Pocket proteins pRb and p107 are required for cortical lamination independent of apoptosis

Developmental Biology

Volumn 384, Issue 1, 2013, Pages 101-113

  Svoboda, D S ^a   Paquin, A ^b,c   Park, D S ^a   Slack, R S ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cell cycle; Pocket proteins; Radial migration; Retinoblastoma

Indexed keywords

PROTEIN BAX; PROTEIN P107; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN NERVE CELL; CELL MIGRATION; CELL POPULATION; FEMALE; MALE; MOLECULAR MECHANICS; MOUSE; NERVE CELL DIFFERENTIATION; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; REGULATORY MECHANISM; WILD TYPE;

EID: 84886949543     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2013.09.015     Document Type: Article

References (42)

1. Andrusiak M.G., McClellan K.A., Dugal-Tessier D., Julian L.M., Rodrigues S.P., Park D.S., Kennedy T.E., Slack R.S. Rb/E2F regulates expression of neogenin during neuronal migration. Mol. Cell. Biol. 2011, 31:238-247.
2. Andrusiak M.G., Vandenbosch R., Park D.S., Slack R.S. The retinoblastoma protein is essential for survival of postmitotic neurons. J. Neurosci. 2012, 32:14809-14814.
3. Berman S.D., West J.C., Danielian P.S., Caron A.M., Stone J.R., Lees J.A. Mutation of p107 exacerbates the consequences of Rb Loss in embryonic tissues and causes cardiac and blood vessel defects. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:14932-14936.
4. Britanova O., de Juan Romero C., Cheung A., Kwan K.Y., Schwark M., Gyorgy A., Vogel T., Akopov S., Mitkovski M., Agoston D., Sestan N., Molnar Z., Tarabykin V. Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. Neuron 2008, 57:378-392.
5. Chen D., Chen Y., Forrest D., Bremner R. E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3. Cell Death. Differ. 2013, 20:931-940.
6. Chen D., Livne-bar I., Vanderluit J.L., Slack R.S., Agochiya M., Bremner R. Cell-specific effects of RB Or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma. Cancer Cell 2004, 5:539-551.
7. Chen D., Opavsky R., Pacal M., Tanimoto N., Wenzel P., Seeliger M.W., Leone G., Bremner R. Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a. PLoS Biol. 2007, 5:e179.
8. Ciavarra G., Zacksenhaus E. Rescue of myogenic defects in Rb-deficient cells by inhibition of autophagy or by hypoxia-induced glycolytic shift. J. Cell Biol. 2010, 191:291-301.
9. Feddersen R.M., Clark H.B., Yunis W.S., Orr H.T. In vivo viability of postmitotic purkinje neurons requires pRb family member function. Mol. Cell. Neurosci. 1995, 6:153-167.
10. Ferguson K.L., McClellan K.A., Vanderluit J.L., McIntosh W.C., Schuurmans C., Polleux F., Slack R.S. A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration. EMBO J. 2005, 24:4381-4391.
11. Ferguson K.L., Slack R.S. The Rb pathway in neurogenesis. Neuroreport 2001, 12:A55-62.
12. Ferguson, K.L., Vanderluit, J.L., Hebert, J.M., McIntosh, W.C., Tibbo, E., MacLaurin, J.G., Park, D.S., Wallace, V.A., Vooijs, M., McConnell, S.K., Slack, R.S., 2002. Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development, EMBO J. 21, 3337-3346.
13. Ferland R.J., Cherry T.J., Preware P.O., Morrisey E.E., Walsh C.A. Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain. J. Comp. Neurol. 2003, 460:266-279.
14. Garcia-Moreno F., Lopez-Mascaraque L., De Carlos J.A. Origins and migratory routes of murine cajal-retzius cells. J. Comp. Neurol. 2007, 500:419-432.
15. Gavathiotis E., Reyna D.E., Bellairs J.A., Leshchiner E.S., Walensky L.D. Direct and selective small-molecule activation of proapoptotic BAX. Nat. Chem. Biol. 2012, 8:639-645.
16. Ghanem N., Andrusiak M.G., Svoboda D., Al Lafi S.M., Julian L.M., McClellan K.A., De Repentigny Y., Kothary R., Ekker M., Blais A., Park D.S., Slack R.S. The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster. J. Neurosci. 2012, 32:8219-8230.
17. Giacinti C., Giordano A. RB and cell cycle progression. Oncogene 2006, 25:5220-5227.
18. Gordon G.M., Du W. Conserved RB functions in development and tumor suppression. Protein Cell 2011, 2:864-878.
