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Volumn 17, Issue 11, 2013, Pages 1275-1285

Identification of MFG-E8 as a novel therapeutic target for diseases

Author keywords

Age related diseases; Apoptosis; Inflammatory diseases; Milk fat globule EGF factor 8; Systemic lupus erythematosus; Tumors

Indexed keywords

AMINOPHOSPHOLIPID; BETA3 INTEGRIN; BETA5 INTEGRIN; CYCLIN DEPENDENT KINASE 4; FRACTALKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 23P19; INTERLEUKIN 6; LACTADHERIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; MYELOPEROXIDASE; OSTEOPONTIN; PHOSPHATIDYLSERINE; PROTEIN BAX; PROTEIN KINASE B; RAC1 PROTEIN; SONIC HEDGEHOG PROTEIN; STAT3 PROTEIN; THIOGLYCOLIC ACID; TUMOR NECROSIS FACTOR ALPHA;

EID: 84886938887     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2013.829455     Document Type: Review
Times cited : (37)

References (75)
  • 1
    • 0036178402 scopus 로고    scopus 로고
    • Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles
    • Oshima K, Aoki N, Kato T, et al. Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles. Eur J Biochem 2002;269:1209-18
    • (2002) Eur J Biochem , vol.269 , pp. 1209-1218
    • Oshima, K.1    Aoki, N.2    Kato, T.3
  • 2
    • 77956931638 scopus 로고    scopus 로고
    • Inefficient clearance of dying cells in patients with SLE: Anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players
    • Kruse K, Janko C, Urbonaviciute V, et al. Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players. Apoptosis 2010;15:1098-113
    • (2010) Apoptosis , vol.15 , pp. 1098-1113
    • Kruse, K.1    Janko, C.2    Urbonaviciute, V.3
  • 3
    • 0037046580 scopus 로고    scopus 로고
    • Identification of a factor that links apoptotic cells to phagocytes
    • Hanayama R, Tanaka M, Miwa K, et al. Identification of a factor that links apoptotic cells to phagocytes. Nature 2002;417:182-7
    • (2002) Nature , vol.417 , pp. 182-187
    • Hanayama, R.1    Tanaka, M.2    Miwa, K.3
  • 4
    • 66149128052 scopus 로고    scopus 로고
    • SED1/MFG-E8: A bi-motif protein that orchestrates diverse cellular interactions
    • Raymond A, Ensslin MA, Shur BD. SED1/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions. J Cell Biochem 2009;106:957-66
    • (2009) J Cell Biochem , vol.106 , pp. 957-966
    • Raymond, A.1    Ensslin, M.A.2    Shur, B.D.3
  • 5
    • 82955213933 scopus 로고    scopus 로고
    • Review: Milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammation
    • Aziz M, Jacob A, Matsuda A, et al. Review: milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammation. Apoptosis 2011;16:1077-86
    • (2011) Apoptosis , vol.16 , pp. 1077-1086
    • Aziz, M.1    Jacob, A.2    Matsuda, A.3
  • 6
    • 2442637158 scopus 로고    scopus 로고
    • Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells
    • Miyasaka K, Hanayama R, Tanaka M, et al. Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells. Eur J Immunol 2004;34:1414-22
    • (2004) Eur J Immunol , vol.34 , pp. 1414-1422
    • Miyasaka, K.1    Hanayama, R.2    Tanaka, M.3
  • 7
    • 55849085357 scopus 로고    scopus 로고
    • MFG-E8 regulates microglial phagocytosis of apoptotic neurons
    • Fuller AD, Van Eldik LJ. MFG-E8 regulates microglial phagocytosis of apoptotic neurons. J Neuroimmune Pharmacol 2008;3:246-56
    • (2008) J Neuroimmune Pharmacol , vol.3 , pp. 246-256
    • Fuller, A.D.1    Van Eldik, L.J.2
  • 8
    • 84862764432 scopus 로고    scopus 로고
    • The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid beta toxicity
    • Li E, Noda M, Doi Y, et al. The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid beta toxicity. J Neuroinflammation 2012;9:148
