메뉴 건너뛰기




Volumn 109, Issue 2, 2010, Pages 292-301

Human ES and iPS cells as cell sources for the treatment of Parkinson's disease: Current state and problems

Author keywords

Dopamine neuron differentiation; Human ES IPS cells; Pakinson's disease

Indexed keywords

CANCER PREVENTION; CARCINOGENESIS; CELL SURVIVAL; DNA MODIFICATION; DOPAMINERGIC NERVE CELL; EMBRYONIC STEM CELL; GRAFT REJECTION; HUMAN; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL TRANSPLANTATION; PARKINSON DISEASE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVIEW; RISK REDUCTION; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 74949118218     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22411     Document Type: Review
Times cited : (34)

References (70)
  • 2
    • 0025893945 scopus 로고
    • Parkinson's disease: Pathophysiology
    • Agid Y. 1991. Parkinson's disease: Pathophysiology. Lancet 337:1321-1324.
    • (1991) Lancet , vol.337 , pp. 1321-1324
    • Agid, Y.1
  • 3
    • 67349133927 scopus 로고    scopus 로고
    • Effects of GDNF pretreatment on function and survival of transplanted fetal ventral mesencephalic cells in the 6-OHDA rat model of Parkinson's disease
    • Andereggen L, Meyer M, Guzman R, Ducray AD, Widmer HR. 2009. Effects of GDNF pretreatment on function and survival of transplanted fetal ventral mesencephalic cells in the 6-OHDA rat model of Parkinson's disease. Brain Res 1276:39-49.
    • (2009) Brain Res , vol.1276 , pp. 39-49
    • Andereggen, L.1    Meyer, M.2    Guzman, R.3    Ducray, A.D.4    Widmer, H.R.5
  • 4
    • 0031905828 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells
    • Apostolides C, Sanford E, Hong M, Mendez I. 1998. Glial cell line-derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells. Neuroscience 83:363-372.
    • (1998) Neuroscience , vol.83 , pp. 363-372
    • Apostolides, C.1    Sanford, E.2    Hong, M.3    Mendez, I.4
  • 5
    • 10444252732 scopus 로고    scopus 로고
    • Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats
    • Dayton, Ohio
    • Ben-Hur T, Idelson M, Khaner H, Pera M, Reinhartz E, Itzik A, Reubinoff BE. 2004. Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats. Stem cells (Dayton, Ohio) 22:1246-1255.
    • (2004) Stem cells , vol.22 , pp. 1246-1255
    • Ben-Hur, T.1    Idelson, M.2    Khaner, H.3    Pera, M.4    Reinhartz, E.5    Itzik, A.6    Reubinoff, B.E.7
  • 6
    • 0015745743 scopus 로고
    • Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations
    • Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F. 1973. Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J Neurol Sci 20:415-455.
    • (1973) J Neurol Sci , vol.20 , pp. 415-455
    • Bernheimer, H.1    Birkmayer, W.2    Hornykiewicz, O.3    Jellinger, K.4    Seitelberger, F.5
  • 8
    • 4444308824 scopus 로고    scopus 로고
    • Generation of tyrosine hydroxylase positive neurons from human embryonic stem cells after coculture with cellular substrates and exposure to GDNF
    • Dayton, Ohio
    • Buytaert-Hoefen KA, Alvarez E, Freed CR. 2004. Generation of tyrosine hydroxylase positive neurons from human embryonic stem cells after coculture with cellular substrates and exposure to GDNF. Stem Cells (Dayton, Ohio) 22:669-674.
    • (2004) Stem Cells , vol.22 , pp. 669-674
    • Buytaert-Hoefen, K.A.1    Alvarez, E.2    Freed, C.R.3
  • 9
    • 34547484764 scopus 로고    scopus 로고
    • Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease
    • Carlsson T, Carta M, Winkler C, Bjorklund A, Kirik D. 2007. Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease. J Neurosci 27:8011-8022.
    • (2007) J Neurosci , vol.27 , pp. 8011-8022
    • Carlsson, T.1    Carta, M.2    Winkler, C.3    Bjorklund, A.4    Kirik, D.5
  • 13
    • 62949103656 scopus 로고    scopus 로고
    • Fibroblast growth factor-20 increases the yield of midbrain dopaminergic neurons derived from human embryonic stem cells
