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Volumn 54, Issue 2, 2013, Pages 211-223

Progress and prospects for genetic modification of nonhuman primate models in biomedical research

Author keywords

Animal model; Human diseases; Nonhuman primates; Transgenesis

Indexed keywords

ANIMAL; ANIMAL DISEASE; ANIMAL MODEL; ARTICLE; DISEASE MODEL; GENE TRANSFER; GENETIC DISORDER; GENETICS; HUMAN; HUMAN DISEASES; MACACA; NONHUMAN PRIMATES; TRANSGENIC ANIMAL; TRANSGENICS;

EID: 84887100741     PISSN: 10842020     EISSN: 19306180     Source Type: Journal    
DOI: 10.1093/ilar/ilt035     Document Type: Article
Times cited : (67)

References (224)
  • 1
  • 2
    • 0038343499 scopus 로고    scopus 로고
    • MicroRNA pathways in flies and worms: Growth, death, fat, stress, and timing
    • Ambros V. 2003. MicroRNA pathways in flies and worms: Growth, death, fat, stress, and timing. Cell 113:673-676.
    • (2003) Cell , vol.113 , pp. 673-676
    • Ambros, V.1
  • 3
    • 53549101290 scopus 로고    scopus 로고
    • The evolution of our thinking about microRNAs
    • Ambros V. 2008. The evolution of our thinking about microRNAs. Nat Med 14:1036-1040.
    • (2008) Nat Med , vol.14 , pp. 1036-1040
    • Ambros, V.1
  • 5
    • 33947604998 scopus 로고    scopus 로고
    • Complex movement behaviour and progression of Huntington's disease
    • Andrich J, Saft C, Ostholt N, Muller T. 2007. Complex movement behaviour and progression of Huntington's disease. Neurosci Lett 416:272-274.
    • (2007) Neurosci Lett , vol.416 , pp. 272-274
    • Andrich, J.1    Saft, C.2    Ostholt, N.3    Muller, T.4
  • 6
    • 83155190329 scopus 로고    scopus 로고
    • Behavioral outcomes of late-onset or early-onset orbital frontal cortex (areas 11/13) lesions in rhesus monkeys
    • Bachevalier J, Machado CJ, Kazama A. 2011. Behavioral outcomes of late-onset or early-onset orbital frontal cortex (areas 11/13) lesions in rhesus monkeys. Ann N YAcad Sci 1239:71-86.
    • (2011) Ann N YAcad Sci , vol.1239 , pp. 71-86
    • Bachevalier, J.1    Machado, C.J.2    Kazama, A.3
  • 7
    • 0034967522 scopus 로고    scopus 로고
    • Effects of selective neonatal temporal lobe lesions on socioemotional behavior in infant rhesus monkeys (Macaca mulatta)
    • Bachevalier J, Malkova L, Mishkin M. 2001. Effects of selective neonatal temporal lobe lesions on socioemotional behavior in infant rhesus monkeys (Macaca mulatta). Behav Neurosci 115:545-559.
    • (2001) Behav Neurosci , vol.115 , pp. 545-559
    • Bachevalier, J.1    Malkova, L.2    Mishkin, M.3
  • 8
    • 38349087744 scopus 로고    scopus 로고
    • Memory for spatial location and objectplace associations are differently processed by the hippocampal formation, parahippocampal areas TH/TF and perirhinal cortex
    • Bachevalier J, Nemanic S. 2008. Memory for spatial location and objectplace associations are differently processed by the hippocampal formation, parahippocampal areas TH/TF and perirhinal cortex. Hippocampus 18:64-80.
    • (2008) Hippocampus , vol.18 , pp. 64-80
    • Bachevalier, J.1    Nemanic, S.2
  • 10
    • 0036630340 scopus 로고    scopus 로고
    • Are peripheral blood cells from patients with Alzheimer disease more sensitive to apoptotic stimuli?
    • Bergman M, Salman H, Beloosesky Y, Djaldetti M, Bessler H. 2002. Are peripheral blood cells from patients with Alzheimer disease more sensitive to apoptotic stimuli? Alzheimer Dis Assoc Disord 16:156-160.
    • (2002) Alzheimer Dis Assoc Disord , vol.16 , pp. 156-160
    • Bergman, M.1    Salman, H.2    Beloosesky, Y.3    Djaldetti, M.4    Bessler, H.5
  • 11
    • 67649945834 scopus 로고    scopus 로고
    • Gene expression and mRNA editing of serotonin receptor 2C in brains of HPRT gene knock-out mice, an animal model of Lesch-Nyhan disease
    • Bertelli M, Alushi B, Veicsteinas A, Jinnah HA, Micheli V. 2009. Gene expression and mRNA editing of serotonin receptor 2C in brains of HPRT gene knock-out mice, an animal model of Lesch-Nyhan disease. J Clin Neurosci 16:1061-1063.
    • (2009) J Clin Neurosci , vol.16 , pp. 1061-1063
    • Bertelli, M.1    Alushi, B.2    Veicsteinas, A.3    Jinnah, H.A.4    Micheli, V.5
  • 15
    • 26444621497 scopus 로고    scopus 로고
    • Millisecond-timescale, genetically targeted optical control of neural activity
    • Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K. 2005. Millisecond-timescale, genetically targeted optical control of neural activity. Nature Neurosci 8:1263-1268.
    • (2005) Nature Neurosci , vol.8 , pp. 1263-1268
    • Boyden, E.S.1    Zhang, F.2    Bamberg, E.3    Nagel, G.4    Deisseroth, K.5
  • 18
    • 84863085579 scopus 로고    scopus 로고
    • Pluripotent stem cells models for Huntington's disease: prospects and challenges
    • Carter RL, Chan AW. 2012. Pluripotent stem cells models for Huntington's disease: prospects and challenges. J Genet Genomics 39:253-259.
    • (2012) J Genet Genomics , vol.39 , pp. 253-259
    • Carter, R.L.1    Chan, A.W.2
  • 20
    • 35348877164 scopus 로고    scopus 로고
    • Transcriptional signatures in Huntington's disease
    • Cha JH. 2007. Transcriptional signatures in Huntington's disease. Prog Neurobiol 83:228-248.
    • (2007) Prog Neurobiol , vol.83 , pp. 228-248
    • Cha, J.H.1
  • 21
    • 77957916358 scopus 로고    scopus 로고
    • Reprogramming Huntington monkey skin cells into pluripotent stem cells
    • Chan AW, Cheng PH, Neumann A, Yang JJ. 2010. Reprogramming Huntington monkey skin cells into pluripotent stem cells. Cell Reprogram 12:509-517.
