Fluorescence in situ hybridization for detection of MAML2 rearrangements in oncocytic mucoepidermoid carcinomas: Utility as a diagnostic test

Human Pathology

Volumn 42, Issue 12, 2011, Pages 2001-2009

  García, Joaquin J ^a   Hunt, Jennifer L ^b   Weinreb, Ilan ^c   McHugh, Jonathan B ^d   Barnes, E Leon ^a   Cieply, Kathleen ^a   Dacic, Sanja ^a   Seethala, Raja R ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

FISH; MAML2; Mucoepidermoid carcinoma; Oncocytic; translocation

Indexed keywords

MAML2 PROTEIN; MUCOEPIDERMOID CARCINOMA TRANSLOCATED 1 PROTEIN; PROTEIN; PROTEIN P63; UNCLASSIFIED DRUG;

ADENOSQUAMOUS CARCINOMA; ADOLESCENT; ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER INVASION; CHILD; CHROMOSOME 11Q; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; MALE; SCHOOL CHILD; SEX RATIO; WARTHIN TUMOR;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, MUCOEPIDERMOID; CHILD; DNA-BINDING PROTEINS; FEMALE; FOLLOW-UP STUDIES; GENE REARRANGEMENT; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NUCLEAR PROTEINS; OXYPHIL CELLS; PAROTID GLAND; PAROTID NEOPLASMS; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC; TREATMENT OUTCOME;

EID: 80955158735     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2011.02.028     Document Type: Article

References (34)