    • (2012) J Neuroinflammation , vol.9 , pp. 148
    • Li, E.1    Noda, M.2    Doi, Y.3
  • 9
    • 4344715014 scopus 로고    scopus 로고
    • Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice
    • Asano K, Miwa M, Miwa K, et al. Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice. J Exp Med 2004;200:459-67
    • (2004) J Exp Med , vol.200 , pp. 459-467
    • Asano, K.1    Miwa, M.2    Miwa, K.3
  • 10
    • 43949172708 scopus 로고
    • Phagocyte recognition of cells undergoing apoptosis
    • Savill J, Fadok V, Henson P, et al. Phagocyte recognition of cells undergoing apoptosis. Immunol Today 1993;14:131-6
    • (1993) Immunol Today , vol.14 , pp. 131-136
    • Savill, J.1    Fadok, V.2    Henson, P.3
  • 11
    • 0029802815 scopus 로고    scopus 로고
    • Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity
    • Martin SJ, Finucane DM, Amarante-Mendes GP, et al. Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity. J Biol Chem 1996;271:28753-6
    • (1996) J Biol Chem , vol.271 , pp. 28753-28756
    • Martin, S.J.1    Finucane, D.M.2    Amarante-Mendes, G.P.3
  • 12
    • 84866455143 scopus 로고    scopus 로고
    • Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor
    • Nakahashi-Oda C, Tahara-Hanaoka S, Shoji M, et al. Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor. J Exp Med 2012;209:1493-503
    • (2012) J Exp Med , vol.209 , pp. 1493-1503
    • Nakahashi-Oda, C.1    Tahara-Hanaoka, S.2    Shoji, M.3
  • 13
    • 0034795821 scopus 로고    scopus 로고
    • Phagocyte receptors for apoptotic cells: Recognition, uptake, and consequences
    • Fadok VA, Bratton DL, Henson PM. Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences. J Clin Invest 2001;108:957-62
    • (2001) J Clin Invest , vol.108 , pp. 957-962
    • Fadok, V.A.1    Bratton, D.L.2    Henson, P.M.3
  • 14
    • 82755163551 scopus 로고    scopus 로고
    • Constitutive exposure of phosphatidylserine on viable cells
    • Segawa K, Suzuki J, Nagata S. Constitutive exposure of phosphatidylserine on viable cells. Proc Natl Acad Sci USA 2011;108:19246-51
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 19246-19251
    • Segawa, K.1    Suzuki, J.2    Nagata, S.3
  • 15
    • 0034705005 scopus 로고    scopus 로고
    • Functional analyses of two cellular binding domains of bovine lactadherin
    • Andersen MH, Graversen H, Fedosov SN, et al. Functional analyses of two cellular binding domains of bovine lactadherin. Biochemistry 2000;39:6200-6
    • (2000) Biochemistry , vol.39 , pp. 6200-6206
    • Andersen, M.H.1    Graversen, H.2    Fedosov, S.N.3
  • 16
    • 0030779146 scopus 로고    scopus 로고
    • Recognition and phagocytosis of cells undergoing apoptosis
    • Savill J. Recognition and phagocytosis of cells undergoing apoptosis. Br Med Bull 1997;53:491-508
    • (1997) Br Med Bull , vol.53 , pp. 491-508
    • Savill, J.1
  • 17
    • 0345731228 scopus 로고    scopus 로고
    • The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells
    • Akakura S, Singh S, Spataro M, et al. The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells. Exp Cell Res 2004;292:403-16
    • (2004) Exp Cell Res , vol.292 , pp. 403-416
    • Akakura, S.1    Singh, S.2    Spataro, M.3
  • 18
    • 45149087942 scopus 로고    scopus 로고
    • Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8
    • Kranich J, Krautler NJ, Heinen E, et al. Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8. J Exp Med 2008;205:1293-302
    • (2008) J Exp Med , vol.205 , pp. 1293-1302
    • Kranich, J.1    Krautler, N.J.2    Heinen, E.3
  • 19
    • 78651484733 scopus 로고    scopus 로고
    • Milk fat globule-EGF factor VIII in sepsis and ischemia-reperfusion injury