    • (2010) Cell Reprogram , vol.12 , pp. 509-517
    • Chan, A.W.1    Cheng, P.H.2    Neumann, A.3    Yang, J.J.4
  • 22
    • 0035847075 scopus 로고    scopus 로고
    • Transgenic monkeys produced by retroviral gene transfer into mature oocytes
    • Chan AW, Chong KY, Martinovich C, Simerly C, Schatten G. 2001. Transgenic monkeys produced by retroviral gene transfer into mature oocytes. Science 291:309-312.
    • (2001) Science , vol.291 , pp. 309-312
    • Chan, A.W.1    Chong, K.Y.2    Martinovich, C.3    Simerly, C.4    Schatten, G.5
  • 24
    • 0033982494 scopus 로고    scopus 로고
    • Foreign DNA transmission by ICSI: Injection of spermatozoa bound with exogenous DNA results in embryonic GFP expression and live rhesus monkey births
    • Chan AW, Luetjens CM, Dominko T, Ramalho-Santos J, Simerly CR, Hewitson L, Schatten G. 2000a. Foreign DNA transmission by ICSI: Injection of spermatozoa bound with exogenous DNA results in embryonic GFP expression and live rhesus monkey births. Mol Hum Reprod 6:26-33.
    • (2000) Mol Hum Reprod , vol.6 , pp. 26-33
    • Chan, A.W.1    Luetjens, C.M.2    Dominko, T.3    Ramalho-Santos, J.4    Simerly, C.R.5    Hewitson, L.6    Schatten, G.7
  • 27
    • 4344712165 scopus 로고    scopus 로고
    • Transgenic nonhuman primates of neurodegenerative diseases
    • Chan AWS. 2004. Transgenic nonhuman primates of neurodegenerative diseases. Reprod Biol Endocrinol 2:39.
    • (2004) Reprod Biol Endocrinol , vol.2 , pp. 39
    • Chan, A.W.S.1
  • 31
    • 84858627916 scopus 로고    scopus 로고
    • Using stem cells and iPS cells to discover new treatments for Parkinson's disease
    • Cooper O, Hallett P, Isacson O. 2012. Using stem cells and iPS cells to discover new treatments for Parkinson's disease. Parkinsonism Relat Disord 18 Suppl 1: S14-16.
    • (2012) Parkinsonism Relat Disord 18 Suppl , vol.1
    • Cooper, O.1    Hallett, P.2    Isacson, O.3
  • 32
    • 77956613688 scopus 로고    scopus 로고
    • Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid
    • Cooper O, Hargus G, Deleidi M, Blak A, Osborn T, Marlow E, Lee K, Levy A, Perez-Torres E, Yow A, Isacson O. 2010. Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Mol Cell Neurosci 45:258-266.
    • (2010) Mol Cell Neurosci , vol.45 , pp. 258-266
    • Cooper, O.1    Hargus, G.2    Deleidi, M.3    Blak, A.4    Osborn, T.5    Marlow, E.6    Lee, K.7    Levy, A.8    Perez-Torres, E.9    Yow, A.10    Isacson, O.11
  • 34
    • 79551655290 scopus 로고    scopus 로고
    • Huntington's disease: Can mice lead the way to treatment?
    • Crook ZR, Housman D. 2011. Huntington's disease: Can mice lead the way to treatment? Neuron 69:423-435.
    • (2011) Neuron , vol.69 , pp. 423-435
    • Crook, Z.R.1    Housman, D.2
  • 36
    • 84861615371 scopus 로고    scopus 로고
    • Optogenetics and psychiatry: Applications, challenges, and opportunities
    • Deisseroth K. 2012. Optogenetics and psychiatry: Applications, challenges, and opportunities. Biol Psychiatry 71:1030-1032.
    • (2012) Biol Psychiatry , vol.71 , pp. 1030-1032
    • Deisseroth, K.1
  • 37
    • 0018375043 scopus 로고
    • Globus Pallidus lesions in the monkey produced by kainic acid: Histologic and behavioral effects
    • DeLong MR, Coyle JT. 1979. Globus Pallidus lesions in the monkey produced by kainic acid: Histologic and behavioral effects. Appl Neurophysiol 42:95-97.
    • (1979) Appl Neurophysiol , vol.42 , pp. 95-97
    • DeLong, M.R.1    Coyle, J.T.2
  • 39
    • 84871949643 scopus 로고    scopus 로고
    • Zincfinger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs
    • Ellis BL, Hirsch ML, Porter SN, Samulski RJ, Porteus MH. 2012. Zincfinger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs. Gene Ther 20:35-42.
    • (2012) Gene Ther , vol.20 , pp. 35-42
    • Ellis, B.L.1    Hirsch, M.L.2    Porter, S.N.3    Samulski, R.J.4    Porteus, M.H.5
  • 40
    • 0036366669 scopus 로고    scopus 로고
    • The mousetrap: What we can learn when the mouse model does not mimic the human disease
    • Elsea SH, Lucas RE. 2002. The mousetrap: What we can learn when the mouse model does not mimic the human disease. ILAR J 43:66-79.
    • (2002) ILAR J , vol.43 , pp. 66-79
    • Elsea, S.H.1    Lucas, R.E.2
  • 41
    • 0030323108 scopus 로고    scopus 로고
    • Embryonic stem cells: The route to experimental mammalian genetics
    • Evans M. 1996. Embryonic stem cells: The route to experimental mammalian genetics. Int J Dev Biol Suppl 1: 55S.
    • (1996) Int J Dev Biol Suppl , vol.1
    • Evans, M.1
  • 42
    • 54349105179 scopus 로고    scopus 로고
    • Embryonic stem cells: the Mouse source-Vehicle for mammalian genetics and beyond (Nobel lecture)
    • Evans M. 2008. Embryonic stem cells: the Mouse source-Vehicle for mammalian genetics and beyond (Nobel lecture). Chembiochem 9:1690-1696.
    • (2008) Chembiochem , vol.9 , pp. 1690-1696
    • Evans, M.1
  • 44
    • 78649527521 scopus 로고    scopus 로고
    • The challenge of immunogenicity in the quest for induced pluripotency
    • Fairchild PJ. 2010. The challenge of immunogenicity in the quest for induced pluripotency. Nat Rev Immunol 10:868-875.
    • (2010) Nat Rev Immunol , vol.10 , pp. 868-875
    • Fairchild, P.J.1
  • 45
    • 84864439768 scopus 로고    scopus 로고
    • Targeted gene knockout by direct delivery of zinc-finger nuclease proteins
    • Gaj T, Guo J, Kato Y, Sirk SJ, Barbas CF 3rd. 2012. Targeted gene knockout by direct delivery of zinc-finger nuclease proteins. Nat Methods 9:805-807.
