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Volumn 3, Issue 3, 2013, Pages 105-109

Intrinsic bio-signature of gene delivery nanocarriers may impair gene therapy goals

Author keywords

Gene delivery; Gene therapy; Genotoxicity; Microarray; Nanotoxicology; Toxicogenomics

Indexed keywords

NANOCARRIER; NANOMATERIAL; NUCLEIC ACID; POLYCATION; POLYETHYLENEIMINE; POLYGLACTIN;

EID: 84887341756     PISSN: 22285652     EISSN: 22285660     Source Type: Journal    
DOI: 10.5681/bi.2013.028     Document Type: Article
Times cited : (28)

References (51)
  • 1
    • 0034915984 scopus 로고    scopus 로고
    • The future of human gene therapy
    • Rubanyi GM. The future of human gene therapy. Mol Aspects Med 2001;22:113-42.
    • (2001) Mol Aspects Med , vol.22 , pp. 113-42
    • Rubanyi, G.M.1
  • 2
    • 84874512835 scopus 로고    scopus 로고
    • Translational Approaches toward Cancer Gene Therapy: Hurdles and Hopes
    • Barar J, Omidi Y. Translational Approaches toward Cancer Gene Therapy: Hurdles and Hopes. BioImpacts 2012;2:127-43.
    • (2012) BioImpacts , vol.2 , pp. 127-43
    • Barar, J.1    Omidi, Y.2
  • 4
    • 0034328925 scopus 로고    scopus 로고
    • Gene therapy: trials and tribulations
    • Somia N, Verma IM. Gene therapy: trials and tribulations. Nat Rev Genet 2000;1:91-9.
    • (2000) Nat Rev Genet , vol.1 , pp. 91-9
    • Somia, N.1    Verma, I.M.2
  • 5
    • 0041383924 scopus 로고    scopus 로고
    • Clinical development of gene therapy for colorectal cancer
    • Kerr D. Clinical development of gene therapy for colorectal cancer. Nat Rev Cancer 2003;3:615-22.
    • (2003) Nat Rev Cancer , vol.3 , pp. 615-22
    • Kerr, D.1
  • 6
    • 0036788304 scopus 로고    scopus 로고
    • Gene silencing in mammals by small interfering RNAs
    • Mcmanus MT, Sharp PA. Gene silencing in mammals by small interfering RNAs. Nat Rev Genet 2002;3:737-47.
    • (2002) Nat Rev Genet , vol.3 , pp. 737-47
    • Mcmanus, M.T.1    Sharp, P.A.2
  • 7
    • 0031729897 scopus 로고    scopus 로고
    • Viral and non-viral vectors for cancer gene therapy
    • Cristiano RJ. Viral and non-viral vectors for cancer gene therapy. Anticancer Res 1998;18:3241-5.
    • (1998) Anticancer Res , vol.18 , pp. 3241-5
    • Cristiano, R.J.1
  • 8
    • 0035030198 scopus 로고    scopus 로고
    • Delivery systems intended for in vivo gene therapy of cancer: targeting and replication competent viral vectors
    • Galanis E, Vile R, Russell SJ. Delivery systems intended for in vivo gene therapy of cancer: targeting and replication competent viral vectors. Crit Rev Oncol Hematol 2001;38:177-92.
    • (2001) Crit Rev Oncol Hematol , vol.38 , pp. 177-92
    • Galanis, E.1    Vile, R.2    Russell, S.J.3
  • 9
    • 0037383050 scopus 로고    scopus 로고
    • Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research
    • Gehl J. Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research. Acta Physiol Scand 2003;177:437-47.
    • (2003) Acta Physiol Scand , vol.177 , pp. 437-47
    • Gehl, J.1
  • 10
    • 0036954247 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: nonviral vectors
    • Niidome T, Huang L. Gene therapy progress and prospects: nonviral vectors. Gene Ther 2002;9:1647-52.
    • (2002) Gene Ther , vol.9 , pp. 1647-52
    • Niidome, T.1    Huang, L.2
  • 11
    • 0038128173 scopus 로고    scopus 로고
    • Application of in vivo electroporation to cancer gene therapy
    • Tamura T, Sakata T. Application of in vivo electroporation to cancer gene therapy. Curr Gene Ther 2003;3:59-64.
