Expression of estrogen receptor-related receptors, a subfamily of orphan nuclear receptors, as new tumor biomarkers in ovarian cancer cells

Journal of Molecular Medicine

Volumn 83, Issue 6, 2005, Pages 457-467

  Sun, Pengming ^a,b   Sehouli, Jalid ^b   Denkert, Carsten ^b   Mustea, Alexander ^b   Könsgen, Dominique ^b   Koch, Ines ^b   Wei, Lihui ^a   Lichtenegger, Werner ^b  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Estrogen receptor related receptor; Orphan receptor; Ovarian cancer; Tumor marker

Indexed keywords

BIOLOGICAL MARKER; CA 125 ANTIGEN; CELL NUCLEUS RECEPTOR; ESTROGEN RECEPTOR; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MESSENGER RNA;

ARTICLE; CANCER CELL CULTURE; CANCER SURVIVAL; CARCINOGENESIS; CELL NUCLEUS; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; KAPLAN MEIER METHOD; MULTIVARIATE ANALYSIS; OVARY CANCER; OVARY CELL CULTURE; PROGNOSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK ASSESSMENT;

CELL LINE, TUMOR; DISEASE-FREE SURVIVAL; FEMALE; GREEN FLUORESCENT PROTEINS; HUMANS; OVARIAN NEOPLASMS; PREDICTIVE VALUE OF TESTS; PROTEIN ISOFORMS; PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, ESTROGEN; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 21544454405     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-005-0639-3     Document Type: Article

References (39)