19. Haigis K., Sage J., Glickman J., Shafer S., Jacks T. The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. J. Biol. Chem. 2006, 281:638-647.
20. Hevner R.F., Shi L., Justice N., Hsueh Y., Sheng M., Smiga S., Bulfone A., Goffinet A.M., Campagnoni A.T., Rubenstein J.L. Tbr1 regulates differentiation of the preplate and layer 6. Neuron 2001, 29:353-366.
21. Honda T., Kobayashi K., Mikoshiba K., Nakajima K. Regulation of cortical neuron migration by the reelin signaling Pathway. Neurochem. Res. 2011, 36:1270-1279.
22. Jacks T., Fazeli A., Schmitt E.M., Bronson R.T., Goodell M.A., Weinberg R.A. Effects of an Rb mutation in the mouse. Nature 1992, 359:295-300.
23. Lazzerini Denchi E., Helin K. E2F1 is crucial for E2F-dependent apoptosis. EMBO Rep. 2005, 6:661-668.
24. LeCouter J.E., Kablar B., Hardy W.R., Ying C., Megeney L.A., May L.L., Rudnicki M.A. Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene. Mol. Cell. Biol. 1998, 18:7455-7465.
25. Lee E.Y., Hu N., Yuan S.S., Cox L.A., Bradley A., Lee W.H., Herrup K. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev. 1994, 8:2008-2021.
26. Macleod K.F., Hu Y., Jacks T. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J. 1996, 15:6178-6188.
27. MacPherson D., Sage J., Kim T., Ho D., McLaughlin M.E., Jacks T. Cell type-specific effects of Rb deletion in the murine retina. Genes Dev. 2004, 18:1681-1694.
28. Manning A.L., Dyson N.J. RB: Mitotic implications of a tumour suppressor. Nat. Rev. Cancer 2012, 12:220-226.
29. Marino S., Hoogervoorst D., Brandner S., Berns A. Rb and p107 are required for normal cerebellar development and granule Cell Survival but not for purkinje cell persistence. Development 2003, 130:3359-3368.
30. Marino S., Vooijs M., van Der Gulden H., Jonkers J., Berns A. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 2000, 14:994-1004.
31. McClellan K.A., Ruzhynsky V.A., Douda D.N., Vanderluit J.L., Ferguson K.L., Chen D., Bremner R., Park D.S., Leone G., Slack R.S. Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions. Mol. Cell. Biol. 2007, 27:4825-4843.
32. McClellan K.A., Slack R.S. Novel functions for cell cycle genes in nervous system development. Cell Cycle 2006, 5:1506-1513.
33. Nguyen L., Besson A., Heng J.I., Schuurmans C., Teboul L., Parras C., Philpott A., Roberts J.M., Guillemot F. P27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes Dev. 2006, 20:1511-1524.
34. Nieto M., Monuki E.S., Tang H., Imitola J., Haubst N., Khoury S.J., Cunningham J., Gotz M., Walsh C.A. Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex. J. Comp. Neurol. 2004, 479:168-180.
35. Nowakowski R.S., Caviness V.S., Takahashi T., Hayes N.L. Population dynamics during cell proliferation and neuronogenesis in the developing murine neocortex. Results Probl. Cell Differ. 2002, 39:1-25.
36. Padmanabhan J., Park D.S., Greene L.A., Shelanski M.L. Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis. J. Neurosci. 1999, 19:8747-8756.
37. Sage C., Huang M., Vollrath M.A., Brown M.C., Hinds P.W., Corey D.P., Vetter D.E., Chen Z.Y. Essential role of retinoblastoma protein in mammalian hair cell development and hearing. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:7345-7350.
38. Shan B., Chang C.Y., Jones D., Lee W.H. The transcription factor E2F-1 mediates the autoregulation of rb gene expression. Mol. Cell. Biol. 1994, 14:299-309.
39. Tury A., Mairet-Coello G., DiCicco-Bloom E. The cyclin-dependent kinase inhibitor p57Kip2 regulates cell cycle exit, differentiation, and migration of embryonic cerebral cortical precursors. Cereb. Cortex 2011, 21:1840-1856.
40. Vanderluit J.L., Ferguson K.L., Nikoletopoulou V., Parker M., Ruzhynsky V., Alexson T., McNamara S.M., Park D.S., Rudnicki M., Slack R.S. P107 Regulates neural precursor cells in the mammalian brain. J Cell Biol 2004, 166:853-863.
41. Vooijs M., van der Valk M., te Riele H., Berns A. Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse. Oncogene 1998, 17:1-12.
42. Wu Z., Zheng S., Yu Q. The E2F family and the role of E2F1 in apoptosis. Int. J. Biochem. Cell Biol. 2009, 41:2389-2397.