Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation

Neurobiology of Aging

Volumn 35, Issue 2, 2014, Pages 421-430

  Lu, Ming ^a   Sun, Xiu Lan ^a   Qiao, Chen ^a   Liu, Yang ^a   Ding, Jian Hua ^a   Hu, Gang ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Astrocyte; Endoplasmic reticulum stress; Neuroinflammation; Parkinson's disease; Uncoupling protein 2

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CASPASE 12; CCAAT ENHANCER BINDING PROTEIN; INFLAMMASOME; NOD LIKE RECEPTOR PROTEIN 3 INFLAMMASOME; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; ASTROCYTE CULTURE; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ENDOPLASMIC RETICULUM STRESS; GENE INACTIVATION; MESENCEPHALON; MOUSE; MURINE MODEL; NERVOUS SYSTEM INFLAMMATION; NEWBORN; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION;

ASTROCYTE; ENDOPLASMIC RETICULUM STRESS; NEUROINFLAMMATION; PARKINSON'S DISEASE; UNCOUPLING PROTEIN 2;

ANIMALS; ASTROCYTES; CARRIER PROTEINS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GLIAL FIBRILLARY ACIDIC PROTEIN; HOMEOSTASIS; INFLAMMASOMES; INTERLEUKIN-1BETA; ION CHANNELS; L-LACTATE DEHYDROGENASE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXIDATION-REDUCTION; PARKINSON DISEASE; PARKINSONIAN DISORDERS; REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE 3-MONOOXYGENASE;

EID: 84887227883     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2013.08.015     Document Type: Article

References (54)