    • (2012) Nat Methods , vol.9 , pp. 805-807
    • Gaj, T.1    Guo, J.2    Kato, Y.3    Sirk, S.J.4    Barbas III, C.F.5
  • 46
    • 34249970183 scopus 로고
    • Experimental allergic encephalomyelitis in the monkey: Humoral immunity and blood-brain barrier function
    • Gallo P, Cupic D, Bracco F, Krzalic L, Tavolato B, Battistin L. 1989. Experimental allergic encephalomyelitis in the monkey: Humoral immunity and blood-brain barrier function. Ital J Neurol Sci 10:561-565.
    • (1989) Ital J Neurol Sci , vol.10 , pp. 561-565
    • Gallo, P.1    Cupic, D.2    Bracco, F.3    Krzalic, L.4    Tavolato, B.5    Battistin, L.6
  • 49
    • 79960877994 scopus 로고    scopus 로고
    • Modelling early responses to neurodegenerative mutations in mice
    • Gilley J, Adalbert R, Coleman MP. 2011. Modelling early responses to neurodegenerative mutations in mice. Biochem Soc Trans 39:933-938.
    • (2011) Biochem Soc Trans , vol.39 , pp. 933-938
    • Gilley, J.1    Adalbert, R.2    Coleman, M.P.3
  • 50
    • 84862169375 scopus 로고    scopus 로고
    • The use of the African green monkey as a preclinical model for ocular pharmacokinetic studies
    • Glogowski S, Ward KW, Lawrence MS, Goody RJ, Proksch JW. 2012. The use of the African green monkey as a preclinical model for ocular pharmacokinetic studies. J Ocul Pharmacol Ther 28:290-298.
    • (2012) J Ocul Pharmacol Ther , vol.28 , pp. 290-298
    • Glogowski, S.1    Ward, K.W.2    Lawrence, M.S.3    Goody, R.J.4    Proksch, J.W.5
  • 52
    • 78650222440 scopus 로고    scopus 로고
    • Animal models of choroidal and retinal neovascularization
    • Grossniklaus HE, Kang SJ, Berglin L. 2010. Animal models of choroidal and retinal neovascularization. Prog Retin Eye Res 29:500-519.
    • (2010) Prog Retin Eye Res , vol.29 , pp. 500-519
    • Grossniklaus, H.E.1    Kang, S.J.2    Berglin, L.3
  • 53
    • 84864628471 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes
    • HD iPSC Consortium
    • HD iPSC Consortium. 2012. Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes. Cell Stem Cell 11:264-278.
    • (2012) Cell Stem Cell , vol.11 , pp. 264-278
  • 54
    • 85009332113 scopus 로고    scopus 로고
    • Unified Huntington's Disease Rating Scale: Reliability and consistency
    • Huntington Study Group
    • Huntington Study Group. 1996. Unified Huntington's Disease Rating Scale: Reliability and consistency. Mov Disord 11:136-142.
    • (1996) Mov Disord , vol.11 , pp. 136-142
  • 55
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • Huntington's Disease Collaborative Research Group
    • Huntington's Disease Collaborative Research Group. 1993. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72:971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 60
    • 0036377184 scopus 로고    scopus 로고
    • Fate of sperm components during assisted reproduction: Implications for infertility
    • Hewitson L, Simerly CR, Schatten G. 2002. Fate of sperm components during assisted reproduction: Implications for infertility. Hum Fertil (Camb) 5:110-116.
    • (2002) Hum Fertil (Camb) , vol.5 , pp. 110-116
    • Hewitson, L.1    Simerly, C.R.2    Schatten, G.3
  • 66
    • 0025248012 scopus 로고
    • The rhesus monkey as a model for studies of pregnancy induced changes in metoprolol metabolism
    • Hogstedt S, Lindberg BS, Regardh CG, Mostrom U, Rane A. 1990. The rhesus monkey as a model for studies of pregnancy induced changes in metoprolol metabolism. Pharmacol Toxicol 66:32-36.
    • (1990) Pharmacol Toxicol , vol.66 , pp. 32-36
    • Hogstedt, S.1    Lindberg, B.S.2    Regardh, C.G.3    Mostrom, U.4    Rane, A.5
  • 68
    • 74949118218 scopus 로고    scopus 로고
    • Human ES and iPS cells as cell sources for the treatment of Parkinson's disease: Current state and problems
    • Hwang DY, Kim DS, Kim DW. 2010. Human ES and iPS cells as cell sources for the treatment of Parkinson's disease: Current state and problems. J Cell Biochem 109:292-301.
    • (2010) J Cell Biochem , vol.109 , pp. 292-301
    • Hwang, D.Y.1    Kim, D.S.2    Kim, D.W.3
  • 69
    • 34848817130 scopus 로고    scopus 로고
    • New advances in iPS cell research do not obviate the need for human embryonic stem cells
    • Hyun I, Hochedlinger K, Jaenisch R, Yamanaka S. 2007. New advances in iPS cell research do not obviate the need for human embryonic stem cells. Cell Stem Cell 1:367-368.
    • (2007) Cell Stem Cell , vol.1 , pp. 367-368
    • Hyun, I.1    Hochedlinger, K.2    Jaenisch, R.3    Yamanaka, S.4
  • 70
    • 77953605709 scopus 로고    scopus 로고
    • The cynomolgus monkey as a model for developmental toxicity studies: Variability of pregnancy losses, statistical power estimates, and group size considerations
    • Jarvis P, Srivastav S, Vogelwedde E, Stewart J, Mitchard T, Weinbauer GF. 2010. The cynomolgus monkey as a model for developmental toxicity studies: Variability of pregnancy losses, statistical power estimates, and group size considerations. Birth Defects Res B Dev Reprod Toxicol 89:175-187.
    • (2010) Birth Defects Res B Dev Reprod Toxicol , vol.89 , pp. 175-187
    • Jarvis, P.1    Srivastav, S.2    Vogelwedde, E.3    Stewart, J.4    Mitchard, T.5    Weinbauer, G.F.6
  • 72
    • 0024588265 scopus 로고
    • Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells
    • Joyner AL, Skarnes WC, Rossant J. 1989. Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells. Nature 338:153-156.
    • (1989) Nature , vol.338 , pp. 153-156
    • Joyner, A.L.1    Skarnes, W.C.2    Rossant, J.3
  • 73
    • 81855166599 scopus 로고    scopus 로고
    • In vitro immunogenicity of undifferentiated pluripotent stem cells (PSC) and derived lineages
    • Kadereit S, Trounson A. 2011. In vitro immunogenicity of undifferentiated pluripotent stem cells (PSC) and derived lineages. Semin Immunopathol 33:551-562.