1. F.W. Stewart, F.W. Foote, and W.F. Becker Mucoepidermoid tumors of salivary glands Ann Surg 122 1945 820 844
2. R.H. Spiro, A.G. Huvos, R. Berk, and E.W. Strong Mucoepidermoid carcinoma of salivary gland origin. A clinicopathologic study of 367 cases Am J Surg 136 1978 461 468 (Pubitemid 9027654)
3. H. Boukheris, R.E. Curtis, C.E. Land, and G.M. Dores Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States Cancer Epidemiol Biomarkers Prev 18 2009 2899 2906
4. R.K. Goode, P.L. Auclair, and G.L. Ellis Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria Cancer 82 1998 1217 1224 (Pubitemid 28155381)
5. M.S. Brandwein, K. Ivanov, and D.I. Wallace Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading Am J Surg Pathol 25 2001 835 845 (Pubitemid 32594976)
6. B. Jahan-Parwar, R.M. Huberman, D.T. Donovan, M.R. Schwartz, and M.L. Ostrowski Oncocytic mucoepidermoid carcinoma of the salivary glands Am J Surg Pathol 23 1999 523 529 (Pubitemid 29214954)
7. R.B. Brannon, and C.C. Willard Oncocytic mucoepidermoid carcinoma of parotid gland origin Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96 2003 727 733 (Pubitemid 37550080)
8. I. Weinreb, R.R. Seethala, B. Perez-Ordonez, R. Chetty, A.P. Hoschar, and J.L. Hunt Oncocytic mucoepidermoid carcinoma: clinicopathologic description in a series of 12 cases Am J Surg Pathol 33 2009 409 416
9. C. Martins, B. Cavaco, G. Tonon, F.J. Kaye, J. Soares, and I. Fonseca A study of MECT1-MAML2 in mucoepidermoid carcinoma and Warthin's tumor of salivary glands J Mol Diagn 6 2004 205 210 (Pubitemid 39136647)
10. G. Tonon, S. Modi, and L. Wu t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway Nat Genet 33 2003 208 213 (Pubitemid 36177076)
11. A. Behboudi, F. Enlund, and M. Winnes Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene Genes Chromosomes Cancer 45 2006 470 481
12. R.R. Seethala, S. Dacic, K. Cieply, L.M. Kelley, and M.N. Nikiforova A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas Am J Surg Pathol 34 2010 1106 1121
13. M.A. Luna Salivary mucoepidermoid carcinoma: revisited Adv Anat Pathol 13 2006 293 307 (Pubitemid 44673445)
14. J.B. McHugh, A.P. Hoschar, E.L. Barnes, and R.R. Seethala P63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma Head Neck Pathol 2 2007 123 131
15. A. Nordkvist, H. Gustafsson, M. Juberg-Ode, and G. Stenman Recurrent rearrangements of 11q14-22 in mucoepidermoid carcinoma Cancer Genet Cytogenet 74 1994 77 83 (Pubitemid 24208871)
16. M. Okabe, S. Miyabe, and H. Nagatsuka MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma Clin Cancer Res 12 2006 3902 3907 (Pubitemid 44078073)
17. S. Miyabe, M. Okabe, and H. Nagatsuka Prognostic significance of p27Kip1, Ki-67, and CRTC1-MAML2 fusion transcript in mucoepidermoid carcinoma: a molecular and clinicopathologic study of 101 cases J Oral Maxillofac Surg 67 2009 1432 1441
18. T. Nakayama, S. Miyabe, and M. Okabe Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma Mod Pathol 22 2009 1575 1581
19. Y. Tirado, M.D. Williams, E.Y. Hanna, F.J. Kaye, J.G. Batsakis, and A.K. El-Naggar CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior Genes Chromosomes Cancer 46 2007 708 715 (Pubitemid 46802338)
20. A. Fehr, K. Roser, K. Heidorn, C. Hallas, T. Loning, and J. Bullerdiek A new type of MAML2 fusion in mucoepidermoid carcinoma Genes Chromosomes Cancer 47 2008 203 206 (Pubitemid 351162851)
21. M.D. Conkright, G. Canettieri, and R. Screaton TORCs: transducers of regulated CREB activity Mol Cell 12 2003 413 423 (Pubitemid 37238928)
22. Iourgenko V., Zhang W., and Mickanin C. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells Proc Natl Acad Sci U S A 100 2003 12147 12152 (Pubitemid 37271529)
23. M. Winnes, F. Enlund, J. Mark, and G. Stenman The MECT1-MAML2 gene fusion and benign Warthin's tumor: is the MECT1-MAML2 gene fusion specific to mucuepidermoid carcinoma? J Mol Diagn 8 2006 394 395 author reply 5-6
24. F. Enlund, A. Behboudi, and Y. Andren Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors Exp Cell Res 292 2004 21 28 (Pubitemid 38058260)
25. D. Bell, M.A. Luna, R.S. Weber, F.J. Kaye, and A.K. El-Naggar CRTC1/MAML2 fusion transcript in Warthin's tumor and mucoepidermoid carcinoma: evidence for a common genetic association Genes Chromosomes Cancer 47 2008 309 314 (Pubitemid 351323760)
26. A. Fehr, K. Roser, G. Belge, T. Loning, and J. Bullerdiek A closer look at Warthin tumors and the t(11;19) Cancer Genet Cytogenet 180 2008 135 139
27. P.L. Auclair Tumor-associated lymphoid proliferation in the parotid gland. A potential diagnostic pitfall Oral Surg, Oral Med Oral Pathol 77 1994 19 26
28. K. Honda, K. Kashima, T. Daa, S. Yokoyama, and I. Nakayama Clonal analysis of the epithelial component of Warthin's tumor Hum Pathol 31 2000 1377 1380
29. M. Arida, E.L. Barnes, and J.L. Hunt Molecular assessment of allelic loss in Warthin tumors Mod Pathol 18 2005 964 968 (Pubitemid 41059958)
30. P.D. Lewis, S.R. Fradley, A.P. Griffiths, P.W. Baxter, J.M. Parry, and D.N.A. Mitochondrial mutations in the parotid gland of cigarette smokers and non-smokers Mutat Res 518 2002 47 54 (Pubitemid 34626844)
31. P.D. Lewis, P. Baxter, A. Paul Griffiths, J.M. Parry, and D.O. Skibinski Detection of damage to the mitochondrial genome in the oncocytic cells of Warthin's tumour J Pathol 191 2000 274 281 (Pubitemid 30441251)
32. J.G. Batsakis Carcinoma ex papillary cystadenoma lymphomatosum. Malignant Warthin's tumor Ann Otol Rhinol Laryngol 96 2 Pt 1 1987 234 235 (Pubitemid 17080417)
33. J.D. Williamson, B.H. Simmons, A. el-Naggar, and L.J. Medeiros Mucoepidermoid carcinoma involving Warthin tumor. A report of five cases and review of the literature Am J Clin Pathol 114 2000 564 570
34. D. Bell, and M.A. Luna Warthin adenocarcinoma: analysis of 2 cases of a distinct salivary neoplasm Ann Diagn Pathol 13 2009 201 207