 로고    scopus 로고
    • The PAX8/PPARgamma fusion oncoprotein transforms immortalized human thyrocytes through a mechanism probably involving wild-type PPARgamma inhibition
    • Powell JG, Wang XY, Allard BL, et al. The PAX8/PPARgamma fusion oncoprotein transforms immortalized human thyrocytes through a mechanism probably involving wild-type PPARgamma inhibition. Oncogene, 2004,23:3634-3641.
    • (2004) Oncogene , vol.23 , pp. 3634-3641
    • Powell, J.G.1    Wang, X.Y.2    Allard, B.L.3
  • 98
    • 9844230424 scopus 로고    scopus 로고
    • Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma
    • Clark J, Lu YJ, Sidhar SK, et al. Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma. Oncogene, 1997,15:2233-2239.
    • (1997) Oncogene , vol.15 , pp. 2233-2239
    • Clark, J.1    Lu, Y.J.2    Sidhar, S.K.3
  • 99
    • 84879890360 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of clear cell renal cell carcinoma
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature, 2013,499:43-49.
    • (2013) Nature , vol.499 , pp. 43-49
  • 101
    • 55349107544 scopus 로고    scopus 로고
    • Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
    • Jones DT, Kocialkowski S, Liu L, et al. Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. Cancer Res, 2008,68:8673-8677.
    • (2008) Cancer Res , vol.68 , pp. 8673-8677
    • Jones, D.T.1    Kocialkowski, S.2    Liu, L.3
  • 102
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature, 2002,417:949-954.
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3


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