    • (2011) Semin Immunopathol , vol.33 , pp. 551-562
    • Kadereit, S.1    Trounson, A.2
  • 78
    • 0018567602 scopus 로고
    • Pharmacokinetic model for 2-amino-1,3,4-thiadiazole in mouse, dog, and monkey
    • King FG, Dedrick RL. 1979. Pharmacokinetic model for 2-amino-1,3,4-thiadiazole in mouse, dog, and monkey. Cancer Treat Rep 63:1939-1947.
    • (1979) Cancer Treat Rep , vol.63 , pp. 1939-1947
    • King, F.G.1    Dedrick, R.L.2
  • 79
    • 34247093668 scopus 로고    scopus 로고
    • Unified Huntington's disease rating scale: Clinical practice and a critical approach
    • Klempir J, Klempirova O, Spackova N, Zidovska J, Roth J. 2006. Unified Huntington's disease rating scale: Clinical practice and a critical approach. Funct Neurol 21:217-221.
    • (2006) Funct Neurol , vol.21 , pp. 217-221
    • Klempir, J.1    Klempirova, O.2    Spackova, N.3    Zidovska, J.4    Roth, J.5
  • 80
    • 84868671846 scopus 로고    scopus 로고
    • Characterization of grape C-repeat-binding factor 2 and B-box-type zinc finger protein in transgenic Arabidopsis plants under stress conditions
    • Kobayashi M, Horiuchi H, Fujita K, Takuhara Y, Suzuki S. 2012. Characterization of grape C-repeat-binding factor 2 and B-box-type zinc finger protein in transgenic Arabidopsis plants under stress conditions. Mol Biol Rep 39:7933-7939.
    • (2012) Mol Biol Rep , vol.39 , pp. 7933-7939
    • Kobayashi, M.1    Horiuchi, H.2    Fujita, K.3    Takuhara, Y.4    Suzuki, S.5
  • 81
    • 0024409025 scopus 로고
    • Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination
    • Koller BH, Smithies O. 1989. Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc Natl Acad Sci U S A 86:8932-8935.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 8932-8935
    • Koller, B.H.1    Smithies, O.2
  • 86
    • 0024320352 scopus 로고
    • Sperm cells as vectors for introducing foreign DNA into eggs: Genetic transformation of mice
    • Lavitrano M, Camaioni A, Fazio VM, Dolci S, Farace MG, Spadafora C. 1989. Sperm cells as vectors for introducing foreign DNA into eggs: Genetic transformation of mice. Cell 57:717-723.
    • (1989) Cell , vol.57 , pp. 717-723
    • Lavitrano, M.1    Camaioni, A.2    Fazio, V.M.3    Dolci, S.4    Farace, M.G.5    Spadafora, C.6
  • 89
    • 0028082007 scopus 로고
    • Animal model for the study of methanol toxicity: Comparison of folate-reduced rat responses with published monkey data
    • Lee EW, Garner CD, Terzo TS. 1994. Animal model for the study of methanol toxicity: Comparison of folate-reduced rat responses with published monkey data. J Toxicol Environ Health 41:71-82.
    • (1994) J Toxicol Environ Health , vol.41 , pp. 71-82
    • Lee, E.W.1    Garner, C.D.2    Terzo, T.S.3
  • 91
    • 0344872757 scopus 로고    scopus 로고
    • Direct and indirect pathways for corticospinal control of upper limb motoneurons in the primate
    • Lemon RN, Kirkwood PA, Maier MA, Nakajima K, Nathan P. 2004. Direct and indirect pathways for corticospinal control of upper limb motoneurons in the primate. Prog Brain Res 143:263-279.
    • (2004) Prog Brain Res , vol.143 , pp. 263-279
    • Lemon, R.N.1    Kirkwood, P.A.2    Maier, M.A.3    Nakajima, K.4    Nathan, P.5
  • 93
    • 60749134645 scopus 로고    scopus 로고
    • Myotoxicity of gemfibrozil in cynomolgus monkey model and its relationship to pharmacokinetic properties
    • Liu A, Xie S, Sun H, Gonzalez FJ,Wei X, Dai R. 2009. Myotoxicity of gemfibrozil in cynomolgus monkey model and its relationship to pharmacokinetic properties. Toxicol Appl Pharmacol 235:287-295.
    • (2009) Toxicol Appl Pharmacol , vol.235 , pp. 287-295
    • Liu, A.1    Xie, S.2    Sun, H.3    Gonzalez, F.J.4    Wei, X.5    Dai, R.6
  • 95
    • 84867894975 scopus 로고    scopus 로고
    • Stem cell models of Alzheimer's disease and related neurological disorders
    • Livesey FJ. 2012. Stem cell models of Alzheimer's disease and related neurological disorders. Alzheimers Res Ther 4:44.
    • (2012) Alzheimers Res Ther , vol.4 , pp. 44
    • Livesey, F.J.1
  • 98
    • 0021129859 scopus 로고
    • Comparison of the pharmacokinetics of several polychlorinated biphenyls in mouse, rat, dog, and monkey by means of a physiological pharmacokinetic model
    • Lutz RJ, Dedrick RL, Tuey D, Sipes IG, Anderson MW, Matthews HB. 1984. Comparison of the pharmacokinetics of several polychlorinated biphenyls in mouse, rat, dog, and monkey by means of a physiological pharmacokinetic model. Drug Metab Dispo 12:527-535.
    • (1984) Drug Metab Dispo , vol.12 , pp. 527-535
    • Lutz, R.J.1    Dedrick, R.L.2    Tuey, D.3    Sipes, I.G.4    Anderson, M.W.5    Matthews, H.B.6
  • 99
    • 79952302385 scopus 로고    scopus 로고
    • De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates doublestrand breaks
    • Mahfouz MM, Li L, Shamimuzzaman M, Wibowo A, Fang X, Zhu JK. 2011. De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates doublestrand breaks. Proc Natl Acad Sci U S A 108:2623-2628.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 2623-2628
    • Mahfouz, M.M.1    Li, L.2    Shamimuzzaman, M.3    Wibowo, A.4    Fang, X.5    Zhu, J.K.6
  • 100
    • 80155144126 scopus 로고    scopus 로고
    • Induced pluripotent stem cells (iPSCs) and neurological disease modeling: Progress and promises
    • Marchetto MC, Brennand KJ, Boyer LF, Gage FH. 2011. Induced pluripotent stem cells (iPSCs) and neurological disease modeling: Progress and promises. Hum Mol Genet 20:R109-115.