    • Matsuda A, Jacob A, Wu R, et al. Milk fat globule-EGF factor VIII in sepsis and ischemia-reperfusion injury. Mol Med 2011;17:126-33
    • (2011) Mol Med , vol.17 , pp. 126-133
    • Matsuda, A.1    Jacob, A.2    Wu, R.3
  • 20
    • 84856137936 scopus 로고    scopus 로고
    • Roles of milk fat globule-epidermal growth factor 8 in intestinal inflammation
    • Kusunoki R, Ishihara S, Aziz M, et al. Roles of milk fat globule-epidermal growth factor 8 in intestinal inflammation. Digestion 2012;85:103-7
    • (2012) Digestion , vol.85 , pp. 103-107
    • Kusunoki, R.1    Ishihara, S.2    Aziz, M.3
  • 21
    • 84863165443 scopus 로고    scopus 로고
    • Novel therapeutic targets for sepsis: Regulation of exaggerated inflammatory responses
    • Matsuda A, Jacob A, Wu R, et al. Novel therapeutic targets for sepsis: regulation of exaggerated inflammatory responses. J Nippon Med Sch 2012;79:4-18
    • (2012) J Nippon Med Sch , vol.79 , pp. 4-18
    • Matsuda, A.1    Jacob, A.2    Wu, R.3
  • 22
    • 65449117641 scopus 로고    scopus 로고
    • Maturation-induced down-regulation of MFG-E8 impairs apoptotic cell clearance and enhances endotoxin response
    • Miksa M, Amin D, Wu R, et al. Maturation-induced down-regulation of MFG-E8 impairs apoptotic cell clearance and enhances endotoxin response. Int J Mol Med 2008;22:743-8
    • (2008) Int J Mol Med , vol.22 , pp. 743-748
    • Miksa, M.1    Amin, D.2    Wu, R.3
  • 23
    • 84860476707 scopus 로고    scopus 로고
    • MFG-E8 released by apoptotic endothelial cells triggers anti-inflammatory macrophage reprogramming
    • Brissette MJ, Lepage S, Lamonde AS, et al. MFG-E8 released by apoptotic endothelial cells triggers anti-inflammatory macrophage reprogramming. PLoS One 2012;7:e36368
    • (2012) PLoS One , vol.7
    • Brissette, M.J.1    Lepage, S.2    Lamonde, A.S.3
  • 24
    • 34247524090 scopus 로고    scopus 로고
    • Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice
    • Ait-Oufella H, Kinugawa K, Zoll J, et al. Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice. Circulation 2007;115:2168-77
    • (2007) Circulation , vol.115 , pp. 2168-2177
    • Ait-Oufella, H.1    Kinugawa, K.2    Zoll, J.3
  • 25
    • 84878434348 scopus 로고    scopus 로고
    • Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages
    • Wang Q, Imamura R, Motani K, et al. Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages. Int Immunol 2013;25:363-72
    • (2013) Int Immunol , vol.25 , pp. 363-372
    • Wang, Q.1    Imamura, R.2    Motani, K.3
  • 26
    • 34447121852 scopus 로고    scopus 로고
    • MFG-E8-mediated uptake of apoptotic cells by APCs links the pro-and antiinflammatory activities of GM-CSF
    • Jinushi M, Nakazaki Y, Dougan M, et al. MFG-E8-mediated uptake of apoptotic cells by APCs links the pro-and antiinflammatory activities of GM-CSF. J Clin Invest 2007;117:1902-13
    • (2007) J Clin Invest , vol.117 , pp. 1902-1913
    • Jinushi, M.1    Nakazaki, Y.2    Dougan, M.3
  • 27
    • 67449164310 scopus 로고    scopus 로고
    • MFG-E8 attenuates intestinal inflammation in murine experimental colitis by modulating osteopontin-dependent alphavbeta3 integrin signaling
    • Aziz MM, Ishihara S, Mishima Y, et al. MFG-E8 attenuates intestinal inflammation in murine experimental colitis by modulating osteopontin-dependent alphavbeta3 integrin signaling. J Immunol 2009;182:7222-32
    • (2009) J Immunol , vol.182 , pp. 7222-7232
    • Aziz, M.M.1    Ishihara, S.2    Mishima, Y.3
  • 28
    • 84860434946 scopus 로고    scopus 로고
    • Pre-treatment of recombinant mouse MFG-E8 downregulates LPS-induced TNF-alpha production in macrophages via STAT3-mediated SOCS3 activation
