메뉴 건너뛰기




Volumn 34, Issue 9, 2013, Pages 1984-1993

FEZF2, a novel 3p14 tumor suppressor gene, represses oncogene EZH2 and MDM2 expression and is frequently methylated in nasopharyngeal carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; FEZ FAMILY ZINC FINGER 2 PROTEIN; HISTONE DEACETYLASE; PROTEIN MDM2; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

EID: 84886997326     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt165     Document Type: Article
Times cited : (44)

References (48)
  • 1
    • 0037370476 scopus 로고    scopus 로고
    • The genetics and genomics of cancer
    • Balmain, A. et al. (2003) The genetics and genomics of cancer. Nat. Genet., 33, 238-244.
    • (2003) Nat. Genet. , vol.33 , pp. 238-244
    • Balmain, A.1
  • 2
    • 33644846509 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat
    • Baylin, S.B. et al. (2006) Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat. Rev. Cancer, 6, 107-116.
    • (2006) Rev. Cancer , vol.6 , pp. 107-116
    • Baylin, S.B.1
  • 3
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein, B. et al. (2004) Cancer genes and the pathways they control. Nat. Med., 10, 789-799.
    • (2004) Nat. Med. , vol.10 , pp. 789-799
    • Vogelstein, B.1
  • 4
    • 34548631786 scopus 로고    scopus 로고
    • Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments
    • Tao, Q. et al. (2007) Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments. Expert Rev. Mol. Med., 9, 1-24.
    • (2007) Expert Rev. Mol. Med. , vol.9 , pp. 1-24
    • Tao, Q.1
  • 5
    • 84863541457 scopus 로고    scopus 로고
    • Recurrent hemizygous deletions in cancers may optimize proliferative potential
    • Solimini, N.L. et al. (2012) Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science, 337, 104-109.
    • (2012) Science , vol.337 , pp. 104-109
    • Solimini, N.L.1
  • 6
    • 0037037787 scopus 로고    scopus 로고
    • Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers
    • Zabarovsky, E.R. et al. (2002) Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers. Oncogene, 21, 6915-6935.
    • (2002) Oncogene , vol.21 , pp. 6915-6935
    • Zabarovsky, E.R.1
  • 7
    • 0028834114 scopus 로고
    • Frequent microsatellite alterations on chromosome 3p in esophageal squamous cell carcinoma
    • Ogasawara, S. et al. (1995) Frequent microsatellite alterations on chromosome 3p in esophageal squamous cell carcinoma. Cancer Res., 55, 891-894.
    • (1995) Cancer Res , vol.55 , pp. 891-894
    • Ogasawara, S.1
  • 8
    • 0034813489 scopus 로고    scopus 로고
    • Chromosome 3p allele loss in early invasive breast cancer: detailed mapping and association with clinicopathological features
    • Martinez, A. et al. (2001) Chromosome 3p allele loss in early invasive breast cancer: detailed mapping and association with clinicopathological features. Mol. Pathol., 54, 300-306.
    • (2001) Mol. Pathol. , vol.54 , pp. 300-306
    • Martinez, A.1
  • 9
    • 84983724119 scopus 로고    scopus 로고
    • Definition of three minimal deleted regions by comprehensive allelotyping and mutational screening of FHIT, p16(INK4A), and p19(ARF) genes in nasopharyngeal carcinoma
    • Ko, J.Y. et al. (2002) Definition of three minimal deleted regions by comprehensive allelotyping and mutational screening of FHIT, p16(INK4A), and p19(ARF) genes in nasopharyngeal carcinoma. Cancer, 94, 1987-1996.
    • (2002) Cancer , vol.94 , pp. 1987-1996
    • Ko, J.Y.1
  • 10
    • 54249092901 scopus 로고    scopus 로고
    • Functional analysis of a cell cycle-associated, tumor-suppressive gene, protein tyrosine phosphatase receptor type G, in nasopharyngeal carcinoma
    • Cheung, A.K. et al. (2008) Functional analysis of a cell cycle-associated, tumor-suppressive gene, protein tyrosine phosphatase receptor type G, in nasopharyngeal carcinoma. Cancer Res., 68, 8137-8145.