1. Landis SH, Murray T, Bolden S, Wingo PA (1999) Cancer statistics. CA Cancer J Clin 49:8-31
2. Sehouli J, Akdogan Z, Heinze T, Konsgen D, Stengel D, Mustea A, Lichtenegger W (2003) Preoperative determination of CASA and CA-125 for the discrimination between benign and malignant pelvic tumor mass: a prospective study. Anticancer Res 23:1115-1118
3. Muramatsu M, Inoue S (2000) Estrogens receptors: how do they control reproductive and nonreproductive functions? Biochem Biophys Res Commun 270:1-10
4. Clinton GM, Hua W (1997) Estrogen action in human ovarian cancer. Crit Rev Oncol Hematol 25:1-9
5. Brandenberger AW, Tee MK, Jaffe RB (1998) Estrogen receptor alpha and beta mRNAs in normal ovary, ovarian serous cyst-adenocarcinoma and ovarian cancer cell lines: down-regulation of ER-β in neoplastic tissues. J Clin Endocrinol Metab 83:1025-1028
6. Lau KM, Mok SC, Ho SM (1999) Expression of human estrogen receptor-α and -β, progesterone receptor and androgen receptor mRNA in normal and malignant ovarian epithelial cells. Proc Natl Acad Sci USA 96:5722-5727
7. Giguere V, Yang N, Segui P, Evans RM (1988) Identification of a new class of steroid hormone receptors. Nature 331:91-94
8. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P (1995) The nuclear receptor superfamily: the second decade. Cell 83:835-839
9. Giguere V (1999) Orphan nuclear receptors: from gene to function. Endocr Rev 20:689-725
10. Horard B, Vanacker JM (2003) Estrogen receptor-related receptors: orphan receptors desperately seeking a ligand. J Mol Endocrinol 31:349-357
11. Giguere V (2002) To ERR in the estrogen pathway. Trends Endocrinol Metab 13:220-225
12. Chen S, Itoh T, Wu K, Zhou D, Yang C (2002) Transcriptional regulation of aromatase expression in human breast tissue. J Steroid Biochem Mol Biol 83:93-99
13. Lu D, Kiriyama Y, Lee KY, Giguere V (2001) Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors. Cancer Res 61: 6755-6761
14. Hong H, Yang L, Stallcup MR (1999) Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. J Biol Chem 274:22618-22626
15. Vanacker JM, Bonnelye E, Chopin-Delannoy S, Delmarre C, Cavailles V, Laudet V (1999) Transcriptional activities of the orphan nuclear receptor ERR alpha (estrogen receptor-related receptor-α). Mol Endocrinol 13:764-773
16. Vanacker JM, Pettersson K, Gustafsson JA, Laudet V (1999) Transcriptional targets shared by estrogen receptor-related receptors (ERRs) and estrogen receptor (ER) alpha but not by ER beta. EMBO J 18:4270-4279
17. Zhang Z, Teng CT (2000) Estrogen receptor-related receptor alpha-1 interacts with coactivator and constitutively activates the estrogen response elements of the human lactoferrin gene. J Biol Chem 275:20837-20846
18. Bonnelye E, Merdad L, Kung V, Aubin JE (2001) The orphan nuclear estrogen receptor-related receptor alpha (ERR alpha) is expressed throughout osteoblast differentiation and regulates bone formation in vitro. J Cell Biol 153:971-984
19. Yang N, Shigeta H, Shi H, Teng CT (1996) Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter. J Biol Chem 271:5795-5804
20. Yang C, Zhou D, Chen S (1998) Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan nuclear receptor. Cancer Res 58:5695-5700
21. Rollerova E, Urbancikova M (2000) Intracellular estrogen receptors, their characterization and function. Endocr Regul 34:203-218
22. Sanchez R, Nguyen D, Rocha W, White JH, Mader S (2002) Diversity in the mechanisms of gene regulation by estrogen receptors. BioEssays 24:244-254
23. Zhang Z, Teng CT (2001) Estrogen receptor α and estrogen receptor-related receptor alphal compete for binding and coactivator. Mol Cell Endocrinol 172:223-233
24. Akahira J, Suzuki T, Ito K, Kaneko C, Darnel AD, Moriya T, Okamura K, Yaegashi N, Sasano H (2002) Differential expression of progesterone receptor isoforms A and B in the normal ovary, and in benign, borderline, and malignant ovarian tumors. Jpn J Cancer Res 93:807-815
25. Kyo S, Kanaya T, Takakura M, Tanaka M, Yamashita A, Inoue H, Inoue M (1999) Expression of human telomerase subunits in ovarian malignant, borderline and benign tumors. Int J Cancer 80:804-809
26. Johnston SD, Liu X, Zuo F, Eisenbraun TL, Wiley SR, Kraus RJ, Mertz JE (1997) Estrogen-related receptor alpha1 functionally binds as a monomer to extended half-site sequence including ones contained within estrogen-response elements. Mol Endocrinol 11:342-352
27. Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM (1999) Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2. Mol Endocrinol 13:2151-2162
28. Kraus RJ, Ariazi EA, Farrell ML, Mertz JE (2002) Estrogen-related receptor α-1 actively antagonizes estrogen receptor-regulated transcription in MCF-7 mammary cells. J Biol Chem 277:24826-24834
29. Coward P, Lee D, Hull MV, Lehmann JM (2001) 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma. Proc Natl Acad Sci USA 98:8880-8884
30. Tremblay GB, Bergeron D, Giguere V (2001) 4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related (ERR) nuclear receptors beta and gamma. Endocrinology 142:4572-4575
31. Ariazi EA, Clark GM, Mertz JE (2002) Estrogen-related receptor alpha and estrogen-relate receptor gamma associated with unfavorable and favorable biomarkers, respectively, in human breast cancer. Cancer Res 62:6510-6518
32. Pettersson K, Svensson K, Mattsson R, Carlsson B, Ohlsson B, Berkenstam A (1996) Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech Dev 54:211-223
33. Tremblay GB, Kunath T, Bergeron D, Lapointe L, Champigny C, Bader JA, Rossant J, Giguere V (2001) Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta. Genes Dev 15:833-838
34. Luo J, Sladek R, Bader JA, Matthyssen A, Rossant J, Giguere V (1997) Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta. Nature 388:778-782
35. Russo J, Hu YF, Yang X, Russo IH (2000) Developmental, cellular and molecular basis of human breast cancer. J Natl Cancer Inst Monogr 27:17-37
36. Chen S, Zhou D, Yang C, Sherman M (2001) Molecular basis for the constitutive activity of estrogen-related receptor alpha-1. J Biol Chem 276:28465-28470
37. Yang C, Chen S (1999) Two organochlorine pesticides, toxaphene and chlordane, are antagonists for estrogen-related receptor alpha-1 orphan receptor. Cancer Res 59:4519-4524
38. Papadimitriou CA, Markaki S, Siapkaras J, Vlachos G, Efstathiou E, Grimani I, Hamilos G, Zorzou M, Dimopoulos MA (2004) Hormonal therapy with letrozole for relapsed epithelial ovarian cancer long-term results of a phase II study. Oncology 66:112-117
39. Williams CJ, Simera I (2004) Tamoxifen for relapse of ovarian cancer. The Cochrane Library, 3rd edn. Wiley, Chichester