    • Aziz M, Jacob A, Matsuda A, et al. Pre-treatment of recombinant mouse MFG-E8 downregulates LPS-induced TNF-alpha production in macrophages via STAT3-mediated SOCS3 activation. PLoS One 2011;6:e27685
    • (2011) PLoS One , vol.6
    • Aziz, M.1    Jacob, A.2    Matsuda, A.3
  • 29
    • 84874604501 scopus 로고    scopus 로고
    • MFGE8 inhibits inflammasome-induced IL-1beta production and limits postischemic cerebral injury
    • Deroide N, Li X, Lerouet D, et al. MFGE8 inhibits inflammasome-induced IL-1beta production and limits postischemic cerebral injury. J Clin Invest 2013;123:1176-81
    • (2013) J Clin Invest , vol.123 , pp. 1176-1181
    • Deroide, N.1    Li, X.2    Lerouet, D.3
  • 30
    • 36849003113 scopus 로고    scopus 로고
    • Milk fat globule-EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium
    • Bu HF, Zuo XL, Wang X, et al. Milk fat globule-EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium. J Clin Invest 2007;117:3673-83
    • (2007) J Clin Invest , vol.117 , pp. 3673-3683
    • Bu, H.F.1    Zuo, X.L.2    Wang, X.3
  • 31
    • 84865654826 scopus 로고    scopus 로고
    • Milk fat globule-epidermal growth factor 8 is decreased in intestinal epithelium of ulcerative colitis patients and thereby causes increased apoptosis and impaired wound healing
    • Zhao QJ, Yu YB, Zuo XL, et al. Milk fat globule-epidermal growth factor 8 is decreased in intestinal epithelium of ulcerative colitis patients and thereby causes increased apoptosis and impaired wound healing. Mol Med 2012;18:497-506
    • (2012) Mol Med , vol.18 , pp. 497-506
    • Zhao, Q.J.1    Yu, Y.B.2    Zuo, X.L.3
  • 32
    • 84865164545 scopus 로고    scopus 로고
    • Enhancing apoptotic cell clearance mitigates bacterial translocation and promotes tissue repair after gut ischemia-reperfusion injury
    • Wu R, Dong W, Wang Z, et al. Enhancing apoptotic cell clearance mitigates bacterial translocation and promotes tissue repair after gut ischemia-reperfusion injury. Int J Mol Med 2012;30:593-8
    • (2012) Int J Mol Med , vol.30 , pp. 593-598
    • Wu, R.1    Dong, W.2    Wang, Z.3
  • 33
    • 84860883438 scopus 로고    scopus 로고
    • MFG-E8 activates proliferation of vascular smooth muscle cells via integrin signaling
    • Wang M, Fu Z, Wu J, et al. MFG-E8 activates proliferation of vascular smooth muscle cells via integrin signaling. Aging Cell 2012;11:500-8
    • (2012) Aging Cell , vol.11 , pp. 500-508
    • Wang, M.1    Fu, Z.2    Wu, J.3
  • 34
    • 67650261018 scopus 로고    scopus 로고
    • Milk fat globule protein epidermal growth factor-8: A pivotal relay element within the angiotensin II and monocyte chemoattractant protein-1 signaling cascade mediating vascular smooth muscle cells invasion
    • Fu Z, Wang M, Gucek M, et al. Milk fat globule protein epidermal growth factor-8: a pivotal relay element within the angiotensin II and monocyte chemoattractant protein-1 signaling cascade mediating vascular smooth muscle cells invasion. Circ Res 2009;104:1337-46
    • (2009) Circ Res , vol.104 , pp. 1337-1346
    • Fu, Z.1    Wang, M.2    Gucek, M.3
  • 35
    • 21044455286 scopus 로고    scopus 로고
    • Lactadherin promotes VEGF-dependent neovascularization
    • Silvestre JS, Thery C, Hamard G, et al. Lactadherin promotes VEGF-dependent neovascularization. Nat Med 2005;11:499-506
    • (2005) Nat Med , vol.11 , pp. 499-506
    • Silvestre, J.S.1    Thery, C.2    Hamard, G.3
  • 36
    • 0034704174 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain
    • Borges E, Jan Y, Ruoslahti E. Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain. J Biol Chem 2000;275:39867-73