    • (2003) Curr Gene Ther , vol.3 , pp. 59-64
    • Tamura, T.1    Sakata, T.2
  • 12
    • 0036229451 scopus 로고    scopus 로고
    • Cytotoxicity issues pertinent to lipoplex-mediated gene therapy in-vivo
    • Dass CR. Cytotoxicity issues pertinent to lipoplex-mediated gene therapy in-vivo. J Pharm Pharmacol 2002;54:593-601.
    • (2002) J Pharm Pharmacol , vol.54 , pp. 593-601
    • Dass, C.R.1
  • 13
    • 0036844766 scopus 로고    scopus 로고
    • In vivo characteristics of cationic liposomes as delivery vectors for gene therapy
    • Audouy SA, de Leij LF, Hoekstra D, Molema G. In vivo characteristics of cationic liposomes as delivery vectors for gene therapy. Pharm Res 2002;19:1599-605.
    • (2002) Pharm Res , vol.19 , pp. 1599-605
    • Audouy, S.A.1    de Leij, L.F.2    Hoekstra, D.3    Molema, G.4
  • 14
    • 0035941087 scopus 로고    scopus 로고
    • Gene therapy. Safer and virus-free?
    • Ferber D. Gene therapy. Safer and virus-free? Science 2001;294:1638-42.
    • (2001) Science , vol.294 , pp. 1638-42
    • Ferber, D.1
  • 15
    • 18044400701 scopus 로고    scopus 로고
    • Gene therapy. Repair kits for faulty genes
    • Ferber D. Gene therapy. Repair kits for faulty genes. Science 2001;294:1639.
    • (2001) Science , vol.294 , pp. 1639
    • Ferber, D.1
  • 16
    • 0032965398 scopus 로고    scopus 로고
    • Cationic lipid-mediated gene transfer: current concepts
    • Clark PR, Hersh EM. Cationic lipid-mediated gene transfer: current concepts. Curr Opin Mol Ther 1999;1:158-76.
    • (1999) Curr Opin Mol Ther , vol.1 , pp. 158-76
    • Clark, P.R.1    Hersh, E.M.2
  • 17
    • 0037805642 scopus 로고    scopus 로고
    • Cationic lipid vectors for plasmid DNA delivery
    • Hirko A, Tang F, Hughes JA. Cationic lipid vectors for plasmid DNA delivery. Curr Med Chem 2003;10:1185-93.
    • (2003) Curr Med Chem , vol.10 , pp. 1185-93
    • Hirko, A.1    Tang, F.2    Hughes, J.A.3
  • 18
    • 0037072576 scopus 로고    scopus 로고
    • Prospects for cationic polymers in gene and oligonucleotide therapy against cancer
    • Merdan T, Kopecek J, Kissel T. Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Adv Drug Deliv Rev 2002;54:715-58.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 715-58
    • Merdan, T.1    Kopecek, J.2    Kissel, T.3
  • 19
    • 0036220676 scopus 로고    scopus 로고
    • Progress in gene delivery by cationic lipids: guanidinium-cholesterol-based systems as an example
    • Aissaoui A, Oudrhiri N, Petit L, Hauchecorne M, Kan E, Sainlos M, et al. Progress in gene delivery by cationic lipids: guanidinium-cholesterol-based systems as an example. Curr Drug Targets 2002;3:1-16.
    • (2002) Curr Drug Targets , vol.3 , pp. 1-16
    • Aissaoui, A.1    Oudrhiri, N.2    Petit, L.3    Hauchecorne, M.4    Kan, E.5    Sainlos, M.6
  • 20
    • 61449164867 scopus 로고    scopus 로고
    • Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity
    • Ellinger-Ziegelbauer H, Aubrecht J, Kleinjans JC, Ahr HJ. Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity. Toxicol Lett 2009;186:36-44.