    • Correia AS, Anisimov SV, Roybon L, Li JY, Brundin P. 2007. Fibroblast growth factor-20 increases the yield of midbrain dopaminergic neurons derived from human embryonic stem cells. Front Neuroanat 1:4.
    • (2007) Front Neuroanat , vol.1 , pp. 4
    • Correia, A.S.1    Anisimov, S.V.2    Roybon, L.3    Li, J.Y.4    Brundin, P.5
  • 14
    • 34250928307 scopus 로고
    • Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system
    • Ehringer H, Hornykiewicz O. 1960. Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system. Klinische Wochenschrift 38:1236-1239.
    • (1960) Klinische Wochenschrift , vol.38 , pp. 1236-1239
    • Ehringer, H.1    Hornykiewicz, O.2
  • 15
    • 0033949290 scopus 로고    scopus 로고
    • Increased survival of dopaminergic neurons in striatal grafts of fetal ventral mesencephalic cells exposed to neurotrophin-3 or glial cell line-derived neurotrophic factor
    • Espejo M, Cutillas B, Arenas TE, Ambrosio S. 2000. Increased survival of dopaminergic neurons in striatal grafts of fetal ventral mesencephalic cells exposed to neurotrophin-3 or glial cell line-derived neurotrophic factor. Cell Transplant 9:45-53.
    • (2000) Cell Transplant , vol.9 , pp. 45-53
    • Espejo, M.1    Cutillas, B.2    Arenas, T.E.3    Ambrosio, S.4
  • 19
    • 46249118063 scopus 로고    scopus 로고
    • One year survival and significant reversal of motor deficits in parkinsonian rats transplanted with hESC derived dopaminergic neurons
    • Geeta R, Ramnath RL, Rao HS, Chandra V. 2008. One year survival and significant reversal of motor deficits in parkinsonian rats transplanted with hESC derived dopaminergic neurons. Biochem Biophys Res Commun 373:258-264.
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 258-264
    • Geeta, R.1    Ramnath, R.L.2    Rao, H.S.3    Chandra, V.4
  • 20
    • 25844465546 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells to neural lineages in adherent culture by blocking bone morphogenetic protein signaling
    • Dayton, Ohio
    • Gerrard L, Rodgers L, Cui W. 2005. Differentiation of human embryonic stem cells to neural lineages in adherent culture by blocking bone morphogenetic protein signaling. Stem Cells (Dayton, Ohio) 23:1234-1241.
    • (2005) Stem Cells , vol.23 , pp. 1234-1241
    • Gerrard, L.1    Rodgers, L.2    Cui, W.3
  • 22
    • 0034921374 scopus 로고    scopus 로고
    • Cell survival and clinical outcome following intrastriatal transplantation in Parkinson disease
    • Hagell P, Brundin P. 2001. Cell survival and clinical outcome following intrastriatal transplantation in Parkinson disease. J Neuropathol Exp Neurol 60:741-752.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 741-752
    • Hagell, P.1    Brundin, P.2
  • 24
    • 48649111174 scopus 로고    scopus 로고
    • Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease
    • Dayton, Ohio
    • Hedlund E, Pruszak J, Lardaro T, Ludwig W, Vinuela A, Kim KS, Isacson O. 2008. Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease. Stem Cells (Dayton, Ohio) 26:1526-1536.
    • (2008) Stem Cells , vol.26 , pp. 1526-1536
    • Hedlund, E.1    Pruszak, J.2    Lardaro, T.3    Ludwig, W.4    Vinuela, A.5    Kim, K.S.6    Isacson, O.7
  • 25
    • 0035148625 scopus 로고    scopus 로고
    • Influence of time in culture and BDNF pretreatment on survival and function of grafted embryonic rat ventral mesencephalon in the 6-OHDA rat model of Parkinson's disease
    • Hoglinger GU, Widmer HR, Spenger C, Meyer M, Seiler RW, Oertel WH, Sautter J. 2001. Influence of time in culture and BDNF pretreatment on survival and function of grafted embryonic rat ventral mesencephalon in the 6-OHDA rat model of Parkinson's disease. Exp Neurol 167:148-157.
    • (2001) Exp Neurol , vol.167 , pp. 148-157