    • (2000) J Biol Chem , vol.275 , pp. 39867-39873
    • Borges, E.1    Jan, Y.2    Ruoslahti, E.3
  • 37
    • 34547131311 scopus 로고    scopus 로고
    • MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis
    • Neutzner M, Lopez T, Feng X, et al. MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis. Cancer Res 2007;67:6777-85
    • (2007) Cancer Res , vol.67 , pp. 6777-6785
    • Neutzner, M.1    Lopez, T.2    Feng, X.3
  • 38
    • 80052148658 scopus 로고    scopus 로고
    • Pericyte-derived MFG-E8 regulates pathologic angiogenesis
    • Motegi S, Leitner WW, Lu M, et al. Pericyte-derived MFG-E8 regulates pathologic angiogenesis. Arterioscler Thromb Vasc Biol 2011;31:2024-34
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 2024-2034
    • Motegi, S.1    Leitner, W.W.2    Lu, M.3
  • 39
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappaB: Linking inflammation and immunity to cancer development and progression
    • Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005;5:749-59
    • (2005) Nat Rev Immunol , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 40
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007;7:41-51
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 41
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • Naugler WE, Sakurai T, Kim S, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 2007;317:121-4
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3
  • 42
    • 41749104586 scopus 로고    scopus 로고
    • The inflammatory response to cell death
    • Rock KL, Kono H. The inflammatory response to cell death. Annu Rev Pathol 2008;3:99-126
    • (2008) Annu Rev Pathol , vol.3 , pp. 99-126
    • Rock, K.L.1    Kono, H.2
  • 43
    • 55349147987 scopus 로고    scopus 로고
    • Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment
    • Jinushi M, Nakazaki Y, Carrasco DR, et al. Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment. Cancer Res 2008;68:8889-98
    • (2008) Cancer Res , vol.68 , pp. 8889-8898
    • Jinushi, M.1    Nakazaki, Y.2    Carrasco, D.R.3
  • 44
    • 41549100208 scopus 로고    scopus 로고
    • Capitalizing on the immunogenicity of dying tumor cells
    • Fonseca C, Dranoff G. Capitalizing on the immunogenicity of dying tumor cells. Clin Cancer Res 2008;14:1603-8
    • (2008) Clin Cancer Res , vol.14 , pp. 1603-1608
    • Fonseca, C.1    Dranoff, G.2
  • 45
    • 79961074770 scopus 로고    scopus 로고
    • Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells
    • Jinushi M, Chiba S, Yoshiyama H, et al. Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells. Proc Natl Acad Sci USA 2011;108:12425-30
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 12425-12430
    • Jinushi, M.1    Chiba, S.2    Yoshiyama, H.3
  • 46
    • 84862649989 scopus 로고    scopus 로고
    • MFG-E8 regulates the immunogenic potential of dendritic cells primed with necrotic cell-mediated inflammatory signals
    • Baghdadi M, Chiba S, Yamashina T, et al. MFG-E8 regulates the immunogenic potential of dendritic cells primed with necrotic cell-mediated inflammatory signals. PLoS One 2012;7:e39607
    • (2012) PLoS One , vol.7
    • Baghdadi, M.1    Chiba, S.2    Yamashina, T.3
  • 47
    • 77952486358 scopus 로고    scopus 로고
    • Meta-analysis of TNF-alpha promoter-238A/G polymorphism and SLE susceptibility
    • Zou YF, Feng XL, Pan FM, et al. Meta-analysis of TNF-alpha promoter-238A/G polymorphism and SLE susceptibility. Autoimmunity 2010;43:264-74
    • (2010) Autoimmunity , vol.43 , pp. 264-274
    • Zou, Y.F.1    Feng, X.L.2    Pan, F.M.3
  • 48
    • 2442665179 scopus 로고    scopus 로고
    • Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice
