Next generation diagnostics in inherited arrhythmia syndromes: A comparison of two approaches

Journal of Cardiovascular Translational Research

Volumn 6, Issue 1, 2013, Pages 94-103

  Ware, James S ^a,b   John, Shibu ^c   Roberts, Angharad M ^a   Buchan, Rachel ^a   Gong, Sungsam ^c   Peters, Nicholas S ^b   Robinson, David O ^d   Lucassen, Anneke ^d,e   Behr, Elijah R ^f   Cook, Stuart A ^a,c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^d SALISBURY NHS FOUNDATION TRUST   (United Kingdom)

^e UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^f ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Genetics; Inherited cardiac conditions; Ion channels; Long QT syndrome; Molecular diagnosis; Next generation sequencing

Indexed keywords

RYANODINE RECEPTOR 2;

ARTICLE; BIOASSAY; DNA HYBRIDIZATION; GENE SEQUENCE; GENE STRUCTURE; GENE TARGETING; GENETIC VARIABILITY; HEART ARRHYTHMIA; HIGH THROUGHPUT SEQUENCING; HUMAN; INHERITED ARRHYTHMIA SYNDROME; INTERMETHOD COMPARISON; MOLECULAR DIAGNOSIS; NEXT GENERATION SEQUENCING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SENSITIVITY ANALYSIS;

ARRHYTHMIAS, CARDIAC; DNA MUTATIONAL ANALYSIS; ETHER-A-GO-GO POTASSIUM CHANNELS; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; HEREDITY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; ION CHANNELS; KCNQ1 POTASSIUM CHANNEL; MUTATION; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; POLYMERASE CHAIN REACTION; POTASSIUM CHANNELS, VOLTAGE-GATED; PREDICTIVE VALUE OF TESTS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SENSITIVITY AND SPECIFICITY;

EID: 84872596130     PISSN: 19375387     EISSN: 19375395     Source Type: Journal    
DOI: 10.1007/s12265-012-9401-8     Document Type: Article

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