    • (2008) Cancer Res , vol.68 , pp. 8137-8145
    • Cheung, A.K.1
  • 11
    • 77954352573 scopus 로고    scopus 로고
    • Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis
    • Lo, P.H. et al. (2010) Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis. Cancer Res., 70, 5567-5576.
    • (2010) Cancer Res , vol.70 , pp. 5567-5576
    • Lo, P.H.1
  • 12
    • 0035872408 scopus 로고    scopus 로고
    • High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma
    • Lo, K.W. et al. (2001) High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma. Cancer Res., 61, 3877-3881.
    • (2001) Cancer Res , vol.61 , pp. 3877-3881
    • Lo, K.W.1
  • 13
    • 1842583637 scopus 로고    scopus 로고
    • Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma
    • Wong, T.S. et al. (2004) Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma. Clin. Cancer Res., 10, 2401-2406.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2401-2406
    • Wong, T.S.1
  • 14
    • 2942737278 scopus 로고    scopus 로고
    • The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma
    • Qiu, G.H. et al. (2004) The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. Oncogene, 23, 4793-4806.
    • (2004) Oncogene , vol.23 , pp. 4793-4806
    • Qiu, G.H.1
  • 15
    • 67650070519 scopus 로고    scopus 로고
    • Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer
    • Hu, X.T. et al. (2009) Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer. Oncogene, 28, 2466-2475.
    • (2009) Oncogene , vol.28 , pp. 2466-2475
    • Hu, X.T.1
  • 17
    • 0034191909 scopus 로고    scopus 로고
    • Cloning and expression of a novel zinc finger gene, Fez, transcribed in the forebrain of Xenopus and mouse embryos
    • Matsuo-Takasaki, M. et al. (2000) Cloning and expression of a novel zinc finger gene, Fez, transcribed in the forebrain of Xenopus and mouse embryos. Mech. Dev., 93, 201-204.
    • (2000) Mech. Dev. , vol.93 , pp. 201-204
    • Matsuo-Takasaki, M.1
  • 18
    • 0037223399 scopus 로고    scopus 로고
    • Zinc finger protein too few controls the development of monoaminergic neurons
    • Levkowitz, G. et al. (2003) Zinc finger protein too few controls the development of monoaminergic neurons. Nat. Neurosci., 6, 28-33.
    • (2003) Nat. Neurosci. , vol.6 , pp. 28-33
    • Levkowitz, G.1
  • 19
    • 0035281647 scopus 로고    scopus 로고
    • A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression
    • Yang, Z. et al. (2001) A zebrafish forebrain-specific zinc finger gene can induce ectopic dlx2 and dlx6 expression. Dev. Biol., 231, 138-148.
    • (2001) Dev. Biol. , vol.231 , pp. 138-148
    • Yang, Z.1
  • 20
    • 77958543720 scopus 로고    scopus 로고
    • Fezf2 directs the differentiation of corticofugal neurons from striatal progenitors in vivo
    • Rouaux, C. et al. (2010) Fezf2 directs the differentiation of corticofugal neurons from striatal progenitors in vivo. Nat. Neurosci., 13, 1345-1347.
    • (2010) Nat. Neurosci. , vol.13 , pp. 1345-1347
    • Rouaux, C.1
  • 21
    • 77952172670 scopus 로고    scopus 로고
    • Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain
    • Shimizu, T. et al. (2010) Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain. Development, 137, 1875-1885.
    • (2010) Development , vol.137 , pp. 1875-1885
    • Shimizu, T.1
  • 22
    • 29144503953 scopus 로고    scopus 로고
    • Zfp312 is required for subcortical axonal projections and dendritic morphology of deep-layer pyramidal neurons of the cerebral cortex
    • Chen, J.G. et al. (2005) Zfp312 is required for subcortical axonal projections and dendritic morphology of deep-layer pyramidal neurons of the cerebral cortex. Proc. Natl Acad. Sci. USA, 102, 17792-17797.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 17792-17797
    • Chen, J.G.1
  • 23
    • 28044463122 scopus 로고    scopus 로고
    • Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex
    • Chen, B. et al. (2005) Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. Proc. Natl Acad. Sci. USA, 102, 17184-17189.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 17184-17189
    • Chen, B.1
  • 24
    • 84861932338 scopus 로고    scopus 로고
    • Cis-regulatory control of corticospinal system development and evolution
    • Shim, S. et al. (2012) Cis-regulatory control of corticospinal system development and evolution. Nature, 486, 74-79.