    • Hanayama R, Tanaka M, Miyasaka K, et al. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 2004;304:1147-50
    • (2004) Science , vol.304 , pp. 1147-1150
    • Hanayama, R.1    Tanaka, M.2    Miyasaka, K.3
  • 49
    • 46949084717 scopus 로고    scopus 로고
    • Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus
    • Yamaguchi H, Takagi J, Miyamae T, et al. Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus. J Leukoc Biol 2008;83:1300-7
    • (2008) J Leukoc Biol , vol.83 , pp. 1300-1307
    • Yamaguchi, H.1    Takagi, J.2    Miyamae, T.3
  • 50
    • 79957905428 scopus 로고    scopus 로고
    • Autoimmunity in MFG-E8-deficient mice is associated with altered trafficking and enhanced cross-presentation of apoptotic cell antigens
    • Peng Y, Elkon KB. Autoimmunity in MFG-E8-deficient mice is associated with altered trafficking and enhanced cross-presentation of apoptotic cell antigens. J Clin Invest 2011;121:2221-41
    • (2011) J Clin Invest , vol.121 , pp. 2221-2241
    • Peng, Y.1    Elkon, K.B.2
  • 51
    • 84865559140 scopus 로고    scopus 로고
    • Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity
    • Miyanishi M, Segawa K, Nagata S. Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity. Int Immunol 2012;24:551-9
    • (2012) Int Immunol , vol.24 , pp. 551-559
    • Miyanishi, M.1    Segawa, K.2    Nagata, S.3
  • 52
    • 77953312484 scopus 로고    scopus 로고
    • Aberrant splicing of the milk fat globule-EGF factor 8 (MFG-E8) gene in human systemic lupus erythematosus
    • Yamaguchi H, Fujimoto T, Nakamura S, et al. Aberrant splicing of the milk fat globule-EGF factor 8 (MFG-E8) gene in human systemic lupus erythematosus. Eur J Immunol 2010;40:1778-85
    • (2010) Eur J Immunol , vol.40 , pp. 1778-1785
    • Yamaguchi, H.1    Fujimoto, T.2    Nakamura, S.3
  • 53
    • 67049160855 scopus 로고    scopus 로고
    • Genetic polymorphism in milk fat globule-EGF factor 8 (MFG-E8) is associated with systemic lupus erythematosus in human
    • Hu CY, Wu CS, Tsai HF, et al. Genetic polymorphism in milk fat globule-EGF factor 8 (MFG-E8) is associated with systemic lupus erythematosus in human. Lupus 2009;18:676-81
    • (2009) Lupus , vol.18 , pp. 676-681
    • Hu, C.Y.1    Wu, C.S.2    Tsai, H.F.3
  • 54
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007;448:427-34
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 55
    • 33847632044 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Past, present, and future
    • Sands BE. Inflammatory bowel disease: past, present, and future. J Gastroenterol 2007;42:16-25
    • (2007) J Gastroenterol , vol.42 , pp. 16-25
    • Sands, B.E.1
  • 56
    • 79957952612 scopus 로고    scopus 로고
    • Milk fat globule-EGF factor 8 is a critical protein for healing of dextran sodium sulfate-induced acute colitis in mice
    • Chogle A, Bu HF, Wang X, et al. Milk fat globule-EGF factor 8 is a critical protein for healing of dextran sodium sulfate-induced acute colitis in mice. Mol Med 2011;17:502-7
    • (2011) Mol Med , vol.17 , pp. 502-507
    • Chogle, A.1    Bu, H.F.2    Wang, X.3
  • 57
    • 84879671585 scopus 로고    scopus 로고
    • Butyric acid attenuates intestinal inflammation in murine DSS-induced colitis model via milk fat globule-EGF factor 8
    • Mishiro T, Kusunoki R, Otani A, et al. Butyric acid attenuates intestinal inflammation in murine DSS-induced colitis model via milk fat globule-EGF factor 8. Lab Invest 2013;93:834-43
    • (2013) Lab Invest , vol.93 , pp. 834-843
    • Mishiro, T.1    Kusunoki, R.2    Otani, A.3
  • 58
    • 33745587596 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis
    • Miksa M, Wu R, Dong W, et al. Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis. Shock 2006;25:586-93
    • (2006) Shock , vol.25 , pp. 586-593
    • Miksa, M.1    Wu, R.2    Dong, W.3
  • 59
    • 36849080928 scopus 로고    scopus 로고
    • Fractalkine-induced MFG-E8 leads to enhanced apoptotic cell clearance by macrophages
    • Miksa M, Amin D, Wu R, et al. Fractalkine-induced MFG-E8 leads to enhanced apoptotic cell clearance by macrophages. Mol Med 2007;13:553-60
    • (2007) Mol Med , vol.13 , pp. 553-560
    • Miksa, M.1    Amin, D.2    Wu, R.3
  • 60
    • 77952094971 scopus 로고    scopus 로고
    • Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor-factor VIII [corrected]
    • Miksa M, Wu R, Dong W, et al. Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor-factor VIII [corrected]. J Immunol 2009;183:5983-90
    • (2009) J Immunol , vol.183 , pp. 5983-5990
    • Miksa, M.1    Wu, R.2    Dong, W.3
  • 61
    • 59849099434 scopus 로고    scopus 로고
    • Milk fat globule epidermal growth factor-factor VIII is down-regulated in sepsis via the lipopolysaccharide-CD14 pathway
    • Komura H, Miksa M, Wu R, et al. Milk fat globule epidermal growth factor-factor VIII is down-regulated in sepsis via the lipopolysaccharide-CD14 pathway. J Immunol 2009;182:581-7
    • (2009) J Immunol , vol.182 , pp. 581-587
    • Komura, H.1    Miksa, M.2    Wu, R.3
  • 62
    • 80053472239 scopus 로고    scopus 로고
    • Expression and characterization of recombinant human milk fat globule-EGF factor VIII
    • Qiang X, Li J, Wu R, et al. Expression and characterization of recombinant human milk fat globule-EGF factor VIII. Int J Mol Med 2011;28:1071-6
    • (2011) Int J Mol Med , vol.28 , pp. 1071-1076
    • Qiang, X.1    Li, J.2    Wu, R.3
  • 63
    • 84859899863 scopus 로고    scopus 로고
    • Recombinant human milk fat globule-EGF factor 8 produces dose-dependent benefits in sepsis
    • Shah KG, Wu R, Jacob A, et al. Recombinant human milk fat globule-EGF factor 8 produces dose-dependent benefits in sepsis. Intensive Care Med 2012;38:128-36
    • (2012) Intensive Care Med , vol.38 , pp. 128-136
    • Shah, K.G.1    Wu, R.2    Jacob, A.3
  • 64
    • 77956020997 scopus 로고    scopus 로고
    • Milk fat globule EGF factor 8 attenuates sepsis-induced apoptosis and organ injury in alcohol-intoxicated rats
    • Wu R, Chaung WW, Zhou M, et al. Milk fat globule EGF factor 8 attenuates sepsis-induced apoptosis and organ injury in alcohol-intoxicated rats. Alcohol Clin Exp Res 2010;34:1625-33
    • (2010) Alcohol Clin Exp Res , vol.34 , pp. 1625-1633
    • Wu, R.1    Chaung, W.W.2    Zhou, M.3
  • 65
    • 84871381369 scopus 로고    scopus 로고
    • Proteomic analysis of aorta and protective effects of grape seed procyanidin B2 in db/db mice reveal a critical role of milk fat globule epidermal growth factor-8 in diabetic arterial damage
    • Yu F, Li BY, Li XL, et al. Proteomic analysis of aorta and protective effects of grape seed procyanidin B2 in db/db mice reveal a critical role of milk fat globule epidermal growth factor-8 in diabetic arterial damage. PLoS One 2012;7:e52541
    • (2012) PLoS One , vol.7
    • Yu, F.1    Li, B.Y.2    Li, X.L.3
  • 66
    • 34247894107 scopus 로고    scopus 로고
    • Evidence of a role for lactadherin in Alzheimer's disease
    • Boddaert J, Kinugawa K, Lambert JC, et al. Evidence of a role for lactadherin in Alzheimer's disease. Am J Pathol 2007;170:921-9
    • (2007) Am J Pathol , vol.170 , pp. 921-929
    • Boddaert, J.1    Kinugawa, K.2    Lambert, J.C.3
  • 67
    • 80052196437 scopus 로고    scopus 로고
    • Expression of milk fat globule epidermal growth factor-VIII may be an indicator of poor prognosis in malignant melanoma