    • (2009) Toxicol Lett , vol.186 , pp. 36-44
    • Ellinger-Ziegelbauer, H.1    Aubrecht, J.2    Kleinjans, J.C.3    Ahr, H.J.4
  • 21
    • 21444432708 scopus 로고    scopus 로고
    • Gene expression profile analysis: an emerging approach to investigate mechanisms of genotoxicity
    • Aubrecht J, Caba E. Gene expression profile analysis: an emerging approach to investigate mechanisms of genotoxicity. Pharmacogenomics 2005;6:419-28.
    • (2005) Pharmacogenomics , vol.6 , pp. 419-28
    • Aubrecht, J.1    Caba, E.2
  • 22
    • 84555191516 scopus 로고    scopus 로고
    • How to analyze gene expression using RNA-sequencing data
    • Ramskold D, Kavak E, Sandberg R. How to analyze gene expression using RNA-sequencing data. Methods Mol Biol 2012;802:259-74.
    • (2012) Methods Mol Biol , vol.802 , pp. 259-74
    • Ramskold, D.1    Kavak, E.2    Sandberg, R.3
  • 23
    • 84876701689 scopus 로고    scopus 로고
    • A glance at DNA microarray technology and applications
    • Saei AA, Omidi Y. A glance at DNA microarray technology and applications. BioImpacts 2011;1:75-86.
    • (2011) BioImpacts , vol.1 , pp. 75-86
    • Saei, A.A.1    Omidi, Y.2
  • 24
    • 0028806048 scopus 로고
    • Quantitative monitoring of gene expression patterns with a complementary DNA microarray
    • Schena M, Shalon D, Davis RW, Brown PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 1995;270:467-70.
    • (1995) Science , vol.270 , pp. 467-70
    • Schena, M.1    Shalon, D.2    Davis, R.W.3    Brown, P.O.4
  • 26
    • 0347756922 scopus 로고    scopus 로고
    • Toxicogenomics of non-viral vectors for gene therapy: a microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells
    • Omidi Y, Hollins AJ, Benboubetra M, Drayton R, Benter IF, Akhtar S. Toxicogenomics of non-viral vectors for gene therapy: a microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells. J Drug Target 2003;11:311-23.
    • (2003) J Drug Target , vol.11 , pp. 311-23
    • Omidi, Y.1    Hollins, A.J.2    Benboubetra, M.3    Drayton, R.4    Benter, I.F.5    Akhtar, S.6
  • 27
    • 24644504130 scopus 로고    scopus 로고
    • Toxicogenomics of cationic lipid-based vectors for gene therapy: impact of microarray technology
    • Omidi Y, Barar J, Akhtar S. Toxicogenomics of cationic lipid-based vectors for gene therapy: impact of microarray technology. Curr Drug Deliv 2005;2:429-41.
    • (2005) Curr Drug Deliv , vol.2 , pp. 429-41
    • Omidi, Y.1    Barar, J.2    Akhtar, S.3
  • 28
    • 34248213490 scopus 로고    scopus 로고
    • Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity
    • Hollins AJ, Omidi Y, Benter IF, Akhtar S. Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity. JDrug Target 2007;15:83-8.
    • (2007) JDrug Target , vol.15 , pp. 83-8
    • Hollins, A.J.1    Omidi, Y.2    Benter, I.F.3    Akhtar, S.4
  • 29
    • 84869193974 scopus 로고    scopus 로고
    • Toxicogenomics of nonviral cationic gene delivery nanosystems
    • Yuan X, editor, Rijeka: InTech
    • Omidi Y, Kafil V, Barar J. Toxicogenomics of nonviral cationic gene delivery nanosystems. In: Yuan X, editor. Nonviral gene therapy. Rijeka: InTech; 2011. p. 547-76.