    • Hoglinger, G.U.1    Widmer, H.R.2    Spenger, C.3    Meyer, M.4    Seiler, R.W.5    Oertel, W.H.6    Sautter, J.7
  • 26
    • 33845277826 scopus 로고    scopus 로고
    • A protocol for the differentiation of human embryonic stem cells into dopaminergic neurons using only chemically defined human additives: Studies in vitro and in vivo
    • Iacovitti L, Donaldson AE, Marshall CE, Suon S, Yang M. 2007. A protocol for the differentiation of human embryonic stem cells into dopaminergic neurons using only chemically defined human additives: Studies in vitro and in vivo. Brain Res 1127:19-25.
    • (2007) Brain Res , vol.1127 , pp. 19-25
    • Iacovitti, L.1    Donaldson, A.E.2    Marshall, C.E.3    Suon, S.4    Yang, M.5
  • 27
    • 67849111372 scopus 로고    scopus 로고
    • Identification of transplantable dopamine neuron precursors at different stages of midbrain neurogenesis
    • Jonsson ME, Ono Y, Bjorklund A, Thompson LH. 2009. Identification of transplantable dopamine neuron precursors at different stages of midbrain neurogenesis. Exp Neurol 219:341-354.
    • (2009) Exp Neurol , vol.219 , pp. 341-354
    • Jonsson, M.E.1    Ono, Y.2    Bjorklund, A.3    Thompson, L.H.4
  • 30
    • 35448952847 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived neural precursors as a continuous, stable, and on-demand source for human dopamine neurons
    • Ko JY, Park CH, Koh HC, Cho YH, Kyhm JH, Kim YS, Lee I, Lee YS, Lee SH. 2007. Human embryonic stem cell-derived neural precursors as a continuous, stable, and on-demand source for human dopamine neurons. J Neurochem 103:1417-1429.
    • (2007) J Neurochem , vol.103 , pp. 1417-1429
    • Ko, J.Y.1    Park, C.H.2    Koh, H.C.3    Cho, Y.H.4    Kyhm, J.H.5    Kim, Y.S.6    Lee, I.7    Lee, Y.S.8    Lee, S.H.9
  • 31
    • 70349880527 scopus 로고    scopus 로고
    • Conditions for tumorfree and dopamine neuron-enriched grafts after transplanting human ES cell-derived neural precursor cells
    • Ko JY, Lee HS, Park CH, Koh HC, Lee YS, Lee SH. 2009. Conditions for tumorfree and dopamine neuron-enriched grafts after transplanting human ES cell-derived neural precursor cells. Mol Ther 17:1761-1770.
    • (2009) Mol Ther , vol.17 , pp. 1761-1770
    • Ko, J.Y.1    Lee, H.S.2    Park, C.H.3    Koh, H.C.4    Lee, Y.S.5    Lee, S.H.6
  • 32
    • 0032497504 scopus 로고    scopus 로고
    • Parkinson's disease. First of two parts
    • Lang AE, Lozano AM. 1998. Parkinson's disease. First of two parts. N Engl J Med 339:1044-1053.
    • (1998) N Engl J Med , vol.339 , pp. 1044-1053
    • Lang, A.E.1    Lozano, A.M.2
  • 33
    • 0034044317 scopus 로고    scopus 로고
    • Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
    • Lee SH, Lumelsky N, Studer L, Auerbach JM, McKay RD. 2000. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol 18:675-679.
    • (2000) Nat Biotechnol , vol.18 , pp. 675-679
    • Lee, S.H.1    Lumelsky, N.2    Studer, L.3    Auerbach, J.M.4    McKay, R.D.5
  • 38
    • 1542269162 scopus 로고    scopus 로고
    • The scientific basis for the current treatment of Parkinson's disease
    • Olanow CW. 2004. The scientific basis for the current treatment of Parkinson's disease. Annu Rev Med 55:41-60.
    • (2004) Annu Rev Med , vol.55 , pp. 41-60
    • Olanow, C.W.1
  • 40
    • 11144354441 scopus 로고    scopus 로고
    • Generation of dopaminergic neurons in vitro from human embryonic stem cells treated with neurotrophic factors
    • Park S, Lee KS, Lee YJ, et al. 2004. Generation of dopaminergic neurons in vitro from human embryonic stem cells treated with neurotrophic factors. Neurosci Lett 359:99-103.
    • (2004) Neurosci Lett , vol.359 , pp. 99-103
    • Park, S.1    Lee, K.S.2    Lee, Y.J.3
  • 46
    • 33750706917 scopus 로고    scopus 로고
    • Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes
    • Roy NS, Cleren C, Singh SK, Yang L, Beal MF, Goldman SA. 2006. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med 12:1259-1268.