    • Oba J, Moroi Y, Nakahara T, et al. Expression of milk fat globule epidermal growth factor-VIII may be an indicator of poor prognosis in malignant melanoma. Br J Dermatol 2011;165:506-12
    • (2011) Br J Dermatol , vol.165 , pp. 506-512
    • Oba, J.1    Moroi, Y.2    Nakahara, T.3
  • 68
    • 47149091674 scopus 로고    scopus 로고
    • Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells
    • Fens MH, Mastrobattista E, de Graaff AM, et al. Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells. Blood 2008;111:4542-50
    • (2008) Blood , vol.111 , pp. 4542-4550
    • Fens, M.H.1    Mastrobattista, E.2    De Graaff, A.M.3
  • 69
    • 84871097003 scopus 로고    scopus 로고
    • Regulation of cancer stem cell activities by tumor-associated macrophages
    • Jinushi M, Baghdadi M, Chiba S, et al. Regulation of cancer stem cell activities by tumor-associated macrophages. Am J Cancer Res 2012;2:529-39
    • (2012) Am J Cancer Res , vol.2 , pp. 529-539
    • Jinushi, M.1    Baghdadi, M.2    Chiba, S.3
  • 70
    • 67449147143 scopus 로고    scopus 로고
    • Milk fat globule epidermal growth factor-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms
    • Jinushi M, Sato M, Kanamoto A, et al. Milk fat globule epidermal growth factor-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms. J Exp Med 2009;206:1317-26
    • (2009) J Exp Med , vol.206 , pp. 1317-1326
    • Jinushi, M.1    Sato, M.2    Kanamoto, A.3
  • 71
    • 84863141913 scopus 로고    scopus 로고
    • MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation
    • Fricker M, Neher JJ, Zhao JW, et al. MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation. J Neurosci 2012;32:2657-66
    • (2012) J Neurosci , vol.32 , pp. 2657-2666
    • Fricker, M.1    Neher, J.J.2    Zhao, J.W.3
  • 72
    • 84862834884 scopus 로고    scopus 로고
    • Milk fat globule-epidermal growth factor-factor 8 attenuates neutrophil infiltration in acute lung injury via modulation of CXCR2
    • Aziz M, Matsuda A, Yang WL, et al. Milk fat globule-epidermal growth factor-factor 8 attenuates neutrophil infiltration in acute lung injury via modulation of CXCR2. J Immunol 2012;189:393-402
    • (2012) J Immunol , vol.189 , pp. 393-402
    • Aziz, M.1    Matsuda, A.2    Yang, W.L.3
  • 73
    • 84873743551 scopus 로고    scopus 로고
    • Milk fat globule-EGF factor VIII ameliorates liver injury after hepatic ischemia-reperfusion
    • Matsuda A, Jacob A, Wu R, et al. Milk fat globule-EGF factor VIII ameliorates liver injury after hepatic ischemia-reperfusion. J Surg Res 2013;180:e37-46
    • (2013) J Surg Res , vol.180
    • Matsuda, A.1    Jacob, A.2    Wu, R.3
  • 74
    • 84862726870 scopus 로고    scopus 로고
    • Milk fat globule epidermal growth factor-factor 8 mitigates inflammation and tissue injury after hemorrhagic shock in experimental animals
    • Zhang F, Shah KG, Qi L, et al. Milk fat globule epidermal growth factor-factor 8 mitigates inflammation and tissue injury after hemorrhagic shock in experimental animals. J Trauma Acute Care Surg 2012;72:861-9
    • (2012) J Trauma Acute Care Surg , vol.72 , pp. 861-869
    • Zhang, F.1    Shah, K.G.2    Qi, L.3
  • 75
    • 84872200008 scopus 로고    scopus 로고
    • The impact of MFG-E8 in chronic pancreatitis: Potential for future immunotherapy?
    • D'Haese JG, Demir IE, Kehl T, et al. The impact of MFG-E8 in chronic pancreatitis: potential for future immunotherapy? BMC Gastroenterol 2013;13:14
    • (2013) BMC Gastroenterol , vol.13 , pp. 14
    • D'Haese, J.G.1    Demir, I.E.2    Kehl, T.3


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