    • (2011) Hum Mol Genet , vol.20
    • Marchetto, M.C.1    Brennand, K.J.2    Boyer, L.F.3    Gage, F.H.4
  • 102
    • 83555177273 scopus 로고    scopus 로고
    • Human pluripotent stem cells for disease modelling and drug screening
    • Maury Y, Gauthier M, Peschanski M, Martinat C. 2012. Human pluripotent stem cells for disease modelling and drug screening. Bioessays 34:61-71.
    • (2012) Bioessays , vol.34 , pp. 61-71
    • Maury, Y.1    Gauthier, M.2    Peschanski, M.3    Martinat, C.4
  • 103
    • 33748296365 scopus 로고    scopus 로고
    • Mammalian nuclear transfer
    • Meissner A, Jaenisch. 2006. Mammalian nuclear transfer. Dev Dyn 235:2460-2469.
    • (2006) Dev Dyn , vol.235 , pp. 2460-2469
    • Jaenisch, M.A.1
  • 105
    • 33847210188 scopus 로고    scopus 로고
    • Nuclear transfer in nonhuman primates
    • Mitalipov SM, Wolf DP. 2006. Nuclear transfer in nonhuman primates. Methods Mol Biol 348:151-168.
    • (2006) Methods Mol Biol , vol.348 , pp. 151-168
    • Mitalipov, S.M.1    Wolf, D.P.2
  • 109
    • 0032191380 scopus 로고    scopus 로고
    • Lentiviruses as gene transfer agents for delivery to nondividing cells
    • Naldini L. 1998. Lentiviruses as gene transfer agents for delivery to nondividing cells. Curr Opin Biotechnol 9:457-463.
    • (1998) Curr Opin Biotechnol , vol.9 , pp. 457-463
    • Naldini, L.1
  • 110
    • 0029993858 scopus 로고    scopus 로고
    • Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector
    • Naldini L, Blomer U, Gage FH, Trono D, Verma IM. 1996. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci U S A 93:11382-11388.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 11382-11388
    • Naldini, L.1    Blomer, U.2    Gage, F.H.3    Trono, D.4    Verma, I.M.5
  • 111
    • 0025666925 scopus 로고
    • Establishment of germ-linecompetent embryonic stem (ES) cells using differentiation inhibiting activity
    • Nichols J, Evans EP, Smith AG.1990. Establishment of germ-linecompetent embryonic stem (ES) cells using differentiation inhibiting activity. Development 110:1341-1348.
    • (1990) Development , vol.110 , pp. 1341-1348
    • Nichols, J.1    Evans, E.P.2    Smith, A.G.3
  • 112
    • 0142226586 scopus 로고    scopus 로고
    • Application of transgenesis in livestock for agriculture and biomedicine
    • Niemann H, KuesWA. 2003. Application of transgenesis in livestock for agriculture and biomedicine. Anim Reprod Sci 79:291-317.
    • (2003) Anim Reprod Sci , vol.79 , pp. 291-317
    • Niemann, H.1    Kues, W.A.2
  • 115
    • 82455210973 scopus 로고    scopus 로고
    • Long-term effect of a simple nest-box on the reproductive efficiency and other life traits of an Aotus lemurinus lemurinus monkey colony: An animal model for malaria research
    • Obaldia N 3rd, Otero W, Marin C, Aparicio J, Cisneros G. 2011. Long-term effect of a simple nest-box on the reproductive efficiency and other life traits of an Aotus lemurinus lemurinus monkey colony: An animal model for malaria research. J Med Primatol 40:383-391.
    • (2011) J Med Primatol , vol.40 , pp. 383-391
    • Obaldia III, N.1    Otero, W.2    Marin, C.3    Aparicio, J.4    Cisneros, G.5
  • 116
    • 84868301266 scopus 로고    scopus 로고
    • The common marmoset as a novel animal model system for biomedical and neuroscience research applications
    • Okano H, Hikishima K, Iriki A, Sasaki E. 2012. The common marmoset as a novel animal model system for biomedical and neuroscience research applications. Semin Fetal Neonatal Med 17:336-340.
    • (2012) Semin Fetal Neonatal Med , vol.17 , pp. 336-340
    • Okano, H.1    Hikishima, K.2    Iriki, A.3    Sasaki, E.4
  • 118
  • 119
    • 80054937413 scopus 로고    scopus 로고
    • Transgenic mice expressing an artificial zinc finger regulator targeting an endogenous gene
    • Passananti C, Corbi N, Onori A, Di Certo MG, Mattei E. 2010. Transgenic mice expressing an artificial zinc finger regulator targeting an endogenous gene. Methods Mol Biol 649:183-206.
    • (2010) Methods Mol Biol , vol.649 , pp. 183-206
    • Passananti, C.1    Corbi, N.2    Onori, A.3    Di Certo, M.G.4    Mattei, E.5
  • 124
    • 84864625221 scopus 로고    scopus 로고
    • How can human pluripotent stem cells help decipher and cure Huntington's disease?
    • Perrier A, Peschanski M. 2012. How can human pluripotent stem cells help decipher and cure Huntington's disease? Cell Stem Cell 11:153-161.
    • (2012) Cell Stem Cell , vol.11 , pp. 153-161
    • Perrier, A.1    Peschanski, M.2
  • 126
    • 10344245101 scopus 로고    scopus 로고
    • Lentiviral transgenesis
    • Pfeifer A. 2004. Lentiviral transgenesis. Transgenic Res 13:513-522.
    • (2004) Transgenic Res , vol.13 , pp. 513-522
    • Pfeifer, A.1
  • 128
    • 84876131051 scopus 로고    scopus 로고
    • Pathogenic cellular phenotypes are germline transmissible in a transgenic primate model of Huntington's disease
    • Epub Date 2012/ 11/30.
    • Putkhao K, Kocerha J, Cho IK, Yang J, Parnpai R, Chan AW. 2013. Pathogenic cellular phenotypes are germline transmissible in a transgenic primate model of Huntington's disease. Stem Cells Dev Epub Date 2012/ 11/30.
    • (2013) Stem Cells Dev
    • Putkhao, K.1    Kocerha, J.2    Cho, I.K.3    Yang, J.4    Parnpai, R.5    Chan, A.W.6
  • 129
    • 84872775649 scopus 로고    scopus 로고
    • The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting
    • Rahman SH, Bobis-Wozowicz S, Chatterjee D, Gellhaus K, Pars K, Heilbronn R, Jacobs R, Cathomen T. 2013. The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting. Hum Gene Ther 24:67-77.