    • (2011) Nonviral gene therapy , pp. 547-76
    • Omidi, Y.1    Kafil, V.2    Barar, J.3
  • 30
    • 84877136426 scopus 로고    scopus 로고
    • EGFR antisense oligonucleotides encapsulated with nanoparticles decrease EGFR, MAPK1 and STAT5 expression in a human colon cancer cell line
    • Najar AG, Pashaei-Asl R, Omidi Y, Farajnia S, Nourazarian AR. EGFR antisense oligonucleotides encapsulated with nanoparticles decrease EGFR, MAPK1 and STAT5 expression in a human colon cancer cell line. Asian Pac J Cancer Prev 2013;14:495-8.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 495-8
    • Najar, A.G.1    Pashaei-Asl, R.2    Omidi, Y.3    Farajnia, S.4    Nourazarian, A.R.5
  • 31
    • 84874011455 scopus 로고    scopus 로고
    • Combined EGFR and c-Src antisense oligodeoxynucleotides encapsulated with PAMAM Denderimers inhibit HT-29 colon cancer cell proliferation
    • Nourazarian AR, Najar AG, Farajnia S, Khosroushahi AY, Pashaei-Asl R, Omidi Y. Combined EGFR and c-Src antisense oligodeoxynucleotides encapsulated with PAMAM Denderimers inhibit HT-29 colon cancer cell proliferation. Asian Pac J Cancer Prev 2012;13:4751-6.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 4751-6
    • Nourazarian, A.R.1    Najar, A.G.2    Farajnia, S.3    Khosroushahi, A.Y.4    Pashaei-Asl, R.5    Omidi, Y.6
  • 32
    • 84872678180 scopus 로고    scopus 로고
    • c-Src antisense complexed with PAMAM denderimes decreases of c-Src expression and EGFR-dependent downstream genes in the human HT-29 colon cancer cell line
    • Nourazarian AR, Pashaei-Asl R, Omidi Y, Najar AG. c-Src antisense complexed with PAMAM denderimes decreases of c-Src expression and EGFR-dependent downstream genes in the human HT-29 colon cancer cell line. Asian Pac J Cancer Prev 2012;13:2235-40.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 2235-40
    • Nourazarian, A.R.1    Pashaei-Asl, R.2    Omidi, Y.3    Najar, A.G.4
  • 33
    • 84887369889 scopus 로고    scopus 로고
    • The design and activity of small interfering RNA (siRNA) as a potential therapeutic agent for the down-regulation of the epidermal growth factor receptor (EGFR)
    • Fox S, Hollins A, Sohail M, Omidi Y, Southern E, Benboubetra M, et al. The design and activity of small interfering RNA (siRNA) as a potential therapeutic agent for the down-regulation of the epidermal growth factor receptor (EGFR). J Pharm Pharmacol 2004;56:28.
    • (2004) J Pharm Pharmacol , vol.56 , pp. 28
    • Fox, S.1    Hollins, A.2    Sohail, M.3    Omidi, Y.4    Southern, E.5    Benboubetra, M.6
  • 34
    • 84887387275 scopus 로고    scopus 로고
    • Polyethylenimine-mediated delivery of small interfering RNA targeting the epidermal growth factor receptor: a comparison of linear and branched polymer architecture
    • Hollins A, Omidi Y, Fox S, Griffiths S, Akhtar S. Polyethylenimine-mediated delivery of small interfering RNA targeting the epidermal growth factor receptor: a comparison of linear and branched polymer architecture. J Pharm Pharmacol 2004; 56: 53.
    • (2004) J Pharm Pharmacol , vol.56 , pp. 53
    • Hollins, A.1    Omidi, Y.2    Fox, S.3    Griffiths, S.4    Akhtar, S.5
  • 35
    • 1542511346 scopus 로고    scopus 로고
    • Evaluation of generation 2 and 3 poly(propylenimine) dendrimers for the potential cellular delivery of antisense oligonucleotides targeting the epidermal growth factor receptor
    • Hollins AJ, Benboubetra M, Omidi Y, Zinselmeyer BH, Schatzlein AG, Uchegbu IF, et al. Evaluation of generation 2 and 3 poly(propylenimine) dendrimers for the potential cellular delivery of antisense oligonucleotides targeting the epidermal growth factor receptor. Pharm Res 2004;21:458-66.