    • (2012) Nature , vol.486 , pp. 74-79
    • Shim, S.1
  • 25
    • 63849168932 scopus 로고    scopus 로고
    • Formation and patterning of the forebrain and olfactory system by zinc-finger genes Fezf1 and Fezf2
    • Shimizu, T. et al. (2009) Formation and patterning of the forebrain and olfactory system by zinc-finger genes Fezf1 and Fezf2. Dev. Growth Differ., 51, 221-231.
    • (2009) Dev. Growth Differ. , vol.51 , pp. 221-231
    • Shimizu, T.1
  • 26
    • 65949113236 scopus 로고    scopus 로고
    • Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene
    • Song, I.S. et al. (2009) Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene. Cancer Res., 69, 3131-3139.
    • (2009) Cancer Res , vol.69 , pp. 3131-3139
    • Song, I.S.1
  • 27
    • 52049115449 scopus 로고    scopus 로고
    • OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation
    • Cui, Y. et al. (2008) OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation. PLoS One, 3, e2990.
    • (2008) PLoS One , vol.3
    • Cui, Y.1
  • 28
    • 77955728660 scopus 로고    scopus 로고
    • KRAB zinc finger protein ZNF382 is a proapoptotic tumor suppressor that represses multiple oncogenes and is commonly silenced in multiple carcinomas
    • Cheng, Y. et al. (2010) KRAB zinc finger protein ZNF382 is a proapoptotic tumor suppressor that represses multiple oncogenes and is commonly silenced in multiple carcinomas. Cancer Res., 70, 6516-6526.
    • (2010) Cancer Res , vol.70 , pp. 6516-6526
    • Cheng, Y.1
  • 29
    • 0037067180 scopus 로고    scopus 로고
    • Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenes
    • Tsao, S.W. et al. (2002) Establishment of two immortalized nasopharyngeal epithelial cell lines using SV40 large T and HPV16E6/E7 viral oncogenes. Biochim. Biophys. Acta, 1590, 150-158.
    • (2002) Biochim. Biophys. Acta , vol.1590 , pp. 150-158
    • Tsao, S.W.1
  • 30
    • 0033799515 scopus 로고    scopus 로고
    • Expression of Epstein-Barr virus lytic gene BRLF1 in nasopharyngeal carcinoma: potential use in diagnosis
    • Feng, P. et al. (2000) Expression of Epstein-Barr virus lytic gene BRLF1 in nasopharyngeal carcinoma: potential use in diagnosis. J. Gen. Virol., 81(Pt 10), 2417-2423.
    • (2000) J. Gen. Virol. , vol.81 , Issue.PART 10 , pp. 2417-2423
    • Feng, P.1
  • 31
    • 80555154347 scopus 로고    scopus 로고
    • The epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling and is frequently silenced in multiple tumors
    • Shu, X.S. et al. (2011) The epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling and is frequently silenced in multiple tumors. PLoS One, 6, e27346.
    • (2011) PLoS One , vol.6
    • Shu, X.S.1
  • 32
    • 33244483580 scopus 로고    scopus 로고
    • Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation
    • Ying, J. et al. (2006) Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation. Oncogene, 25, 1070-1080.
    • (2006) Oncogene , vol.25 , pp. 1070-1080
    • Ying, J.1
  • 33
    • 0036712913 scopus 로고    scopus 로고
    • Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells
    • Tao, Q. et al. (2002) Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells. Hum. Mol. Genet., 11, 2091-2102.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 2091-2102
    • Tao, Q.1
  • 34
    • 77953099661 scopus 로고    scopus 로고
    • The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma
    • Li, L. et al. (2010) The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma. Clin. Cancer Res., 16, 2949-2958.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 2949-2958
    • Li, L.1
  • 35
    • 84865417923 scopus 로고    scopus 로고
    • The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/beta-catenin signaling and silenced in common carcinomas
    • Li, L. et al. (2011) The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/beta-catenin signaling and silenced in common carcinomas. Oncogene, 23, 3901-3912.