    • (2013) Hum Gene Ther , vol.24 , pp. 67-77
    • Rahman, S.H.1    Bobis-Wozowicz, S.2    Chatterjee, D.3    Gellhaus, K.4    Pars, K.5    Heilbronn, R.6    Jacobs, R.7    Cathomen, T.8
  • 131
    • 77955363739 scopus 로고    scopus 로고
    • In vivo analysis of gene knockdown in tetracycline-inducible shRNA mice
    • Raymond CS, Zhu L, Vogt TF, Shin MK. 2010. In vivo analysis of gene knockdown in tetracycline-inducible shRNA mice. Methods Enzymol 477:415-427.
    • (2010) Methods Enzymol , vol.477 , pp. 415-427
    • Raymond, C.S.1    Zhu, L.2    Vogt, T.F.3    Shin, M.K.4
  • 133
    • 84861926549 scopus 로고    scopus 로고
    • Animal models: Not close enough
    • Rice J. 2012. Animal models: Not close enough. Nature 484:S9-S9.
    • (2012) Nature , vol.484
    • Rice, J.1
  • 134
    • 0037023568 scopus 로고    scopus 로고
    • Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy
    • Rideout WM 3rd, Hochedlinger K, Kyba M, Daley GQ, Jaenisch R. 2002. Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell 109: 17-27.
    • (2002) Cell , vol.109 , pp. 17-27
    • Rideout III, W.M.1    Hochedlinger, K.2    Kyba, M.3    Daley, G.Q.4    Jaenisch, R.5
  • 135
    • 78650278301 scopus 로고    scopus 로고
    • Huntington's disease: A clinical review
    • Roos RA. 2010. Huntington's disease: A clinical review. Orphanet J Rare Dis 5:40.
    • (2010) Orphanet J Rare Dis , vol.5 , pp. 40
    • Roos, R.A.1
  • 136
    • 72149084425 scopus 로고    scopus 로고
    • Huntington disease: pathogenesis, biomarkers, and approaches to experimental therapeutics
    • Ross CA, Shoulson I. 2009. Huntington disease: pathogenesis, biomarkers, and approaches to experimental therapeutics. Parkinsonism Relat Disord 15 Suppl 3: S135-138.
    • (2009) Parkinsonism Relat Disord 15 Suppl , vol.3
    • Ross, C.A.1    Shoulson, I.2
  • 137
    • 0036533795 scopus 로고    scopus 로고
    • Lessons from animal models of Huntington's disease
    • Rubinsztein DC. 2002. Lessons from animal models of Huntington's disease. Trends Genet 18:202-209.
    • (2002) Trends Genet , vol.18 , pp. 202-209
    • Rubinsztein, D.C.1
  • 140
    • 70450285340 scopus 로고    scopus 로고
    • Technical challenges in using human induced pluripotent stem cells to model disease
    • Saha K, Jaenisch R. 2009. Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell 5:584-595.
    • (2009) Cell Stem Cell , vol.5 , pp. 584-595
    • Saha, K.1    Jaenisch, R.2
  • 146
    • 0842304125 scopus 로고    scopus 로고
    • Macaque ventral premotor cortex exerts powerful facilitation of motor cortex outputs to upper limb motoneurons
    • Shimazu H, Maier MA, Cerri G, Kirkwood PA, Lemon RN. 2004. Macaque ventral premotor cortex exerts powerful facilitation of motor cortex outputs to upper limb motoneurons. J Neurosci 24:1200-1211.
    • (2004) J Neurosci , vol.24 , pp. 1200-1211
    • Shimazu, H.1    Maier, M.A.2    Cerri, G.3    Kirkwood, P.A.4    Lemon, R.N.5
  • 148
    • 0347418924 scopus 로고    scopus 로고
    • Nuclear transfer in the rhesus monkey: Opportunities and challenges
    • Simerly CR, Navara CS. 2003. Nuclear transfer in the rhesus monkey: Opportunities and challenges. Cloning Stem Cells 5:319-331.
    • (2003) Cloning Stem Cells , vol.5 , pp. 319-331
    • Simerly, C.R.1    Navara, C.S.2
  • 149
    • 0018119761 scopus 로고
    • Metabolic bone disease resembling osteosarcoma in a wooly monkey (Lagothrix lagotricha)
    • Smith K, Dillingham L, Giddens WE Jr. 1978. Metabolic bone disease resembling osteosarcoma in a wooly monkey (Lagothrix lagotricha). Lab Anim Sci 28:451-456.
    • (1978) Lab Anim Sci , vol.28 , pp. 451-456
    • Smith, K.1    Dillingham, L.2    Giddens Jr., W.E.3
  • 153
    • 66149105139 scopus 로고    scopus 로고
    • AAV-mediated gene therapy for retinal disorders in large animal models
    • Stieger K, Lheriteau E, Moullier P, Rolling F. 2009. AAV-mediated gene therapy for retinal disorders in large animal models. ILAR J 50:206-224.
    • (2009) ILAR J , vol.50 , pp. 206-224
    • Stieger, K.1    Lheriteau, E.2    Moullier, P.3    Rolling, F.4
  • 155
    • 84858380027 scopus 로고    scopus 로고
    • Targeting DNA to a previously integrated transgenic locus using zinc finger nucleases
    • Strange TL, Petolino JF. 2012. Targeting DNA to a previously integrated transgenic locus using zinc finger nucleases. Methods Mol Biol 847:391-397.
    • (2012) Methods Mol Biol , vol.847 , pp. 391-397
    • Strange, T.L.1    Petolino, J.F.2
  • 160
    • 33744456740 scopus 로고    scopus 로고
    • Huntington's disease: A transcriptional report card from the peripheral blood: Can it measure disease progression in Huntington's disease?
    • Tabchy A, Housman D. 2006. Huntington's disease: A transcriptional report card from the peripheral blood: Can it measure disease progression in Huntington's disease? Eur J Hum Genet 14:649-650.
    • (2006) Eur J Hum Genet , vol.14 , pp. 649-650
    • Tabchy, A.1    Housman, D.2
  • 165
  • 166
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. 2006. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 168
    • 0020036458 scopus 로고
    • Differential effects of intravenous anaesthetic agents on cell-mediated immunity in the Rhesus monkey
    • Thomas J, Carver M, Haisch C, Thomas F,Welch J, Carchman R. 1982. Differential effects of intravenous anaesthetic agents on cell-mediated immunity in the Rhesus monkey. Clin Exp Immunol 47:457-466.
    • (1982) Clin Exp Immunol , vol.47 , pp. 457-466
    • Thomas, J.1    Carver, M.2    Haisch, C.3    Thomas, F.4    Welch, J.5    Carchman, R.6
  • 171
    • 84856112882 scopus 로고    scopus 로고
    • Diseases in a dish: Modeling human genetic disorders using induced pluripotent cells
    • Tiscornia G, Vivas EL, Izpisua Belmonte JC. 2011. Diseases in a dish: Modeling human genetic disorders using induced pluripotent cells. Nat Med 17:1570-1576.
