Potential roles of PI3K/Akt and Nrf2-Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation

Neuropharmacology

Volumn 62, Issue 4, 2012, Pages 1659-1670

  Qi, Hongyi ^a   Han, Yifan ^b   Rong, Jianhui ^a  

^a THE UNIVERSITY OF HONG KONG   (Hong Kong)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Heme oxygenase 1; Hormetic effect; Nrf2 pathway; Oxygen glucose deprivation; PI3K; Z ligustilide

Indexed keywords

GLUCOSE; GLUTATHIONE; HEME OXYGENASE 1; LIGUSTILIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OXYGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; Z LIGUSTILIDE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BIOSYNTHESIS; CELL DAMAGE; CELL HYPOXIA; CELL PROTECTION; CELLULAR STRESS RESPONSE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INDUCTION; HORMESIS; INTRACELLULAR SPACE; MOLECULAR INTERACTION; NERVE CELL NECROSIS; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

4-BUTYROLACTONE; ANIMALS; ANOXIA; GLUCOSE; HEME OXYGENASE-1; HORMESIS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PC12 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84856429809     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.11.012     Document Type: Article

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