PET imaging of the gastrointestinal absorption of orally administered drugs in conscious and anesthetized rats

Journal of Nuclear Medicine

Volumn 52, Issue 2, 2011, Pages 249-256

  Yamashita, Shinji ^a   Takashima, Tadayuki ^b   Kataoka, Makoto ^a   Oh, Hiroyuki ^a   Sakuma, Shinji ^a   Takahashi, Masayuki ^c   Suzuki, Norio ^c   Hayashinaka, Emi ^b   Wada, Yasuhiro ^b   Cui, Yilong ^b   Watanabe, Yasuyoshi ^b  

^a SETSUNAN UNIVERSITY   (Japan)

^b RIKEN   (Japan)

^c DAIICHI SANKYO CO   (Japan)

Author keywords

Gastrointestinal drug absorption; Molecular imaging; Positron emission tomography (PET)

Indexed keywords

ESCAIN; FLUORODEOXYGLUCOSE; FLUORODEOXYGLUCOSE F 18; ISOFLURANE; NITROUS OXIDE PLUS OXYGEN; PROPOFOL; PROPOFOL HOSPIRA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG PENETRATION; GASTROINTESTINAL ABSORPTION; IMAGE ANALYSIS; INTESTINE ABSORPTION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; STOMACH EMPTYING;

ALGORITHMS; ANESTHESIA; ANIMALS; CONSCIOUSNESS; FLUORODEOXYGLUCOSE F18; GASTRIC EMPTYING; IMAGE PROCESSING, COMPUTER-ASSISTED; INTESTINAL ABSORPTION; INTESTINES; MALE; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; STOMACH;

EID: 79851501697     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.110.081539     Document Type: Article

References (25)

1. Hidalgo IJ, Raub TJ, Borchardt RT. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology. 1989;96:736-749. (Pubitemid 19057595)
2. Salphati L, Childers K, Pan L, Tsutsui K, Takahashi L. Evaluation of a single-pass intestinal-perfusion method in rat for the prediction of absorption in man. J Pharm Pharmacol. 2001;53:1007-1013. (Pubitemid 32640284)
3. Artursson P, Karlsson J. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Commun. 1991;175:880-885.
4. Irvine JD, Takahashi L, Lockhart K, et al. MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening. J Pharm Sci. 1999;88:28-33. (Pubitemid 29037364)
5. Dressman JB, Amidon GL, Reppas C, Shah VP. Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms. Pharm Res. 1998;15:11-22. (Pubitemid 28080861)
6. Dressman JB, Reppas C. In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs. Eur J Pharm Sci. 2000;11(suppl):S73-S80.
7. Hatanaka S, Kondoh M, Kawarabayashi K, Furuhama K. The measurement of gastric emptying in conscious rats by monitoring serial changes in serum acetaminophen level. J Pharmacol Toxicol Methods. 1994;31:161-165. (Pubitemid 24195219)
8. Azad Khan AK, Piris J, Truelove SC. An experiment to determine the active therapeutic moiety of sulphasalazine. Lancet. 1977;2:892-895.
9. Murata K, Noda K, Kohno K, Samejima M. Pharmacokinetic analysis of concentration data of drugs with irregular absorption profiles using multi-fraction absorption models. J Pharm Sci. 1987;76:109-113. (Pubitemid 17043675)
10. Riker A, Libutti SK, Bartlett DL. Advances in the early detection, diagnosis, and staging of pancreatic cancer. Surg Oncol. 1997;6:157-169. (Pubitemid 28119140)
11. 18F] FDG positron emission tomography. J Comput Assist Tomogr. 1990;14:370-374.
12. Bares R, Klever P, Hauptmann S, et al. F-18 fluorodeoxyglucose PET in vivo evaluation of pancreatic glucose metabolism for detection of pancreatic cancer. Radiology. 1994;192:79-86. (Pubitemid 24191522)
13. Guide for the Care and Use of Laboratory Animals. Washington, DC: Government Printing Office; 1985; NIH publication 86-23.
14. Yamaoka K, Tanigawara Y, Nakagawa T, Uno T. A pharmacokinetic analysis program (multi) for microcomputer. J Pharmacobiodyn. 1981;4:879-885. (Pubitemid 12174128)
15. Fagerholm U, Lindahl A, Lennernäs H. Regional intestinal permeability in rats of compounds with different physicochemical properties and transport mechanisms. J Pharm Pharmacol. 1997;49:687-690. (Pubitemid 27341714)
16. Ikumi Y, Kida T, Sakuma S, Yamashita S, Akashi M. Polymer-phloridzin conjugates as an anti-diabetic drug that inhibits glucose absorption through the Na+/glucose cotransporter (SGLT1) in the small intestine. J Control Release. 2008;125:42-49. (Pubitemid 350198679)
17. Takano A, Kusuhara H, Suhara T, et al. Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using 11C-verapamil. J Nucl Med. 2006;47:1427-1433. (Pubitemid 47544927)
18. Zoghbi SS, Liow JS, Yasuno F, et al. 11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux. J Nucl Med. 2008;49:649-656. (Pubitemid 351520614)
19. Kimura T, Higaki K. Gastrointestinal transit and drug absorption. Biol Pharm Bull. 2002;25:149-164. (Pubitemid 39592096)
20. 14C-polyethylene glycol (PEG) 4000. Pharm Res. 1993;10:130-135.
21. Sawamoto T, Haruta S, Kurosaki Y, Higaki K, Kimura T. Prediction of the plasma concentration profiles of orally administered drugs in rats on the basis of gastrointestinal transit kinetics and absorbability. J Pharm Pharmacol. 1997;49:450-457. (Pubitemid 27207703)
22. Thorens B. Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes. Am J Physiol. 1996;270:G541-G553.
23. Silverman M. Glucose transport in the kidney. Biochim Biophys Acta. 1976;457:303-351.
24. Kleinzeller A, McAvoy EM, McKibbin RD. Active renal hexose transport: structural requirements. Biochim Biophys Acta. 1980;600:513-529. (Pubitemid 10023561)
25. Torjman MC, Joseph JI, Munsick C, Morishita M, Grunwald Z. Effects of isoflurane on gastrointestinal motility after brief exposure in rats. Int J Pharm. 2005;294:65-71. (Pubitemid 40462323)