    • (2011) Nat Med , vol.17 , pp. 1570-1576
    • Tiscornia, G.1    Vivas, E.L.2    Izpisua Belmonte, J.C.3
  • 173
    • 79955711373 scopus 로고    scopus 로고
    • Transplantation of adult mouse iPS cellderived photoreceptor precursors restores retinal structure and function in degenerative mice
    • Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ. 2011. Transplantation of adult mouse iPS cellderived photoreceptor precursors restores retinal structure and function in degenerative mice. PLoS One 6: e18992.
    • (2011) PLoS One , vol.6
    • Tucker, B.A.1    Park, I.H.2    Qi, S.D.3    Klassen, H.J.4    Jiang, C.5    Yao, J.6    Redenti, S.7    Daley, G.Q.8    Young, M.J.9
  • 175
    • 0034646743 scopus 로고    scopus 로고
    • Single-molecule mechanics of R403Q cardiac myosin isolated from the mouse model of familial hypertrophic cardiomyopathy
    • Tyska MJ, Hayes E, Giewat M, Seidman CE, Seidman JG, Warshaw DM. 2000. Single-molecule mechanics of R403Q cardiac myosin isolated from the mouse model of familial hypertrophic cardiomyopathy. Circ Res 86:737-744.
    • (2000) Circ Res , vol.86 , pp. 737-744
    • Tyska, M.J.1    Hayes, E.2    Giewat, M.3    Seidman, C.E.4    Seidman, J.G.5    Warshaw, D.M.6
  • 177
    • 0032466976 scopus 로고    scopus 로고
    • Animal models of human disease for the 21st century
    • Vaitukaitis JL. 1998. Animal models of human disease for the 21st century. Lab Anim Sci 48:562-564.
    • (1998) Lab Anim Sci , vol.48 , pp. 562-564
    • Vaitukaitis, J.L.1
  • 179
    • 62149090287 scopus 로고    scopus 로고
    • Diffusion-weighted versus volumetric imaging of the striatum in early symptomatic Huntington disease
    • Vandenberghe W, Demaerel P, Dom R, Maes F. 2009. Diffusion-weighted versus volumetric imaging of the striatum in early symptomatic Huntington disease. J Neurol 256:109-114.
    • (2009) J Neurol , vol.256 , pp. 109-114
    • Vandenberghe, W.1    Demaerel, P.2    Dom, R.3    Maes, F.4
  • 180
    • 80051960183 scopus 로고    scopus 로고
    • Early presymptomatic and long-term changes of rest activity cycles and cognitive behavior in a MPTP-monkey model of Parkinson's disease
    • Vezoli J, Fifel K, Leviel V, Dehay C, Kennedy H, Cooper HM, Gronfier C, Procyk E. 2011. Early presymptomatic and long-term changes of rest activity cycles and cognitive behavior in a MPTP-monkey model of Parkinson's disease. PLoS One 6: e23952.
    • (2011) PLoS One , vol.6
    • Vezoli, J.1    Fifel, K.2    Leviel, V.3    Dehay, C.4    Kennedy, H.5    Cooper, H.M.6    Gronfier, C.7    Procyk, E.8
  • 182
    • 33947141882 scopus 로고    scopus 로고
    • Production of cloned mice and ES cells from adult somatic cells by nuclear transfer: how to improve cloning efficiency?
    • Wakayama T. 2007. Production of cloned mice and ES cells from adult somatic cells by nuclear transfer: how to improve cloning efficiency? J Reprod Dev. 53:13-26.
    • (2007) J Reprod Dev , vol.53 , pp. 13-26
    • Wakayama, T.1
  • 183
    • 0035111620 scopus 로고    scopus 로고
    • Mouse cloning with nucleus donor cells of different age and type
    • Wakayama T, Yanagimachi R. 2001. Mouse cloning with nucleus donor cells of different age and type. Mol Reprod Dev 58:376-383.
    • (2001) Mol Reprod Dev , vol.58 , pp. 376-383
    • Wakayama, T.1    Yanagimachi, R.2
  • 184
    • 33846225133 scopus 로고    scopus 로고
    • Huntington's disease
    • Walker FO. 2007. Huntington's disease. Lancet 369:218-228.
    • (2007) Lancet , vol.369 , pp. 218-228
    • Walker, F.O.1
  • 186
    • 84858052771 scopus 로고    scopus 로고
    • Cell Biology Symposium: Zinc finger nucleases to create custom-designed modifications in the swine (Sus scrofa) genome
    • Whyte JJ, Prather RS. 2012. Cell Biology Symposium: Zinc finger nucleases to create custom-designed modifications in the swine (Sus scrofa) genome. J Anim Sci 90:1111-1117.
    • (2012) J Anim Sci , vol.90 , pp. 1111-1117
    • Whyte, J.J.1    Prather, R.S.2
  • 188
    • 56549087765 scopus 로고    scopus 로고
    • Artificial insemination and the assisted reproductive technologies in non-human primates
    • Wolf DP. 2009. Artificial insemination and the assisted reproductive technologies in non-human primates. Theriogenology 71:123-129.
    • (2009) Theriogenology , vol.71 , pp. 123-129
    • Wolf, D.P.1
  • 190
    • 33645788618 scopus 로고    scopus 로고
    • Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice
    • Xia XG, Zhou H, Samper E, Melov S, Xu Z. 2006. Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice. PLoS Genet 2: e10.
    • (2006) PLoS Genet , vol.2
    • Xia, X.G.1    Zhou, H.2    Samper, E.3    Melov, S.4    Xu, Z.5
  • 191
    • 84860624792 scopus 로고    scopus 로고
    • Transgenic animal models of Huntington's disease
    • Yang SH, Chan AW. 2011. Transgenic animal models of Huntington's disease. Curr Top Behav Neurosci 7:61-85.
    • (2011) Curr Top Behav Neurosci , vol.7 , pp. 61-85
    • Yang, S.H.1    Chan, A.W.2
  • 194
    • 33847275530 scopus 로고    scopus 로고
    • Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning
    • Yang X, Smith SL, Tian XC, Lewin HA, Renard JP,Wakayama T. 2007. Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning. Nat Genet 39:295-302.
    • (2007) Nat Genet , vol.39 , pp. 295-302
    • Yang, X.1    Smith, S.L.2    Tian, X.C.3    Lewin, H.A.4    Renard, J.P.5    Wakayama, T.6
  • 195
    • 84867131908 scopus 로고    scopus 로고
    • Alzheimer's disease in a dish: Promises and challenges of human stem cell models
    • Young JE, Goldstein LS. 2012. Alzheimer's disease in a dish: Promises and challenges of human stem cell models. Hum Mol Genet 21:R82-89.