    • (2004) Pharm Res , vol.21 , pp. 458-66
    • Hollins, A.J.1    Benboubetra, M.2    Omidi, Y.3    Zinselmeyer, B.H.4    Schatzlein, A.G.5    Uchegbu, I.F.6
  • 36
    • 84886010774 scopus 로고    scopus 로고
    • Dendrimeric delivery systems for siRNA and gene therapy intrinsically alter gene expression in human epithelial cells
    • Omidi Y, Benboubetra M, Hollins A, Drayton R, Akhtar S. Dendrimeric delivery systems for siRNA and gene therapy intrinsically alter gene expression in human epithelial cells. J Pharm Pharmacol 2004; 56: 52.
    • (2004) J Pharm Pharmacol , vol.56 , pp. 52
    • Omidi, Y.1    Benboubetra, M.2    Hollins, A.3    Drayton, R.4    Akhtar, S.5
  • 37
    • 45949106581 scopus 로고    scopus 로고
    • Microarray analysis of the toxicogenomics and the genotoxic potential of a cationic lipid-based gene delivery nanosystem in human alveolar epithelial a549 cells
    • Omidi Y, Barar J, Heidari HR, Ahmadian S, Yazdi HA, Akhtar S. Microarray analysis of the toxicogenomics and the genotoxic potential of a cationic lipid-based gene delivery nanosystem in human alveolar epithelial a549 cells. Toxicol Mech Methods 2008;18:369-78.
    • (2008) Toxicol Mech Methods , vol.18 , pp. 369-78
    • Omidi, Y.1    Barar, J.2    Heidari, H.R.3    Ahmadian, S.4    Yazdi, H.A.5    Akhtar, S.6
  • 38
    • 70350336452 scopus 로고    scopus 로고
    • Genomic signature and toxicogenomics comparison of polycationic gene delivery nanosystems in human alveolar epithelial A549 cells
    • Barar J, Hamzeiy H, Mortazavi-Tabatabaei SA, Hashemi-Aghdam SE, Omidi Y. Genomic signature and toxicogenomics comparison of polycationic gene delivery nanosystems in human alveolar epithelial A549 cells. Daru 2009;17:139-47.
    • (2009) Daru , vol.17 , pp. 139-47
    • Barar, J.1    Hamzeiy, H.2    Mortazavi-Tabatabaei, S.A.3    Hashemi-Aghdam, S.E.4    Omidi, Y.5
  • 39
    • 84874951656 scopus 로고    scopus 로고
    • Cellular Trafficking and Subcellular Interactions of Cationic Gene Delivery Nanomaterials
    • Barar J, Omidi Y. Cellular Trafficking and Subcellular Interactions of Cationic Gene Delivery Nanomaterials. J Pharm Nut Sci 2011;1:68-81.
    • (2011) J Pharm Nut Sci , vol.1 , pp. 68-81
    • Barar, J.1    Omidi, Y.2
  • 40
    • 83655181480 scopus 로고    scopus 로고
    • Cytotoxic impacts of linear and branched polyethylenimine nanostructures in A431 cells
    • Kafil V, Omidi Y. Cytotoxic impacts of linear and branched polyethylenimine nanostructures in A431 cells. BioImpacts 2011;1:23-30.
    • (2011) BioImpacts , vol.1 , pp. 23-30
    • Kafil, V.1    Omidi, Y.2
  • 41
    • 68649083000 scopus 로고    scopus 로고
    • Induction of human alveolar epithelial cell growth factor receptors by dendrimeric nanostructures
    • Omidi Y, Barar J. Induction of human alveolar epithelial cell growth factor receptors by dendrimeric nanostructures. Int J Toxicol 2009;28:113-22.
    • (2009) Int J Toxicol , vol.28 , pp. 113-22
    • Omidi, Y.1    Barar, J.2
  • 42
    • 0035946624 scopus 로고    scopus 로고
    • Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications
    • Pedroso de Lima MC, Simoes S, Pires P, Faneca H, Duzgunes N. Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications. Adv Drug Deliv Rev 2001;47:277-94.