1. Allaman I., Belanger M., Magistretti P.J. Astrocyte-neuron metabolic relationships: for better and for worse. Trends Neurosci. 2011, 34:76-87.
2. Andrews Z.B. Uncoupling protein-2 and the potential link between metabolism and longevity. Curr. Aging Sci. 2010, 3:102-112.
3. Andrews Z.B., Diano S., Horvath T.L. Mitochondrial uncoupling proteins in the CNS: in support of function and survival. Nat. Rev. Neurosci. 2005, 6:829-840.
4. Andrews Z.B., Horvath B., Barnstable C.J., Elsworth J., Yang L., Beal M.F., Roth R.H., Matthews R.T., Horvath T.L. Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. J.Neurosci. 2005, 25:184-191.
5. Arduino D.M., Esteves A.R., Cardoso S.M., Oliveira C.R. Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: relevance to Parkinson's disease. Neurochem. Int. 2009, 55:341-348.
6. Arsenijevic D., Onuma H., Pecqueur C., Raimbault S., Manning B.S., Miroux B., Couplan E., Alves-Guerra M.C., Goubern M., Surwit R., Bouillaud F., Richard D., Collins S., Ricquier D. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat. Genet. 2000, 26:435-439.
7. Azzu V., Brand M.D. The on-off switches of the mitochondrial uncoupling proteins. Trends Biochem. Sci. 2010, 35:298-307.
8. Baker R.G., Hayden M.S., Ghosh S. NF-kappaB, inflammation, and metabolic disease. Cell Metab. 2011, 13:11-22.
9. Bakhshi J., Weinstein L., Poksay K.S., Nishinaga B., Bredesen D.E., Rao R.V. Coupling endoplasmic reticulum stress to the cell death program in mouse melanoma cells: effect of curcumin. Apoptosis 2008, 13:904-914.
10. Bence N.F., Sampat R.M., Kopito R.R. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 2001, 292:1552-1555.
11. Bernardo A., Minghetti L. Regulation of glial cell functions by PPAR-gamma natural and synthetic agonists. PPAR Res. 2008, 2008:864140.
12. Brand M.D., Esteves T.C. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab. 2005, 2:85-93.
13. Brand M.D., Parker N., Affourtit C., Mookerjee S.A., Azzu V. Mitochondrial uncoupling protein 2 in pancreatic beta-cells. Diabetes Obes. Metab. 2010, 12(suppl2):134-140.
14. Bueler H. Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease. Exp. Neurol. 2009, 218:235-246.
15. Chen L.W., Yung K.L., Chan Y.S. Reactive astrocytes as potential manipulation targets in novel cell replacement therapy of Parkinson's disease. Curr. Drug Targets 2005, 6:821-833.
16. Chen P.C., Vargas M.R., Pani A.K., Smeyne R.J., Johnson D.A., Kan Y.W., Johnson J.A. Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: critical role for the astrocyte. Proc. Natl. Acad. Sci. U.S.A 2009, 106:2933-2938.
17. Cudna R.E., Dickson A.J. Endoplasmic reticulum signaling as a determinant of recombinant protein expression. Biotechnol. Bioeng. 2003, 81:56-65.
18. Echtay K.S., Winkler E., Frischmuth K., Klingenberg M. Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone). Proc. Natl. Acad. Sci. U.S.A 2001, 98:1416-1421.
19. Eda H., Shimada H., Beidler D.R., Monahan J.B. Proinflammatory cytokines, IL-1beta and TNF-alpha, induce expression of interleukin-34 mRNA via JNK- and p44/42 MAPK-NF-kappaB pathway but not p38 pathway in osteoblasts. Rheumatol. Int. 2010, 31:1525-1530.
20. Egawa N., Yamamoto K., Inoue H., Hikawa R., Nishi K., Mori K., Takahashi R. The endoplasmic reticulum stress sensor, ATF6alpha, protects against neurotoxin-induced dopaminergic neuronal death. J.Biol. Chem. 2011, 286:7947-7957.
21. Emre Y., Hurtaud C., Karaca M., Nubel T., Zavala F., Ricquier D. Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes. Proc. Natl. Acad. Sci. U.S.A 2007, 104:19085-19090.
22. Gao H.M., Liu B., Hong J.S. Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J.Neurosci. 2003, 23:6181-6187.
23. Ghosh S., Hayden M.S. New regulators of NF-kappaB in inflammation. Nat. Rev. Immunol. 2008, 8:837-848.
24. Hara H., Kamiya T., Adachi T. Endoplasmic reticulum stress inducers provide protection against 6-hydroxydopamine-induced cytotoxicity. Neurochem. Int. 2011, 58:35-43.
25. Himeda T., Watanabe Y., Tounai H., Hayakawa N., Kato H., Araki T. Time dependent alterations of co-localization of S100beta and GFAP in the MPTP-treated mice. J.Neural. Transm. 2006, 113:1887-1894.
26. Ho P.W., Liu H.F., Ho J.W., Zhang W.Y., Chu A.C., Kwok K.H., Ge X., Chan K.H., Ramsden D.B., Ho S.L. Mitochondrial uncoupling protein-2 (UCP2) mediates leptin protection against MPP+ toxicity in neuronal cells. Neurotox. Res. 2010, 17:332-343.