    • (2012) Hum Mol Genet , vol.21
    • Young, J.E.1    Goldstein, L.S.2
  • 196
    • 77954474714 scopus 로고    scopus 로고
    • Animals as models of age-related macular degeneration: An imperfect measure of the truth
    • Zeiss CJ. 2010. Animals as models of age-related macular degeneration: An imperfect measure of the truth. Vet Pathol 47:396-413.
    • (2010) Vet Pathol , vol.47 , pp. 396-413
    • Zeiss, C.J.1
  • 197
    • 0024420342 scopus 로고
    • Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells
    • Zijlstra M, Li E, Sajjadi F, Subramani S, Jaenisch R. 1989. Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 342:435-438.
    • (1989) Nature , vol.342 , pp. 435-438
    • Zijlstra, M.1    Li, E.2    Sajjadi, F.3    Subramani, S.4    Jaenisch, R.5
  • 198
    • 0024599099 scopus 로고
    • Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination
    • Zimmer A, Gruss P. 1989. Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination. Nature 338:150-153.
    • (1989) Nature , vol.338 , pp. 150-153
    • Zimmer, A.1    Gruss, P.2
  • 202
    • 33645788618 scopus 로고    scopus 로고
    • Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice
    • Xia XG, Zhou H, Samper E, Melov S, Xu Z. 2006. Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice. PLoS Genet 2: e10.
    • (2006) PLoS Genet , vol.2
    • Xia, X.G.1    Zhou, H.2    Samper, E.3    Melov, S.4    Xu, Z.5
  • 203
    • 84860624792 scopus 로고    scopus 로고
    • Transgenic animal models of Huntington's disease
    • Yang SH, Chan AW. 2011. Transgenic animal models of Huntington's disease. Curr Top Behav Neurosci 7:61-85.
    • (2011) Curr Top Behav Neurosci , vol.7 , pp. 61-85
    • Yang, S.H.1    Chan, A.W.2
  • 206
    • 33847275530 scopus 로고    scopus 로고
    • Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning
    • Yang X, Smith SL, Tian XC, Lewin HA, Renard JP,Wakayama T. 2007. Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning. Nat Genet 39:295-302.
    • (2007) Nat Genet , vol.39 , pp. 295-302
    • Yang, X.1    Smith, S.L.2    Tian, X.C.3    Lewin, H.A.4    Renard, J.P.5    Wakayama, T.6
  • 207
    • 84867131908 scopus 로고    scopus 로고
    • Alzheimer's disease in a dish: Promises and challenges of human stem cell models
    • Young JE, Goldstein LS. 2012. Alzheimer's disease in a dish: Promises and challenges of human stem cell models. Hum Mol Genet 21:R82-89.
    • (2012) Hum Mol Genet , vol.21
    • Young, J.E.1    Goldstein, L.S.2
  • 208
    • 77954474714 scopus 로고    scopus 로고
    • Animals as models of age-related macular degeneration: An imperfect measure of the truth
    • Zeiss CJ. 2010. Animals as models of age-related macular degeneration: An imperfect measure of the truth. Vet Pathol 47:396-413.
    • (2010) Vet Pathol , vol.47 , pp. 396-413
    • Zeiss, C.J.1
  • 209
    • 0024420342 scopus 로고
    • Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells
    • Zijlstra M, Li E, Sajjadi F, Subramani S, Jaenisch R. 1989. Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 342:435-438.
    • (1989) Nature , vol.342 , pp. 435-438
    • Zijlstra, M.1    Li, E.2    Sajjadi, F.3    Subramani, S.4    Jaenisch, R.5
  • 210
    • 0024599099 scopus 로고
    • Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination
    • Zimmer A, Gruss P. 1989. Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination. Nature 338:150-153.
    • (1989) Nature , vol.338 , pp. 150-153
    • Zimmer, A.1    Gruss, P.2
  • 214
    • 33645788618 scopus 로고    scopus 로고
    • Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice
    • Xia XG, Zhou H, Samper E, Melov S, Xu Z. 2006. Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice. PLoS Genet 2: e10.
    • (2006) PLoS Genet , vol.2
    • Xia, X.G.1    Zhou, H.2    Samper, E.3    Melov, S.4    Xu, Z.5
  • 215
    • 84860624792 scopus 로고    scopus 로고
    • Transgenic animal models of Huntington's disease
    • Yang SH, Chan AW. 2011. Transgenic animal models of Huntington's disease. Curr Top Behav Neurosci 7:61-85.
    • (2011) Curr Top Behav Neurosci , vol.7 , pp. 61-85
    • Yang, S.H.1    Chan, A.W.2
  • 218
    • 33847275530 scopus 로고    scopus 로고
    • Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning
    • Yang X, Smith SL, Tian XC, Lewin HA, Renard JP,Wakayama T. 2007. Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning. Nat Genet 39:295-302.
    • (2007) Nat Genet , vol.39 , pp. 295-302
    • Yang, X.1    Smith, S.L.2    Tian, X.C.3    Lewin, H.A.4    Renard, J.P.5    Wakayama, T.6
  • 219
    • 84867131908 scopus 로고    scopus 로고
    • Alzheimer's disease in a dish: Promises and challenges of human stem cell models
    • Young JE, Goldstein LS. 2012. Alzheimer's disease in a dish: Promises and challenges of human stem cell models. Hum Mol Genet 21:R82-89.
    • (2012) Hum Mol Genet , vol.21
    • Young, J.E.1    Goldstein, L.S.2
  • 220
    • 77954474714 scopus 로고    scopus 로고
    • Animals as models of age-related macular degeneration: An imperfect measure of the truth
    • Zeiss CJ. 2010. Animals as models of age-related macular degeneration: An imperfect measure of the truth. Vet Pathol 47:396-413.
    • (2010) Vet Pathol , vol.47 , pp. 396-413
    • Zeiss, C.J.1
  • 221
    • 0024420342 scopus 로고
    • Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells
    • Zijlstra M, Li E, Sajjadi F, Subramani S, Jaenisch R. 1989. Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 342:435-438.
    • (1989) Nature , vol.342 , pp. 435-438
    • Zijlstra, M.1    Li, E.2    Sajjadi, F.3    Subramani, S.4    Jaenisch, R.5
  • 222
    • 0024599099 scopus 로고
    • Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination
    • Zimmer A, Gruss P. 1989. Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination. Nature 338:150-153.
    • (1989) Nature , vol.338 , pp. 150-153
    • Zimmer, A.1    Gruss, P.2


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