    • (2001) Adv Drug Deliv Rev , vol.47 , pp. 277-94
    • Pedroso de Lima, M.C.1    Simoes, S.2    Pires, P.3    Faneca, H.4    Duzgunes, N.5
  • 43
    • 0032579975 scopus 로고    scopus 로고
    • Liposomal transfection efficiency and toxicity on glioma cell lines: in vitro and in vivo studies
    • Bell H, Kimber WL, Li M, Whittle IR. Liposomal transfection efficiency and toxicity on glioma cell lines: in vitro and in vivo studies. Neuroreport 1998;9:793-8.
    • (1998) Neuroreport , vol.9 , pp. 793-8
    • Bell, H.1    Kimber, W.L.2    Li, M.3    Whittle, I.R.4
  • 44
    • 0037133088 scopus 로고    scopus 로고
    • Optimization of factors influencing the transfection efficiency of folate-PEG-folate-graft-polyethylenimine
    • Benns JM, Mahato RI, Kim SW. Optimization of factors influencing the transfection efficiency of folate-PEG-folate-graft-polyethylenimine. J Control Release 2002;79:255-69.
    • (2002) J Control Release , vol.79 , pp. 255-69
    • Benns, J.M.1    Mahato, R.I.2    Kim, S.W.3
  • 45
    • 2442534371 scopus 로고    scopus 로고
    • Transfection efficiency and cytotoxicity of cationic liposomes in salmonid cell lines of hepatocyte and macrophage origin
    • Romoren K, Thu BJ, Bols NC, Evensen O. Transfection efficiency and cytotoxicity of cationic liposomes in salmonid cell lines of hepatocyte and macrophage origin. Biochim Biophys Acta 2004;1663:127-34.
    • (2004) Biochim Biophys Acta , vol.1663 , pp. 127-34
    • Romoren, K.1    Thu, B.J.2    Bols, N.C.3    Evensen, O.4
  • 46
    • 0036725868 scopus 로고    scopus 로고
    • Non-viral approach toward gene therapy of cystic fibrosis lung disease
    • Bragonzi A, Conese M. Non-viral approach toward gene therapy of cystic fibrosis lung disease. Curr Gene Ther 2002;2:295-305.
    • (2002) Curr Gene Ther , vol.2 , pp. 295-305
    • Bragonzi, A.1    Conese, M.2
  • 47
    • 0034997403 scopus 로고    scopus 로고
    • Non-viral vectors in cancer gene therapy: principles and progress
    • Schatzlein AG. Non-viral vectors in cancer gene therapy: principles and progress. Anti-Cancer Drugs 2001;12:275-304.
    • (2001) Anti-Cancer Drugs , vol.12 , pp. 275-304
    • Schatzlein, A.G.1
  • 48
  • 49
    • 84898716476 scopus 로고    scopus 로고
    • Impacts of biodegradable polymers: Towards biomedical applications
    • Sharma SK, Mudhoo A, editors, Cambridge: Royal Society of Chemistry
    • Omidi Y, Davaran S. Impacts of biodegradable polymers: Towards biomedical applications. In: Sharma SK, Mudhoo A, editors. Handbook of applied biopolymer technology: Synthesis, degradation and applications. Cambridge: Royal Society of Chemistry; 2011. p. 388-418.
    • (2011) Handbook of applied biopolymer technology: Synthesis, degradation and applications , pp. 388-418
    • Omidi, Y.1    Davaran, S.2
  • 50
    • 30644478022 scopus 로고    scopus 로고
    • Polypropylenimine dendrimer-induced gene expression changes: the effect of complexation with DNA, dendrimer generation and cell type
    • Omidi Y, Hollins AJ, Drayton RM, Akhtar S. Polypropylenimine dendrimer-induced gene expression changes: the effect of complexation with DNA, dendrimer generation and cell type. J Drug Target 2005;13:431-43.
    • (2005) J Drug Target , vol.13 , pp. 431-43
    • Omidi, Y.1    Hollins, A.J.2    Drayton, R.M.3    Akhtar, S.4
  • 51
    • 0028535919 scopus 로고
    • Gene therapy: hopes, hypes, and hurdles
    • Verma IM. Gene therapy: hopes, hypes, and hurdles. Mol Med 1994;1:2-3.
    • (1994) Mol Med , vol.1 , pp. 2-3
    • Verma, I.M.1


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