    • (2006) Nat Med , vol.12 , pp. 1259-1268
    • Roy, N.S.1    Cleren, C.2    Singh, S.K.3    Yang, L.4    Beal, M.F.5    Goldman, S.A.6
  • 49
    • 62949168196 scopus 로고    scopus 로고
    • Differentiation of dopaminergic neurons from human embryonic stem cells: Modulation of differentiation by FGF-20
    • Shimada H, Yoshimura N, Tsuji A, Kunisada T. 2009. Differentiation of dopaminergic neurons from human embryonic stem cells: Modulation of differentiation by FGF-20. J Biosci Bioeng 107:447-454.
    • (2009) J Biosci Bioeng , vol.107 , pp. 447-454
    • Shimada, H.1    Yoshimura, N.2    Tsuji, A.3    Kunisada, T.4
  • 51
    • 33846904764 scopus 로고    scopus 로고
    • Enhanced yield of neuroepithelial precursors and midbrainlike dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin
    • Dayton, Ohio
    • Sonntag KC, Pruszak J, Yoshizaki T, van Arensbergen J, Sanchez-Pernaute R, Isacson O. 2007. Enhanced yield of neuroepithelial precursors and midbrainlike dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin. Stem Cells (Dayton, Ohio) 25:411-418.
    • (2007) Stem Cells , vol.25 , pp. 411-418
    • Sonntag, K.C.1    Pruszak, J.2    Yoshizaki, T.3    van Arensbergen, J.4    Sanchez-Pernaute, R.5    Isacson, O.6
  • 52
    • 0041906554 scopus 로고    scopus 로고
    • Strategies for the augmentation of grafted dopamine neuron survival
    • Sortwell CE. 2003. Strategies for the augmentation of grafted dopamine neuron survival. Front Biosci 8:s522-s532.
    • (2003) Front Biosci , vol.8
    • Sortwell, C.E.1
  • 54
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. 2006. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 57
    • 0032491416 scopus 로고    scopus 로고
    • Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. 1998. Embryonic stem cell lines derived from human blastocysts. Science (New York, NY) 282:1145-1147.
    • Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. 1998. Embryonic stem cell lines derived from human blastocysts. Science (New York, NY) 282:1145-1147.
  • 58
    • 0037246310 scopus 로고    scopus 로고
    • Systematic review of incidence studies of Parkinson's disease
    • Twelves D, Perkins KS, Counsell C. 2003. Systematic review of incidence studies of Parkinson's disease. Mov Disord 18:19-31.
    • (2003) Mov Disord , vol.18 , pp. 19-31
    • Twelves, D.1    Perkins, K.S.2    Counsell, C.3
  • 67
    • 65649116572 scopus 로고    scopus 로고
    • Yu J, Hu K, Smuga-Otto K, Tian S, Stewart R, Slukvin II, Thomson JA. 2009. Human induced pluripotent stem cells free of vector and transgene sequences. Science (New York, NY) 324:797-801.
    • Yu J, Hu K, Smuga-Otto K, Tian S, Stewart R, Slukvin II, Thomson JA. 2009. Human induced pluripotent stem cells free of vector and transgene sequences. Science (New York, NY) 324:797-801.
  • 69
    • 0035200623 scopus 로고    scopus 로고
    • In vitro differentiation of transplantable neural precursors from human embryonic stem cells
    • Zhang SC, Wernig M, Duncan ID, Brustle O, Thomson JA. 2001. In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat Biotechnol 19:1129-1133.
    • (2001) Nat Biotechnol , vol.19 , pp. 1129-1133
    • Zhang, S.C.1    Wernig, M.2    Duncan, I.D.3    Brustle, O.4    Thomson, J.A.5
  • 70
    • 73349101833 scopus 로고    scopus 로고
    • Embryonic stem cells with GFP knocked into the dopamine transporter yield purified dopamine neurons in vitro and from knock-in mice
    • Dayton, Ohio, Epub ahead of print
    • Zhou W, Lee YM, Guy VC, Freed CR. 2009. Embryonic stem cells with GFP knocked into the dopamine transporter yield purified dopamine neurons in vitro and from knock-in mice. Stem Cells (Dayton, Ohio) [Epub ahead of print].
    • (2009) Stem Cells
    • Zhou, W.1    Lee, Y.M.2    Guy, V.C.3    Freed, C.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.