    • (2011) Oncogene , vol.23 , pp. 3901-3912
    • Li, L.1
  • 36
    • 79956328426 scopus 로고    scopus 로고
    • Genomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes
    • Chen, L. et al. (2011) Genomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes. J. Biol. Chem., 286, 18641-18649.
    • (2011) J. Biol. Chem. , vol.286 , pp. 18641-18649
    • Chen, L.1
  • 37
    • 24944545948 scopus 로고    scopus 로고
    • Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13
    • Hui, A.B. et al. (2005) Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma. Cancer Res., 65, 8125-8133.
    • (2005) 3 in nasopharyngeal carcinoma. Cancer Res. , vol.65 , pp. 8125-8133
    • Hui, A.B.1
  • 39
    • 0038793721 scopus 로고    scopus 로고
    • Cancer and the FRA3B/FHIT fragile locus: it's a HIT
    • Huebner, K. et al. (2003) Cancer and the FRA3B/FHIT fragile locus: it's a HIT. Br. J. Cancer, 88, 1501-1506.
    • (2003) Br. J. Cancer , vol.88 , pp. 1501-1506
    • Huebner, K.1
  • 40
    • 79551484520 scopus 로고    scopus 로고
    • A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma
    • Loyo, M. et al. (2011) A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma. Int. J. Cancer, 128, 1393-1403.
    • (2011) Int. J. Cancer , vol.128 , pp. 1393-1403
    • Loyo, M.1
  • 41
    • 78449284644 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase receptor type {gamma} is a functional tumor suppressor gene specifically downregulated in chronic myeloid leukemia
    • Della Peruta, M. et al. (2010) Protein tyrosine phosphatase receptor type {gamma} is a functional tumor suppressor gene specifically downregulated in chronic myeloid leukemia. Cancer Res., 70, 8896-8906.
    • (2010) Cancer Res , vol.70 , pp. 8896-8906
    • Della Peruta, M.1
  • 42
    • 77955071133 scopus 로고    scopus 로고
    • Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells
    • Shu, S.T. et al. (2010) Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells. Anticancer Res., 30, 1937-1946.
    • (2010) Anticancer Res , vol.30 , pp. 1937-1946
    • Shu, S.T.1
  • 44
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones, P.A. et al. (2002) The fundamental role of epigenetic events in cancer. Nat. Rev. Genet., 3, 415-428.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 415-428
    • Jones, P.A.1
  • 45
    • 22844457491 scopus 로고    scopus 로고
    • DNA methylation and human disease
    • Robertson, K.D. (2005) DNA methylation and human disease. Nat. Rev. Genet., 6, 597-610.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 597-610
    • Robertson, K.D.1
  • 46
    • 84868592742 scopus 로고    scopus 로고
    • Chromatin regulators with tumor suppressor properties and their alterations in human cancers
    • Shu, X.S. et al. (2012) Chromatin regulators with tumor suppressor properties and their alterations in human cancers. Epigenomics, 4, 537-549.
    • (2012) Epigenomics , vol.4 , pp. 537-549
    • Shu, X.S.1
  • 47
    • 1642377561 scopus 로고    scopus 로고
    • ONCOMINE: a cancer microarray database and integrated data-mining platform
    • Rhodes, D.R. et al. (2004) ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia, 6, 1-6.
    • (2004) Neoplasia , vol.6 , pp. 1-6
    • Rhodes, D.R.1
  • 48
    • 79959426070 scopus 로고    scopus 로고
    • Human ZNF312b oncogene is regulated by Sp1 binding to its promoter region through DNA demethylation and histone acetylation in gastric cancer
    • Song, I.S. et al. (2011) Human ZNF312b oncogene is regulated by Sp1 binding to its promoter region through DNA demethylation and histone acetylation in gastric cancer. Int. J. Cancer, 129, 2124-2133.
    • (2011) Int. J. Cancer , vol.129 , pp. 2124-2133
    • Song, I.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.