Cytotoxic impacts of linear and branched polyethylenimine nanostructures in A431 cells

BioImpacts

Volumn 1, Issue 1, 2011, Pages 23-30

  Kafil, Vala ^a   Omidi, Yadollah ^a  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Akt kinase; Cationic polymers; Cytotoxicity; Gene delivery systems; Polyethylenimine

Indexed keywords

DNA; NANOMATERIAL; POLYETHYLENEIMINE; POLYMER; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; CELL DENSITY; CELL SUSPENSION; CELLULAR DISTRIBUTION; CHEMICAL STRUCTURE; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE DELIVERY SYSTEM; HUMAN; HUMAN CELL; INTERNALIZATION; PARTICLE SIZE; PHYSICAL CHEMISTRY; WESTERN BLOTTING; ZETA POTENTIAL;

EID: 83655181480     PISSN: 22285652     EISSN: 22285660     Source Type: Journal    
DOI: 10.5681/bi.2011.004     Document Type: Article

References (23)

1. Aravindan L, Bicknell KA, Brooks G, Khutoryanskiy VV and Williams AC. 2009. Effect of acyl chain length on transfection efficiency and toxicity of polyethylenimine. Int J Pharm, 378(1-2), 201-210.
2. Boussif O, Lezoualc'h F, Zanta MA, Mergny MD, Scherman D, Demeneix B et al. 1995. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A, 92(16), 7297-7301.
3. Conwell CC and Huang L. 2005. Recent advances in non-viral gene delivery. Adv Genet, 53 3-18.
4. Dai J, Zou S, Pei Y, Cheng D, Ai H and Shuai X. 2011. Polyethylenimine-grafted copolymer of poly(l-lysine) and poly(ethylene glycol) for gene delivery. Biomaterials, 32(6), 1694-1705.
5. Davis ME. 2002. Non-viral gene delivery systems. Curr Opin Biotechnol, 13(2), 128-131.
6. Florea BI, Meaney C, Junginger HE and Borchard G. 2002. Transfection efficiency and toxicity of polyethylenimine in differentiated Calu-3 and nondifferentiated COS-1 cell cultures. AAPS PharmSci, 4(3), E12.
7. Forrest ML, Koerber JT and Pack DW. 2003. A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery. Bioconjug Chem, 14(5), 934-940.
8. Hollins AJ, Omidi Y, Benter IF and Akhtar S. 2007. Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity. J Drug Target, 15(1), 83-88.
9. Lechardeur D and Lukacs GL. 2006. Nucleocytoplasmic transport of plasmid DNA: a perilous journey from the cytoplasm to the nucleus. Hum Gene Ther, 17(9), 882-889.
10. Leclercq F, Dubertret C, Pitard B, Scherman D and Herscovici J. 2000. Synthesis of glycosylated polyethylenimine with reduced toxicity and high transfecting efficiency. Bioorg Med Chem Lett, 10(11), 1233-1235.
11. Lungwitz U, Breunig M, Blunk T and Gopferich A. 2005. Polyethylenimine-based non-viral gene delivery systems. Eur J Pharm Biopharm, 60(2), 247-266.
12. Moret I, Esteban PJ, Guillem VM, Benet M, Revert F, Dasi F et al. 2001. Stability of PEI-DNA and DOTAP-DNA complexes: effect of alkaline pH, heparin and serum. J Control Release, 76(1-2), 169-181.
13. Omidi Y and Barar J. 2009. Induction of human alveolar epithelial cell growth factor receptors by dendrimeric nanostructures. Int J Toxicol, 28(2), 113-122.
14. Omidi Y, Barar J and Akhtar S. 2005a. Toxicogenomics of cationic lipid-based vectors for gene therapy: impact of microarray technology. Curr Drug Deliv, 2(4), 429-441.
15. Omidi Y, Barar J, Heidari HR, Ahmadian S, Yazdi HA and Akhtar S. 2008. Microarray analysis of the toxicogenomics and the genotoxic potential of a cationic lipid-based gene delivery nanosystem in human alveolar epithelial A549 cells. Toxicol Mech Methods, 18(4), 369-378
16. Omidi Y, Hollins AJ, Drayton RM and Akhtar S. 2005b. Polypropylenimine dendrimer-induced gene expression changes: the effect of complexation with DNA, dendrimer generation and cell type. J Drug Target, 13(7), 431-443.
17. Oskuee RK, Dehshahri A, Shier WT and Ramezani M. 2009. Alkylcarboxylate grafting to polyethylenimine: a simple approach to producing a DNA nanocarrier with low toxicity. J Gene Med, 11(10), 921-932.
18. Peng L, Jiang H and Bradely C. 2002. Detection of B lymphoma cells undergoing apoptosis by Annexin-V assay. Chin Med Sci J, 17(1), 17-21.
19. Steele TW and Shier WT. 2010. Dendrimeric alkylated polyethylenimine nano-carriers with acid-cleavable outer cationic shells mediate improved transfection efficiency without increasing toxicity. Pharm Res, 27(4), 683-698.
20. Wen Y, Pan S, Luo X, Zhang X, Zhang W and Feng M. 2009. A biodegradable low molecular weight polyethylenimine derivative as low toxicity and efficient gene vector. Bioconjug Chem, 20(2), 322-332.
21. Wiethoff CM, Smith JG, Koe GS and Middaugh CR. 2001. The potential role of proteoglycans in cationic lipid-mediated gene delivery. Studies of the interaction of cationic lipid-DNA complexes with model glycosaminoglycans. J Biol Chem, 276(35), 32806-32813.
22. Xiong MP, Forrest ML, Ton G, Zhao A, Davies NM and Kwon GS. 2007. Poly(aspartate-g-PEI800), a polyethylenimine analogue of low toxicity and high transfection efficiency for gene delivery. Biomaterials, 28(32), 4889-4900.
23. Yoon CS, Jung HS, Kim TK, Kwon MJ, Kim MK, Lee M et al. 2008. Comparison of the efficiency and toxicity of sonoporation with branched polyethylenimine-mediated gene transfection in various cultured cell lines. J Drug Target, 16(10), 773-779.