27. Iravani M.M., Kashefi K., Mander P., Rose S., Jenner P. Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration. Neuroscience 2002, 110:49-58.
28. Knott C., Stern G., Wilkin G.P. Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2. Mol. Cell. Neurosci. 2000, 16:724-739.
29. Krauss S., Zhang C.Y., Lowell B.B. The mitochondrial uncoupling-protein homologues. Nat. Rev. Mol. Cell Biol. 2005, 6:248-261.
30. Lemasters J.J. Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism. J.Gastroenterol. Hepatol. 2007, 22(suppl 1):S31-S37.
31. Liu H.T., Akita T., Shimizu T., Sabirov R.Z., Okada Y. Bradykinin-induced astrocyte-neuron signalling: glutamate release is mediated by ROS-activated volume-sensitive outwardly rectifying anion channels. J.Physiol. 2009, 587:2197-2209.
32. Mailloux R.J., Harper M.E. Uncoupling proteins and the control of mitochondrial reactive oxygen species production. Free Radic. Biol. Med. 2011, 51:1106-1115.
33. Mattiasson G., Sullivan P.G. The emerging functions of UCP2 in health, disease, and therapeutics. Antioxid. Redox Signal 2006, 8:1-38.
34. McGeer P.L., McGeer E.G. Inflammation and neurodegeneration in Parkinson's disease. Parkinsonism Relat. Disord. 2004, 10(suppl 1):S3-S7.
35. Morais V.A., De Strooper B. Mitochondria dysfunction and neurodegenerative disorders: Cause or consequence. J.Alzheimers Dis. 2010, 20(suppl 2):S255-S263.
36. Moreno S., Farioli-Vecchioli S., Ceru M.P. Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS. Neuroscience 2004, 123:131-145.
37. Pi J., Collins S. Reactive oxygen species and uncoupling protein 2 in pancreatic beta-cell function. Diabetes Obes. Metab. 2010, 12(suppl 2):141-148.
38. Rao R.V., Ellerby H.M., Bredesen D.E. Coupling endoplasmic reticulum stress to the cell death program. Cell. Death. Differ. 2004, 11:372-380.
39. Rao R.V., Hermel E., Castro-Obregon S., del Rio G., Ellerby L.M., Ellerby H.M., Bredesen D.E. Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J.Biol. Chem. 2001, 276:33869-33874.
40. Rousset S., Emre Y., Join-Lambert O., Hurtaud C., Ricquier D., Cassard-Doulcier A.M. The uncoupling protein 2 modulates the cytokine balance in innate immunity. Cytokine 2006, 35:135-142.
41. Rutkowski D.T., Kaufman R.J. Atrip to the ER: coping with stress. Trends Cell Biol. 2004, 14:20-28.
42. Ryu E.J., Harding H.P., Angelastro J.M., Vitolo O.V., Ron D., Greene L.A. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J.Neurosci. 2002, 22:10690-10698.
43. Schintu N., Frau L., Ibba M., Garau A., Carboni E., Carta A.R. Progressive dopaminergic degeneration in the chronic MPTPp mouse model of Parkinson's disease. Neurotox. Res. 2009, 16:127-139.
44. Simpson J.E., Ince P.G., Haynes L.J., Theaker R., Gelsthorpe C., Baxter L., Forster G., Lace G.L., Shaw P.J., Matthews F.E., Savva G.M., Brayne C., Wharton S.B. Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathol. Appl. Neurobiol. 2010, 36:25-40.
45. Straus D.S., Glass C.K. Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol. 2007, 28:551-558.
46. Teismann P., Schulz J.B. Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation. Cell Tissue Res. 2004, 318:149-161.
47. Triantafilou K., Hughes T.R., Triantafilou M., Morgan B.P. The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation. J.Cell Sci. 2013, 126:2903-2913.
48. Van Laar V.S., Berman S.B. Mitochondrial dynamics in Parkinson's disease. Exp. Neurol. 2009, 218:247-256.
49. Verkhratsky A. Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons. Physiol. Rev. 2005, 85:201-279.
50. Wen H., Ting J.P., O'Neill L.A. Arole for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation?. Nature Immunol. 2012, 13:352-357.
51. West M.J. New stereological methods for counting neurons. Neurobiol. Aging 1993, 14:275-285.
52. Yonezawa T., Kurata R., Hosomichi K., Kono A., Kimura M., Inoko H. Nutritional and hormonal regulation of uncoupling protein 2. IUBMB Life 2009, 61:1123-1131.
53. Zhang C.Y., Baffy G., Perret P., Krauss S., Peroni O., Grujic D., Hagen T., Vidal-Puig A.J., Boss O., Kim Y.B., Zheng X.X., Wheeler M.B., Shulman G.I., Chan C.B., Lowell B.B. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 2001, 105:745-755.
54. Zhou C., Huang Y., Przedborski S. Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance. Ann. N. Y. Acad. Sci. 2008, 1147:93-104.